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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Characteristics and efficacy of modified adenomyomectomy in the treatment of uterine adenomyoma显示文摘背景 Adenomyoma 是影响生活的质量的很严重的疾病并且在结束导致不孕,和子宫切除。Unfortunetly,我们仍然没有有效方法治疗这种疾病。这研究被瞄准评估功效和这是的修改 adenomyomectomy.Methods 的外科的特征回顾的研究和这些题目在过去的 5 年里被收集。我们由二个不同外科的过程划分了这些题目。经历了保守外科,修改 adenomyomectomy 或 adenomyoma 损害的楔切除术的 adenomyoma 病人的盒子被散布到二个组 retrospectively.Surgical 特征,症状消除,和复发在每个 group.Results 将军特征被分析,包括操作时间,血损失,和手术后的复杂并发症在两个组是类似的。在修改 adenomyometomy 组,中部的后续时间是 27.6 个月和痛经的地势的率, menorrhagia 症状分别地是 91.2% 和 40.0% 。在楔切除术组,痛经和 menorrhagia 症状的 reliefe 的率分别地是 88.9% 和 50.0% 。在两个组的病人有统计上重要的症状地势,但是他们之间没有统计差别。在下列时间期间,在修改修改 adenomyomectomy 组的 ultrasonography 恶化率比楔切除术组显著地低 15.0% 对 69.2%(P 0.001 ) 。以症状,恶化率在修改 adenomyomectomy 组是 5.0% ,它类似于在楔切除术组的恶化率。以繁殖结果,有在修改 adenomyomectomy 组的不孕复杂并发症的33.3%病人成为了 pregnant.Among 他们,由帮助繁殖技术的怀孕的率是45.5%,它比自然怀孕的率显著地高,23.1%( P=0.039 ) .Conclusion 修改了 adenomyomectomy 看起来是一只保险箱和在在外科以后减少恶化的率显示出优点的有效起作用的方法。 | SUN Ai-jun LUO Min WANG Wei CHEN Rong LANG Jing-he | 2011 | Chinese Medical Journal2011，，9： | 15 |
| 3 | Investigating metal-organic framework as a new pseudo-capacitive material for supercapacitors显示文摘A new application of metal organic framework(MOF) as a pseudo-capacitive material for supercapacitors is investigated.To this end,a simple nickel-based MOF,formulated Ni_3(btc)_2-12H_2O,is synthesized via a hydrothermal reaction.As an electro-active material,such nickel-based MOF exhibits superior pseudocapacitive behavior in KOH aqueous electrolyte with a high specific capacitance of 726 Fg^(-1).Also,it displays good electrochemical stability with 94.6%of the initial capacitance over consecutive 1000 cycles.In addition,a simple asymmetric supercapacitor with a high energy density of 16.5 Wh kg^(-1) is successfully built using the nickel-based MOF as positive electrode and commercial activated carbon as negative electrode in KOH electrolyte. | Long Kang Shi-Xiong Sun Ling-Bin Kong Jun-Wei Lang Yong-Chun Luo | 2014 | Chinese Chemical Letters2014，25，6： | 13 |
| 4 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 5 | Heteroclitins R-S: new dibenzocylooctadiene lignans from Kadsura heteroclita显示文摘AIM: To study the dibenzocylooctadiene lignans from the stems of Kadsura heteroclita. METHOD: Chromatographic separations of silica gel and semi-preparative HPLC were used. All of the structures were elucidated on the basis of spectroscopic analysis,including 2D-NMR and HR-MS techniques. RESULTS: Four dibenzocylooctadiene lignans were isolated from K. heteroclita. Their structures were identified as heteroclitin R(1), heteroclitin S(2), gonisin O(3), and schisanlignone A(4). CONCLUSION: Heteroclitin R(1) and heteroclitin S(2) are new natural lignans. | CHEN Min LUO You-Ping ZOU Yan-Lin LANG Ling-Hu CHEN Dao-Feng | 2014 | Chinese Journal of Natural Medicines2014，12，9： | 8 |
| 6 | Altered expression of mitochondrial related genes in the native Tibetan placents by mitochondrial cDNA array analysis显示文摘Objective: To explore the mechanism of native Tibetan fetuses adaptation to hypoxia, we tried to find the different expression genes about mitochondrial function in the native Tibetan placents. Methods: In this study, the placents of native Tibetan and the high-altitude Han (ha-Han) were collected. After the total RNA extraction, the finally synthesized cDNAs were hybridized to mitochondrial array to find the altered expression genes between them. Then, the cytochrome c oxidase 17 (Cox17), dynactin 2 (DCTN2, also known as p50), and vascular endothelial growth factor receptor (VEGFR, also known as KDR) were chosen from the altered expression genes to further verify the array results using the SYBR Green real-time PCR. Because the altered expression genes (such as Cybb and Cox17) in the array results related to the activities of COXI and COXIV, the placental mitochondria activities of COXI and COXIV were measured to find their changes in the hypoxia. Results: By a standard of ≥1.5 or ≤0.67, there were 24 different expressed genes between the native Tibetan and the ha-Han placents, including 3 up-regulated genes and 21 down-regulated genes. These genes were related to energy metabolism, signal transduction, cell proliferation, electron transport, cell adhesion, nucleotide-excision repair. The array results of Cox17, DCTN2 and KDR were further verified by the real-time RT-PCR. Through the mitochondria respiration measurements, the activity of COXI in the native Tibetan placents were higher than that of ha-Han, there was no difference in COXIV activity between them. Conclusion: The altered mitochondrial related genes in the native Tibetan placents may have a role in the high altitude adaptation for fetuses through changing the activity of mitochondrial COX. | Luo Yongjun Gao Wenxiang Zhao Xiuxin SUO Lang Chen Li Liu Fuyu Song Tonglin Chen Jian Gao Yuqi | 2009 | Journal of Medical Colleges of PLA(China)2009，24，1： | 7 |
| 7 | 雷帕霉素对小鼠百草枯中毒导致肺纤维化的治疗作用(英文)显示文摘目的:评估雷帕霉素(RAPA)对小鼠百草枯(PQ)中毒导致肺纤维化的治疗作用,并初步探讨其作用机制。创新点:首次在小鼠PQ中毒的模型中证明RAPA可明显抑制肺纤维化,且此作用与转化生长因子-β1(TGF-β1)的抑制相关。方法:将C57BL/6J雄鼠分为对照组(腹腔注射生理盐水)和实验组(腹腔注射10 mg/kg PQ)。实验组根据采用的治疗不同,可分为以下四组:PQ组、PQ+RAPA组、PQ+MP(甲强龙)组和PQ+MP+RAPA组。用苏木精-伊红染色法(H&E)和马松(Masson)三色染色法观察肺组织病理结构变化,用酶联免疫吸附测定(ELISA)试剂盒检测肺组织中的羟脯氨酸(HYP)含量,用免疫组化和免疫印迹的方法检测TGF-β1和α-平滑肌肌动蛋白(α-SMA)的表达水平。结论:本实验中小鼠的肺组织病理染色结果显示,RAPA治疗能缓解肺纤维化导致的病理改变(图3)。ELISA实验结果显示,RAPA治疗28天后可显著降低肺组织中HYP的含量(图4)。免疫组化和免疫印迹实验结果显示,RAPA治疗能明显下调肺组织中TGF-β1和α-SMA的高表达(图5和6)。综上所述,RAPA在治疗PQ中毒导致的肺纤维化中有重要价值。 | Xue SHAO Meng LI Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG Jiang-hua CHEN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 7 |
| 8 | Clinicopathological study on TTV infection in hepatitis of unknown etiology显示文摘AIM: To investigate the state of infection, replication site,pathogenicity and clinical significance of transfusiontransmitted virus (TTV) in patients with hepatitis, especiallyin patients of unknown etiology.METHODS: Liver tissues taken from 136 cases of non-A non-G hepatitis were tested for Tr virus antigen and nucleic acidby in situ hybridization (ISH) and nested-polymerase chainreaction (PCR). Among them, TT virus genome and itscomplemental strand were also detected in 24 cases ofautopsy liver and extrahepatic tissues with ISH. Meanwhile,TTV DNA was detected in the sera of 187 hepatitis patientsby nested-PCR. The pathological and clinical data of thecases infected with nv only were analyzed.RESULTS: In liver, the total positive rate of rrv DNA was32.4 % and the positive signals were located in the nuclei ofhepatocytes. In serus, rrv DNA was detected in 21. 4 %cases of hepatitis A-G, 34.4 % of non-A non-G hepatitis and15 % of healthy donors. The correspondence rate of lrvDNA detection between liver tissue with ISH and sera withPCR was 63.2 % and 89.3 % in the same liver tissues by ISHand by PCR, respectively. Using double-strand probes andsingle-strand probes designed to detect TTV genome, thecorrespondence rate of Trv DNA detected in liver andextrahepatic tissues was 85. 7 %. Using single-strandprobes, TTV genome could he detected in liver andextrahepatic tissues by PCR, but its complemental strands(replication strands) could be observed only in livers. Theliver function of most cases infected with TTV alone wasabnormal and the liver tissues had different pathologicaldamage such es ballooning, acidophilia degeneration,formation of apoptosis bodies and focus of necrosis, but the inflammation in the Iobule and portal area was mild.CONCLUSION: The positive rate of TTV DNA among cases ofhepatitis was higher than that of donors, especially inpatients with nonA non-G hepatitis, but most of them werecoinfected with other hepatitis viruses. Lrv can infect notonly hepatocytes, but also extrahepstic tissues. However,the chief replication place may be liver. The infection of lrvmay have some pathogenicity. Although the pathogenicity iscomparatively weak, it can still damage the liver tissues.The lesions in acute hepatitis (AH) and chronic hepatitis(CH) am mild, but in severe hepatitis (SH) , it can be veryserious and cause liver function failure, therefore, we shouldpay more attention to TTV when studying the possiblepathogens of so-called 'liver hepatitis of unknown etiology'. | Zhong-Jie Hu Zhen-Wei Lang Yu-Sen Zhou Hui-Ping Yan De-Zhuang Huang Wan-Rong Chen Zhao-Xia Luo,Department of Pathology,Beijing You’an Hospital,Beijing 100054,China | 2002 | World Journal of Gastroenterology2002，8，2： | 6 |
| 9 | Yearly tropical cyclone potential impact index in China显示文摘A new composite index called the yearly tropical cyclone potential impact(YTCPI)is introduced.The relationship between YTCPI and activities of tropical cyclones(TCs)in China,disaster loss,and main ambient fields are investigated to show the potential of YTCPI as a new tool for short-term climate prediction of TCs.YTCPI can indicate TC activity and potential disaster loss.As correlation coefficients between YTCPI and frequency of landfalling TCs,the frequency of TCs traversing or forming inside a 24 h warning line in China from 1971 to 2010 are 0.58 and 0.56,respectively(both are at a statistically significant level,aboveα=0.001).Furthermore,three simple indexes are used to compare with YTCPI.They all have very close relationships with it,with correlation coefficients 0.75,0.82 and 0.78.For economic loss and YTCPI,the correlation coefficient is 0.57 for 1994–2009.Information on principal ambient fields(sea surface temperature,850 and 500 hPa geopotential heights)during the previous winter is reflected in the relationship with YTCPI.Spatial and temporal variabilities of ambient fields are extracted through empirical orthogonal function(EOF)analysis.Spatial distributions of correlation coefficient between YTCPI and ambient fields match the EOF main mode.Correlation coefficients between YTCPI and the EOF time array for the three ambient fields are 0.46,0.44 and 0.4,respectively,all statistically significant,aboveα=0.01.The YTCPI has the overall potential to be an improved prediction tool. | YIN YiZhou LUO Yong XIAO FengJing LANG XianMei | 2014 | Science China Earth Sciences2014，57，3： | 4 |
| 10 | Plasmon Assisted Highly Efficient Visible Light Catalytic CO_(2) Reduction Over the Noble Metal Decorated Sr-Incorporated g-C_(3)N_(4)显示文摘The photocatalytic performance of g-C_(3)N_(4) for CO_(2) conversion is still inadequate by several shortfalls including the instability,insu cient solar light absorption and rapid charge carrier's recombination rate. To solve these problems,herein,noble metals(Pt and Au)decorated Sr-incorporated g-C_(3)N_(4) photocatalysts are fabricated via the simple calcination and photo-deposition methods. The Sr-incorporation remarkably reduced the g-C_(3)N_(4) band gap from 2.7 to 2.54 eV,as evidenced by the UV–visible absorption spectra and the density functional theory results. The CO_(2) conversion performance of the catalysts was evaluated under visible light irradiation. The Pt/0.15 Sr-CN sample produced 48.55 and 74.54 μmol h-1 g-1 of CH_(4) and CO,respectively.These amounts are far greater than that produced by the Au/0.15 Sr-CN,0.15 Sr-CN,and CN samples. A high quantum e ciency of 2.92% is predicted for the Pt/0.15 Sr-CN sample. Further,the stability of the photocatalyst is confirmed via the photocatalytic recyclable test. The improved CO_(2) conversion performance of the catalyst is accredited to the promoted light absorption and remarkably enhanced charge separation via the Sr-incorporated mid gap states and the localized surface plasmon resonance e ect induced by noble metal nanoparticles.This work will provide a new approach for promoting the catalytic e ciency of g-C_(3)N_(4) for e cient solar fuel production. | Muhammad Humayun Habib Ullah Lang Shu Xiang Ao Asif Ali Tahir Chungdong Wang Wei Luo | 2021 | Nano-Micro Letters2021，13，12： | 4 |
| 11 | Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library显示文摘Currently,display-based methods are well established and widely used in antibody engineering for affinity maturation and structural stability improvement.We obtained a novel anti-human programmed death 1(PD-1)antibody using computer-aided design and a mammalian cell display technology platform.We used computer-aided modeling and distance geometry methods to predict and assign the key residues that contributed to the binding of human PD-L1 to PD-1.Then,we analyzed the sequence of nivolumab(an anti-human PD-1 antibody,referred to as MIL75 in the article)to determine the template for antibody design and library construction.We identified a series of potential substitutions on the obtained template and constructed a virtual epitope-targeted antibody library based on the physicochemical properties and each possible location of the assigned key residues.The virtual antibody libraries were displayed on the surface of mammalian cells as the antigen-binding fragments of full-length immunoglobulin G.Then,we used flow cytometry and sequencing approaches to sort and screen the candidates.Finally,we obtained a novel anti-human PD-1 antibody named FV78.FV78 competitively recognized the PD-1 epitopes that interacted with MIL75 and possessed an affinity comparable to MIL75.Our results implied that FV78 possessed equivalent bioactivity in vitro and in vivo compared with MIL75,which highlighted the probability and prospect of FV78 becoming a new potential antibody therapy. | Longlong Luo Shi Wang Xiaoling Lang Tingting Zhou Jing Geng Xinying Li Chunxia Qiao Jiannan Feng Beifen Shen Ming Lv Yan Li | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 12 | Screening high-quality fetal bovine serum for porcine oocyte maturation in vitro显示文摘Fetal bovine serum(FBS) is widely used in cell cultures due to its high stability and easy access. It was also used as a substitute for porcine follicular fluid(PFF) in previous studies. However, FBS components are unclear, and the presence of FBS in culture media may introduce a variation from batch to batch. This study aimed to establish an effective method to screen FBS in place of PFF in the culture media for porcine oocytes in vitro. We screened FBS from different sources by using porcine fetal fibroblast cells. The effects of six FBS samples on porcine fetal fibroblast cell growth were tested via frozen cell survival assay, cell clone formation assay, cell growth curve, and cell passage activity assay. The best serum that we called GFBS(heat-inactivated FBS, cat. no. 10500-64;Gibco) showed a similar effect on the maturation and development of porcine oocytes to that of PFF and can be used as a good substitute for PFF. These results suggested that the porcine fetal fibroblast cell culture test can be used as a valuable method to screen FBS for porcine oocyte maturation and embryonic development in vitro. | Xueqing Liu Qiaoli Lang Meng Wu Xiaoyan You Qiling He Ling Luo Zijia Liu Puying Xiao Nan Huang Xi Yang Liangpeng Ge | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 13 | Safety and efficacy of polymer-free paclitaxel-eluting microporous stent in real-world practice: 1-year follow-up of the SERY-I registry显示文摘冠的 stents 上的 BackgroundPolymer 涂层导致脉管的煽动性的反应,还原剂 re-endothelialization ,并且在经皮的冠的干预(一种总线标准) .The SERY-1 登记试图决定是否以后,影响长期的结果多微孔的 Yinyi stent 能改进的新奇没有聚合物的 paclitaxel-eluting 在在临床的真实世界的临床的 practice.Methods 和 angiographic 数据的索引过程以后的1年的结果和后续结果在与 implantati 经历了一种总线标准的 1045 | Zhang Rui-yan Zhang Qi Zhu Jin-zhou Chen Liang-long Zhang Chen-yun Zhou Xu-chen Yuan Yong Zhong Zhi-xiong Li Lang Qiu Jian Wang Wei Chen Xi-ming Yang Zhi-jian Yan Jin-chuan Chen Shao-liang Hou Yu-qing Wu Yan-qing Luo Hai-ming Qiu Jian-ping Zhu Li Wang Yan Fu Guo-sheng Wang Jian-an Ma Kang-hua Yin Yue-hui Zhang Dai-fu Hu Xue-song Zhu Guo-ying Shen Wei-feng | 2011 | Chinese Medical Journal2011，，21： | 3 |
| 14 | Statistical Analysis of Regularity of Pesticide Residues in Vegetables Produced in Inner Mongoli显示文摘[Objective]The paper was to study regularity of pesticide residues in vegetables produced in Inner Mongolia.[Method]Mathematical statistic analysis was carried out on 6 800 samples of veggies,fruits,leguminous vegetables,nuts and seeds produced in Inner Mongolia.[Result]The dominated vegetables in Inner Mongolia were green leafy vegetables,solanaceous vegetables and melon vegetables,and their yields accounted for 70%of the total vegetables production.Since 2003,with the rapid increase of detected vegetable numbers,the status of vegetable quality safety had entered into a new stage of sustainable steady after a rapid decline or periodic fluctuation,and the differences in safety levels were obvious,of which the range of exceeding standard rate of pesticide residues in solanaceous vegetables,melon vegetables and leguminous vegetables(about 55%of the total vegetables)was under 2%,with average values of 1.1%,1.6%and 3.1%,respectively.They belonged to stable type.The exceeding standard rate of pesticide residues in green leafy vegetables and Chinese cabbage group(about 30%of total vegetables)presented a decreasing trend year by year,wondering in the range of 7%-10%.They belonged to main risk type.The time period of exceeding standard of pesticide residues in root vegetables and cole vegetables was under predictable,and its exceeding standard rate in some years was over 5%(amplitude variation is over 15percentage points).They belonged to random risk type.The kinds of pesticides,which exceeding standard rate in vegetables were relatively intensive,presented variance in different vegetable species.70%of the pesticides belonged to intermittent over-limits and the probability was below 5%.About 20%tradition pesticides often exceeded standard and their probabilities were over 30%.The exceeding standard of organophosphorus and carbamates pesticides in vegetables presented a decreasing tend,while the risk of some new pesticides containing nitrogen element and high effective pyrethroids showed an increasing tendency.[Conclusion]The paper provided decision making services for agricultural management departments. | Fujin ZHANG Dekun HOU Jiang HE Tianyun GAO Hong LUO Songyan LANG Xinxin ZHANG Yiping YAO | 2013 | Agricultural Science & Technology2013，14，10： | 2 |
| 15 | The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Thl immune response in mice显示文摘肺结核遗体一个主要全球健康问题和有效疫苗着急地被需要。在这研究,我们使用了联合了 immunodominant 抗原 Rv0577 的基于 DNA 、基于蛋白质的疫苗增加 BCG 并且在 BALB/c 老鼠评估了他们的 immunogenicity。我们的数据建议增强软件疫苗可以实质地提高 BCG 的 immunogenicity 并且加强两 CD4+ T 调停房间的 Th1 和 CD8+ T 调停房间的 cytolytic 回答。与基于蛋白质的疫苗相比,基于 DNA 的疫苗能导致更持久的 Th1 有免疫力的反应,在刺激抗原的 splenocyte 文化由抗体反应,增长反应, CD4+/CD8+ 的百分比和 cytokine 分泌物的高水平描绘了。在结论,我们第一次,开发了蛋白质 -- 并且 plasmid 基于 DNA 的增强软件疫苗基于 Rv0577。我们的调查结果建议那抗原基于 Rv0577 的 DNA 疫苗是产生免疫性的并且能高效地增加 BCG,它能在对 TB 的有效种痘策略的设计是有用的。 | Dongqing Gu Wei Chen Youjun Mi Xueli Gong Tao Luo Lang Bao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 2 |
| 16 | Identification of sources,characteristics and photochemical transformations of dissolved organic matter with EEM-PARAFAC in the Wei River of China显示文摘Dissolved organic matter(DOM)in rivers is a critical regulator of the cycling and toxicity of pollutants and the behavior of DOM is a key indicator for the health of the environment.We investigated the sources and characteristics of DOM in surface water and sediment samples of the Wei River,China.Dissolved organic carbon(DOC)concentration and ultraviolet absorbance at 254 nm(UV254)increased in the surface water and were decreased in the sediment downstream,indicating that the source of DOM in the water differed from the sediment.Parallel factor(PARAFAC)analysis of the excitation-emission matrices(EEM)revealed the presence of terrestrial humus-like,microbial humus-like and tryptophan-like proteins in the surface water,whereas the sediment contained UVA humic-like,UVC humic-like and fulvic-like in the sediment.The DOM in the surface water and sediment were mainly derived from microbial metabolic activity and the surrounding soil.Surface water DOM displayed greater photodegradation potential than sediment DOM.PARAFAC analysis indicated that the terrestrial humic-like substance in the water and the fulvic-like component in the sediment decomposed more rapidly.These data describe the characteristics of DOM in the Wei River and are crucial to understanding the fluctuations in environmental patterns. | Yuanyuan Luo Yangyang Zhang Mengfan Lang Xuetao Guo Tianjiao Xia Tiecheng Wang Hanzhong Jia Lingyan Zhu | 2021 | Frontiers of Environmental Science & Engineering2021，15，5： | 2 |
| 17 | REDUCING THE PEAK-TO-AVERAGE POWER RATIO OF OFDM SYSTEM WITH LOW COMPLEXITY显示文摘This paper proposes a companding scheme, where small signals are enlarged and large signals are reduced, to reduce the Peak-to-Average Power Ratio(PAPR). Computer simulation results show that the proposed technique has two advantages at least when compared with the conventional methods such as partial transmit sequence, selective mapping and the previous companding. First, it gets better PAPR performances with a lower complexity. Second, the scheme achieves greater performances gain with hardly any damnification of OFDM signals in some degree. | Luo Renze Jing Longjiang Luo Lang Li Jie Zhu Weile | 2006 | Journal of Electronics(China)2006，23，1： | 2 |
| 18 | Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies显示文摘AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed a comprehensive search of Pub Med and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis(Ps A)]. We used a random-effects model to calculate the pooled relative risks(RRs) adjusted for confounders, along with the 95% confidence intervals(CIs). RESULTS: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis(RR=1.49;95%CI: 1.08-2.07), and Ps A(RR=3.16;95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis(RR=1.62;95%CI: 1.44-1.83), and Ps A(RR=4.44;95%CI: 3.52-5.60).CONCLUSION: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease(psoriasis and Ps A), warranting increased awareness among clinicians involved in the management of these two conditions.Therefore, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis. | Chao-Ran Li Lang Chen Long-Fei Wang Bin Yan You-Ling Liang Jing Luo | 2020 | International Journal of Ophthalmology(English edition)2020，13，4： | 2 |
| 19 | Fabrication of YSZ Film by Aqueous Tape CastingUsing PVA-B1070 Cobinder for IT-SOFC显示文摘 | Linghong Luo Ying Lang Zuzhi Huang | 2010 | KeyEngineering Materials2010，，： | 1 |
| 20 | Transforming growth fac_ tor betal regulates the pression of ases in cultured cor_ tical astrocytes and neurons显示文摘 | Lang JA Millerny | 1998 | J Neurochem1998，71，2： | 1 |
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