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43篇 您的检索式:作者名="Junling Lu"
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1Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu 2017Nano Research2017,10,4:16
2Insight of the stability and activity of platinum single atoms on ceria显示文摘Single-atom catalysts (SACs) have recently attracted broad attention in the catalysis field due to their maximized atom efficiency and unique catalytic properties.An atomic-level understanding of the interaction between the metal atoms and support is vital for developing stable and high-performance SACs.In this work,Pt1 single atoms with Ioadings up to 4 wt.% were fabricated on ceria nanorods using the atomic layer deposition technique.To understand the Pt-O-Ce bond interfacial interactions,the stability of Pt1 single atoms in the hydrogen reducing environment was extensively investigated by using in situ diffuse reflectance infrared Fourier transform spectroscopy CO chemisorption measurements.It was found that ceria defect sites,metal Ioadings and high-temperature calcination are effective ways to tune the stability of Pt1 single atoms in the hydrogen environment.X-ray photoemission spectroscopy further showed that Pt1 single atoms on ceria are dominantly at a +2 valence state at the defect and step edge sites,while those on terrace sites are at a +4 state.The above tailored stability and electronic properties of Pt1 single atoms are found to be strongly correlated with the catalytic activity in the dry and water-mediated CO oxidation reactions.Xuxu Ye Hengwei Wang Yue Lin Xinyu Liu Lina Cao Jian Gu Junling Lu 2019Nano Research2019,12,6:13
3High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations.Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li 2019Acta Pharmaceutica Sinica B2019,9,5:10
4Characteristics of microbial community involved in early biofilms formation under the influence of wastewater treatment plant effluent显示文摘Effluents from wastewater treatment plants(WWTPs) containing microorganisms and residual nutrients can influence the biofilm formation. Although the process and mechanism of bacterial biofilm formation have been well characterized, little is known about the characteristics and interaction of bacteria, archaea and eukaryotes in the early colonization, especially under the influence of WWTP effluent. The aim of this study was to characterize the important bacterial, archaeal and eukaryotic species in the early stage of biofilm formation downstream of the WWTP outlet. Water and biofilm samples were collected 24 and 48 hr after the deposition of bio-cords in the stream. Illumina Miseq sequencing of the 16 S and 18 S rDNA showed that, among the three domains, the bacterial biofilm community had the largest alpha and beta diversity. The early bacterial colonizers appeared to be 'biofilm-specific', with only a few dominant operational taxonomic units(OTUs) shared between the biofilm and the ambient water environment. Alpha-proteobacteria and Ciliophora tended to dominate the bacterial and eukaryotic communities, respectively, of the early biofilm already at 24 hr, whereas archaea played only a minor role during the early stage of colonization. The network analysis showed that the three domains of microbial community connected highly during the early colonization and it might be a characteristic of the microbial communities in the biofilm formation process where co-occurrence relationships could drive coexistence and diversity maintenance within the microbial communities.Yuke Peng Jie Li Junling Lu Lin Xiao Liuyan Yang 2018Journal of Environmental Sciences2018,30,4:6
5Sequential therapy according to distinct disease progression patterns in advanced ALK-positive non-small-cell lung cancer after crizotinib treatment显示文摘Objective: Crizotinib is recommended as the first-line therapy for advanced anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC). Despite its initial efficacy, patients ultimately acquire resistance to crizotinib within 1 year. In such patients, the optimal sequential therapy after crizotinib treatment remains unknown. This study explored which sequential therapy option confers the greatest benefit.Methods: A total of 138 patients with advanced ALK-positive NSCLC resistant to crizotinib were studied. Based on patterns of disease progression of metastases, patients were divided into 3 groups: brain progression, non-liver progression, and liver progression. Sequential therapies included crizotinib continuation plus local therapy, nextgeneration ALK inhibitors(ALKi's), and chemotherapy. The primary endpoint was overall survival(OS) from the time of crizotinib resistance to death or last follow-up.Results: The 138 patients included 64 cases with progression in brain, 57 cases in non-liver sites and 17 cases in liver. A significant difference in OS was observed among the distinct progression pattern(median OS, 25.4 months in brain, 15.8 months in non-liver, and 10.8 months in liver, respectively, P=0.020). The difference in OS among sequential therapies was statistically significant in the non-liver progression group(median OS, 27.6 months with next-generation ALKi's, 13.3 months with crizotinib continuation, and 10.8 months with chemotherapy,respectively, P=0.019). However, crizotinib continuation plus local therapy seems to provide non-inferior median OS compared with next-generation ALKi's for patients with brain progression(median OS, 28.9 months vs.32.8 months, P=0.204). And no significant differences in OS were found in patients with progression in liver(P=0.061).Conclusions: Crizotinib continuation together with local therapy might be a feasible strategy for patients with progression in brain beyond crizotinib resistance, as well as next-generation ALKi's. Next-generation ALKi's tended to provide a survival benefit in patients with non-liver progression.Haiyan Xu Di Ma Guangjian Yang Junling Li Xuezhi Hao Puyuan Xing Lu Yang Fei Xu Yan Wang 2019Chinese Journal of Cancer Research2019,31,2:6
6The Characteristics of the Shear-Vibrating Quartz Crystal Resonator显示文摘<正>According to the piezoelectric equation and the vibration theory of the quartz crystal,the relations between the vibrating frequency and structural parameters under the thickness-shear-vibration of AT-cut quartz crystal have been studied. The frequency conditions under which quartz crystal resonator formed stationary wave inside the electrode district and the transmission characteristics of wave outside the electrode district have also been discussed.A quartz crystal resonator was developed based on this analysis.The experiment showed that the force-sensing characteristics were independent of the fixation of the crystal edge.The detecting distinguish ability was up to 0.001°,and the short-term frequency stability was up to 1.38×10~ (-10)/min.Wenjie Tian Lingling Liu Junling Lu Fuxue Zhang 2006稀有金属材料与工程2006,35,A03:6
7A Review on Particle Size Effect in Metal-Catalyzed Heterogeneous Reactions显示文摘Size of metal nanoparticles(NPs)plays decisive roles in metal-catalyzed heterogeneous reactions,due to the drastic variation of the geometric and electronic properties of metal NPs with size.Along with the development of controlled catalyst synthesis,tremendous efforts have been devoted to understanding the nature of the particle size effect.In particular,identification of the individual roles of size-dependent geometric and electronic effects on metal-catalyzed reactions is essential,but remains challenging since they are tightly hybridized together with particle size variation.In this review,w e first discuss the fundamentals of the size-dependent geometric and electronic properties of metal NPs and their crucial roles in catalysis in general.Then we summarize the previous representative studies of the particle size effect,metal-by-metal,in heterogeneous catalysis.We highlighted the extension of particle size effect to ultrafine cluster and single-atom catalysts,the new frontiers in heterogeneous catalysis.In the followings,we further introduce the recent advances in disentangling the size-dependent geometric and electronic effects and unveiling their individual contributions to catalysis.Finally,we discuss the challenges and perspectives of investigations on the size effect in metal catalysis for the future studies.Hengwei Wang Junling Lu 2020Chinese Journal of Chemistry2020,38,11:5
8Interference-Aware Probabilistic Routing for Wireless Sensor Networks显示文摘Wireless communications are prone to the interference, so the data transmission among the nodes in wireless sensor networks deployed in complex environments has the obvious uncertainty. This paper adopts probability theory to extend the existed interference model, and gives an interference analysis model and implements it through the cross-layer method. In addition, the isotonic property of the interference-aware routing metric is proved. Then, a probabilistic routing algorithm is proposed and its correctness and time-space complexity are analyzed. Simulation results show that the proposed algorithm can achieve better packet delivery ratio, throughput, jitter and average delay in dense deployment under the different loads at the expense of the comparable average length of paths compared with the Adhoc On-Demand Distance Vector (AODV) algorithm.Junling Lu Xiaoming Wang 2012Tsinghua Science and Technology2012,17,5:3
9Atomic layer deposition on Pd nanocrystals for forming Pd-TiO_2 interface toward enhanced CO oxidation显示文摘Pd typically exhibits relatively low catalytic activity in CO oxidation, as CO is apt to be adsorbed on Pd to poison the surface for O_2 activation. In this Letter, we report that this limitation can be overcome by integrating Pd withTiO_2 . The TiO_2 was coated on Pd nanocubes with a controllable thickness using atomic layer deposition(ALD) method. Given the different work functions of TiO_2 and Pd, the electrons inTiO_2 semiconductor will flow toward Pd. With the electron density increased on Pd, the adsorption of CO to Pd will be weakened while the oxygen activation can be facilitated. Meanwhile, the interface-confined sites at Pd-TiO_2 may further enhance the oxygen activation. As the species adsorption and activation are strongly correlated with electron density, the performance of Pd-TiO_2 in CO oxidation turns out to depend on the TiO_2 thickness, which determines the number of transferred electrons, within a certain range(<1.8 nm). This work provides a new strategy for enhancing catalytic performance through tailoring charge densities in hybrid catalysts.Yu Bai Chunlei Wang Xingyi Zhou Junling Lu Yujie Xiong 2016Progress in Natural Science:Materials International2016,26,3:2
10A 220 GHz dynamic frequency divider in 0.5μm InP DHBT technology显示文摘A high performance 3 inch 0.5 μm InP DHBT technology with three interconnecting layers has been developed.The epitaxial layer structure and geometry parameters of the device were carefully studied to get the required performances.The 0.5 × 5 μm^2 InP DHBTs demonstrated f_t = 350 GHz,f_(max) = 532 GHz and BV_(CEO) = 4.8 V,which were modeled using Agilent-IIBT large signal model.As a benchmark circuit,a dynamic frequency divider operating from 110 to 220 GHz has been designed,fabricated and measured with this technology.The ultra-high-speed 0.5 μm InP DHBT technology offers a combination of ultra-high-speed and high breakdown voltage,which makes it an ideal candidate for next generation 100 GHz+ mixed signal integrated circuits.Wei Cheng Youtao Zhang Yuan Wang Bin Niu Haiyan Lu Long Chang Junling Xie 2017Journal of Semiconductors2017,38,5:1
11The APOE ε2 allele may decrease the age at onset in patients with spinocerebellar ataxia type 3 or Machado-Joseph disease from the Chinese Han population显示文摘Huirong Peng Chunrong Wang Zhao Chen Zhanfang Sun Bin Jiao Kai Li Fengzhen Huang Xuan Hou Junling Wang Lu Shen Kun Xia Beisha Tang Hong Jiang 2014Neurobiology of Aging2014,,9:1
12Plasma and urinarytanshinol from Salvia miltiorrhiza ( Danshen) can be used aspharmacokinetic markers for cardiotonic pills, a cardiovascularherbal medicine显示文摘Lu Tong Yang Junling Gao Xiumei 2008Drug Metab Dispos2008,36,8:1
13Seasonal variations of tris (2-chloroethyl) phosphate and cytotoxicity of organic extracts in water samples from Wuhan, China显示文摘Tris(2-chloroethyl) phosphate(TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants(DWTPs) in China, and evaluated the cytotoxicity and apoptosis/necrosis of organic extracts(OEs) in water samples. We enriched TCEP and OEs in water samples by solid-phase extraction method. The TCEP concentrations in water samples were determined by gas chromatography–mass spectrometry. Normal human liver cell line L02 was treated with OEs in the water samples, and then the cytotoxicity and apoptosis/necrosis were measured by 3-(4, 5-dimethyithiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and flow cytometry, respectively. The results showed that cytotoxicities of OEs in raw water samples from both DWTPs in summer and winter were stronger than those in spring and autumn, cytotoxicity of OEs in finished and tap water samples from both DWTPs in summer and autumn were stronger than those in spring and winter. In all seasons, the maximal concentrations(100 mL water/mL cell culture) of OEs in the raw water samples from both DWTPs induced late apoptosis/necrosis. The reasons for seasonal variations of TCEP in water samples and potential toxic effects of other pollutants in the water samples need to be further investigated.Youjian Zhang Wenjuan Zhang Jian Hou Xian Wang Wenhong Lu Hongyan Zheng Wei Xiong Junling Liu Jing Yuan 2019Journal of Environmental Sciences2019,31,2:1
14Optimal integration of offshore wind power for a steadier, environmentally friendlier, supply of electricity in China显示文摘Xi Lu Michael B. McElroy Chris P. Nielsen Xinyu Chen Junling Huang 2013Energy Policy2013,,:1
15Plasma and Urinary Tanshinol from Salvia miltiorrhiza (Danshen) Can Be Used as Pharmacokinetic Markers for Cardiotonic Pills,a Cardiovascular Herbal Medicine显示文摘Tong Lu Junling Yang Chuan Li 2008Drug Metabolism and Disposition2008,36,:1
16Inverse single-site Fe_(1)(OH)_(x)/Pt(111)model catalyst for preferential oxidation of CO in H_(2)显示文摘Inverse oxide/metal model systems are frequently used to investigate catalytic structure-function relationships at an atomic level.By means of a novel atomic layer deposition process,growth of single-site Fe_(1)O_(x) on a Pt(111)single crystal surface was achieved,as confirmed by scanning tunneling microscopy(STM).The redox properties of the catalyst were characterized by synchrotron radiation based ambient pressure X-ray photoelectron spectroscopy(AP-XPS).After calcination treatment at 373 K in 1 mbar O_(2).the chemical state of the catalyst was determined as Fe^(3+).Reduction in 1 mbar H_(2) at 373 K demonstrates a facile reduction to Fe2+and complete hydroxylation at significantly lower temperatures than what has been reported for iron oxide nanoparticles.At reaction conditions relevant for preferential oxidation of CO in H_(2)(PROX),the catalyst exhibits a Fe3+state(ferric hydroxide)at 298 K while re-oxidation of iron oxide clusters does not occur under the same condition.CO oxidation proceeds on the single-site Fei(OH)3 through a mechanism including the loss of hydroxyl groups in the temperature range of 373 to 473 K,but no reaction is observed on iron oxide clusters.The results highlight the high flexibility of the single iron atom catalyst in switching oxidation states,not observed for iron oxide nanoparticles under similar reaction conditions,which may indicate a higher intrinsic activity of such single interfacial sites than the conventional metal-oxide interfaces.In summary,our findings of the redox properties on inverse single-site iron oxide model catalyst may provide new insights into applied Fe-Pt catalysis.Chunlei Wang Heloise Tissot Markus Soldemo Junling Lu Jonas Weissenrieder 2022Nano Research2022,15,1:1
17Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen.Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou 2022Cancer Communications2022,42,1:1
18Prenatal diagnosis of spinocerebellar ataxia type 3/Machado-Joseph disease in China's Mainland A case report显示文摘Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is a progressive, currently untreatable and ultimately fatal ataxic disorder that belongs to the group of neurological disorders known as CAG-repeat or polyglutamine diseases. Here, we present the first prenatal diagnosis of SCA3/MJD in China's Mainland in a woman who was known to carry an expanded CAG-trinucleotide repeat in the MJD1 gene. After evaluating motivation and psychological tolerance of the couple, amniocentesis was performed after 14 weeks of gestation. Polymerase chain reactions followed by T-vector cloning and direct sequencing were employed to evaluate the CAG-repeat number of the fetal MJD1 gene. We identified a truncated CAG expansion of 78 repeats in the MJD1 gene of the fetus compared with 81 repeats in his mother.Lifang Lei Junling Wang Shen Zhang Hong Jiang Lu Shen Qian Xu Xinxiang Yan Yi Yuan Qian Pan Kun Xia Beisha Tang 2011Neural Regeneration Research2011,6,26:1
19OBV(obscure vein),a C_(2)H_(2)zinc finger transcription factor,positively regulates chloroplast development and bundle sheath extension formation in tomato(Solanum lycopersicum)leaf veins显示文摘Leaf veins play an important role in plant growth and development,and the bundle sheath(BS)is believed to greatly improve the photosynthetic efficiency of C_(4) plants.The OBV mutation in tomato(Solanum lycopersicum)results in dark veins and has been used widely in processing tomato varieties.However,physiological performance has difficulty explaining fitness in production.In this study,we confirmed that this mutation was caused by both the increased chlorophyll content and the absence of bundle sheath extension(BSE)in the veins.Using genome-wide association analysis and map-based cloning,we revealed that OBV encoded a C_(2)H_(2) L domain class transcription factor.It was localized in the nucleus and presented cell type-specific gene expression in the leaf veins.Furthermore,we verified the gene function by generating CRISPR/Cas9 knockout and overexpression mutants of the tomato gene.RNA sequencing analysis revealed that OBV was involved in regulating chloroplast development and photosynthesis,which greatly supported the change in chlorophyll content by mutation.Taken together,these findings demonstrated that OBV affected the growth and development of tomato by regulating chloroplast development in leaf veins.This study also provides a solid foundation to further decipher the mechanism of BSEs and to understand the evolution of photosynthesis in land plants.Jinghua Lu Chunyang Pan Xin Li Zejun Huang Jinshuai Shu Xiaoxuan Wang Xiaoxiao Lu Feng Pan Junling Hu Hui Zhang Wenyue Su Min Zhang Yongchen Du Lei Liu Yanmei Guo Junming Li 2021Horticulture Research2021,8,1:1
20Synthesis of Na-stabilized nonporous t-ZrO2supports and Pt-t-ZrO2catalysts and application to water-gas-shift reaction显示文摘Xie Hong Lu Junling Mayank Shekhar 2013Catal2013,3,:1
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