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| 1 | Quantitation of HBsAg predicts response to entecavir therapy in HBV genotype C patients显示文摘AIM:To analysis the factors that predict the response to entecavir therapy in chronic hepatitis patients with hepatitis B virus (HBV) genotype C. METHODS:Fifty patients [hepatitis B e antigen (HBeAg)-negative:HBeAg-positive = 26:24] with HBV genotype C, who received nave entecavir therapy for > 2 years, were analyzed. Patients who showed HBV DNA levels ≥ 3.0 log viral copies/mL after 2 years of entecavir therapy were designated as slow-responders, while those that showed < 3.0 log copies/mL were termed rapid- responders. Quantitative hepatitis B surface antigen (HBsAg) levels (qHBsAg) were determined by the Architect HBsAg QT immunoassay. Hepatitis B core-related antigen was detected by enzyme immunoassay. Pre-C and Core promoter mutations were determined using by polymerase chain reaction (PCR). Drug-resistance mutations were detected by the PCR-Invader method. RESULTS:At year 2, HBV DNA levels in all patients in the HBeAg-negative group were < 3.0 log copies/mL. In contrast, in the HBeAg-positive group, 41.7% were slow-responders, while 58.3% were rapid-responders. No entecavir-resistant mutants were detected in the slow-responders. When the pretreatment factors were compared between the slow-and rapid-responders; the median qHBsAg in the slow-responders was 4.57 log IU/mL, compared with 3.63 log IU/mL in the rapid-responders (P < 0.01). When the pretreatment factors predictive of HBV DNA-negative status at year 2 in all 50 patients were analyzed, HBeAg-negative status, low HBV DNA levels, and low qHBsAg levels were significant (P < 0.01). Multivariate analysis revealed that the low qHBsAg level was the most significant predictive factor (P = 0.03). CONCLUSION:Quantitation of HBsAg could be a useful indicator to predict response to entecavir therapy. | Etsuro Orito Kei Fujiwara Hiroshi Kanie Tesshin Ban Tomonori Yamada Katsumi Hayashi | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
| 2 | Laparoscopic liver resection: Toward a truly minimally invasive approach显示文摘In the surgical treatment of hepatocellular carcinoma and colorectal liver metastasis, it is important to preserve sufficient liver volume after resection in order to avoid post-hepatectomy liver sufficiency and to increase the feasibility of repeated hepatectomyin case of intrahepatic recurrence. Parenchymasparing approach, which minimizes the extent of resection while obtaining sufficient surgical margins, has been developed in open hepatectomy. Although this approach can possibly have positive impacts on morbidity and mortality, it is not popular in laparoscopic approach because parenchyma-sparing resection is technically demanding especially by laparoscopy due to its intricate curved transection planes. 'Small incision, big resection' is the words to caution laparoscopic surgeons against an easygoing trend to seek for a superficial minimal-invasiveness rather than substantial patient-benefits. Minimal parenchyma excision is often more important than minimal incision. Recently, several reports have shown that technical evolution and accumulation of experience allow surgeons to overcome the hurdle in laparoscopic parenchymasparing resection of difficult-to-access liver lesions in posterosuperior segments, paracaval portion, and central liver. Laparoscopic surgeons should now seek for the possibility of laparoscopic parenchyma-sparing hepatectomy as open approach can, which we believe is beneficial for patients rather than just a small incision and lead laparoscopic hepatectomy toward a truly minimally-invasive approach. | Satoshi Ogiso Etsuro Hatano Takeo Nomi Shinji Uemoto | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 6 |
| 3 | Classifying genotype F of hepatitis B virus into F1 and F2 subtypes显示文摘AIM: To explore the propriety of providing hepatitis B virus(HBV) genotypes F and H with two distinct genotypes.METHODS: Eleven HBV isolates of genotype F (HBV/F)were recovered from patients living in San Francisco,Japan, Panama, and Venezuela, and their full-length sequences were determined. Phylogenetic analysis was carried out among them along with HBV isolates previously reported.RESULTS: Seven of them clustered with reported HBV/F isolates in the phylogenetic tree constructed on the entire genomic sequence. The remaining four flocked on another branch along with three HBV isolates formerly reported as genotype H. These seven HBV isolates, including the four in this study and the three reported, had a sequence divergence of 7.3-9.5% from the other HBV/F isolates,and differed by > 13.7% from HBV isolates of the other six genotypes (A-E and G). Based on a marked genomic divergence, falling just short of >8% separating the seven genotypes, these seven HBV/F isolates were classified into F2 subtype and the former seven into F1 subtype provisionally. In a pairwise comparison of the S-gene sequences among the 7 HBV/F2 isolates and against 47HBV/F1 isolates as well as 136 representing the other six genotypes (A-E and G), two clusters separated by distinct genetic distances emerged.CONCLUSION: Based on these analyses, classifying HBV/F isolates into two subtypes (F1 and F2) would be more appropriate than providing them with two distinct genotypes (F and H). | Hideaki Kato Kei Fujiwara Robert G. Gish Hiroshi Sakugawa Hiroshi Yoshizawa Fuminaka Sugauchi Etsuro Orito Ryuzo Ueda Yasuhito Tanaka Takanobu Kato Yuzo Miyakawa Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，40： | 6 |
| 4 | Risk of lymph node metastases from intramucosal gastric cancer in relation to histological types: how to manage the mixed histological type for endoscopic submucosal dissection显示文摘 | Kohei Takizawa Hiroyuki Ono Naomi Kakushima Masaki Tanaka Noriaki Hasuike Hiroyuki Matsubayashi Yuichiro Yamagichi Etsuro Bando Masanori Terashima Kimihide Kusafuka Takashi Nakajima | 2013 | Gastric Cancer2013，，4： | 4 |
| 5 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 6 | Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis显示文摘 | Kojiro Taura Samuele De Minicis Ekihiro Seki Etsuro Hatano Keiko Iwaisako Christoph H. Osterreicher Yuzo Kodama Kouichi Miura Iwao Ikai Shinji Uemoto David A. Brenner | 2008 | Gastroenterology2008，，5： | 3 |
| 7 | Surgical Resection of Hilar Cholangiocarcinoma: Analysis of Survival and Postoperative Complications显示文摘 | Suguru Hasegawa Iwao Ikai Hideaki Fujii Etsuro Hatano Yasuyuki Shimahara | 2007 | World Journal of Surgery2007，，6： | 3 |
| 8 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 2 |
| 9 | Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii显示文摘AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.METHODS: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic methods.Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.RESULTS: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P<0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with T-1858.In addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast Asia.CONCLUSION: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii. | Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2004 | World Journal of Gastroenterology2004，10，15： | 2 |
| 10 | Prognostic Index for Patients with Hepatocellular Carcinoma Combined with Tumor Thrombosis in the Major Portal Vein显示文摘 | Iwao Ikai Etsuro Hatano Suguru Hasegawa Hideaki Fujii Kojiro Taura Naoki Uyama Yasuyuki Shimahara | 2006 | Journal of the American College of Surgeons2006，，3： | 2 |
| 11 | 超细水泥的分散特性对悬浮薄浆可灌性的影响显示文摘以前人们认为悬浮薄浆很难灌入由细小料粒组成的地基中(例如 Mori等人,1991年),但是近年来,在日本随着市政建设的发展,增强改善这种类型地基的需求也日益增长。本文中作者对一些造成薄浆灌入困难的主要因素进行了研究,并提出了一些确保安全灌入的对策。 | 刘新菊 Etsuro ASAKURA | 1999 | 国外建材科技1999，20，1： | 2 |
| 12 | A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C显示文摘 | Etsuro Orito Masashi Mizokami Hiroshi Sakugawa Kojiro Michitaka Kazuyoshi Ishikawa Takafumi Ichida Takeshi Okanoue Hiroshi Yotsuyanagi Shiro Iino | 2001 | Hepatology2001，，1： | 2 |
| 13 | Preparation of dense cordierite ceramics from magnesium compounds and kaolinite without additives显示文摘 | YUICHI Kobayashi KATSUHIRO Sumi ETSURO Kato | 2000 | Ceram Int2000，26，： | 2 |
| 14 | Long-term outcomes of standard discectomy for lumbar disc herniation:a follow-up study of more than 10 years显示文摘 | Yorimitsu Etsuro MD Chiba Kazuhiro MD | 2001 | Spine2001，26，： | 1 |
| 15 | Perfusion weighted magnetic resonance imaging to distinguish the recurrence of metastatic brain tumors from radiation necrosis after stereotactic radiosurgery显示文摘 | Koichi Mitsuya Yoko Nakasu Satoshi Horiguchi Hideyuki Harada Tetsuo Nishimura Etsuro Bando Hiroto Okawa Yoshihiro Furukawa Tatsuo Hirai Masahiro Endo | 2010 | Journal of Neuro - Oncology2010，，1： | 1 |
| 16 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 1 |
| 17 | Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C显示文摘 | Fuminaka Sugauchi Etsuro Orito Takafumi Ichida Hideaki Kato Hiroshi Sakugawa Shinichi Kakumu Takafumi Ishida Anuchit Chutaputti Ching-Ling Lai Robert G. Gish Ryuzo Ueda Yuzo Miyakawa Masashi Mizokami | 2003 | Gastroenterology2003，，4： | 1 |
| 18 | Akt activation protects rat liver from ischemia/reperfusion injury显示文摘 | Nobuko Harada Etsuro Hatano Naoki Koizumi | 2004 | J Surgical Res2004，121，2： | 1 |
| 19 | Influence of volcanic activity on vegetation succession and growth environment on the hillslope of Sakurajima Volcano in southern Kyushu,Japan显示文摘This study was conducted in order to examine the influence of long-term volcanic activity on vegetative succession and growth on the slope of Sakurajima in southern Kyushu, Japan. We investigated the vegetation,depth of the volcanic ash layer, and dry density and p H of the surface soil at six places on the north-northwestern slope, 2.3–3.4 km from the Minami-dake crater, where a layer of pumice stone was deposited by the Taisho eruption in 1914. The height and diameter at breast height(DBH) of the trees increased with increasing distance from the Minami-dake crater, as did the number of individuals and species, and basal area. The Shannon–Wiener diversity index(H') demonstrates that vegetative succession is significantly affected by distance from the Minami-dake crater, as areas farther from the crater exhibited later seral stages. Comparison of the diversity index and species number of the crater region with that of the climax forest in Kagoshima indicates that vegetative growth alone cannot advance succession in the study area, as the local vegetative community is heavily influenced by the harsh environmental conditions associated with continual exposure to long-term volcanic activity. Seral stage, ash layer depth,dry density, and p H of the soil surface layer are governed by distance from the Minami-dake crater. The results of this study indicate that conditions for vegetative growth and succession improve with increasing distance from the source of constant volcanic activity. Thus, soil development is promoted by the acidification of the soil, which decreases the dry density and p H of the soil surface layer.The introduction of plant species resistant to volcanic ash and gas is recommended to promote soil development and improve the infiltration capacity of the soil. | Yukiyoshi Teramoto Etsuro Shimokawa Tsugio Ezaki Kun-Woo Chun Suk-Woo Kim Youn-Tae Lee | 2017 | Journal of Forestry Research2017，28，2： | 1 |
| 20 | Sentinel lymphadenectomy in breast cancer: identification of sentinel lymph node and detection of metastases显示文摘 | Masakuni Noguchi Koichiro Tsugawa Etsuro Bando Futoshi Kawahara Koichi Miwa Kunihiko Yokoyama Ken-ichi Nakajima Norihisa Tonami | 1999 | Breast Cancer Research and Treatment1999，，2： | 1 |
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