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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Third-order point contact approach for five-axis sculptured surface machining using non-ball-end tools(II): Tool positioning strategy显示文摘Based on the mathematical model describing the third-order approximation of the cutter envelope surface according to one given cutter location(CL),a tool positioning strategy is proposed for efficiently machining free-form surfaces with non-ball-end cutters.The optimal CL is obtained by adjusting the inclination and tilt angles of the cutter until its envelope surface and the design surface have the third-order contact at the cutter contact(CC)point,which results in a wide machining strip.The strategy can handle the constraints of machine joint angle limits,global collision avoidance and tool path smoothness in a nature way,and can be applied to general rotary cutters and complex surfaces.Numerical examples demonstrate that the third-order point contact approach can improve the machining strip width greatly as compared with the recently reported second-order one. | ZHU LiMin 1 ,DING Han 2 &XIONG YouLun 2 1State Key Laboratory of Mechanical System and Vibration,Shanghai Jiao Tong University,Shanghai 200240,China 2State Key Laboratory of Digital Manufacturing Equipment and Technology,Huazhong University of Science and Technology,Wuhan 430074, China | 2010 | Science China(Technological Sciences)2010，53，8： | 23 |
| 3 | Role of secondary aerosols in haze formation in summer in the Megacity Beijing显示文摘A field experiment from 18 August to 8 September 2006 in Beijing, China, was carried out. A hazy day was defined as visibility < 10 km and RH(relative humidity) < 90%. Four haze episodes, which accounted for ~ 60% of the time during the whole campaign, were characterized by increases of SNA(sulfate, nitrate, and ammonium) and SOA(secondary organic aerosol) concentrations. The average values with standard deviation of SO2-+4, NO-3, NH4 and SOA were 49.8(± 31.6), 31.4(±22.3), 25.8(±16.6) and 8.9(±4.1) μg/m3, respectively, during the haze episodes, which were 4.3, 3.4, 4.1, and 1.7 times those in the non-haze days. The SO2-4,NO-3, NH+4, and SOA accounted for 15.8%, 8.8%, 7.3%, and 6.0% of the total mass concentration of PM10 during the non-haze days. The respective contributions of SNA species to PM10 rose to about27.2%, 15.9%, and 13.9% during the haze days, while the contributions of SOA maintained the same level with a slight decrease to about 4.9%. The observed mass concentrations of SNA and SOA increased with the increase of PM10 mass concentration, however, the rate of increase of SNA was much faster than that of the SOA. The SOR(sulfur oxidation ratio) and NOR(nitrogen oxidation ratio) increased from non-haze days to hazy days, and increased with the increase of RH. High concentrations of aerosols and water vapor favored the conversion of SO2 to SO2-4and NO2 to NO-3, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing. | Tingting Han Xingang Liu Yuanhang Zhang Yu Qu Limin Zeng Min Hu Tong Zhu | 2015 | Journal of Environmental Sciences2015，27，5： | 22 |
| 4 | Single whispering-gallery mode lasing in polymer bottle microresonators via spatial pump engineering显示文摘Single-mode lasing in whispering-gallery mode(WGM)microresonators is challenging to achieve.In bottle microresonators,the highly non-degenerated WGMs are spatially well-separated along the long-axis direction and provide mode-selection capability.In this work,by engineering the pump intensity to modify the spatial gain profiles of bottle microresonators,we demonstrate a simple and general approach to realizing single-mode WGM lasing in polymer bottle microresonators.The pump intensity is engineered into an interference distribution on the bottle microresonator surface.By tuning the spacing between axial positions of the interference pump patterns,the mode intensity profiles of single-bottle WGMs can be spatially overlapped with the interference stripes,intrinsically enabling single-mode lasing and selection.Attractive advantages of the system,including high sidemode suppression factors 420 dB,large spectral tunability 48 nm,low-lasing threshold and reversible control,are presented.Our demonstrated approach may have a variety of promising applications,ranging from tunable single-mode lasing and sensing to nonlinear optics. | Fuxing Gu Fuming Xie Xing Lin Shuangyi Linghu Wei Fang Heping Zeng Limin Tong Songlin Zhuang | 2017 | Light(Science & Applications)2017，6，1： | 17 |
| 5 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 6 | MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ显示文摘 | Min He Zhenqun Xu Tong Ding Dong-Ming Kuang Limin Zheng | 2009 | Cellular & Molecular Immunology2009，6，5： | 12 |
| 7 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 8 | Functionalized polymer nanofibers: a versatile platform for manipulating light at the nanoscale显示文摘As an organic optical fiber with a diameter comparable to or less than the wavelength of light,polymer nanofibers have been attracting increasing attention as a platform for manipulating light at the nanoscale.A variety of applications for polymer optical nanofibers,including waveguides,light sources and sensors,have been reported in recent years.In this article,the recent progress in the field of polymer optical nanofibers is reviewed in terms of their fabrication,characterization and applications.In particular,we focus on functionalized polymer nanofibers doped with functional materials,such as dye molecules,noble metal nanoparticles,quantum dots and rare earth ions,which greatly expand their capabilities of generating,propagating,converting and modulating light at the nanoscale. | Pan Wang Yipei Wang Limin Tong | 2013 | Light(Science & Applications)2013，2，1： | 9 |
| 9 | Micro/Nanofiber Optical Sensors显示文摘As a low-dimensional optical fiber with diameter close to or below the wavelength of light,optical micro/nanofiber(MNF)offers a number of favorable properties for optical sensing,which have been exploited in a variety of sensing applications,including physical,chemical,and biological sensors.In this paper we review the principles and applications of silica,glass,and polymer optical micro/nanofibers for physical and chemical sensing. | Lei ZHANG Jingyi LOU Limin TONG | 2011 | Photonic Sensors2011，1，1： | 8 |
| 10 | Daytime HONO formation in the suburban area of the megacity Beijing, China显示文摘Nitrous acid(HONO),as a primary precursor of OH radicals,has been considered one of the most important nitrogencontaining species in the atmosphere.Up to 30%of primary OH radical production is attributed to the photolysis of HONO.However,the major HONO formation mechanisms are still under discussion.During the Campaigns of Air Quality Research in Beijing and Surrounding Region(CAREBeijing2006)campaign,comprehensive measurements were carried out in the megacity Beijing,where the chemical budget of HONO was fully constrained.The average diurnal HONO concentration varied from 0.33 to 1.2 ppbv.The net OH production rate from HONO,POH(HONO)net,was on average(from 05:00 to 19:00)7.1×106 molecule/(cm3 s),2.7 times higher than from O3 photolysis.This production rate demonstrates the important role of HONO in the atmospheric chemistry of megacity Beijing.An unknown HONO source(Punknown)with an average of 7.3×106molecule/(cm3 s)was derived from the budget analysis during daytime.Punknown provided four times more HONO than the reaction of NO with OH did.The diurnal variation of Punknown showed an apparent photo-enhanced feature with a maximum around 12:00,which was consistent with previous studies at forest and rural sites.Laboratory studies proposed new mechanisms to recruit NO2 and J(NO2)in order to explain a photo-enhancement of of Punknown.In this study,these mechanisms were validated against the observation-constraint Punknown.The reaction of exited NO2 accounted for only 6%of Punknown,and Punknown poorly correlated with[NO2](R=0.26)and J(NO2)[NO2](R=0.35).These results challenged the role of NO2 as a major precursor of the missing HONO source. | YANG Qiang SU Hang LI Xin CHENG YaFang LU KeDing CHENG Peng GU JianWei GUO Song HU Min ZENG LiMin ZHU Tong ZHANG YuanHang | 2014 | Science China Chemistry2014，57，7： | 8 |
| 11 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 12 | Silver nanowire ring resonator显示文摘We demonstrate a silver nanowire ring resonator with a ring diameter of 10.2μm.The ring cavity is formed by coupling both ends of a 145-nm-diameter single silver nanowire into a closed loop.A Q-factor of 160 and a free spectral range of 10.6 nm are obtained for light centered around 800 nm.The self-coupled ring structure offers opportunities for realizing compact plasmonic resonators with tight confinement for hybrid optical and plasmonic signal processing. | GUO Xin ZHANG XiNing TONG LiMin | 2010 | Chinese Science Bulletin2010，55，24： | 5 |
| 13 | Optical Micro/Nano Fibers Enabled Smart Textiles for Human-Machine Interface显示文摘Wearable human-machine interface(HMI)is an advanced technology that has a wide range of applications from robotics to augmented/virtual reality(AR/VR).In this study,an optically driven wearable human-interactive smart textile is proposed by integrating a polydimethylsiloxane(PDMS)patch embedded with optical micro/nanofibers(MNF)array with a piece of textiles.Enabled by the highly sensitive pressure dependent bending loss of MNF,the smart textile shows high sensitivity(65.5 kPa^(−1))and fast response(25 ms)for touch sensing.Benefiting from the warp and weft structure of the textile,the optical smart textile can feel slight finger slip along the MNF.Furthermore,machine learning is utilized to classify the touch manners,achieving a recognition accuracy as high as 98.1%.As a proof-of-concept,a remote-control robotic hand and a smart interactive doll are demonstrated based on the optical smart textile.This optical smart textile represents an ideal HMI for AR/VR and robotics applications. | Shuqi Ma Xiaoyu Wang Pan Li Ni Yao Jianliang Xiao Haitao Liu Zhang Zhang Longteng Yu Guangming Tao Xiong Li Limin Tong Lei Zhang | 2022 | Advanced Fiber Materials2022，4，5： | 5 |
| 14 | Self-organized phase-transition lithography for all-inorganic photonic textures显示文摘Realizing general processing applicable to various materials by one basic tool has long been considered a distant dream.Fortunately,ultrafast laser-matter interaction has emerged as a highly universal platform with unprecedented optical phenomena and provided implementation paths for advanced manufacturing with novel functionalities.Here,we report the establishment of a three-dimensional(3D)focal-area interference field actively induced by a single ultrafast laser in transparent dielectrics.Relying on this,we demonstrate a radically new approach of self-organized phase-transition lithography(SOPTL)to achieve super-resolution construction of embedded all-inorganic photonic textures with extremely high efficiency.The generated textures exhibit a tunable photonic bandgap(PBG)in a wide range from〜1.3 to〜2 pm.More complicated interlaced textures with adjustable structural features can be fabricated within a few seconds,which is not attainable with any other conventional techniques.Evidenee suggests that the SOPTL is extendable to more than one material system.This study augments light-matter interaction physics,offers a promising approach for constructing robust photonic devices,and opens up a new research direction in advaneed lithography. | Bo Zhang Dezhi Tan Zhuo Wang Xiaofeng Liu Beibei Xu Min Gu Limin Tong Jianrong Qiu | 2021 | Light(Science & Applications)2021，10，6： | 3 |
| 15 | Mid-infrared chalcogenide microfiber knot resonators显示文摘A novel type of mid-IR microresonator,the chalcogenide glass(ChG)microfiber knot resonator(MKR),is demonstrated,showing easy fabrication,fiber-compatible features,resonance tunability,and high robustness.ChG micro fibers with typical diameters around 3μm are taper-drawn from As2S3 glass fibers and assembled into MKRs in liquid without surface damage.The measured Q factor of a typical 824μm diameter ChG MKR is about 2.84×104 at the wavelength of 4469.14 nm.The free spectral range(FSR)of the MKR can be tuned from2.0 nm(28.4 GHz)to 9.6 nm(135.9 GHz)by tightening the knot structure in liquid.Benefitting from the high thermal expansion coefficient of As2S3 glass,the MKR exhibits a thermal tuning rate of 110 pm·℃^-1 at the resonance peak.When embedded in polymethyl methacrylate(PMMA)film,a 551μm diameter MKR retains a Q factor of 1.1×10^4.The ChG MKRs demonstrated here are highly promising for resonator-based optical technologies and applications in the mid-IR spectral range. | YU XIE DAWEI CAI HAO WU JING PAN NING ZHOU CHENGUANG XIN SHAOLIANG YU PAN WANG XIAOSHUN JIANG JIANRONG QIU XIN GUO LIMIN TONG | 2020 | Photonics Research2020，8，4： | 3 |
| 16 | Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1显示文摘17β-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPARγ. The decrease in PPARγ expression is mediated by increased degradation of PPARγ. Here we report that PPARγ is ubiquitinated by HECT E3 ubiquitin ligase NEDD4-1 and degraded, along with PPARγ, in response to E2 stimulation. The PPARγ interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif. The WW3 domain in NEDD4-1 is critical for binding to PPARΓ. NEDD4-1 overexpression leads to PPARγ ubiquitination and reduced expression of PPARγ. Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARΓ ubiquitination. These data indicate that NEDD4-1 is the E3 ubiquitin ligase responsible for PPARγ ubiquitination. Here, we show that NEDD4-1 delays cellular senescence by degrading PPARΓ expression. Taken together, our data show that E2 could upregulate SIRT1 expression via promoting the PPARΓ ubiquitination-proteasome degradation pathway to delay the process of cell senescence. | Limin Han Pan Wang Ganye Zhao Hui Wang Meng Wang Jun Chen Tanjun Tong | 2013 | Protein & Cell2013，4，4： | 3 |
| 17 | High-Q, low-mode-volume microsphere-integrated Fabry–Perot cavity for optofluidic lasing applications显示文摘We develop a hybrid optofluidic microcavity by placing a microsphere with a diameter ranging from 1 to 4 μm in liquid-filled plano-plano Fabry–Perot(FP) cavities, which can provide an extremely low effective mode volume down to 0.3–5.1 μm^3 while maintaining a high Q-factor up to 1 × 10~4–5 × 10~4 and a finesse of ~2000. Compared to the pure plano-plano FP cavities that are known to suffer from the lack of mode confinement, diffraction, and geometrical walk-off losses as well as being highly susceptible to mirror misalignment, our microsphere-integrated FP(MIFP) cavities show strong optical confinement in the lateral direction with a tight mode radius of only 0.4–0.9 μm and high tolerance to mirror misalignment as large as 2°. With the microsphere serving as a waveguide, the MIFP is advantageous over a fiber-sandwiched FP cavity due to the open-cavity design for analytes/liquids to interact strongly with the resonant mode, the ease of assembly, and the possibility to replace the microsphere. In this work, the main characteristics of the MIFP, including Q-factor, finesse, effective mode radius and volume, and their dependence on the surrounding medium's refractive index, mirror spacing, microsphere position inside the FP cavity, and mirror misalignment, are systematically investigated using a finite-element method.Then, by inserting dye-doped polystyrene microspheres of various sizes into the FP cavity filled with water, we experimentally realize single-mode MIFP optofluidic lasers that have a lasing threshold as low as a few microjoules per square millimeter and a lasing spot radius of only ~0.5 μm. Our results suggest that the MIFP cavities provide a promising technology platform for novel photonic devices and biological/chemical detection with ultra-small detection volumes. | XIAOQIN WU YIPEI WANG QIUSHU CHEN YU-CHENG CHEN XUZHOU LI LIMIN TONG XUDONG FAN | 2019 | Photonics Research2019，7，1： | 3 |
| 18 | Degradation of acid fuchsine by a modified electro-Fenton system with magnetic stirring as oxygen supplying显示文摘The current modified electro-Fenton system was designed to develop a more convenient and efficient undivided system for practical wastewater treatment.The system adopted a cathode portion that employed magnetic stirring instead of common oxygen gas difflusion or gas sparging to supply oxygen gas for the electrolyte solution.Key factors influencing the cathode fabrication and activity were investigated.The degradation of acid fuchsine with a self-made graphite-polytetrafluorethylene cathode was studied using a spectrophotometer.It was found that the cathode generated hydrogen peroxide with high current efficiency and the hydrogen peroxide yield of the cathode did not decay after 10 times reuse.With the Pt anode at a ferrous ion concentration of 0.5 mmol/L,a pH of 3,and using magnetic stirring,dye decolorization could be rapidly accomplished but the destruction of benzene rings and intermediates was fairly difficult.With a Fe anode,dye degradation was more complete. | Yiping Sheng,Limin Zhen,Xiuli Wang,Ning Li,Qi Tong College of Environmental and Chemical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,China. | 2010 | Journal of Environmental Sciences2010，22，4： | 2 |
| 19 | Single optical microfiber enabled tactile sensor for simultaneous temperature and pressure measurement显示文摘The ability to sense heat and touch is essential for healthcare,robotics,and human–machine interfaces.By taking advantage of the engineerable waveguiding properties,we design and fabricate a flexible optical microfiber sensor for simultaneous temperature and pressure measurement based on theoretical calculation.The sensor exhibits a high temperature sensitivity of 1.2 nm/℃ by measuring the shift of a high-order mode cutoff wavelength in the short-wavelength range.In the case of pressure sensing,the sensor shows a sensitivity of 4.5%per kilopascal with a fast temporal frequency response of 1000 Hz owing to the strong evanescent wave guided outside the microfiber.The cross talk is negligible because the temperature and pressure signals are measured at different wavelengths based on different mechanisms.The properties of fast temporal response,high temperature,and pressure sensitivity enable the sensor for real-time skin temperature and wrist pulse measurements,which is critical to the accurate analysis of pulse waveforms.We believe the sensor will have great potential in wearable optical devices ranging from healthcare to humanoid robots. | NI YAO XIAOYU WANG SHUQI MA XINGDA SONG SHAN WANG ZHANGXING SHI JING PAN SHIPENG WANG JIANLIANG XIAO HAITAO LIU LONGTENG YU YAO TANG ZHANG ZHANG XIONG LI WEI FANG LEI ZHANG LIMIN TONG | 2022 | Photonics Research2022，10，9： | 2 |
| 20 | Highly sensitive and fast response strain sensor based on evanescently coupled micro/nanofibers显示文摘Flexible strain sensors play an important role in electronic skins,wearable medical devices,and advanced robots.Herein,a highly sensitive and fast response optical strain sensor with two evanescently coupled optical micro/nanofibers(MNFs)embedded in a polydimethylsiloxane(PDMS)film is proposed.The strain sensor exhibits a gauge factor as high as 64.5 for strain≤0.5%and a strain resolution of 0.0012%which corresponds to elongation of 120 nm on a 1 cm long device.As a proof-of-concept,highly sensitive fingertip pulse measurement is realized.The properties of fast temporal frequency response up to 30 kHz and a pressure sensitivity of 102 kPa^(−1) enable the sensor for sound detection.Such versatile sensor could be of great use in physiological signal monitoring,voice recognition and micro-displacement detection. | Wen Yu Ni Yao Jing Pan Wei Fang Xiong Li Limin Tong Lei Zhang | 2022 | Opto-Electronic Advances2022，5，9： | 2 |
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