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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | Effects of dietary yeast β-glucan on nutrient digestibility and serum profiles in pre-ruminant Holstein calves显示文摘This study aimed to investigate the effects of dietary supplementation of yeast β-glucan on the nutrient digestibility and serum profiles in pre-ruminant Holstein calves. Forty-two neonatal Holstein calves((39.6±4.2) kg) were randomly allotted to six groups, and each was offered one of the following diets: a basal diet(control) or the basal diet supplemented with 25, 50, 75, 100 or 200 mg of yeast β-glucan kg–1 feed(dry matter basis). The basal diet consisted of a milk replacer and a starter feed. The trial lasted for 56 d. Two digestibility trials were conducted from d 14 to 20 and from d 42 to 48. Blood samples were collected on d 0, 14, 28 and 42 for serum profile analyses. On d 56, three calves from each group were slaughtered, and intestinal samples were collected to assess the villous height, crypt depth and mucosal thickness. Although feed intake was not affected by dietary treatment(P>0.05), the average daily gain(ADG) and gain-to-feed ratios were higher(P<0.05) for the calves fed 75 mg of yeast β-glucan kg–1 feed than those in the other groups. The supplementation of yeast β-glucan at 75 mg kg–1 feed increased the apparent digestibility of dry matter(DM), crude protein(CP), ether extract(EE), and phosphorus(P)(P<0.05) and the ratio of intestinal villous height to crypt depth(V/C)(P<0.05) when compared with the control group. No effects of yeast β-glucan on the serum concentrations of total protein(TP), albumin(ALB), serum urea nitrogen(SUN) and glucose(GLU) were observed(P>0.05). Compared with the control group, supplementation of yeast β-glucan decreased(P<0.05) the serum concentrations of triglycerides(TG) and total cholesterol(TC). The serum concentration of immunoglobulin G(Ig G) and immunoglobulin M(Ig M) increased quadratically(P<0.05), whereas the serum concentration of immunoglobulin A(Ig A) was unaffected by dietary treatments(P>0.05). The supplementation of yeast β-glucan stimulated the enzymatic activity of alkaline phosphatase(ALP)(P<0.05) compared with the control group. The lysozyme(LYZ) concentration increased quadratically(P<0.05) with increasing yeast β-glucan levels. The results suggested that dietary supplementation of yeast β-glucan at 75 mg kg–1 feed improved nutrient digestibility, enhanced immunity by increasing the immunoglobulin concentration and stimulating ALP, and exerted no adverse effects on metabolism in pre-ruminant calves. | MA Tao TU Yan ZHANG Nai-feng GUO Jiang-peng DENG Kai-dong ZHOU Yi YUN Qiang DIAO Qi-yu | 2015 | Journal of Integrative Agriculture2015，14，4： | 23 |
| 3 | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma显示文摘Serum enzymes that play potential roles in tumor growth have recently been reported to have prognostic relevance in a diverse array of tumors.However,prognosis-related serum enzymes are rarely reported for nasopharyngeal carcinoma(NPC).To clarify whether the level of serum enzymes is linked to the prognosis of NPC,we reviewed the pretreatment data of lactate dehydrogenase(LDH),alkaline phosphatase (ALP),and glutamyl transferase (GGT) in 533 newly diagnosed NPC patients who underwent radical radiotherapy between May 2002 and October 2003 at Sun Yat-sen University Cancer Center.Patients were grouped according to the upper limit of normal values of LDH,ALP,and GGT.The Kaplan-Meier method and log-rank test were used for selecting prognostic factors from clinical characteristics and serum enzymes,and the chi-square test was applied to analyze the relationships of clinical characteristics and serum enzymes.Finally,a Cox proportional hazards model was used to identify the independent prognostic factors.We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival(P=0.009 and 0.035,respectively),and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival(P=0.037 and 0.039,respectively).In multivariate analysis,increased LDH level was identified as an independent prognostic factor for overall survival.Therefore,we conclude that increased pretreatment serum LDH and ALP levels are poor prognostic factors for NPC. | Guo Li Jin Gao Ya-Lan Tao Bing-Qing Xu Zi-Wei Tu Zhi-Gang Liu Mu-Sheng Zeng Yun-Fei Xia | 2012 | Chinese Journal of Cancer2012，31，4： | 21 |
| 4 | Health-related quality of life in gastroesophageal reflux patients with noncardiac chest pain: Emphasis on the role of psychological distress显示文摘AIM To investigate the effects of depression and anxiety on health-related quality of life(QoL)in gastroesophageal reflux disease(GERD)patients and those suffering from cardiac(CCP)and noncardiac(NCCP)chest pain in Wuhan,China.METHODS In this cross-sectional study,a total of 358 consecutive patients with GERD were enrolled in Wuhan,China,of which 176 subjects had complaints of chest pain.Those with chest pain underwent coronary angiography and were divided into a CCP group(52 cases)and NCCP group(124 cases).Validated GERD questionnaires were completed,and the 36-item Short-Form Health Survey and Hospital Anxiety/Depression Scale were used for evaluation of Qo L and psychological symptoms,respectively.RESULTS There were similar ratios and levels of depression and anxiety in GERD with NCCP and CCP.However,the QoL was obviously lower in GERD with CCP than NCCP(48.34±17.68 vs 60.21±20.27,P<0.01).In the GERD-NCCP group,rather than the GERD-CCP group,the physical and mental QoL were much poorer in subjects with depression and/or anxiety than those without anxiety or depression.Anxiety and depression had strong negative correlations with both physical and mental health in GERD-NCCP(all P<0.01),but only a weak relationship with mental components of QoL in GERD-CCP.CONCLUSION High levels of anxiety and depression may be more related to the poorer QoL in GERD patients with NCCP than those with CCP.This highlights the importance of evaluation and management of psychological impact for improving QoL in GERD-NCCP patients. | Lei Zhang Lei Tu Jie Chen Jun Song Tao Bai Xue-Lian Xiang Rui-Yun Wang Xiao-Hua Hou | 2017 | World Journal of Gastroenterology2017，23，1： | 14 |
| 5 | Effects of mulberry leaf flavonoid and resveratrol on methane emission and nutrient digestion in sheep显示文摘As a new type of methane control agent, natural plant extract has been widely studied in recent years,but in vivo studies are few. This study was to investigate the effects of the dietary supplementation of 2 different polyphenols on the methane(CH4) emission and digestion metabolism in sheep. Ten healthy crossbred sheep(Dorper(?)× small-tailed Han ♀; BW 60.0 ± 1.73 kg) were used in a change-over design.The sheep were fed the following 3 diets in the present study: the basal diet(CON) with no supplementation; the basal diet supplemented with 2 g mulberry leaf flavonoid(MLF) per day per sheep; the basal diet supplemented with 0.25 g resveratrol(RES) per day per sheep. Both MLF and RES reduced CH4 emission scaled to metabolic weight per kilogram of DMI and CO2 output scaled to metabolic weight, but the effect of RES was significant(P < 0.05). Both MLF and RES significantly improved apparent digestibility of DM, OM, NDF, ADF, and nitrogen, but the effect of RES was significant(P < 0.05). Both MLF and RES significantly improved ME(P < 0.05) and reduced energy losses in CH4 emission(P > 0.05). In conclusion, MLF and RES can improve the digestibility of nutrients, the utilization of nutrients and energy, and reduce CH4 emission, but they are not conducive to nitrogen retention. | Dandan Chen Xiaolin Chen Yan Tu Bo Wang Can Lou Tao Ma Qiyu Diao | 2015 | Animal Nutrition2015，，4： | 14 |
| 6 | Effects of weaning age on growth, nutrient digestibility and metabolism,and serum parameters in Hu lambs显示文摘This study was conducted to investigate the effect of weaning age on growth performance, nutrient digestion and metabolism, and serological indicators, and to obtain an optimal weaning age in Hu lambs.Forty-eight newborn Hu lambs(birth weight, 2.53 ± 0.14 kg) were randomly divided into 4 groups. The lambs in control group(ER) suckled their dams. The lambs in other three experimental groups were weaned on milk replacer at 10.20, and 30 days of age(EW10, EW20, and EW30 groups),respectively. The results were as follows: 1) lambs in EW10 and EW30 groups had a lower(P < 0.05) ADG than those in ER group within 10 days post-weaning; the weaned lambs began to show a higher(P < 0.05) ADG than those in ER group after 20 days post-weaning. 2) EW10 and EW20 groups had a higher(P < 0.05) creep feed intake than EW30 and ER groups from 15 to 60 days of age. 3) The apparent digestibility of dry matter, organic matter, gross energy, nitrogen, ether extract and phosphorus, and the deposition of nitrogen and phosphorus did not differ(P > 0.05) among groups; however, the apparent digestibility and deposition of calcium in early weaned lambs were lower(P < 0.05) than those in ewe-reared lambs. 4)The albumin content in EW30 group was lower(P < 0.05) than that in ER group; the globulin content in EW30 group was higher(P < 0.05) than that in other groups; the content of serum insulin-like growth factor-1 in weaned lambs tended to increase compared with lambs in ER group. Finally, the growth rate of lambs decreased within 10 days post-weaning, but early weaning boosted creep feed intake, leading to better growth and health later in life. The Hu lambs can be weaned on milk replacer and creep feed at 10 days of age. | Jianmin Chai Qiyu Diao Haichao Wang Yan Tu Xiaojing Tao Naifeng Zhang | 2015 | Animal Nutrition2015，，4： | 10 |
| 7 | Effect of supplementation of allicin on methanogenesis and ruminal microbial flora in Dorper crossbred ewes显示文摘Background: Garlic extracts have been reported to be effective in reducing methanogenesis. Related mechanisms are not well illustrated, however, and most studies have been conducted in vitro. This study investigates the effects of supplementary allicin(AL) in sheep diet on in vivo digestibility, rumen fermentation, and shifts of microbial flora.Methods: Two experiments were conducted using Dorper × thin-tailed Han crossbred ewes. In experiment 1,eighteen ewes(60.0 ± 1.73 kg BW) were randomly assigned for 29 days to either of two dietary treatments: a basal diet or the basal diet supplemented with 2.0 g AL/head?day to investigate supplementary AL on nutrient digestibility and methane emissions. In experiment 2, six ewes(65.2 ± 2.0 kg BW) with ruminal canulas were assigned to the same two dietary treatments as in experiment 1 for 42 days to investigate supplementary AL on ruminal fermentation and microbial flora. The methane emissions were determined using an open-circuit respirometry system and microbial assessment was done by q PCR of 16 S r RNA genes.Results: Supplementary AL increased the apparent digestibility of organic matter(P < 0.001), nitrogen(P = 0.006),neutral detergent fiber(P < 0.001), and acid detergent fiber(P = 0.002). Fecal nitrogen output was reduced(P = 0.001)but urinary nitrogen output was unaffected(P = 0.691), while nitrogen retention(P = 0.077) and nitrogen retention/nitrogen intake(P = 0.077) tended to increase. Supplementary AL decreased methane emissions scaled to metabolic bodyweight by 5.95 %(P = 0.007) and to digestible organic matter intake by 8.36 %(P = 0.009). Ruminal p H was unaffected(P = 0.601) while ammonia decreased(P = 0.024) and total volatile fatty acids increased(P = 0.024) in response to supplementary AL. Supplementary AL decreased the population of methanogens(P = 0.001) and tended to decrease that of protozoans(P = 0.097), but increased the populations of F. succinogenes(P < 0.001), R. flavefaciens(P = 0.001), and B. fibrisolvens(P = 0.001).Conclusions: Supplementation of AL at 2.0 g/head?day effectively enhanced OM, N, NDF, and ADF digestibility and reduced daily methane emissions(L/kg BW0.75) in ewes, probably by decreasing the population of ruminal protozoans and methanogens. | Tao Ma Dandan Chen Yan Tu Naifeng Zhang Bingwen Si Kaidong Deng Qiyu Diao | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 9 |
| 8 | Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis显示文摘 | Tao Zhu Wan-Ting Luo Gui-Hua Chen Yue-Sheng Tu Shuo Tang Huo-Jin Deng Wei Xu Wei Zhang Di Qi Dao-Xin Wang Chang-Yi Li He Li Yan-Qiao Wu Shen-Jin Li | 2018 | Chinese Medical Journal2018，，18： | 7 |
| 9 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 10 | Energy Requirements for Maintenance and Growth of German Mutton Merino Crossbred Lambs显示文摘A comparative slaughter trial and a metabolism trial were conducted to determine the requirement of net energy (NE) and metabolizable energy (ME) by the crossbreed of German Mutton Merino×Inner Mongolia Merino for fattening from 35 to 50 kg of body weight (BW). 49 crossbred female lambs ((33.9±2.3) (SD) kg BW) of German Mutton Merino×Inner Mongolia Merino were used. 34 lambs were randomly chosen for comparative slaughter, which were offered an identical mixture diet (concentrate:roughage=55:45) at 100, 75 or 55% of ad libitum intake, whereas the remainders were used in the metabolism trial to evaluate the ME of the diet after methane production was measured by open-circuit respirometry. As feed intake decreased from 100 to 75 and 55% of ad libitum intake, the apparent digestibility of dry matter (DM) linearly increased (P=0.010) from 60.8 to 63.6 and 66.9%, respectively, and methane production decreased from 52.1 to 44.3 and 39.9 Ld-1, respectively, but the ratio of methane energy to gross energy intake increased linearly (P=0.010) from 8.20 to 8.96 and 10.97%, respectively. Consequently, the ME values of the diet increased from 9.35 to 9.64 and 9.85 MJ kg-1 DM, respectively. The NE requirement for maintenance (NEm) was 255 kJ kg-1 BW0.75, and the ME requirement for maintenance (MEm ) was 352 kJ kg-1 BW0.75, with a partial energy efficiency for maintenance (km) of 0.72. The NE requirement for growth (NEg ) ranged from 1.26 to 4.66 MJ d-1 as average daily gains increased from 100 to 300 g d-1, with a partial energy efficiency for growth (kg ) of 0.45. These results indicated that the NE g required by crossbred female lambs of German Mutton Merino×Inner Mongolia Merino was lower than the recommendation of the American or British nutritional system. | DENG Kai-dong DIAO Qi-yu JIANG Cheng-gang TU Yan ZHANG Nai-feng LIU Jie MA Tao ZHAO Yi-guang XU Gui-shan | 2013 | Journal of Integrative Agriculture2013，12，4： | 6 |
| 11 | Loss of Gn1a/OsCKX2 confers heavy-panicle rice with excellent lodging resistance显示文摘Significant achievements have been made in breeding programs for the heavy-panicle-type(HPT)rice(Oryza sativa) in Southwest China. The HPT varieties now exhibit excellent lodging resistance,allowing them to overcome the greater pressures caused by heavy panicles. However, the genetic mechanism of this lodging resistance remains elusive. Here, we isolated a major quantitative trait locus, Panicle Neck Diameter 1(PND1), andidentified the causal gene as GRAIN NUMBER 1 A/CYTOKININ OXIDASE 2(Gn1 A/Os CKX2). The null gn1 a allele from rice line R498(gn1 aR498) improved lodging resistance through increasing the culm diameter and promoting crown root development.Loss-of-function of Gn1 a/Os CKX2 led to cytokinin accumulation in the crown root tip and accelerated the development of adventitious roots. Gene pyramiding between the null gn1 aR498 allele with two gain-of-function alleles, STRONG CULM 2(SCM2)and SCM3, further improved lodging resistance.Moreover, Gn1 a/Os CKX2 had minimal influence on overall rice quality. Our research thus highlights the distinct genetic components of lodging resistance of HPT varieties and provides a strategy for tailormade crop improvement of both yield and lodging resistance in rice. | Bin Tu Zhang Tao Shiguang Wang Lei Zhou Ling Zheng Chun Zhang Xinzi Li Xiaoyu Zhang Junjie Yin Xiaobo Zhu Hua Yuan Ting Li Weilan Chen Peng Qin Bingtian Ma Yuping Wang Shigui Li | 2022 | Journal of Integrative Plant Biology2022，64，1： | 5 |
| 12 | Quantum computation on gate-defined semiconductor quantum dots显示文摘During the past few years, researchers have made significant progress on quantum information processing in gate controlled semiconductor quantum dots. We review the global research efforts, including works by our group, which provides pathways towards applications in quantum computation. | LI HaiOu YAO Bing TU Tao GUO GuoPing | 2012 | Chinese Science Bulletin2012，57，16： | 5 |
| 13 | Age-specific differences in non-cardiac comorbidities among elderly patients hospitalized with heart failure: a special focus on young-old, old-old, and oldest-old显示文摘Background:Despite the growing epidemic of heart failure(HF),there is limited data available to systematically compare noncardiac comorbidities in the young-old,old-old,and oldest-old patients hospitalized for HF.The precise differences will add valuable information for better management of HF in elderly patients.Methods:A total of 1053 patients aged 65 years or older hospitalized with HF were included in this study.Patients were compared among three age groups:(1)young-old:65 to 74 years,(2)old-old:75 to 84 years,and(3)oldest-old:≥85 years.Clinical details of presentation,comorbidities,and prescribed medications were recorded.Results:The mean age was 76.7 years and 12.7%were 85 years or older.Most elderly patients with HF(97.5%)had at least one of the non-cardiac comorbidities.The patterns of common non-cardiac comorbidities were different between the young-old and oldestold group.The three most common non-cardiac comorbidities were anemia(53.6%),hyperlipidemia(45.9%),and diabetes(42.4%)in the young-old group,while anemia(73.1%),infection(58.2%),and chronic kidney disease(44.0%)in the oldest-old group.Polypharmacy was observed in 93.0%elderly patients with HF.Additionally,29.2%patients were diagnosed with infection,and 67.0%patients were prescribed antibiotics.However,60.4%patients were diagnosed with anemia with only 8.9%of them receiving iron repletion.Conclusions:Non-cardiac comorbidities are nearly universal in three groups but obviously differ by age,and inappropriate medications are very common in elderly patients with HF.Further treatment strategies should be focused on providing optimal medications for age-specific non-cardiac conditions. | Meng-Xi Yang Hui An Xue-Qiang Fan Li-Yuan Tao Qiang Tu Li Qin Li-Fang Zhang Dong-Ping Feng Yu Wang Li Sun Si Gao Wen-Zhuo Guan Jin-Gang Zheng Jing-Yi Ren | 2019 | Chinese Medical Journal2019，，24： | 4 |
| 14 | High-efficiency simultaneous extraction of rare earth elements and iron from NdFeB waste by oxalic acid leaching显示文摘Iron can not be recovered at high value because only rare earth elements are effectively recovered from NdFeB waste via oxidation roasting-hydrochloric acid leaching process.In this study,a new method for leaching NdFeB waste with oxalic acid was developed.The high-efficiency,simultaneous and high-value recovery of rare earth elements and iron was realized to simplify the process and improve the economic benefit.Results of the oxalic acid leaching experiments show that under the optimum leaching conditions at 90℃ for 6 h in the aqueous solution of oxalic acid(2 mol/L) with a liquid-solid ratio of60 mL/g,the iron leaching efficiency and precipitation rate of rare earth oxalate reach 93.89% and 93.17%,respectively.Rare earth oxalate and Fe(C_(2)O_(4))3^(3-) were left in the residue and the leaching solution,respectively.The leaching mechanism was further analyzed by characterising the leach residues obtained through X-ray powder diffraction(XRD) and scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDS).Results of the leaching kinetics study indicate that the process of oxalic acid leaching follows the shrinking nucleus model,and the leaching kinetics model is controlled by the mixed factors of diffusion and chemical reaction.The leaching residue was calcined at 850℃ for 3 h and then decomposed into rare earth oxide,which can be directly used to prepare rare earth alloy via molten salt electrolysis.For the leaching solution,ferric oxalate solution was reduced using Fe powder to prepare the ferrous oxalate(FeC_(2)O_(4)-2H_(2)O). | Qingsheng Liu Tao Tu Hao Guo Huajin Cheng Xuezhong Wang | 2021 | Journal of Rare Earths2021，39，3： | 4 |
| 15 | Correlation between miR-564, TGF-β1, and radiation-induced lung injury显示文摘Objective Our study aimed to analyze the expression of miR-564 and TGF-β1 in cancer tissues and the serum of patients with radiation-induced lung injury,and to investigate the relationship between them and radiation-induced lung injury.Methods In situ hybridization and real-time fluorescence quantitative method were used to detect the expression of miR-564.Additionally,immunohistochemistry and enzyme-linked immunosorbent assay(ELISA)were performed to detect the expression of TGF-β1.Results The overall incidence of acute radiation pneumonia was 55.9%(100/179).The incidence of≥grade 2 radioactive pneumonia was 24.0%(43/179)and that of grade 1 was 31.8%(57/179).The expression of miR-564 in grade≥2 was slightly higher than that in patients without or with grade 1,but there was no statistical difference(P=0.86).The serum level and ratio of miR-564 in patients with grade≥2 were significantly higher than those without or with grade 1(P=0.005,P=0.025,respectively).The expression of TGF-β1 in grade≥2 was significantly higher than that of patients without or with grade 1(P=0.017).The serum levels of TGF-β1 in grade≥2 were significantly higher than those in patients without or with grade 1(P=0.038).Although the ratio of TGF-β1 in radiation pneumonia of grade≥2 was significantly higher than that of without or with grade 1,there was no significant difference(P=0.24).Moreover,patients with higher expression of miR-564 and lower expression of TGF-β1 had better prognosis.Conclusion MiR-564 and TGF-β1 are predictors of radiation-induced lung injury.Monitoring its changing trend can improve the accuracy of predicting radiation-induced lung injury.The levels and ratio of serum miR-564 and TGF-β1 in patients with radiation-induced lung injury are related to the severity of radiationinduced lung injury. | Yunzhang Ge Tao Xie Bin Yang Qianxia Li Qingrong Ren Xiaoyi Zhou Desheng Hu Zhongshu Tu | 2019 | Oncology and Translational Medicine2019，5，5： | 4 |
| 16 | Effects of Epidural Spinal Cord Stimulation and Treadmill Training on Locomotion Function and Ultrastructure of Spinal Cord Anterior Horn after Moderate Spinal Cord Injury in Rats显示文摘Objective:To investigate the effects of epidural spinal cord stimulation(ESCS) and treadmill training on the locomotion function and ultrastructure of spinal cord anterior horn after moderate spinal cord injury in rats.Method:Nine adult female Sprague-Dawley rats were randomly distributed into three groups:①spinal cord injury group(SI,n=3).②spinal cord injury plus ESCS group(SE,n=3).③spinal cord injury plus treadmill training group(TT,n=3).All rats received a moderate spinal cord injury surgery.Four weeks after surgery,rats in SE group received an electrode implantation procedure,with the electrode field covering spinal cord segments L2-S1.Four weeks after electrode implantation,rats received subthreshold ESCS for 30 min/d.Rats in TT group received 4cm/s treadmill training for 30min/d.Rats in SI group received no intervention,as a control group.All procedures in these three groups lasted four weeks.The open field Basso,Beattie and Bresnahan(BBB) scale was used before and after intervention to evaluate rats' hindlimb motor function.Result:After four weeks intervention,rats in TT group improved their open field locomotion scores to 20.In contrast,no significant improvement was observed in groups SI and SE.The morphology of synapses and neurons were similar regardless of whether rats had undergone ESCS,treadmill training or not.Conclusion:ESCS alone was not sufficient to improve the walking ability of spinal cord injured rats.ESCS or treadmill training alone might not contribute to the changes of ultrastructure in anterior horn of spinal cord that underlie the recovery of walking ability.Further research is needed to understand the contributions of combination of ESCS and treadmill training to the rehabilitation of spinal cord injured rats. | WANG Yizhao HUANG Xiaolin XU Jiang XU Tao FANG Zhengyu XU Qi TU Xikai YANG Peipei | 2009 | 中国康复医学杂志2009，24，6： | 4 |
| 17 | Stability analysis of particle swarm optimization without Lipschitz constraint显示文摘There are some adjustable parameters which direcdy influence the performance and stability of Particle Swarm Op-ttimization algorithm. In this paper, stabilities of PSO with constant parameters and time-varying parameters are analyzed withoutLipschitz constraint. Necessary and sufficient stability conditions for acceleration factor ψand inertia weight w are presented. Exper-iments on benchmark functions show the good perfomance of PSO satisfying the stability condition, even without Lipschitz con-straint. And the inertia weight w value is enhanced to ( - 1,1 ). | Jie CHEN, Feng PAN, Tao CAI, Xuyan TU(Department of Automatic Control, School of Information Science Technology, Beijing Institute of Technology, Beijing 100081, China) | 2003 | 控制理论与应用(英文版)2003，1，1： | 4 |
| 18 | Clinical Outcomes and Risks of Single-stage Bilateral Unicompartmental Knee Arthroplasty via Oxford Phase III显示文摘 | Tong Ma Yi-Hui Tu Hua-Ming Xue Tao Wen Min-Wei Cai | 2015 | Chinese Medical Journal2015，，21： | 3 |
| 19 | Protein requirements of early-weaned Dorper crossbred female lambs显示文摘The net protein(NP) and metabolizable protein(MP) requirements of Dorper crossbred female lambs from 20 to 35 kg body weight(BW) were assessed in a comparative slaughter trial. Thirty-five Dorper×thin-tailed Han crossbred lambs weaned at approximately 50 d of age((19.1±2.37) kg of BW) were used. Seven randomly selected lambs were slaughtered at the beginning of the trial as baseline group(BL). An intermediate group of seven randomly selected lambs fed ad libitum(AL) intake was slaughtered when the lambs reached an average BW of 28.6 kg. The remaining 21 lambs were allotted randomly to three levels of dry matter intake: AL or restricted to 70 or 40% of the AL intake. All lambs were slaughtered when the sheep fed AL intake reached 35 kg of BW. Total body N and N retention were determined. The results showed that the maintenance requirements for NP and MP were 1.75 and 3.37 g kg^(–1) metabolic shrunk body weight(SBW0.75), respectively. The partial efficiency of protein use for maintenance was 0.52. The NP requirements for growth ranged from 10.9 to 42.4 g d^(–1) for the lambs gaining 100 to 350 g d^(–1) from 20 to 35 kg BW. The partial efficiency of MP for growth was 0.52. In conclusion, the NP and MP requirements for the maintenance and growth of Dorper crossbred female lambs were lower than those reported by AFRC(1993) and NRC(2007) recommendations. | MA Tao DENG Kai-dong TU Yan ZHANG Nai-feng SI Bing-wen XU Gui-shan DIAO Qi-yu | 2017 | Journal of Integrative Agriculture2017，16，5： | 3 |
| 20 | Involvement of hydrogen sulfide in the progression of renal fibrosis显示文摘Objective:Renal fibrosis is the most common manifestation of chronic kidney disease(CKD).Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it,there is an urgent need to identify novel therapies.Hydrogen sulfide(H2S)is a newly discovered endogenous small gas signaling molecule exerting a wide range of biologic actions in our body.This review illustrates recent experimental findings on the mechanisms underlying the therapeutic effects of H2S against renal fibrosis and highlights its potential in future clinical application.Data sources:Literature was collected from PubMed until February 2019,using the search terms including'Hydrogen sulfide,''Chronic kidney disease'MRenal interstitial fibrosis,'Kidney disease,''Inflammation factor,''Oxidative stress,''Epithelialto-mesenchymal transition,''H2S donor,''Hypertensive kidney dysfunction,''Myofibroblasts,''Vascular remodeling,''transforming growth factor(TGF)-beta/Smads signaling,'and'Sulfate potassium channels.'Study selection:Literature was mainly derived from English articles or articles that could be obtained with English abstracts.Article type was not limited.References were also identified from the bibliographies of identified articles and the authors5 files.Results:The experimental data confirmed that H2S is widely involved in various renal pathologies by suppressing inflammation and oxidative stress,inhibiting the activation of fibrosis-related cells and their cytokine expression,ameliorating vascular remodeling and high blood pressure,stimulating tubular cell regeneration,as well as reducing apoptosis,autophagy,and hypertrophy.Therefore,H2S represents an alternative or additional therapeutic approach for renal fibrosis.Conclusions:We postulate that H2S may delay the occurrence and progress of renal fibrosis,thus protecting renal function.Further experiments are required to explore the precise role of H2S in renal fibrosis and its application in clinical treatment. | Yu Wang Qi-Qi Xing Jing-Ke Tu Wen-Bin Tang Xiang-Ning Yuan Yan-Yun Xie Wei Wang Zhang-Zhe Peng Ling Huang Hui Xu Jiao Qin Xiang-Cheng Xiao Li-Jian Tao Qiong-Jing Yuan | 2019 | Chinese Medical Journal2019，，23： | 3 |
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