|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy显示文摘AIM: Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy (CRT), but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT.METHODS: The intensities of expression of p53, Ki67,Bcl-2, Bax, cyclin D1, VEGF, CDC25B, and metallothionein (MT)were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT.RESULTS: The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respomd well to CRT.CONCLUSION: Esophageal squamous cell carcinomas with negative p53,positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity,if with CDC25B positivity, CRT can be expected. | Fumiko Sunada Masayuki Itabashi Hisanao Ohkura Toshiyuki Okumura | 2005 | World Journal of Gastroenterology2005，11，36： | 13 |
| 2 | 在有类型 1 自体免疫的肝炎的日本病人的尖锐表示的 Centrilobular 坏死显示文摘 AIM:To compare clinicopathological features of acute presentation of type 1 autoimmune hepatitis(AIH) with or without centrilobular necrosis(CN).METHODS:Our study comprised 41 patients with biopsy-proven acute presentation(acute exacerbation phase 36,acute hepatitis phase 5) of type 1 AIH at our hospital from 1975 to 2009.Elevated serum alanine aminotransferase(ALT)(> 5x upper limit of normal) identified acute presentation of the disease.We compared clinicopathological features of these AIH patients with or without CN.The data used for analysis included patient background(age,sex,type of disease,presence of complications with other autoimmune diseases,human leukocyte antigen,and International Autoimmune Hepatitis Group score),clinical parameters at presentation(ALT,alkaline phosphatase,IgG,anti-nuclear antibodies,and anti-smooth muscle antibodies),histology and therapy.RESULTS:CN was found in 13(31.7%) patients with acute presentation(acute exacerbation phase 10,acute hepatitis phase 3) of AIH.Serum IgG levels of patients with CN were significantly lower than those of patients without CN(mean:2307 mg/dL vs 3126 mg/dL,P < 0.05),while antinuclear antibody-negative rates were significantly higher(30.7%vs 3.5%,P < 0.05).However,other clinical features were similar between the two groups.The frequency of advanced fibrosis in patients with CN was significantly lower than in patients without CN(F0-2:84.6% vs 35.7%,F3-4:15.4% vs 64.3%,P < 0.05).Other histological features were similar between the two groups.Although there was no significant difference between groups when evaluated using the revised original score(12 vs 14),the simplified AIH score of patients with CN was significantly lower(6 vs 7,P < 0.05).Frequency of DR4 was similar between patients with and without CN.CONCLUSION:CN is observed in both Japanese patients with acute hepatitis phase and acute exacerbation phase of type 1 AIH,although AIH with CN often shows clinical features of the genuine acute form. | Kazumichi Abe Yukiko Kanno Ken Okai Fumiko Katsushima Kyoko Monoe Hironobu Saito Atsushi Takahashi Junko Yokokawa Hiromasa Ohira | 2012 | World Journal of Hepatology2012，4，9： | 5 |
| 3 | A Study of Mechanization of Cotton Harvesting in India and Its Implications显示文摘 | Srinivasa Konduru Fumiko Yamazaki Mechel Paggi | 2013 | Journal of Agricultural Science and Technology(B)2013，3，11： | 3 |
| 4 | 中国内蒙自治区马饲育环境土壤中马红球菌的分布(英文)显示文摘对中国内蒙古自治区饲育马土壤环境中马红球菌的分布知之甚少;为此,在中国内蒙古通辽近郊、内蒙古南部锡林郭勒盟大草原、内蒙古东部呼伦贝尔大草原等马场共收集了108份土壤样品进行了马红球菌的检测。结果,锡林郭勒盟大草原和呼伦贝尔大草原的马红球菌分离率为25.9%~30.0%,通辽近郊土壤中分离率高达82.3%。这说明在通辽近郊马红球菌的分离菌数是草原土壤中马红球菌分离菌数的10倍。应用PCR技术检测了488株的毒力相关基因,相对分子质量分别为15000~17000(VapA)和20000(VapB)。所有的分离株都未检出毒力相关基因。这些无毒力分离株的质粒资料显示,各种大小的潜在质粒的发生率为13.3%~21.5%。本研究结果截然不同于我们新近对蒙古国的调查结论:马红球菌在蒙古国乌兰巴托的马群中不存在。造成这一差异的原因可能在于蒙古国的游牧生活和内蒙古的非游牧生活。 | 丁壮 Shinji TAKAI Hiroo MADARAME 常爽 黄海楠 霍晓伟 高明华 谭忠田 高双成 Fumiko HATORI Yukako SASAKI Tsutomu KAKUDA Shiro TSUBAKI | 2008 | 中国兽医学报2008，28，1： | 3 |
| 5 | OBSERVATION ON THE EFFECTS OF CHINESE MEDICINE ZHENXUANYIN FOR IMPROVING CEREBRAL BLOOD FLOW IN RATS WITH CEREBRAL ISCHEMIA显示文摘Zhenxuanyin (镇眩饮) is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes’ complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03g kg, 0.3g kg, Ig kg, or 3g/ kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3g/ kg can increase cerebral blood flow (CBF) to the normal level. | 王静怡 Yasuhiro Magata Naoya Hattori Yoshiharu Yonekura Nagara Tamaki Fumiko Tanaka Junji Konishi Seok Rye Choi Shigeru Matsuzaki | 1997 | Journal of Traditional Chinese Medicine1997，17，4： | 2 |
| 6 | Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study显示文摘瞄准:进行一个双窗帘,控制安慰剂使随机化并且评估 Ganoderma 的摘录的安全和功效的变化剂量的学习易懂嗯(G。易懂嗯) 在有更低的泌尿道症状(LUTS ) 的人。方法:我们注册了男志愿者(≥ 50 年) 与一个国际前列腺症状分数(IPSS;问题 1-7 ) ≥ 5 并且前列腺特定的抗原(PSA ) 价值 <
4 ng/mL。志愿者被使随机化进一些安慰剂(n = 12 ) , G。易懂 0.6 mg 的 um (n = 12 ) , 6 mg (n = 12 ) 或 60 mg (n = 14 ) ,管理从前每日。功效在 IPSS 和山峰尿流动率(Q_( 最大)) 从基线作为一个变化被测量。前列腺体积和残余尿被 ultrasonography 估计,并且包括 PSA 层次,验血在基线并且在处理的结束被测量。结果:全面管理很好被容忍,没有主要不利效果。在在试验性的组之间的变化的大小的统计意义在星期被观察 4 和 8。没有变化被观察关于 Q_( 最大) ,残余尿,前列腺体积或 PSA 铺平。结论:G 的摘录。易懂嗯很好被容忍,在 IPSS 的改进被观察。G 的摘录的推荐剂量。易懂嗯是在有 LUTS 的人的 6 mg。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 7 | A Study of Indian Government Policy on Production and Processing of Cotton and Its Implications显示文摘 | Srinivasa Konduru Fumiko Yamazaki Mechel Paggi | 2012 | Journal of Agricultural Science and Technology(B)2012，2，9： | 2 |
| 8 | Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘 | Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka | 2007 | Cancer Chemotherapy and Pharmacology2007，，6： | 2 |
| 9 | Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms显示文摘瞄准:评估 Ganoderma 的一篇摘录的安全和功效易懂嗯那出现最强壮 5 α-reductase 在由一个双窗帘的 19 朵可食、药用的蘑菇的摘录之中的禁止的活动,控制安慰剂,使随机化并且在有更低的尿道症状(LUTS ) 的人的变化剂量的学习。方法:在这试用,我们随机分配了与 G 有 slight-to-moderate LUTS 到 12 星期处理的超过 49 年岁的 88 个人。易懂嗯摘录(6 mg 一次一天) 或安慰剂。主要结果措施是在国际前列腺症状分数(IPSS ) 和 uroflowmetry 的变量的变化。第二等的结果措施在前列腺尺寸包括了变化,剩余在 voiding,实验室价值和报导不利效果以后的尿体积。结果: G。易懂嗯对为改进全部的 IPSS, 2.1 个点在处理的目的减少的安慰剂有效、显著地优异(吝啬的差别, −1.18 点;95% 信心间隔, −1.74 到 −0.62;P <
0.0001 ) 。没有变化关于生活分数的质量被观察,山峰尿流动,吝啬的尿流动,剩余尿,前列腺体积,浆液前列腺特定的抗原或睾丸激素层次。全面处理很好没有严重不利效果被容忍。结论:G 的摘录。易懂嗯很好被容忍并且改进了 IPSS 分数。这些结果用 G 的摘录为长持续时间鼓励了植物治疗法的进一步的、大规模评估。易懂嗯在有 LUTS 的人上。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，5： | 2 |
| 10 | Ecdysone has an effect on the regeneration of midgut epithelial cells that is distinct from 20-hydroxyecdysine in the silkworm Bombyx mori显示文摘 | YOSHIAKI TANAKA FUMIKO YUKUHIRO | 1999 | General and Cndodrinology1999，116，： | 1 |
| 11 | Presenilin-2 in the cynomolgus monkey brain: investigation of age-related changes显示文摘 | Nobuyuki Kimura Shin’ ichiro Nakamura Fumiko Ono Ippei Sakakibara Yoshiyuki Ishii Shigeru Kyuwa Yasuhiro Yoshikawa | 2004 | Primates2004，，3： | 1 |
| 12 | Biologically active human and mouse nerve growth factors secreted by the yeast Saccharomyces cerevisiae显示文摘 | Masafumi Nishizawa Fumiko Ozawa Takako Higashizaki Keiko Hirai Fumio Hishinuma | 1993 | Applied Microbiology and Biotechnology1993，，5： | 1 |
| 13 | Evaluation of skin damage of cyclic monoterpenes,percutaneous absorption enhancers,by using cultured human skin cells显示文摘 | Megumi K Fumiko I | 1993 | Biol Pharm Bull1993，16，9： | 1 |
| 14 | Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘 | Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka | 2007 | Cancer Chemotherapy and Pharmacology2007，，6： | 1 |
| 15 | Study of pH dependence using molecular modeling in reversed-phase liquid chromatography of 1-pheny1-3-methyl-5-pyrazolone derivatives of aldose显示文摘 | Fumiko M Yamamoto Souji Rokushika | 2004 | Analytica Chimica Acta2004，501，： | 1 |
| 16 | AntiAndrogenic Activities of the Triterpenoids Fraction of Ganoderma Lucidum显示文摘 | Jie Liu Kuniyoshi Shimizu Fumiko Konishi | 2007 | Food Chemistry2007，100，4： | 1 |
| 17 | MorphologyBased Prediction of Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells显示文摘 | Fumiko Matsuoka Ichiro Takeuchi Hideki Agata | 2013 | PLOS ONE2013，8，55： | 1 |
| 18 | Effects of hindlimb unloading at early postnatal growth on cell body size in spinal motoneurons innervating soleus muscle of rats显示文摘 | Fumiko Nagatomo Akihiko Ishihara Yoshinobu Ohira | 2008 | International Journal of Developmental Neuroscience2008，，1： | 1 |
| 19 | Pregnanes in the root bark of Nerium odorum显示文摘 | Fumiko A Tatsuo Y | 1976 | Phytochemistry1976，15，： | 1 |
| 20 | ,Evaluation of slab images in the northwestern pacific显示文摘 | Fumiko Tajima Yoshio Fukav Masayuki Obayashi | 1998 | Earth planet space1998，50，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员