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| 1 | AOX contamination status and genotoxicity of AOX-bearing pharmaceutical wastewater显示文摘Adsorbable organic halogens(AOX) are a general indicator for the total amount of compounds containing organically bonded halogens. AOX concentrations and components were investigated along the wastewater treatment process in four large-scale pharmaceutical factories of China, and genotoxicity based on the SOS/umu test was also evaluated. The results showed that AOX concentrations in wastewater of four factories ranged from 4.6 to 619.4 mg/L, which were high but greatly different owing to differences in the raw materials and products. The wastewater treatment process removed 50.0%–89.9% of AOX, leaving 1.3–302.5 mg/L AOX in the effluents. Genotoxicity levels ranged between 2.1 and 68.0 μg 4-NQO/L in the raw wastewater and decreased to 1.2–41.2 μg 4-NQO/L in the effluents of the wastewater treatment plants(WWTPs). One of the main products of factory I, ciprofloxacin, was identified as the predominant contributor to its genotoxicity. However, for the other three factories, no significant relationship was observed between genotoxicity and detected AOX compounds. | Yawei Xie Lujun Chen Rui Liu | 2017 | Journal of Environmental Sciences2017，29，2： | 15 |
| 2 | Bioaugmentation with a pyridine-degrading bacterium in a membrane bioreactor treating pharmaceutical wastewater显示文摘The bacterial strain Paracoccus denitrificans W12,which could utilize pyridine as its sole source of carbon and nitrogen,was added into a membrane bioreactor(MBR)to enhance the treatment of a pharmaceutical wastewater.The treatment efciencies investigated showed that the removal of chemical oxygen demand,total nitrogen,and total phosphorus were similar between bioaugmented and non-bioaugmented MBRs,however,significant removal of pyridine was obtained in the bioaugmented reactor.When the hydraulic retention time was 60 hr and the influent concentration of pyridine was 250–500 mg/L,the mean efuent concentration of pyridine without adding W12 was 57.2 mg/L,while the pyridine was degraded to an average of 10.2 mg/L with addition of W12.The bacterial community structure of activated sludge during the bioaugmented treatment was analyzed using polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE).The results showed that the W12 inoculum reversed the decline of microbial community diversity,however,the similarity between bacterial community structure of the original sludge and that of the sludge after bioaugmentation decreased steadily during the wastewater treatment.Sequencing of the DNA recovered from DGGE gel indicated that Flavobacteriaceae sp.,Sphingobium sp.,Comamonas sp.,and Hyphomicrobium sp.were the dominant organisms in time sequence in the bacterial community in the bioaugmented MBR.This implied that the bioaugmentation was afected by the adjustment of whole bacterial community structure in the inhospitable environment,rather than being due solely to the degradation performance of the bacterium added. | Donghui Wen Jing Zhang Ruilin Xiong Rui Liu Lujun Chen | 2013 | Journal of Environmental Sciences2013，25，11： | 9 |
| 3 | Revealing the anaerobic acclimation of microbial community in a membrane bioreactor for coking wastewater treatment by Illumina Miseq sequencing显示文摘The dynamic change of microbial community during sludge acclimation from aerobic to anaerobic in a MBR for coking wastewater treatment was revealed by Illumina Miseq sequencing in this study. The diversity of both Bacteria and Archaea showed an increase–decrease trajectory during acclimation, and exhibited the highest at the domestication interim. Ignavibacteria changed from a tiny minority(less than 1%) to the dominant bacterial group(54.0%) along with acclimation. The relative abundance of Betaproteobacteria kept relatively steady, as in this class some species increased coupled with some other species decreased during acclimation. The dominant Archaea shifted from Halobacteria in initial aerobic sludge to Methanobacteria in the acclimated anaerobic sludge. The dominant bacterial and archaeal groups in different acclimation stages were indigenous microorganisms in the initial sludge, though some of them were very rare. This study supported that the species in'rare biosphere' might eventually become dominant in response to environmental change. | Jiadi Zhu Lujun Chen Yan Zhang Xiaobiao Zhu | 2018 | Journal of Environmental Sciences2018，30，2： | 7 |
| 4 | Synergistic effect of ozonation and ionizing radiation for PVA decomposition显示文摘Ozonation and ionizing radiation are both advanced oxidation processes(AOPs) without chemical addition and secondary pollution. Also, the two processes' efficiency is determined by different p H conditions, which creates more possibilities for their combination. Importantly,the combined process of ozonation and ionizing radiation could be suitable for treating wastewaters with extreme p H values, i.e., textile wastewater. To find synergistic effects, the combined process of ozonation and ionizing radiation mineralization was investigated for degradation of polyvinyl alcohol(PVA) at different p H levels. A synergistic effect was found at initial p H in the range 3.0–9.4. When the initial p H was 3.0, the combined process of ozonation and ionizing radiation gave a PVA mineralization degree of 17%. This was 2.7 times the sum achieved by the two individual processes, and factors of 2.1 and 1.7 were achieved at initial p H of7.0 and 9.4, respectively. The combined process of ozonation and ionizing radiation was demonstrated to be a feasible strategy for treatment of PVA-containing wastewater. | Weihua Sun Lujun Chen Yongming Zhang Jianlong Wang | 2015 | Journal of Environmental Sciences2015，27，8： | 7 |
| 5 | Biological removal of antiandrogenic activity in gray wastewater and coking wastewater by membrane reactor process显示文摘A recombinant human androgen receptor yeast assay was applied to investigate the occurrence of antiandrogens as well as the mechanism for their removal during gray wastewater and coking wastewater treatment. The membrane reactor(MBR) system for gray wastewater treatment could remove 88.0% of antiandrogenic activity exerted by weakly polar extracts and 97.3% of that by moderately strong polar extracts, but only 32.5%of that contributed by strong polar extracts. Biodegradation by microorganisms in the MBR contributed to 95.9% of the total removal. After the treatment, the concentration of antiandrogenic activity in the effluent was still 1.05 μg flutamide equivalence(FEQ)/L, 36.2%of which was due to strong polar extracts. In the anaerobic reactor, anoxic reactor, and membrane reactor system for coking wastewater treatment, the antiandrogenic activity of raw coking wastewater was 78.6 mg FEQ/L, and the effluent of the treatment system had only 0.34 mg FEQ/L. The antiandrogenic activity mainly existed in the medium strong polar and strong polar extracts. Biodegradation by microorganisms contributed to at least 89.2%of the total antiandrogenic activity removal in the system. Biodegradation was the main removal mechanism of antiandrogenic activity in both the wastewater treatment systems. | Dehua Ma Lujun Chen Cong Liu Chenjun Bao Rui Liu | 2015 | Journal of Environmental Sciences2015，27，7： | 5 |
| 6 | Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR: simultaneous removal of nitrogen and antibiotics显示文摘 | Xiaoyan Song Rui Liu Lujun Chen Tomoki Kawagishi | 2017 | Frontiers of Environmental Science & Engineering2017，11，2： | 5 |
| 7 | Structural Engineering of Hierarchical Aerogels Comprised of Multi-dimensional Gradient Carbon Nanoarchitectures for Highly Efficient Microwave Absorption显示文摘Recently,multilevel structural carbon aerogels are deemed as attractive candidates for microwave absorbing materials.Nevertheless,excessive stack and agglomeration for low-dimension carbon nanomaterials inducing impedance mismatch are significant challenges.Herein,the delicate“3D helix-2D sheet-1D fiber-0D dot”hierarchical aerogels have been successfully synthesized,for the first time,by sequential processes of hydrothermal self-assembly and in-situ chemical vapor deposition method.Particularly,the graphene sheets are uniformly intercalated by 3D helical carbon nanocoils,which give a feasible solution to the mentioned problem and endows the as-obtained aerogel with abundant porous structures and better dielectric properties.Moreover,by adjusting the content of 0D core-shell structured particles and the parameters for growth of the 1D carbon nanofibers,tunable electromagnetic properties and excellent impedance matching are achieved,which plays a vital role in the microwave absorption performance.As expected,the optimized aerogels harvest excellent performance,including broad effective bandwidth and strong reflection loss at low filling ratio and thin thickness.This work gives valuable guidance and inspiration for the design of hierarchical materials comprised of dimensional gradient structures,which holds great application potential for electromagnetic wave attenuation. | Yongpeng Zhao Xueqing Zuo Yuan Guo Hui Huang Hao Zhang Ting Wang Ningxuan Wen Huan Chen Tianze Cong Javid Muhammad Xuan Yang Xinnan Wang Zeng Fan Lujun Pan | 2021 | Nano-Micro Letters2021，13，9： | 5 |
| 8 | Performance and microbial community of a membrane bioreactor system--Treating wastewater from ethanol fermentation of food waste显示文摘In this study, a lab-scale biological anaerobic/anaerobic/anoxic/membrane bioreactor(A_-~3MBR) was designed to treat wastewater from the ethanol fermentation of food waste,a promising way for the disposal of food waste and reclamation of resources. The 454 pyrosequencing technique was used to investigate the composition of the microbial community in the treatment system. The system yielded a stable effluent concentration of chemical oxygen demand(202 ± 23 mg/L), total nitrogen(62.1 ± 7.1 mg/L), ammonia(0.3 ±0.13 mg/L) and total phosphorus(8.3 ± 0.9 mg/L), and the reactors played different roles in specific pollutant removal. The exploration of the microbial community in the system revealed that:(1) the microbial diversity of anaerobic reactors A_1 and A_2, in which organic pollutants were massively degraded, was much higher than that in anoxic A_3 and aerobic MBR;(2) although the community composition in each reactor was quite different, bacteria assigned to the classes Clostridia, Bacteroidia, and Synergistia were important and common microorganisms for organic pollutant degradation in the anaerobic units, and bacteria from Alphaproteobacteria and Betaproteobacteria were the dominant microbial population in A_3 and MBR;(3) the taxon identification indicated that Arcobacter in the anaerobic reactors and Thauera in the anoxic reactor were two representative genera in the biological process. Our results proved that the biological A_-~3MBR process is an alternative technique for treating wastewater from food waste. | Xiaobiao Zhu Mengqi Li Wei Zheng Rui Liu Lujun Chen | 2017 | Journal of Environmental Sciences2017，29，3： | 4 |
| 9 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 10 | Radiation induced decomposition of a refractory cefathiamidine intermediate显示文摘Diisopropylthiourea(DPT),an intermediate of a widely used cephalosporin,has been found to be one of the most refractory components in cephalosporin synthesis wastewater.This compound cannot be completely removed by conventional biological processes due to its antimicrobial property.Ionizing radiation has been applied in the decomposition of refractory pollutants in recent years and has proved effective.Therefore,the decomposition of DPT byγ-irradiation was studied.The compound was irradiated at the dose of 150–2000 Gy before a change of concentration and UV absorption of the solutions was detected.Furthermore,the decomposition kinetics and radiation yield(G-value)of DPT was investigated.The results of radiation experiments on DPT-containing aqueous showed that the DPT can be effectively degraded byγ-radiation.DPT concentration decreased with increasing absorbed doses.G-values of radiolytic decomposition for DPT(20 mg/L)were 1.04and 0.47 for absorbed doses of 150 and 2000 Gy,respectively.The initial concentration and p H of the solutions affected the degradation.As the concentration of substrate increased,the decomposition was reduced.The decrease of removal rate and radiation efficacy under alkaline condition suggested that lower p H values benefit theγ-induced degradation.UV absorption from 190 to 250 nm decreased after radiation while that from 250 to 300 nm increased,indicating the formation of by-products. | Qiburi Bao Lujun Chen Jianlong Wang | 2014 | Journal of Environmental Sciences2014，26，12： | 4 |
| 11 | Growth of Carbon Nanocoils by Porous α-Fe2O3/SnO2 Catalyst and Its Buckypaper for High Efficient Adsorption显示文摘High-purity(99%)carbon nanocoils(CNCs)have been synthesized by using porousα-Fe2O3/SnO2 catalyst.The yield of CNCs reaches 9,098%after a 6 h growth.This value is much higher than the previously reported data,indicating that this method is promising to synthesize high-purity CNCs on a large scale.It is considered that an appropriate proportion of Fe and Sn,proper particle size distribution,and a loose-porous aggregate structure of the catalyst are the key points to the high-purity growth of CNCs.Benefiting from the high-purity preparation,a CNC Buckypaper was successfully prepared and the electrical,mechanical,and electrochemical properties were investigated comprehensively.Furthermore,as one of the practical applications,the CNC Buckypaper was successfully utilized as an efficient adsorbent for the removal of methylene blue dye from wastewater with an adsorption efficiency of 90.9%.This study provides a facile and economical route for preparing high-purity CNCs,which is suitable for large-quantity production.Furthermore,the fabrication of macroscopic CNC Buckypaper provides promising alternative of adsorbent or other practical applications. | Yongpeng Zhao Jianzhen Wang Hui Huang Tianze Cong Shuaitao Yang Huan Chen Jiaqi Qin Muhammad Usman Zeng Fan Lujun Pan | 2020 | Nano-Micro Letters2020，12，2： | 3 |
| 12 | Comparative study on microbial community in intermittently aerated sequencing batch reactors (SBR) and a traditional SBR treating digested piggery wastewater显示文摘 | Xiaolin Sheng Rui Liu Xiaoyan Song Lujun Chen Kawagishi Tomoki | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 3 |
| 13 | Gamma irradiation of 2-mercaptobenzothiazole aqueous solution in the presence of persulfate显示文摘Recently, water treatment by ionizing radiation has gained increasing attention as a powerful technology for the destruction of refractory pollutants. 2-Mercaptobenzothiazole(MBT) is known as a widespread, toxic and poorly biodegradable pollutant. This paper studied the gamma irradiation of aqueous solutions of MBT. Moreover, the effect of the addition of persulfate(S2O82-) on the radiolytic destruction of MBT was investigated. The main transformation products of the studied compound were detected and the sequence of occurrence of the products was described. The change of biodegradability of MBT solution was also observed. The main results obtained in this study indicated that gamma radiation was effective for removing MBT in aqueous solution. Persulfate addition, which induced the formation of reactive sulfate radicals(SO4-U), greatly enhanced the degradation of MBT. Benzothiazole was identified as the first radiation product, followed by 2-hydroxybenzothiazole. Decomposition of MBT started with the oxidation of –SH groups to sulfate ions. Possible pathways for MBT decomposition by gamma irradiation were proposed. The BOD/COD ratios of MBT samples were increased after radiation,indicating the improvement of biodegradability and reduction of toxicity. | Qiburi Bao Lujun Chen Jinping Tian Jianlong Wang | 2016 | Journal of Environmental Sciences2016，28，8： | 3 |
| 14 | NS1结合蛋白通过转录抑制c-Myc增强食管鳞状细胞癌的放疗敏感性显示文摘背景与目的基于顺铂的化疗联合放疗是晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的标准疗法。NS1结合蛋白(NS1-binding protein,NS1-BP)是BTB-kelch蛋白家族中的一员,已被证明可通过抑制c-Myc进而抑制HeLa细胞增殖。在本研究中,我们检测NS1-BP表达在ESCC中的潜在作用,特别是其在ESCC放疗敏感性方面的作用。方法对于两组接受基于顺铂化疗且联合放疗的ESCC患者(研究组n=98;验证组n=46),采用免疫组化方法分别检测NS1-BP表达。使用正常食管黏膜组织块作为对照。我们也进行了一系列体外和体内实验来检测过表达NS1-BP对ESCC细胞各方面的潜在影响,尤其关注的是对电离辐射的敏感性方面的影响。结果在研究组中,59%(85/144)的ESCC样本观察到了NS1-BP下调。在研究组和验证组中,NS1-BP下调与放化疗抵抗和较短的疾病特异生存期(disease-specific survival,DSS)均具有相关性。体内和体外培养条件下过表达NS1-BP均能大幅度提高ECSS细胞对放疗的敏感性。NS1-BP也显著增强IR诱导的凋亡,阻断IR诱导的G2/M细胞周期阻滞和ATM/Chk1磷酸化。免疫沉淀反应显示NS1-BP可以与c-Myc启动子区相互作用从而抑制其转录。在ESCC组织中,c-Myc表达与NS1-BP水平负相关,与较短的疾病特异生存期相关。结论我们的研究结果显示了NS1-BP在ESCC放疗敏感性中的作用和重要性。以NS1-BP/c-Myc通路为靶标有望开发一种新的ESCC治疗策略。 | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2019 | 癌症2019，38，2： | 2 |
| 15 | Tissue factor expression in rheumatoid synovium: A potential role in pannus invasion of rheumatoid arthritis显示文摘 | Lujun Chen Yahua Lu Yang Chu Jun Xie Wen’ge Ding Fengming Wang | 2013 | Acta Histochemica2013，，： | 2 |
| 16 | A preliminary study on the characterization of follicular helper T (Tfh) cells in rheumatoid arthritis synovium显示文摘 | Yang Chu Fengming Wang Meng Zhou Lujun Chen Yahua Lu | 2013 | Acta Histochemica2013，，： | 2 |
| 17 | Molecular cloning, tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-coenzyme A reductase ( HMGR ) gene显示文摘 | Xiao Chen Xiaofeng Wang Zongjin Li Lujun Kong Guifen Liu Jinluan Fu Aiguo Wang | 2011 | Gene2011，，2： | 2 |
| 18 | Striatal extracts promote the dopaminergic differentiation of GFP-bone mesenchymal stem cells显示文摘 | Shuhua Yang Qing Gao Lihua Bao Jing Zhang Yanlai Hu Lujun Bing Jinlong Sun Jing Hao Chao Chen Shangzhi Li W.S. Poon Jinhao Sun Yingmao Gao | 2012 | Neuroscience Letters2012，，2： | 2 |
| 19 | Temporal and spatial changes of microbial community in an industrial effluent receiving area in Hangzhou Bay显示文摘Anthropogenic activities usually contaminate water environments, and have led to the eutrophication of many estuaries and shifts in microbial communities. In this study, the temporal and spatial changes of the microbial community in an industrial effluent receiving area in Hangzhou Bay were investigated by 454 pyrosequencing. The bacterial community showed higher richness and biodiversity than the archaeal community in all sediments. Proteobacteria dominated in the bacterial communities of all the samples; Marine_Group_Ⅰ and Methanomicrobia were the two dominant archaeal classes in the effluent receiving area. PCoA and AMOVA revealed strong seasonal but minor spatial changes in both bacterial and archaeal communities in the sediments. The seasonal changes of the bacterial community were less significant than those of the archaeal community, which mainly consisted of fluctuations in abundance of a large proportion of longstanding species rather than the appearance and disappearance of major archaeal species. Temperature was found to positively correlate with the dominant bacteria, Betaproteobacteria, and negatively correlate with the dominant archaea,Marine_Group_Ⅰ; and might be the primary driving force for the seasonal variation of the microbial community. | Yan Zhang Lujun Chen Renhua Sun Tianjiao Dai Jinping Tian Wei Zheng Donghui Wen | 2016 | Journal of Environmental Sciences2016，28，6： | 2 |
| 20 | EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation显示文摘Objective:To investigate the potential of HS-10182,a second-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI),as a radiosensitizer in non-small cell lung cancer(NSCLC).Methods:Two cell lines of NSCLCs,A549 that possesses wild-type(WT)EGFRs and H1975 that possesses EGFR L858R/T790M double mutations,were treated with HS-10182 at various concentrations,and cell viabilities were determined using the MTS assay.The cells were tested by clonogenic survival assays to identify the radiosensitivity of both groups.Western blot was performed to analyze the expression of phosphorylated EGFR,AKT,DNA-dependent protein kinase,and catalytic subunit(DNA-PKcs)proteins.Immunofluorescence analyses were performed to examine the formation and changes in nuclearγ-H2AX foci.Cell apoptosis was examined by flow cytometry and Western blots for cleaved caspase-3,-8,-9,and cleaved poly ADP-ribose polymerase(PARP).Furthermore,we established xenograft models in mice and the effects of different treatments on tumor growth were then assessed.Results:Clonogenic survival assays revealed that HS-10182 significantly enhanced the radiosensitivity of H1975 cells but not A549cells[dose enhancement ratios(DERs)=2.36(P<0.05)vs.1.43(P>0.05)].Western blot results showed that HS-10182 increased the levels of cleaved caspase-3,-8,-9,and cleaved PARP in H1975 cells but not in A549 cells.In addition,flow cytometry analysis showed that HS-10182 enhanced irradiation-induced apoptosis in H1975.Immunofluorescence results found that HS-10182increased the average number ofγ-H2AX foci after irradiation in H1975 cells,but not in A549 cells.Combined radiation and HS-10182 treatment increased the expression of DNA-PKcs but this increase was more significant in H1975 cells than in A549 cells.Moreover,HS-10182 suppressed the increased expression of Rad50 in H1975 cells in response to irradiation.In vivo experiments found that the combined therapy significantly inhibited tumor growth.Conclusions:HS-10182 enhances the radiosensitivity of H1975 cells which is possibly because that HS-10182 could enhance irradiation-induced apoptosis,increase irradiation-induced DNA damage,and cause a delay in DNA damage repair.Our findings suggest that radiotherapy combined HS-10182 is a novel treatment for lung cancer cells which have acquired the T790M mutation.HS-10182 could be brought to the clinic as a radiosensitizer in NSCLCs with the EGFR T790M mutation. | Yang Chen Youyou Wang Lujun Zhao Ping Wang Jifeng Sun Rudi Bao Chenghai Li Ningbo Liu | 2018 | Cancer Biology & Medicine2018，15，1： | 2 |
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