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| 1 | Hyperuricemia Accompanied with Changes in the Retinal Microcirculation in a Chinese High-risk Population for Diabetes显示文摘Objective To investigate the association of retinal vascular calibers with hyperuricemia in a middle‐aged and elderly population. Methods A cross‐sectional design was applied in this study and 869 participants aged ≥40 years from a high‐risk group for diabetes were recruited. All participants received the anthropometrical measurements and laboratory tests. Retinal arteriolar and venular caliber of the participants were measured with a semi‐automated system. Hyperuricemia was defined as a serum uric acid level >420 μmol/L in men and >360 μmol/L in women. Linear regression models were used to assess the association of hyperuricemia with retinal vascular calibers. These models were additionally adjusted for age, central obesity, hypertension, dyslipidemia, weekly activity, smoking status, and education. Results Among the 869 participants, 133 (15.3%) suffered from hyperuricemia. The crude mean serum uric acid level was 312.3 μmol/L (Standard Deviation 79.5); mean concentration was 355.0 μmol/L (SD 75.5) in male participants, and 288.0 μmol/L (SD 71.1) in female participants (age‐adjusted difference 58.1 μmol/L, 95% Confidence Internal 48.5, 67.6). After adjusting for additional covariates, male participants with hyperuricemia had 3.77 μm (95% CI ‐0.46, 8.00) smaller arteriolar caliber and 6.20 μm (95% CI 0.36, 12.04) larger venule than those without hyperuricemia; the corresponding numbers among female participants were 1.57 μm (95% CI ‐1.07, 4.21) for retinal arteriolar caliber and 2.28 μm (95% CI ‐1.72, 6.27) for retinal venular caliber. Conclusion Hyperuricemia was associated with smaller retinal arteriolar caliber and larger venular caliber mainly in male participants in this study. | YUAN YuanZhi M. Kamran IKRAM JIANG SunFang LIN HuanDong REN LiMin YAN HongMei SHENG JianHua CHEN XuSheng GAO Xin | 2011 | Biomedical and Environmental Sciences2011，24，2： | 6 |
| 2 | Lipopolysaccharide induced intestinal epithelial injury:a novel organoids-based model for sepsis in vitro显示文摘Background: Advances in organoid culture technology have provided a greater understanding of disease pathogenesis, which has been rarely studied in sepsis before. We aim to establish a suitable organoids-based intestinal injury model for sepsis.Methods: Stable passaged organoids were constructed and pre-treated with lipopolysaccharide (LPS) to mimic sepsis-induced intestinal injury. The LPS-induced sepsis model was used as a reference. We used quantitative real-time polymerase chain reaction to evaluate the RNA levels of inflammatory factors and antimicrobial peptides. Enzyme-linked immunosorbent assay was used to evaluate the protein levels, hematoxylin and eosin staining was used to evaluate the pathology of the small intestine of mice, and immunohistochemistry and immunofluorescence were used to evaluate the intestinal epithelial barrier function. Perkin Elmer OperettaTM was used to obtain high-resolution images of three-dimensional organoids.Results: An LPS concentration >150 μg/mL after 24 h was identified to cause organoid growth restriction. The fluorescence intensity of zonula occludens-1 and occludins at LPS concentrations >100 μg/mL decreased significantly after 24 h. After LPS stimulation for 8 h, the RNA expression levels of interleukin (IL)-1α, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, IL-6, and regenerating islet-derived protein 3 alpha, beta, and gamma increased. These results resembled those of intestinal epithelial layer alterations in a mouse sepsis model. For IL-10, the RNA expression level increased only when the LPS level >200 μg/mL for 24 h.Conclusions: This study provides the primary intestinalin vitro model to study the effects of LPS-induced intestinal injury resembling sepsis. This model provides a platform for immune associated mechanism exploration and effective drug screening. | Sisi Huang Sheng Zhang Limin Chen Xiaojun Pan Zhenliang Wen Yizhu Chen Lidi Zhang Jiao Liu Dechang Chen | 2022 | Chinese Medical Journal2022，135，18： | 3 |
| 3 | 超深井高速率连续波MWD信道传输系统(英文)显示文摘At present,the MWD systems continuous wave mud pulse telemetry transmit is not faster than 1or 2bits/s from deep wells containing highly attenuative mud,because positive pulsers create strong signals but large axial flow forces impede fast reciprocation while mud sirens provide high data rates without higher signal strength.A high-data-rate system providing 10bits/s and operable up to30 000 ft is described,which creates strong source signals by using downhole constructive wave interference in two novel ways.Telemetry schemes,frequencies and pulser locations in the MWD drill collar are selected for positive wave phasing,and sirens-in-series are used to create additive signals——both without incurring power and erosion penalties.The positions normally occupied by pulsers and turbines are reversed to minimize times required for constructive interference and modulation.A system design approach is undertaken,e.g.,strong source signals are augmented with new multiple-transducer surface signal processing methods to remove mudpump noise and signal reflections at both pump and desurger,and mud,bottomhole assembly and drill pipe properties,to the extent possible in practice,are controlled to reduce signal attenuation.The results of detailed acoustic modeling in realistic drilling telemetry channels are described,and short and long wind tunnels for signal strength,torque,erosion and jamming testing,and telemetry and signal processing evaluation,respectively,are introduced.Special scaling methods are developed to extrapolate cost-effective wind tunnel test results to real muds flowing at any downhole speed.New siren concept prototype hardware and also typical acoustic test results are also given. | Wilson CHIN SU Yinao SHENG Limin LI Lin BIAN Hailong SHI Rong | 2014 | 测井技术2014，38，6： | 3 |
| 4 | Degradation of acid fuchsine by a modified electro-Fenton system with magnetic stirring as oxygen supplying显示文摘The current modified electro-Fenton system was designed to develop a more convenient and efficient undivided system for practical wastewater treatment.The system adopted a cathode portion that employed magnetic stirring instead of common oxygen gas difflusion or gas sparging to supply oxygen gas for the electrolyte solution.Key factors influencing the cathode fabrication and activity were investigated.The degradation of acid fuchsine with a self-made graphite-polytetrafluorethylene cathode was studied using a spectrophotometer.It was found that the cathode generated hydrogen peroxide with high current efficiency and the hydrogen peroxide yield of the cathode did not decay after 10 times reuse.With the Pt anode at a ferrous ion concentration of 0.5 mmol/L,a pH of 3,and using magnetic stirring,dye decolorization could be rapidly accomplished but the destruction of benzene rings and intermediates was fairly difficult.With a Fe anode,dye degradation was more complete. | Yiping Sheng,Limin Zhen,Xiuli Wang,Ning Li,Qi Tong College of Environmental and Chemical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,China. | 2010 | Journal of Environmental Sciences2010，22，4： | 2 |
| 5 | Operational-space wrench and acceleration capability analysis for multi-link cable-driven robots显示文摘Multi-link cable-driven robots(MCDRs)have potential advantages in confined spaces exploration because of their redundancy and flexibility.Operational space wrench and acceleration capability analysis of MCDRs is important for their design,manipulability optimization,and motion planning.However,existing works mainly focus on capability analysis in the joint space.In this paper,we present a zonotope-based iterative method and a simplified capability zonotope to analyze the operational-space wrench and acceleration capability of MCDRs.In the iterative method,the capability generated by some cables can be iteratively added to the initial capability zonotope based on the Minkowski sum.In the simplified zonotope capability representation,a threshold is put forward to reduce redundant vertices and faces with little volume loss.Finally,simulations on a 24 DOFs MCDR are performed to verify the effectiveness of the developed method.The results demonstrate that our iterative algorithm can easily generate the capability zonotope with a few MB ROM,while traditional operational wrench capability evaluation without our iterative algorithm needs 18432 GB ROM.Furthermore,our simplified representation reduces the vertices and faces from 1260 and 2516 to 88 and 172,respectively,but with only 3.3%volume loss,which decreases the constraints of the robot and is conducive to manipulability optimization and motion planning. | SHENG XinJun TANG Lei HUANG XinJia ZHU LiMin ZHU XiangYang GU GuoYing | 2020 | Science China(Technological Sciences)2020，63，10： | 1 |
| 6 | Removal of NOx and SO2 in flue gas by corona discharge reactor with water film 显示文摘 | Dong Limin Sheng Shouguo Liu Lutao | 2002 | IEEE Annual Report Conference on Electrical Insulation and Dielectric Phenomena2002，，： | 1 |
| 7 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 8 | Annealing-induced Grain Refinement in a Nanostructured Ferritic Steel显示文摘A nanostructured surface layer with a mean ferrite grain size of ~8 nm was produced on a Fe-9Cr steel by means of surface mechanical attrition treatment. Upon annealing, ferrite grains coarsen with increasing temperature and their sizes increase to ~40 nm at 973 K. Further increasing annealing temperature leads to an obvious reduction of ferrite grain sizes, to ~14 nm at 1173 K. The annealing-induced grain refinement is analyzed in terms of phase transformations in the nanostructured steel. | Limin Wang Zhenbo Wang Sheng Guo Ke Lu | 2012 | Journal of Materials Science & Technology2012，28，1： | 1 |
| 9 | A Convenient Synthesis of α,α′-Bis(substituted benzylidene)cycloalkanones Catalyzed by Yb(OTf)3 Under Solvent-Free Conditions显示文摘 | Limin Wang Jia Sheng He Tian Jianwei Han Zhaoyu Fan Changtao Qian | 2004 | Synthesis2004，，18： | 1 |
| 10 | Angiotensinogen gene polymorphism and ischemic stroke in East Asians:A meta-analysis显示文摘OBJECTIVE: To investigate the association between angiotensinogen gene M235T polymorphism and ischemic stroke in East Asians. DATA RETRIEVAL: A computer-based online search was conducted in PubMed, Google scholar, China National Knowledge lnfrastructure database between January 1990 and April 2012 for relevant studies. The were angiotensinogen or AGT, polymorphism or genetic and ischemic stroke or cerebral infarction. SELECTION CRITERIA: Case-controlled studies addressing the correlation between angiotensinogen gene M235T polymorphism and ischemic stroke in East Asians were included. The distribution of genotypes in the included studies was tested for Hardy-Weinberg equilibrium. Quality evaluation of the included studies was conducted by two physicians. Statistical analyses were carried out using Stata 12.0 software for meta-analysis. Heterogeneity tests, sensitivity analysis and publication bias were also conducted. MAIN OUTCOME MEASURES: The association between angiotensinogen gene M235T polymorphism and ischemic stroke risk in East Asians was assessed. RESULTS: Six relevant studies involving 891 patients with ischemic stroke and 727 controls were included in this meta-analysis. Results showed that there was a significant association between angiotensinogen gene M235T polymorphism and the risk of ischemic stroke in East Asians (T vs. M: odds ratio (OR) = 1.54, 95% confidence interval (CI) = 1.10-2.16; TT vs. MM: OR = 2.24, 95%CI = 1.37-3.66; TT vs. MT: OR = 1.76, 95%CI = 1.41-2.20; MM + MT vs. TT: OR = 0.57, 95%CI = 0.46-0.70). Sensitivity analysis confirmed that the study results were stable and reliable, with no publication bias. CONCLUSION: The angiotensinogen gene M235T polymorphism is associated with ischemic stroke in East Asians, and the TT genotype and T allele are risk factors for ischemic stroke. | Sheng Wang Rong Zeng Limin Lei Jinsong Huang | 2013 | Neural Regeneration Research2013，8，13： | 1 |
| 11 | The influence of interface phenomenon on removal of NO and SO2 in corona discharge reactor with water film显示文摘 | Dong Limin Chen Chuntian Sheng Shouguo | 2002 | Industry Applications Conference2002，3，： | 1 |
| 12 | Abnormalities of quantities and functions of linker for activations of T cells in severe aplastic anemia显示文摘 | Weiwei Sheng Chunyan Liu Rong Fu Huaquan Wang Wen Qu Erbao Ruan Guojin Wang Hong Liu Yuhong Wu Jia Song Limin Xing Jing Guan Lijuan Li Hui Liu Zonghong Shao | 2014 | Eur J Haematol2014，，3： | 1 |
| 13 | Abnormalities of quantities and functions of natural killer cells in severe aplastic anemia显示文摘 | Chunyan Liu Zhishang Li Weiwei Sheng Rong Fu Lijuan Li Tian Zhang Yuhong Wu Limin Xing Jia Song Huaquan Wang Zonghong Shao | 2014 | Immunological Investigations2014，，5： | 1 |
| 14 | Boosting reversible charging of Li-ion batteries at low temperatures by a synergy of propylene carbonate-based electrolyte and defective graphite显示文摘Propylene carbonate(PC)-based electrolytes have exhibited significant advantages in boosting the low-temperature discharging of graphite-based Li-ion batteries.However,it is still unclear whether they can improve the charging property and suppress lithium plating.Studying this topic is challenging due to the problem of electrochemical compatibility.To overcome this issue,we introduced graphite with phase defects.The results show that the pouch-type full batteries using PC-based electrolyte exhibit steady performance over 500 cycles and can be reversibly charged over 30 times at-20℃ with an average Coulombic efficiency of 99.95%,while the corresponding value for the conventional ethylene carbonate(EC)-based electrolyte sample is only 31.20%.This indicates that the use of PC-based electrolyte significantly suppresses lithium plating during low-temperature charging.We further demonstrate that the improved performance is mainly attributed to the unique solvation structure,where PF-6more anions participate in solvation,leading to the formation of a stable F-rich solid state electrolyte interface on the graphite surface and a lower reduction tendency of Li+ions.This work inspires new ideas for the design of PC-based electrolytes for low-temperature charging and fast-charging batteries. | Yingqiang Wu Jiao Zhang Jinli Liu Li Sheng Bo Zhang Limin Wang Siqi Shi Li Wang Hong Xu Xiangming He | 2024 | Nano Research2024，17，3： | 0 |
| 15 | An Overview of Power System Emergency Management in China显示文摘The emergency management of power systems in China is reviewed in this paper.The current situation of emergency management is given firstly,then the organization system,warning and plan,emergency headquarter,and emergency power supply are separately discussed in theory and in practice.The advantages and disadvantages in the emergency management are also analyzed. | Sheng Xing Zhang Yu Yin Juan Liang Baosheng Li Limin Xu Xin | 2012 | Electricity2012，23，2： | 0 |
| 16 | HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation显示文摘Ultra-stable fibrous structure is a hallmark of amyloids.In contrast to canonical disease-related amyloids,emerging research indicates that a significant number of cellular amyloids,termed‘functional amyloids’,contribute to signal transduction as temporal signaling hubs in humans.However,it is unclear how these functional amyloids are effectively disassembled to terminate signal transduction.RHIM motif-containing amyloids,the largest functional amyloid family discovered thus far,play an important role in mediating necroptosis signal transduction in mammalian cells.Here,we identify heat shock protein family A member 8(HSPA8)as a new type of enzyme—which we name as‘amyloidase’—that directly disassembles RHIM-amyloids to inhibit necroptosis signaling in cells and mice.Different from its role in chaperone-mediated autophagy where it selects substrates containing a KFERQ-like motif,HSPA8 specifically recognizes RHIM-containing proteins through a hydrophobic hexapeptide motif N(X_(1))φ(X_(3)).The SBD domain of HSPA8 interacts with RHIM-containing proteins,preventing proximate RHIM monomers from stacking into functional fibrils;furthermore,with the NBD domain supplying energy via ATP hydrolysis,HSPA8 breaks down pre-formed RHIM-amyloids into non-functional monomers.Notably,HSPA8’s amyloidase activity in disassembling functional RHIM-amyloids does not require its co-chaperone system.Using this amyloidase activity,HSPA8 reverses the initiator RHIM-amyloids(formed by RIP1,ZBP1,and TRIF)to prevent necroptosis initiation,and reverses RIP3-amyloid to prevent necroptosis execution,thus eliminating multi-level RHIM-amyloids to effectively prevent spontaneous necroptosis activation.The discovery that HSPA8 acts as an amyloidase dismantling functional amyloids provides a fundamental understanding of the reversibility nature of functional amyloids,a property distinguishing them from disease-related amyloids that are unbreakable in vivo. | Erpeng Wu Wenyan He Chenlu Wu Zhangcheng Chen Shijie Zhou Xialian Wu Zhiheng Hu Kelong Jia Jiasong Pan Limin Wang Jie Qin Dan Liu Junxia Lu Huayi Wang Jixi Li Sheng Wang Liming Sun | 2023 | Cell Research2023，33，11： | 0 |
| 17 | Identification and validation of prognostic factors in patients with COVID-19: A retrospective study based on artificial intelligence algorithms显示文摘Background:Novel coronavirus disease 2019(COVID-19)is an ongoing global pandemic with high mortality.Although several studies have reported different risk factors for mortality in patients based on traditional analytics,few studies have used artificial intelligence(AI)algorithms.This study investigated prognostic factors for COVID-19 patients using AI methods.Methods:COVID-19 patients who were admitted in Wuhan Infectious Diseases Hospital from December 29,2019 to March 2,2020 were included.The whole cohort was randomly divided into training and testing sets at a 6:4 ratio.Demographic and clinical data were analyzed to identify predictors of mortality using least absolute shrinkage and selection operator(LASSO)regression and LASSO-based artificial neural network(ANN)models.The predictive performance of the models was evaluated using receiver operating characteristic(ROC)curve analysis.Results:A total of 1145 patients(610 male,53.3%)were included in the study.Of the 1145 patients,704 were assigned to the training set and 441 were assigned to the testing set.The median age of the patients was 57 years(range:47-66 years).Severity of illness,age,platelet count,leukocyte count,prealbumin,C-reactive protein(CRP),total bilirubin,Acute Physiology and Chronic Health Evaluation(APACHE)II score,and Sequential Organ Failure Assessment(SOFA)score were identified as independent prognostic factors for mortality.Incorporating these nine factors into the LASSO regression model yielded a correct classification rate of 0.98,with area under the ROC curve(AUC)values of 0.980 and 0.990 in the training and testing cohorts,respectively.Incorporating the same factors into the LASSO-based ANN model yielded a correct classification rate of 0.990,with an AUC of 0.980 in both the training and testing cohorts.Conclusions:Both the LASSO regression and LASSO-based ANN model accurately predicted the clinical outcome of patients with COVID-19.Severity of illness,age,platelet count,leukocyte count,prealbumin,CRP,total bilirubin,APACHE II score,and SOFA score were identified as prognostic factors for mortality in patients with COVID-19. | Sheng Zhang Sisi Huang Jiao Liu Xuan Dong Mei Meng Limin Chen Zhenliang Wen Lidi Zhang Yizhu Chen Hangxiang Du Yongan Liu Tao Wang Dechang Chen | 2021 | Journal of Intensive Medicine2021，1，2： | 0 |
| 18 | ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression显示文摘The clinical oncogenic functions and mechanisms of activating transcription factor 1(ATF1)in the progression of lung adenocarcinoma have not been completely elucidated.In this study,by employing human lung adenocarcinoma tissues and cells,we detect the correlation of ATF1 expression with the clinicopathological features and prognosis of patients with lung adenocarcinoma and find that ATF1 promotes lung adenocarcinoma cell proliferation and migration by transcriptionally enhancing zinc finger protein 143(ZNF143)expression.ATF1 and ZNF143 are strongly expressed in lung adenocarcinoma tissues compared with those in the adjacent normal tissues,and high ATF1 and ZNF143 expressions are related to poor disease-free survival of lung adenocarcinoma patients.ATF1 overexpression results in increased proliferation and migration of lung adenocarcinoma cells,whereas knockdown of ATF1 inhibits cell proliferation and migration.Furthermore,ATF1 transcriptionally regulates the expression of ZNF143,and ATF1 and ZNF143 expressions are positively correlated in lung adenocarcinoma tissues.ZNF143 knockdown blocks lung adenocarcinoma cell migration,which is mediated by ATF1 upregulation.Hence,this study provides a potential therapeutic candidate for the treatment of lung adenocarcinoma. | Jinhong Mei Yu Liu Yiyun Sheng Ying Liu Limin Chen Hailong Wang Minzhang Cheng Zhenyu Zhai Linlin Xu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
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