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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Chinese medicine CGA formula ameliorates DMN- induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways显示文摘 | Xue-mei LI Jing-hua PENG Zhao-lin SUN Hua-jie TIAN Xiao-hua DUAN Lin LIU Xin MA Qin FENG Ping LIU Yi-yang HU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 34 |
| 3 | Endoscopic Surgery versus External Ventricular Drainage Surgery for Severe Intraventricular Hemorrhage显示文摘The efficacy and applied value of endoscopic hematoma evacuation vs. external ventricular drainage (EVD) in the treatment of severe ventficular hemorrhage (IVH) were explored and compared.From Jan.2015 to Dec.2016,the clinical data of 42 cases of IVH were retrospectively analyzed,including 18 patients undergoing endoscopic hematoma evacuation (group A),and 24patients receiving EVD (group B).The hematoma clearance rate was calculated by 3D Slicer software,and complications and outcomes were compared between the two groups.There were no significant differences in age,sex and Graeb score between groups A and B (P>0.05).The hematoma clearance rate was 70.81%±27.64% in group A and 48.72%±36.58% in group B with a statistically significant difference (P<0.05).The operative time in groups A and B was 72.45±25.26 min and 28.54±15.27min,respectively (P<0.05).The Glasgow Coma Scale (GCS) score increased from 9.28±2.72 at baseline to 11.83±2.91 at 1 week postoperatively in group A,and from 8.25±2.62 at baseline to 10.79±4.12 at 1 week postoperatively in group B (P<0.05).The length of hospital stay was 12.67±5.97 days in group A and 17.33±8.91 days in group B with a statistically significant difference (P<0.05).The GOS scores at 6 months after surgery were 3.83±1.12 in group A,and 2.75±1.23 in group B (P<0.05). These results suggested that endoscopic hematoma evacuation has an advantage of a higher hematoma clearance rate,fewer complications and better outcomes in the treatment of severe IVH,indicating it is a safe,effective and promising approach for severe IVH. | Ping SONG Fa-liang DUAN Qiang CAI Jing-lei WU Xiao-bin CHEN Yuan WANG Cong-gang HUANG Ji-qiang LI Zhu-qiang HE Qiao-chun HUANG Mei LIU Yan-gao ZHANG Ming LUO | 2018 | Current Medical Science2018，38，5： | 21 |
| 4 | Reference genes identified in the silkworm Bombyx moil during metamorphism based on oligonucleotide microarray and confirmed by qRT-PCR显示文摘在 mRNA 水平的基因表达式数量化离子为 post-genomic 研究是很重要的,因为基因表达式水平是目标基因的特殊生物函数的思考。方法为基因表达式数量化离子使用了,例如微数组或量的即时聚合酶链反应(qRT-PCR ) ,要求稳定的表示引用基因。因此,发现合适的控制基因为基因数量化离子是必要的。在这研究,参考基因的染色体宽的调查在蚕 Bombyx 粗腐殖质 i 上在变态期间被执行。12 基因基于微数组由外部控制使正常化的整个染色体 oligonucleotide 被选择为通常认为的参考基因。然后, qRT-PCR 为潜在的参考基因候选人的进一步的确认和选择被采用。结果被分析,并且稳定的基因用 geNorm 被选择 3.4 并且 NormFinder 软件。最后,从每个方面考虑因素,翻译开始因素 4A ,翻译开始因素 3 子单元 4 ,和翻译开始因素 3 子单元 5 (由 sw22934 , swl4876 ,和 swl3956 代表了)越过检验发展阶段作为可靠内部控制被选择,当时细胞质的肌动朊( sw22671 ),在以前的研究的通常使用的参考基因被显示在整个检验发展阶段急速地变化。为未来研究,我们在变态期间为不同发展阶段的数据正规化推荐那些三稳定的引用基因的几何平均数的使用为一个精确正规化因素。 | Gen-Hong Wang Qing-You Xia Dao-Jun Cheng Jun Duan Ping Zhao Jie Chen Li Zhu | 2008 | Insect Science2008，15，5： | 18 |
| 5 | Regulation of OsSPX1 and OsSPX3 on Expression of OsSPX Domain Genes and Pi-starvation Signaling in Rice显示文摘The rice(Oryza sativa L.) genome contains at least six genes exclusively with an SPX(SYG1/PHO81/XPR1) domain at the N-terminal,designated as OsSPX1-6.Here we report the diverse expression patterns of the OsSPX genes in different tissues and their responses to Pi-starvation.Among them,five genes,OsSPX1,2,3,5 and 6 are responsive to Pi-starvation in shoots and/or in roots.The subcellular localization analysis indicates that OsSPX1 and OsSPX2 is exclusively located in nucleus,OsSPX3 in the cytoplasm,and OsSPX4 is a membrane localization protein.OsSPX1 regulates OsSPX2,3 and 5 at the transcription level and is positively involved in the responses of the genes to Pi-starvation.Overexpression of OsSPX3 downregulates OsSPX5 in shoots under Pi-sufficiency.OsSPX3 negatively regulates the PSI(Pi-starvation induced) gene,OsIPS1 and is involved in the responses of miR399 and OsPHO2 to Pi-starvation.Our results suggest that OsSPX1 may be a regulator involved in the transcriptions of OsSPX2,3 and 5.OsSPX3 plays a role in OsIPS1/miR399 mediated long distance regulation on OsPHO2.Our results also indicate that OsSPX3 is involved in plant tolerance to Pi-starvation stress. | Zhiye Wang Han Hu Hongjie Huang Ke Duan Zhong changWu Ping Wu | 2009 | Journal of Integrative Plant Biology2009，51，7： | 18 |
| 6 | Two new terpenoids from fruits of Ziziphus jujuba显示文摘一新 ceanothane 类型 triterpene 和一新 sesquiterpene,和二,已知的 triterpenes 从 Ziziphus jujuba 米尔的水果被孤立。(Rhamnaceae ) 。基于光谱分析,二新混合物的结构作为 2 α 被阐明; -aldehydo-A(1)-norlup-20(29)-en-27,28-dioic 酸(zizyberanal 酸)(1 ) ,和 zizyberanone (2 ) 。当二已知的 triterpenes 作为 zizyberanalic 酸(3 ) 和 ursolic 酸(4 ) 被识别时。 | Sheng Guo Yu Ping Tang Jin Ao Duan Shu Lan Su An Wei Ding | 2009 | Chinese Chemical Letters2009，20，2： | 13 |
| 7 | Antidepressant effect of electroacupuncture regulates signal targeting in the brain and increases brain- derived neurotrophic factor levels显示文摘Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupuncture at Yintang(EX-HN3) and Baihui(DU20) with sparse waves at 2 Hz and 0.6 m A for 30 minutes, once a day. We found increased horizontal and vertical activity, and decreased immobility time, at 2 and 4 weeks after treatment. Moreover, levels of neurotransmitters(5-hydroxytryptamine, glutamate, and γ-aminobutyric acid) and protein levels of brain-derived neurotrophic factor and brain-derived neurotrophic factor-related proteins(Trk B, protein kinase A, and phosphorylation of cyclic adenosine monophosphate response element binding protein) were increased in the hippocampus. Similarly, protein kinase A and Trk B m RNA levels were increased, and calcium-calmodulin-dependent protein kinase II levels decreased. These findings suggest that electroacupuncture increases phosphorylation of cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor levels by regulating multiple targets in the cyclic adenosine monophosphate response element binding protein signaling pathway, thereby promoting nerve regeneration, and exerting an antidepressive effect. | Dong-mei Duan Ya Tu Ping Liu Shuang Jiao | 2016 | Neural Regeneration Research2016，11，10： | 11 |
| 8 | Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-KB pathway显示文摘 | Min Ruan Tong Ji Wen Hu Duan Wan Tao Chen Chen Ping Zhang | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 11 |
| 9 | Saliva: potential diagnostic value and transmission of 2019-nCoV显示文摘2019-n Co V epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now.Saliva,a biofluid largely generated from salivary glands in oral cavity,has been reported 2019-n Co V nucleic acid positive.Besides lungs,salivary glands and tongue are possibly another hosts of 2019-n Co V due to expression of ACE2.Close contact or short-range transmission of infectious saliva droplets is a primary mode for 2019-n Co V to disseminate as claimed by WHO,while long-distance saliva aerosol transmission is highly environment dependent within indoor space with aerosol-generating procedures such as dental practice.So far,no direct evidence has been found that 2019-n Co V is vital in air flow for long time.Therefore,to prevent formation of infectious saliva droplets,to thoroughly disinfect indoor air and to block acquisition of saliva droplets could slow down2019-n Co V dissemination.This review summarizes diagnostic value of saliva for 2019-n Co V,possibly direct invasion into oral tissues,and close contact transmission of 2019-n Co V by saliva droplets,expecting to contribute to 2019-n Co V epidemic control. | Ruoshi Xu Bomiao Cui Xiaobo Duan Ping Zhang Xuedong Zhou Quan Yuan | 2020 | International Journal of Oral Science2020，12，2： | 9 |
| 10 | Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells显示文摘Prostate inflammation (PI) is closely related to the development and progression of chronic prostatic diseases: benign prostatic hyperplasia and prostate cancer. Toll-like receptor (TLR) 2 has been reported to be associated with inflammatory diseases, such as infections, autoimmune diseases, and cancers. Meanwhile, TLR10, which can form heterodimers with TLR2, has been considered an orphan receptor without an exact function. The present study therefore aims to examine the effects of TLR2 and TLR10 on PI. Prostate samples and clinical data were obtained from the patients diagnosed with benign prostatic hyperplasia. The inflammatory cell model was established by adding lipopolysaccharide to RWPE-1 cells. Prostate tissues/cells were examined by histological, molecular, and biochemical approaches. Both TLR2 and TLR10 were found to be expressed in prostate tissues and RWPE-1 cells. mRNA/protein expression levels of TLR2 and TLR10 were both positively correlated with prostate tissue inflammatory grades. Lipopolysaccharide-stimulated RWPE-1 cells expressed higher levels of TLR2, TLR10, high mobility group box 1 (HMGB1), phosphonuclear factor kappa-light-chain-enhancer of activated B-cells P65 (phospho-NF-κB P65), interleukin (IL)-6, and IL-8 than control cells. Moreover, HMGB1, phospho-NF-κB P65, IL-6, and IL-8 were down regulated after TLR2 knockdown and upregulated after TLR10 knockdown in RWPE-1 cells. TLR2 stimulation can activate the inflammatory signaling cascade in prostate epithelial cells. Conversely, TLR10 exhibited suppressive effects on inflammation. With antagonistic functions, both TLR2 and TLR10 were invoIved in PI. TLR10 could be a novel target in modulating inflammatory signal transduction of prostate epithelial cells. | Yu Fan Lu Yang Qiang Wei Yu Ding Zhuang Tang Ping Tan Tao Lin Duan Guo Shi Qiu | 2019 | Asian Journal of Andrology2019，21，4： | 9 |
| 11 | Myelin protein zero and its antibody in serum as biomarkers of n-hexane-induced peripheral neuropathy and neurotoxicity effects显示文摘 | Jia Xiaowei Liu Qingjun Zhang Yanshu Dai Yufei Duan Huawei Bin Ping Niu Yong Liu Jie Zhong Liuzhen Guo Jisheng Liu Xiaofeng Zheng Yuxin | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 12 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
| 13 | Detection of Human Bocavirus in Children with Acute Respiratory Tract Infections in Lanzhou and Nanjing,China显示文摘Objective The aim of this study was to explore the prevalent characteristics of HBoV1 and its co-infection.Methods PCR was used to detect HBoV1-DNA(HBoV1) and other viruses.A multivariate logistic regression model was used to explore possibility of co-detected for related viruses.Results The positivity rates in Nanjing and Lanzhou were 9.38%(74/789) and 11.62%(161/1386),respectively(P>0.05).The HBoV1 positive group was younger than negative group(P<0.05).Seasonal differences were noted,with a higher frequency of infection in December and July.HBoV1-positive children [72.34%(169/235)] were co-infected with other respiratory viruses.Multifactorial analysis showed no correlations between HBoV1 and the clinical classification,region,gender,age,or treatment as an outpatient or in a hospital.Correlations were identified between HBoV1 infections with ADV(OR=1.53,95% CI 1.03-2.28),RSV(OR=0.71,95% CI 0.52-0.98),and IFVA(OR=1.77,95% CI 1.00-3.13).Conclusions Presence of HBoV1 in nasopharyngeal aspirates did not correlate with region or gender,although the prevalence of HBoV1 was higher in younger children.There were no correlations between HBoV1 and other variables,except for the season and ADV,RSV,or IFVA infections. | WU Jian Jun JIN Yu LIN Na XIE Zhi Ping YU Jie Mei LI Jin Song CAO Chang Qing YUAN Xin Hui SONG Jin Rong ZHANG Jing ZHAO Yang GAO Xiao Qian DUAN Zhao Jun | 2014 | Biomedical and Environmental Sciences2014，27，11： | 7 |
| 14 | Decreased expression of DAB2IP in pancreatic cancer with wild-type KRAS显示文摘BACKGROUND: KRAS mutation plays an important role in the pathogenesis of pancreatic cancer. However, the role of wild-type KRAS in the progression of pancreatic cancer remains unknown. The present study was to investigate the expression of the Ras GTPase activating protein (DAB2IP) in pancreatic cancer and its clinical significance. METHODS: The expression of DAB2IP in pancreatic cancer cell lines and normal human pancreatic ductal epithelial cells was analyzed by Western blotting and realtime quantitative reverse transcription-PCR (qRT-PCR). The KRAS mutational types of pancreatic cancer tissues obtained from pancreatic cancer patients (n=20) were also analyzed. Subsequently, DAB2IP expression was detected in pancreatic cancer tissues, adjacent and normal pancreatic tissues (n=2) by immunohistochemistry, and the relationship between DAB2IP expression and the clinical characteristics of patients was evaluated. RESULTS: Western blotting and qRT-PCR results showed that DAB2IP expression in pancreatic cancer cells with wild-type KRAS was lower than that in those with mutation-type KRAS and normal human pancreatic ductal epithelial cells (P<0.05). Immunohistochemistry showed that DAB2IP expression was lower in pancreatic cancer tissues than that in adjacent and normal pancreatic tissues (Z=-4.000, P=0.000). DAB2IP expression was lower in pancreatic cancer patients with the wild-type KRAS gene than that in those with KRAS mutations (WilcoxonW=35.000, P=0.042). Furthermore,DAB2IP expression in patients with perineurial invasion was lower than that in those without invasion (WilcoxonW=71.500, P=0.028). DAB2IP expression was lower in patients with more advanced stage than that in those with early clinical stage (WilcoxonW=54.000, P=0.002). CONCLUSIONS: DAB2IP expression was reduced in patients with pancreatic cancer compared with those with no cancer. DAB2IP expression was correlated with the KRAS gene, perineurial invasion and clinical stage of the disease. Our data indicated that DAP2IP expression can be used as a potential prognostic indicator and a promising molecular target for therapeutic intervention in patients with pancreatic cancer. | Yi-Fan Duan Dong-Feng Li Yan-Hui Liu Ping Mei Yu-Xuan Qin Liang-Fang Li Qiu-Xiong Lin Zi-Jun Li | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 7 |
| 15 | Percutaneous extraction of leads from coronary sinus vein and branch by modified techniques显示文摘 | CHU Xian-ming LI Xue-bin ZHANG Ping, WANG Long LI Ding LI Bing AN Yi LENG Min DUAN Jiang-bo GUO Ji-hong | 2012 | Chinese Medical Journal2012，，20： | 6 |
| 16 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 17 | An UHPLC-MS/MS method for simultaneous determination of quercetin 3-O-rutinoside, kaempferol 3-O-rutinoside, isorhamnetin 3-O-rutinoside, bilobalide and ligustrazine in rat plasma, and its application to pharmacokinetic study of Xingxiong injection显示文摘The present study was designed to develop and validate a rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with tandem mass spectrometry(UHPLC-MS/MS) method for the simultaneous determination of five major active constituents in the traditional Chinese medicinal preparation Xingxiong injection(XXI) in rat plasma, including quercetin 3-O-rutinoside(QCR), kaempferol 3-O-rutinoside(KFR), isorhamnetin 3-O-rutinoside(ISR), bilobalide(BB), and ligustrazine(LGT). The plasma samples were pretreated by protein precipitation with acetonitrile. The chromatographic separation was achieved on a Waters Symmetry C18 analytical column(2.1 mm × 100 mm, 3.5 mm) with a mobile phase of 0.1% aqueous formic acid(A)-acetonitrile(B). Quantitation of the five bioactive constituents was achieved. Naringin was used as the internal standard(IS). All the calibration curves showed good linearity(r > 0.996) over the concentration range, with the lowest limit of quantification(LLOQ) between 2-18 ng·m L^(-1). The intraand inter-day accuracy and precision of the analytes were both within acceptable limits. Moreover, satisfactory extraction recoveries(90.92%-104.03%) were obtained by protein precipitation. The validated method was successfully applied to a pharmacokinetic study of XXI in rats after intravenous administration at three doses. The pharmacokinetic parameters of the five compounds varied in a dose-dependent manner within the tested dosage range. The present study was the first report of pharmacokinetic study for XXI. | DOU Li-Li DUAN Li GUO Long LIU Le-Le ZHANG Yu-Dong LI Ping LIU E-Hu | 2017 | Chinese Journal of Natural Medicines2017，15，9： | 6 |
| 18 | A 357.9 nm GaN/AlGaN multiple quantum well ultraviolet laser diode显示文摘Ultraviolet(UV)and deep-UV light emitters are prom-ising for various applications including bioagent detection,wa-ter and air purification,dermatology,high-density optical stor-age,and lithography.However,to achieve shorter UV laser di-odes(LDs),especially for the LDs with lasing wavelength less than 360 nm,requires high AlN mole fraction AlGaN clad-ding layer(CL)and waveguide(WG)layers,which usually leads to generate cracks in AlGaN epilayer due to lack of lat-tice-matched substrates.Meanwhile,due to high resistivity of high AlN mole fraction Mg doped AlGaN layers,only few groups have reported GaN-based LDs with emission wavelength shorter than 360 nm[1−8],and up to now,there is no room temperature continuous-wave(CW)operation UV LDs with a lasing wavelength shorter than 360 nm ever repor-ted.Previously,we have reported a UV LD with lasing wavelength of 366 nm[9].In this paper,a higher AlN mole frac-tion of AlGaN WG layers is employed to shorten the LD emis-sion wavelength to less than 360 nm.A lasing wavelength of 357.9 nm is achieved. | Jing Yang Degang Zhao Zongshun Liu Feng Liang Ping Chen Lihong Duan Hai Wang Yongsheng Shi | 2022 | Journal of Semiconductors2022，43，1： | 6 |
| 19 | GaN-based blue laser diode with 6.0 W of output power under continuous-wave operation at room temperature显示文摘In this work,we reported the room-temperature continuous-wave operation of 6.0 W GaN-based blue laser diode(LD),and its stimulated emission wavelength is around 442 nm.The GaN-based high power blue LD is grown on a c-plane GaN substrate by metal organic chemical vapor deposition(MOCVD),and the width and length of the ridge waveguide structure are 30 and 1200μm,respectively.The threshold current is about 400 mA,and corresponding threshold current density is 1.1 kA/cm2. | Feng Liang Degang Zhao Zongshun Liu Ping Chen Jing Yang Lihong Duan Yongsheng Shi Hai Wang | 2021 | Journal of Semiconductors2021，42，11： | 6 |
| 20 | Preparation of imprinted monolithic column under molecular crowding conditions显示文摘分子的拥挤是一个新概念与更大的能力和选择获得分子地印的聚合物(MIP ) 。在这个工作,分子的拥挤代理人第一被用于 MIP 整体的列的准备。一个新聚合系统基于包围的分子的拥挤被开发准备印 enrofloxacin 的独块巨石,它聚苯乙烯和 tetrahydrofuran 是镇静的。结果证明在分子的拥挤的条件下面的整体的 MIP 与 3.03 的一个印的因素为 enrofloxacin 介绍了好分子的识别。 | Xiao Xia Li Xin Liu Li Hong Bai Hong Quan Duan Yan Ping Huang Zhao Sheng Liu | 2011 | Chinese Chemical Letters2011，22，8： | 6 |
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