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| 1 | Two distinct pathways of p16 gene inactivation in gallbladder cancer显示文摘AIM: To examine the mechanism of inactivation of the p16 gene in gallbladder cancer,and to investigate p16 alterations and their correlation with clinicopathological features. METHODS: Specimens were collected surgically from 51 patients with gallbladder cancer. We evaluated the status of protein expression,loss of heterozygosity (LOH),homozygous deletion and promoter hypermethylation using immunohistochemistry,microsatellite analysis,quantitative real-time polymerase chain reaction (PCR) and methylation-specific PCR,respectively. In addition,mutations were examined by direct DNA sequencing. RESULTS: Homozygous deletions of the p16 gene exon2,LOH at 9p21-22,p16 promoter hypermethylation,and loss of p16 protein expression were detected in 26.0% (13/50),56.9% (29/51),72.5% (37/51) and 62.7% (32/51),respectively. No mutations were found. LOH at 9p21 correlated with the loss of p16 protein expression (P < 0.05). Homozygous deletion of the p16 gene,a combination LOH and promoter hypermethylation,and multiple LOH at 9p21 were significantly correlated with the loss of p16 protein expression (P < 0.05). LOH at 9p21 and promoter hypermethylation of the p16 gene were detected in 15.4% (2/13) and 92.3% (12/13) of the tumors with homozygous deletion of the p16 gene,respectively. P16 alterations were not associated with clinicopathological features. CONCLUSION: Our results suggest that LOH and homozygous deletion may be two distinct pathways in the inactivation of the p16 gene. Homozygous deletion,a combination of LOH and promoter hypermethylation,and multiple LOH are major mechanisms of p16 inactivation in gallbladder cancer. | Hiroyuki Tadokoro Takako Shigihara Tomomi Ikeda Masaru Takase Masafumi Suyama | 2007 | World Journal of Gastroenterology2007，13，47： | 6 |
| 2 | Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases显示文摘The gene encoding bone morphogenetic protein-7(BMP7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of BMP7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to provide them with competence to respond to differentiation cues, each relying on distinct signaling pathways. Intriguingly, in the adult organ, BMP7 has been implicated in protection against and regeneration from injury. Exogenous administration of recombinant BMP7 to animal models of kidney diseases has shown promising effects in counteracting inflammation, apoptosis and fibrosis evoked upon injury. Although the expression pattern of BMP7 has been well described, the mechanisms by which it is regulated have remained elusive and the processes by which the secretion sites of BMP7 impinge upon its functions in kidney development and diseases have not yet been assessed. Understanding the regulatory mechanisms will pave the way towards gaining better insight into the roles of BMP7, and to achieving desired control of the gene expression as a therapeutic strategy for kidney diseases. | Taro Tsujimura Mana Idei Masahiro Yoshikawa Osamu Takase Keiichi Hishikawa | 2016 | World Journal of Stem Cells2016，8，9： | 6 |
| 3 | A radical scavenger edaravone and oligodendrocyte protection/regeneration显示文摘Cerebral white matter is vulnerable to oxidative stress:Oxidative stress is one of the major harmful conditions for the central nervous system(CNS).Oxidative stress is a state from an imbalance between free radical production and their removal by antioxidants,resulting in an excessive amount of reactive oxygen species(ROS)in cells and tissues.ROS causes cell damage due to oxidation of cellular components,including DNAs,proteins,and lipids. | Hajime Takase Josephine Lok Ken Arai | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 4 | Three-dimensional viscoelastic numerical analysis of the encapsulation phenomena in coextrusion显示文摘 | Masanori Takase Shin-ichi Kihara K. Funatsu | 1998 | Rheologica Acta1998，，6： | 4 |
| 5 | ICRF Heated Long-Pulse Plasma Discharges in LHD显示文摘A long-pulse plasma discharge for more than 30 min.was achieved on the LargeHelical Device(LHD).A plasma of n_e=0.8×10^(19)m^(-3)and T_(iO)=2.0 keV was sustained withP_(ICH)=0.52 MW,P_(ECH)=0.1 MW and averaged P_(NBI)=0.067 MW.Total injected heatingenergy was 1.3 GJ,which was a quarter of the prepared RF heating energy.One of the keys to thesuccess of the experiment was a dispersion of the local plasma heat load to divertors,accomplishedby shifting the magnetic axis inward and outward. | R. KUMAZAWA T. SEKI T. MUTOH K. SAITO T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIHARA M. SHOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. ASHIKAWA K. NISHIMURA H. FUNABA H. CHIKARAISHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.NOMURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK H. YAMADA K. KAWAHATA N. OHYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA | 2006 | Plasma Science and Technology2006，8，1： | 4 |
| 6 | A case of mucosa-associated lymphoid tissue lymphoma of the gastrointestinal tract showing extensive plasma cell differentiation with prominent Russell bodies显示文摘A 73-year-old Japanese woman was hospitalized for detailed examination of nausea, diarrhea and loss of appetite. Atypical erosion in the ileum was found on endoscopy. Biopsy of this erosion showed proliferation of cells containing numerous Russell bodies. Differential diagnoses considered were Russell body enteritis, crystal-storing histiocytosis, Mott cell tumor, immunoproliferative small intestinal disease(IPSID) and mucosaassociated lymphoid tissue(MALT) lymphoma. The cells containing prominent Russell bodies showed diffuse positivity for CD79 a and CD138, but negative results for CD20, CD3, UCHL-1, CD38 and CD68. Russell bodies were diffusely positive for lambda light chain, but negative for kappa light chain, and immunoglobulin(Ig)G, Ig A and Ig M. Based on these findings, Russell body enteritis, crystal-storing histiocytosis and IPSID were ruled out. As the tumor formed no mass lesions and was restricted to the gastrointestinal tract, MALT lymphoma with extensive plasma cell differentiation was finally diagnosed. The patient showed an unexpectedly aggressive clinical course. The number of atypical lymphocytes in peripheral blood gradually increased and T-prolymphocytic leukemia(T-PLL) emerged. The patient died of T-PLL 7 mo after admission. Autopsy was not permitted. | Keita Kai Masaharu Miyahara Yasunori Tokuda Shinich Kido Masanori Masuda Yukari Takase Osamu Tokunaga | 2013 | World Journal of Clinical Cases2013，1，5： | 4 |
| 7 | 负载型K_2CO_3/ZrO_2固体碱催化水飞蓟籽油制备生物柴油显示文摘采用浸渍法制备了负载型固体碱K2CO3/ZrO2催化剂,并用X射线衍射(XRD)和扫描电镜(SEM)对其结构进行表征,研究了固体碱K2CO3/ZrO2催化水飞蓟籽油与甲醇酯交换反应制备生物柴油,考察了催化剂的制备条件和反应条件对甲酯收率的影响。在K2CO3负载量(质量分数)为20%、在500℃下焙烧6 h的K2CO3/ZrO2催化剂,当催化剂用量是水飞蓟籽油重量的8.0%、甲醇与水飞蓟籽油的摩尔比为12∶1、在65℃下反应90 min后,甲酯收率为82.6%。该工艺操作简单、产品易分离,为药厂水飞蓟副产品———水飞蓟籽油的利用提供了一条新途径。 | 张敏 朱伯乐 Mohammed Takase 张祯 邵晓玲 许辉 梁国熙 仰榴青 吴向阳 | 2012 | 江苏农业科学2012，40，12： | 3 |
| 8 | Complications of Partial Splenic Embolization in Cirrhotic Patients显示文摘 | Takahisa Sakai Katsuya Shiraki Hidekazu Inoue Kazushi Sugimoto Shigeru Ohmori Kazumoto Murata Koujiro Takase Takeshi Nakano | 2002 | Digestive Diseases and Sciences2002，，2： | 3 |
| 9 | Carvedilol Attenuates the Progression of Alcohol Fatty Liver Disease in Rats显示文摘 | Jinyao Liu Izumi Takase Ayako Hakucho Nanako Okamura Tatsuya Fujimiya | 2012 | Alcohol Clin Exp Res2012，，9： | 2 |
| 10 | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission显示文摘 | Tetsuya Eto Ken Takase Toshihiro Miyamoto Yuju Ohno Tomohiko Kamimura Koji Nagafuji Yasushi Takamatsu Takanori Teshima Hisashi Gondo Shuichi Taniguchi Koichi Akashi Mine Harada | 2013 | International Journal of Hematology2013，，2： | 2 |
| 11 | Aspartate aminotransferase-immunoglobulin complexes in patients with chronic liver disease显示文摘AIM: To determine the complex of AST and immunoglobulin and to investigate its clinical significance in patients with liver disease.METHODS: The complex of AST and immunoglobulin was determined by encounter immunoelectrophoresis and its clinical significance was investigated in 128 patients with liver disease.RESULTS: AST was bound to immunoglobulin of antiimmunoglobulin A (IgA) class, but any binding to antiimmunoglobulin G and anti-immunoglobulin M classes was not observed. Although the incidence of ASTimmunoglobulin complex was 41.8% in chronic hepatitis (CH), the incidences in liver cirrhosis and hepatocellular carcinoma were 62.2 and 90.0%, respectively. In alcoholic liver disease with high level of serum IgA, the incidence of the complex was 66.7%, which was higher than that in CH. The ratio of binding to lambda-chain of IgA was higher than that to kappa-chain of IgA. The serum level of IgA and the ratio of AST/alanine aminotransferase (ALT) were significantly higher in patients with AST-IgA complex than in those without complex.CONCLUSION: These results suggest that AST-IgA complex in patients with progressive liver diseases and alcoholic liver injury can lead to elevation of the ratio of AST/ALT. | Masahiko Tameda Katsuya Shiraki Kinue Ooi Koujirou Takase Yoshitane Kosaka Tsutomu Nobori Yukihiko Tameda | 2005 | World Journal of Gastroenterology2005，11，10： | 2 |
| 12 | Smad 6 inhibits signalling by the TGF-beta superfamily显示文摘 | Imamura T Takase M Nishihara A | 1997 | Nature1997，389，6651： | 2 |
| 13 | Motor tract reorganization after acute central nervous system injury: a translational perspective显示文摘Acute central nervous system injuries are among the most common causes of disability worldwide,with widespread social and economic implications.Motor tract injury accounts for the majority of this disability;therefore,there is impetus to understand mechanisms underlying the pathophysiology of injury and subsequent reorganization of the motor tract that may lead to recovery.After acute central nervous system injury,there are changes in the microenvironment and structure of the motor tract.For example,ischemic stroke involves decreased local blood flow and tissue death from lack of oxygen and nutrients.Traumatic injury,in contrast,causes stretching and shearing injury to microstructures,including myelinated axons and their surrounding vessels.Both involve blood-brain barrier dysfunction,which is an important initial event.After acute central nervous system injury,motor tract reorganization occurs in the form of cortical remapping in the gray matter and axonal regeneration and rewiring in the white matter.Cortical remapping involves one cortical region taking on the role of another.cAMP-response-element binding protein is a key transcription factor that can enhance plasticity in the peri-infarct cortex.Axonal regeneration and rewiring depend on complex cell-cell interactions between axons,oligodendrocytes,and other cells.The RhoA/Rho-associated coiled-coil containing kinase signaling pathway plays a central role in axon growth/regeneration through interactions with myelin-derived axonal growth inhibitors and regulation of actin cytoskeletal dynamics.Oligodendrocytes and their precursors play a role in myelination,and neurons are involved through their voltage-gated calcium channels.Understanding the pathophysiology of injury and the biology of motor tract reorganization may allow the development of therapies to enhance recovery after acute central nervous system injury.These include targeted rehabilitation,novel pharmacotherapies,such as growth factors and axonal growth inhibitor blockade,and the implementation of neurotechnologies,such as central nervous system stimulators and robotics.The translation of these advances depends on careful alignment of preclinical studies and human clinical trials.As experimental data mount,the future is one of optimism. | Hajime Takase Robert W.Regenhardt | 2021 | Neural Regeneration Research2021，16，6： | 2 |
| 14 | Induction of Smad6 mRNA by bone morphogenetic proteins显示文摘 | Takase M Imamura T Sampath TK | 1998 | Biochem Biophys Res Commu1998，244，1： | 2 |
| 15 | Paroxysmal itching and magnetic resonance imaging of the spinal cord in multiple sclerosis 显示文摘 | Yamamoto K Kawazawa S Takase Y | 1989 | Rinsho Shinkeigaku1989，29，11： | 1 |
| 16 | Identification of the bactericidal domain of lactoferrin 显示文摘 | Bellamy W Takase M Yamauehi K | 1992 | Biochimica et biophysica acta1992，1121，： | 1 |
| 17 | Transient detection of early wal- lerian degeneration on diffusion-weighted MRI after an acute cerebro- vascular accident显示文摘 | Uchino A Sawada A Takase Y | 2004 | Neuroradiology2004，46，3： | 1 |
| 18 | The significance of urine cytology three consecutive days after transurethral resection as a predictor of superficial bladder cancer recurrence显示文摘 | Yumura Y Takase K Kato Y | 2004 | Hinyokika Kiyo2004，50，3： | 1 |
| 19 | Nurse-environment misfit and nursing practice显示文摘 | Takase M Kershaw E Burt L | 2001 | Journal of Advanced Nursing2001，35，6： | 1 |
| 20 | Microscopic observatio n and X-ray diffractometry of heat/moisture-treated starch granules显示文摘 | Kawabata A Takase N Migoshi E | 1994 | Starc h/Strke1994，46，： | 1 |
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