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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 3 | Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease显示文摘The pathogenesis of the second major neurodegenerative disorder, Parkinson's disease(PD), is closely associated with the dysfunction of potassium(K^+ ) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K^+ channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K^+ channels enhances the spontaneous firing frequency of nigral dopamine(DA)neurons, induces a transition from tonic firing to burst discharge, and promotes the release of DA in the striatum.Recently, three K^+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models: small conductance(SK)channels, A-type K^+ channels, and KV7/KCNQ channels.In this review, we summarize the physiological and pharmacological effects of the three K^+ channels. We also describe in detail the laboratory investigations regarding K^+ channels as a potential therapeutic target for PD. | Xiaoyan Chen Bao Xue Jun Wang Haixia Liu Limin Shi Junxia Xie | 2018 | Neuroscience Bulletin2018，34，2： | 13 |
| 4 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 5 | Effects of impregnation sequence on the microstructure and performances of Cu-Co based catalysts for the synthesis of higher alcohols显示文摘支持硅石的 CuCo 催化剂被受精方法为更高的白酒合成与不同受精顺序作好准备。这些催化剂被 H 2-TPR, XRD, N 2 吸附, XPS 技术和公司描绘选择加氢反应测量。催化剂的结构和表演上的受精顺序的效果被调查,并且到更高的白酒的选择上有重要影响。为共同使妊娠的样品在铜和钴之间有强壮的 synergistic 效果。合作受精准备的 CuCo/SiO 2 催化剂显示了全部的白酒,和一种更高的选择的更好的收益总计到达了 51.5% 的白酒。 | Siyu Deng Wei Chu Huiyuan Xu Limin Shi Lihong Huang | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 10 |
| 6 | Catalytic properties of Cu-Co catalysts supported on HNO_3-pretreated CNTs for higher-alcohol synthesis显示文摘HNO 3 -pretreated CNTs were employed as supports, and a special ultrasound-assisted impregnation method was designed to prepare supported Cu-Co catalysts for higher-alcohol synthesis from syngas. The catalysts used in this work were characterized by N 2 adsorption-desorption, TEM, XRD, H 2 -TPR, CO-TPD techniques. It was found that the pre-treatment procedure of CNTs remarkably promoted the catalytic properties of the Cu-Co/CNTs catalysts. For the Cu-Co catalyst supported on CNTs pre-treated by 68 wt% HNO 3 , some active components were introduced into the CNTs channels, their dispersions and the amount of strongly adsorbed CO-species were improved. The CO conversion and alcohol yield on the HNO 3 -pretreated Cu-Co/CNTs catalyst were increased by ~21% and ~69%, respectively, compared with those on the normal Cu-Co/CNTs catalyst. | Limin Shi Wei Chu Siyu Deng | 2011 | Journal of Natural Gas Chemistry2011，20，1： | 9 |
| 7 | Catalytic properties of Cu/Co/Zn/Zr oxides prepared by various methods显示文摘基于的新 Cu 公司(Cu/Co/Zn/Zr ) 为高白酒的合成的催化剂用一起沉淀方法被准备,血浆在超声照耀下面的提高的方法和反向的一起沉淀方法。催化剂被赌注, SEM, XRD, H 2-TPR 和 XPS 的工具调查。各种各样的方法准备的催化剂的催化性质用公司加氢反应被检验。血浆提高了方法,在超声照耀下面的反向的一起沉淀方法在提高 Cu/Co/Zn/Zr 的催化性质两个都是有效的,这被发现混合氧化物。小粒子尺寸,活跃部件的高分散,特定的表面区域的改进和活跃阶段的表面内容能说明试验性的 Cu/Co/Zn/Zr 催化剂的优秀表演。 | Limin Shi Wei Chu Siyu Deng Huiyuan Xu | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 8 |
| 8 | Catalytic performance of Zr-doped CuO-CeO2 oxides for CO selective oxidation in H2-rich stream显示文摘Zr-doped CuO-CeO2 catalysts for CO selective oxidation were designed and prepared by the hydrothermal method and coprecipitation. The experimental samples were characterized by means of N2 adsorption-desorption isotherms, powder X-ray diffraction, temperature-programmed reduction and Xray photoelectron spectroscopy. It is observed that the catalyst prepared by hydrothermal method exhibits larger specific surface area, smaller crystalline size and higher dispersion of active components compared with those of the catalyst obtained by coprecipitation. Meanwhile, redox properties of copper oxide are improved significantly and highly dispersed copper species providing CO oxidation sites are present on the surface. Furthermore, adsorptive centers of CO and active oxygen species increase on the copper-ceria interfaces. The Zr-doped CuO-CeO2 catalyst prepared by hydrothermal method possesses superior catalytic activity and selectivity for selective oxidation of CO at low temperature compared with those of the sample prepared by coprecipitation. The temperature corresponding to 50% CO conversion is only 73 ℃ and the temperature span of total CO conversion is expanded from 120 to 160 ℃. | Limin Shi Chuanlei Gao Fenghai Guo Yujing Wang Tiebang Zhang | 2019 | Journal of Rare Earths2019，37，7： | 7 |
| 9 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 10 | Uncommon EGFR mutations in a cohort of Chinese NSCLC patients and outcomes of first-line EGFR-TKIs and platinum-based chemotherapy显示文摘Objective: Data on the clinical activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in patients with non-small-cell lung cancer(NSCLC) and uncommon EGFR mutations remain insufficient.This study aimed to investigate the effect of first-line EGFR-TKIs or platinum-based chemotherapy in NSCLC patients with uncommon EGFR mutations.Methods: We retrospectively enrolled 504 patients with EGFR-mutant NSCLC.The clinical characteristics and treatment outcomes were collected and compared between patients with common and uncommon EGFR-mutant NSCLC.Results: Seventy patients(13.9%) harboring uncommon EGFR mutations were included.Thirty of these patients received EGFR-TKIs and 40 received platinum-based chemotherapy as first-line therapy.The objective response rate(ORR) and median progression-free survival(m PFS) of patients treated with TKIs in the uncommon mutation group was significantly inferior to that in the common mutation group(ORR: 23.3% vs.51.8%,P=0.003; m PFS:7.1 vs.10.9 months,P<0.001).In the uncommon group,m PFS was similar between first-line EGFR-TKIs treatment and platinum-based chemotherapy(7.1 vs.6.1 months,P=0.893).In patients with EGFR G719 X or L861 Q mutations,the m PFS was longer in the first-line EGFR-TKIs treatment group than in the chemotherapy group,but the difference was not statistically significant(G719 X: 8.2 vs.5.8 months,P=0.061; L861 Q: 7.6 vs.4.1 months,P=0.872).Multivariate analyses identified adenocarcinoma(P=0.003) as the independent predictive factor for PFS in patients with uncommon EGFR mutations who were treated with first-line EGFR-TKIs.Conclusions: The current study demonstrated that the effect of first-line EGFR-TKIs was similar to that of platinum-based chemotherapy in patients with uncommon EGFR-mutant NSCLC.Adenocarcinoma was the independent predictive factor for PFS in uncommon EGFR-mutant NSCLC patients treated with first-line EGFRTKIs. | Jinpeng Shi Hui Yang Tao Jiang Xuefei Li Chao Zhao Limin Zhang Sha Zhao Xiaozhen Liu Yijun Jia Yan Wang Lei Xi Shijia Zhang Chunxia Su Shengxiang Ren Caicun Zhou | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 11 | Synthesis, crystal structures and fluorescence properties of four mixed-ligands Zn(Ⅱ) and Cd(Ⅱ) coordination compounds显示文摘Four new coordination compounds, [Zn(dba)(bpy)]n (1), {[Zn(dba)(phen)]·2H2O}n (2), [Cd(dba)(bpy)(H2O)2] (3) and [Cd2(dba)2(phen)2]n (4) (H2dba = 2,5-dihydroxy-p-benzenediacetic acid, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline) have been prepared via solvothermal method and characterized by sin-gle-crystal X-ray diffraction, infrared spectroscopy, elemental analysis and powder X-ray diffraction. 1 and 2 possess 1D infinite chain structures. Complex 3 exhibits a mononuclear structure. Complex 4 owns binuclear symmetry units, which were bridged via the dba ligands forming a 2D framework. The fluorescence properties of 1―4 have been studied. | ZHAO LiMin, REN Peng, ZHANG ZhenJie, FANG Ming, SHI Wei & CHENG Peng Department of Chemistry, Nankai University, Tianjin 300071, China | 2009 | Science China Chemistry2009，52，9： | 3 |
| 12 | 超深井高速率连续波MWD信道传输系统(英文)显示文摘At present,the MWD systems continuous wave mud pulse telemetry transmit is not faster than 1or 2bits/s from deep wells containing highly attenuative mud,because positive pulsers create strong signals but large axial flow forces impede fast reciprocation while mud sirens provide high data rates without higher signal strength.A high-data-rate system providing 10bits/s and operable up to30 000 ft is described,which creates strong source signals by using downhole constructive wave interference in two novel ways.Telemetry schemes,frequencies and pulser locations in the MWD drill collar are selected for positive wave phasing,and sirens-in-series are used to create additive signals——both without incurring power and erosion penalties.The positions normally occupied by pulsers and turbines are reversed to minimize times required for constructive interference and modulation.A system design approach is undertaken,e.g.,strong source signals are augmented with new multiple-transducer surface signal processing methods to remove mudpump noise and signal reflections at both pump and desurger,and mud,bottomhole assembly and drill pipe properties,to the extent possible in practice,are controlled to reduce signal attenuation.The results of detailed acoustic modeling in realistic drilling telemetry channels are described,and short and long wind tunnels for signal strength,torque,erosion and jamming testing,and telemetry and signal processing evaluation,respectively,are introduced.Special scaling methods are developed to extrapolate cost-effective wind tunnel test results to real muds flowing at any downhole speed.New siren concept prototype hardware and also typical acoustic test results are also given. | Wilson CHIN SU Yinao SHENG Limin LI Lin BIAN Hailong SHI Rong | 2014 | 测井技术2014，38，6： | 3 |
| 13 | Effects of carrier and Mn loading on supported manganese oxide catalysts for catalytic combustion of methane显示文摘支持的锰氧化物催化剂被早期的湿受精方法为甲烷作好准备支持的催化燃烧,和效果(艾尔 2 装载的 O 3, SiO 2 和 TiO 2) 和 Mn 被调查。这些催化剂与 N 2 吸附, X 光检查衍射, X 光检查光电子光谱学和规划温度的减小技术被描绘。甲烷变换在取决于支持或 Mn 装载的一个大范围变化了。艾尔 2 O 3 支持了更好展出的 15% Mn 催化剂向甲烷的活动催化氧化。锰状态和氧种类在催化表演起了一个重要作用。 | Jinyan Hu Wei Chu Limin Shi | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 3 |
| 14 | Ghrelin Reduces A-Type Potassium Currents in Dopaminergic Nigral Neurons via the PLC/PKCδPathway显示文摘Dear Editor,Ghrelin,an endogenous ligand of growth hormone secretagogue receptor 1a(GHS-R1a),is a 28-amino-acid peptide that regulates growth hormone secretion,metabolism,food intake,mood,cognition,memory,and neuroprotection[1-3]. | Bao Xue Chen Li Xiaoli Chang Hong Jiang Limin Shi Junxia Xie | 2020 | Neuroscience Bulletin2020，36，8： | 3 |
| 15 | Biomimetic Chiral Pyridoxal and Pyridoxamine Catalysts显示文摘What is the most favorite and original chemistry developed in your research group? Vitamin B6-based biomimetic asymmetric catalysis. How do you get into this specific field? Could you please share some experiences with our readers? Enzymatic transformations are characterized by high efficiency, specific selectivities, and mild conditions, which attracts me to do some chemistry related to biological systems. | Jianfeng Chen Yong Ethan Liu Xing Gong Limin Shi Baoguo zhao | 2019 | Chinese Journal of Chemistry2019，37，2： | 3 |
| 16 | Landform classification using soil data and remote sensing in northern Ordos Plateau of China显示文摘地形分类通常仅仅用地志的高度被做。然而,实践显示在一样的高度的地点可以有显然不同的地形,取决于在那些地点下面的土壤的特征。这研究的目的到过:1 ) 开发基于高度和土壤特征的一条地形分类途径;并且 2 ) 使用这条途径在位于中国的北 Ordos 高原的一个分水岭以内决定地形。用从 200 个采样地点在 134 点收集的数据,这研究决定了那 D10 (土壤粒子的直径10%由重量更好)并且在 2010 获得的长期的平均土壤潮湿,能从遥感形象在合理精确性被估计,能被用来代表学习分水岭的土壤特征。另外,采样数据表明这个分水岭由地形的九个班组成,也就是活动的沙丘( MD ),活动半活动的沙丘( SMD ),滚动固定修理半的沙丘(讨论请求),完全沙的土地( FD ),草多的沙的土地( GS ),基岩( BR ),完全沙的基岩( FSB ),山谷农业土地( VA )和盐湖( SW )。一套逻辑回归方程用在 134 个采样地点收集并且验证了在留下使用数据的数据被导出 66 个地点。确认显示这些方程有中等分类精确性(Kappa 系数[^(K)]\hat K >43%) 。结果表明在学习分水岭的主导的班是 FD (36.3%), BR (27.0%),和 MD (23.5%)地形的另外的六种类型(即, SMD ,讨论请求, GS , FSB , VA ,并且 SW )在为13.2%的联合报道。进一步,在这研究决定的地形与一张地质上基于的分类地图介绍的班相比。比较显示地质上基于的分类不能在依赖于土壤特征的一个班以内识别多重地形。 | LUO Yanyun LIU Tingxi WANG Xixi DUAN Limin ZHANG Shengwei SHI Junxiao | 2012 | Journal of Geographical Sciences2012，22，4： | 3 |
| 17 | Preparation and thermochromic property of tungsten-doped vanadium dioxide particles显示文摘 | Jianqiu Shi Shuxue Zhou Bo You Limin Wu | 2007 | Solar Energy Materials and Solar Cells2007，，19： | 2 |
| 18 | Single optical microfiber enabled tactile sensor for simultaneous temperature and pressure measurement显示文摘The ability to sense heat and touch is essential for healthcare,robotics,and human–machine interfaces.By taking advantage of the engineerable waveguiding properties,we design and fabricate a flexible optical microfiber sensor for simultaneous temperature and pressure measurement based on theoretical calculation.The sensor exhibits a high temperature sensitivity of 1.2 nm/℃ by measuring the shift of a high-order mode cutoff wavelength in the short-wavelength range.In the case of pressure sensing,the sensor shows a sensitivity of 4.5%per kilopascal with a fast temporal frequency response of 1000 Hz owing to the strong evanescent wave guided outside the microfiber.The cross talk is negligible because the temperature and pressure signals are measured at different wavelengths based on different mechanisms.The properties of fast temporal response,high temperature,and pressure sensitivity enable the sensor for real-time skin temperature and wrist pulse measurements,which is critical to the accurate analysis of pulse waveforms.We believe the sensor will have great potential in wearable optical devices ranging from healthcare to humanoid robots. | NI YAO XIAOYU WANG SHUQI MA XINGDA SONG SHAN WANG ZHANGXING SHI JING PAN SHIPENG WANG JIANLIANG XIAO HAITAO LIU LONGTENG YU YAO TANG ZHANG ZHANG XIONG LI WEI FANG LEI ZHANG LIMIN TONG | 2022 | Photonics Research2022，10，9： | 2 |
| 19 | Single-atom Sn-Zn pairs in CuO catalyst promote dimethyldichlorosilane synthesis显示文摘Single-atom catalysts are of great interest because they can maximize the atom-utilization efficiency and generate unique catalytic properties;however,much attention has been paid to single-site active components,rarely to catalyst promoters.Promoters can significantly affect the activity and selectivity of a catalyst,even at their low concentrations in catalysts.In this work,we designed and synthesized CuO catalysts with atomically dispersed co-promoters of Sn and Zn.When used as the catalyst in the Rochow reaction for the synthesis of dimethyldichlorosilane,this catalyst exhibited much-enhanced activity,selectivity and stability compared with the conventional CuO catalysts with promoters in the form of nanoparticles.Density functional theory calculations demonstrate that single-atomic Sn substitution in the CuO surface can enrich surface Cu vacancies and promote dispersion of Zn to its atomic levels.Sn and Zn single sites as the co-promoters cooperatively generate electronic interaction with the CuO support,which further facilitates the adsorption of the reactant molecules on the surface,thereby leading to the superior catalytic performance. | Qi Shi Yongjun Ji Wenxin Chen Yongxia Zhu Jing Li Hezhi Liu Zhi Li Shubo Tian Ligen Wang Ziyi Zhong Limin Wang Jianmin Ma Yadong Li Fabing Su | 2020 | National Science Review2020，7，3： | 2 |
| 20 | The association of interleukin-16 gene polymorphisms with IL-16 serum levels and risk of nasopharyngeal carcinoma in a Chinese population显示文摘 | Xue Qin Qiliu Peng Xiaoxia Lao Zhiping Chen Yu Lu Xianjun Lao Cuiju Mo Jingzhe Sui Junrong Wu Limin Zhai Shi Yang Shan Li Jinmin Zhao | 2014 | Tumor Biology2014，，3： | 2 |
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