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| 1 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 2 | miR-503-3p promotes epithelialemesenchymal transition in breast cancer by directly targeting SMAD2 and E-cadherin显示文摘Although progress in clinical and basic research has significantly increased our understanding of breast cancer, little is known about the molecular mechanism underlying breast cancer metastasis. Identification of effective therapeutic targets to prevent breast cancer metastasis is urgently needed. The function of mi R-503-3p has been investigated in other cancers, but its role in breast cancer remains undefined.Here, we found that mi R-503-3p was overexpressed in breast cancer tissue and plasma compared with adjacent normal breast tissue and with plasma from healthy individuals. Moreover, we identified mi R-503-3p to be an oncogene of breast cancer cell proliferation, migration and invasion. Upregulation of mi R-503-3p in breast cancer cells inhibited expression of epithelialemesenchymal transition(EMT)-related protein SMAD2 and the epithelial marker protein E-cadherin by directly binding to their m RNA30 untranslated region, whereas increased expression of mesenchymal marker proteins, including vimentin and N-cadherin. Taken together, our findings support a critical role for mi R-503-3p in induction of breast cancer EMT and suggest that plasma mi R-503-3p may be a useful diagnostic biomarker for breast cancer. | Zitong Zhao Xinyi Fan Lanfang Jiang Zhongqiu Xu Liyan Xue Qimin Zhan Yongmei Song | 2017 | Journal of Genetics and Genomics2017，44，2： | 15 |
| 3 | Downregulation of miR-503 Promotes ESCC Cell Proliferation,Migration,and Invasion by Targeting Cyclin D1显示文摘Esophageal squamous cell carcinoma(ESCC) is one of the most aggressive cancers in China,but the underlying molecular mechanism of ESCC is still unclear.Involvement of microRNAs has been demonstrated in cancer initiation and progression.Despite the reported function of miR-503 in several human cancers,its detailed anti-oncogenic role and clinical significance in ESCC remain undefined.In this study,we examined miR-503 expression by q PCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues.Further investigation in the effect of miR-503 on ESCC cell proliferation,migration,and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpression of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype.Our study further identified CCND1 as the target gene of miR-503.Thus,miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1. | Lanfang Jiang Zitong Zhao Leilei Zheng Liyan Xue Qimin Zhan Yongmei Song | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 5 |
| 4 | Development of an Inactivated Iridovirus Vaccine Against Turbot Viral Reddish Body Syndrome显示文摘Turbot(Scophthalmus maximus L.) reddish body iridovirus(TRBIV) was propagated in turbot fin cells(TF cells) and inactivated as the TRBIV vaccine with its protection efficiency evaluated in this study.TF cells were cultured in 10% bovine calf serum(BCS)-containing MEM medium(pH7.0) at 22℃,in which TRBIV propagated to a titer as high as 105.6 TCID50 mL-1.The TRBIV was inactivated with 0.1% formalin and formulated with 0.5% aluminum hydroxide.The inactivated vaccine caused neither cytopathogenic effect(CPE) on TF cells nor pathogenic effect on turbots.After being administered with the vaccine twice via muscle injection,the turbot developed high-tittered TRBIV neutralizing antibodies in a dose-dependent manner.The vaccine protected the turbot from dying with an immunoprotection rate of 83.3% as was determined via subcutaneous vaccination in the laboratory and 90.5% via bath vaccination in turbot farms,respectively.The inactivated vaccine was very immunogenic,efficiently preventing tur-bot from death.It holds the potential of being applied in aquaculture. | FAN Tingjun HU Xiuzhong WANG Liyan GENG Xiaofen JIANG Guojian YANG Xiuxia YU Miaomiao | 2012 | Journal of Ocean University of China2012，11，1： | 5 |
| 5 | Preparation and luminescence properties of orange-red Ba3Y4O9:Sm3+phosphors显示文摘A novel orange-red emitting Ba_3 Y_4 O_9:Sm^(3+) phosphors were prepared by a high temperature solidstate reaction in air. X-ray diffraction(XRD), photoluminescence spectra, fluorescence decay and temperature-dependent emission spectra were utilized to characterize the structure and luminescence properties. The results show that the excitation spectrum includes a series of linear peaks at350, 367, 382, 410, 424, 445, 470 and 495 nm, respectively. Under 410 nm excitation, the emission peaks were located at 574 nm(~4 G_(5/2)-~6 H_(5/2)), 608 nm(~4 G_(5/2)-~6 H_(7/2)),659 nm(~4 G_(5/2)-~6 H_(9/2)) and722 nm(~4 G_(5/2)-~6 H_(11/2)), respectively. The concentration quenching occurs when x equals 0.08 for Ba_3 Y_(4-x)O_9:xSm^(3+) phosphor and its mechanism is ascribed to the dipole-dipole interaction. The chromaticity coordinates of Ba_3 Y_(3.92)O_9:0.08 Sm^(3+) phosphor are in the orange-red region. The temperature-dependent study shows that this phosphor has excellent luminescence thermal-stability.And the luminescence intensity of Ba_3 Y_(3.92)O_9:0.08 Sm^(3+) phosphor at 473 K only declines by about25.75% of its initial intensity. The experimental data indicate that Ba_3 Y_4 O_9:Sm^(3+) phosphor may be promising as an orange-red emitting phosphor for white light emitting diodes. | Jiayu Li Ran Pang Zhan Yu Liyan Liu Haiyan Wu Huimin Li Lihong Jiang Su Zhang Jing Feng Chengyu Li | 2018 | Journal of Rare Earths2018，36，7： | 3 |
| 6 | Role of helicity of a-helical antimicrobia peptides to improve specificity显示文摘 | Yibing Huang Liyan He Guirong Li Naicui Zhai Hongyu Jiang Yuxin Chen | 2014 | Protein & Cell2014，5，8： | 3 |
| 7 | Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis显示文摘Chuangxinmycin is an antibiotic isolated from Actinoplanes tsinanensis CPCC 200056 in the1970 s with a novel indole-dihydrothiopyran heterocyclic skeleton. Chuangxinmycin showed in vitro antibacterial activity and in vivo efficacy in mouse infection models as well as preliminary clinical trials.But the biosynthetic pathway of chuangxinmycin has been obscure since its discovery. Herein, we report the identification of a stretch of DNA from the genome of A. tsinanensis CPCC 200056 that encodes genes for biosynthesis of chuangxinmycin by bioinformatics analysis. The designated cxn cluster was then confirmed to be responsible for chuangxinmycin biosynthesis by direct cloning and heterologous expressing in Streptomyces coelicolor M1146. The cytochrome P450 CxnD was verified to be involved in the dihydrothiopyran ring closure reaction by the identification of seco-chuangxinmycin in S. coelicolor M1146 harboring the cxn gene cluster with an inactivated cxn D. Based on these results, a plausible biosynthetic pathway for chuangxinmycin biosynthesis was proposed, by hijacking the primary sulfur transfer system for sulfur incorporation. The identification of the biosynthetic gene cluster of chuangxinmycin paves the way for elucidating the detail biochemical machinery for chuangxinmycin biosynthesis, and provides the basis for the generation of novel chuangxinmycin derivatives by means of combinatorial biosynthesis and synthetic biology. | Yuanyuan Shi Zhibo Jiang Xingxing Li Lijie Zuo Xuan Lei Liyan Yu Linzhuan Wu Jiandong Jiang Bin Hong | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 2 |
| 8 | A method for improving dispersion of starch nanocrystals in water through crosslinking modification with sodium hexametaphosphate显示文摘 | Lili Ren Man Jiang Liyan Wang Jiang Zhou Jin Tong | 2011 | Carbohydrate Polymers2011，，2： | 1 |
| 9 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 10 | Three alginate lyases from marine bacterium Pseudomonasfluorescens HZJ216: purification and characterization显示文摘 | LI Liyan JIANG Xiaolu GUAN Huashi | 2011 | Applied Biochemistry Biotechnology2011，164，3： | 1 |
| 11 | Prognostic factors in patients with stage IV non-small cell lung cancer显示文摘Objective: To investigate the prognostic factors for stage IV non-small cell lung cancer (NSCLC) with distant metas- tasis and establish a reliable model of clinical prognostic index. Methods: From January 1990 to April 2005, 313 primary NSCLC patients with metastasis, who had been treated in Shanghai Chest Hospital, were reviewed. Survival time was estimated accord- ing to the Kaplan-Meier method. Cox proportional hazard regression model was used for multivariate analysis. Results: Among the 313 cases of non-small cell lung cancer (NSCLC) at stage IV, there were 218 and 95 patients with metastasis to single and different organs, respectively. The overall median survival time for all 313 cases of NSCLC patients was 10.8 (9.00, 12.30) months and the overall 1-, 2-, 3-, 4- and 5-year survival rate was 45%, 18%, 12%, 4% and 0%. There were 63, 174, 127, 36, 18, 11 and 5 patients with metastasis to brain (20.13%), bone (55.59%), lung (40.58%), liver (11.50%), adrenal gland (5.75%), subcutaneous (3.51%) and others, respectively. The survival time was shortest in subcutaneous metastasis (4.6 months), and liver 7.0 months, brain 8.0 months, adrenal gland 8.6 months, bone 10.6 months, lung 11.8 months. Kaplan-Meier estimation showed that patients anatomic typing, KPS, numbers of organ with metastasis, appetite, liver, adrenal gland and subcutane- ous metastasis, body weight loss, smoking, index of smoking, chemotherapy, cycles of chemotherapy were the predictors of survival. Multivariate analysis showed survival statistically significant correlation with anatomic typing, KPS, appetite, liver and subcutaneous metastasis, body weight loss, cycles of chemotherapy. The relative risk (RR) was 1.51, 1.97, 1.55, 1.67, 2.56, and 2.56 respectively. Conclusion: Survival time decreases distinctly in patients who had distant metastasis to more than two different organs (P<0.01). Bone is the commonest organ for distant metastasis in lung cancer. The prognosis is poor when lung cancer appears subcutaneous metastasis and liver metastasis. Independent prognostic factors in patient with stage IV non-small cell lung cancer were liver and subcutaneous metastasis, anatomic typing, KPS, appetite, body weight loss, cycles of chemotherapy. | Meili Ma Jie Shen Liyan Jiang Baohui Han Hao Bai Hao Ji Yizuo Zhao Bo Jin Yongfeng Yu Jun Pei Wei Zhang | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，5： | 1 |
| 12 | Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer显示文摘Cancer cells aberrantly express immunosuppressive checkpoint ligands and produce certain metabolites that lead to T cell exhaustion.Immune checkpoint blockade(ICB)therapy that reinvigorates exhausted T cells have achieved impressive response in clinical cancer treatment.However,the limited clinical response rate and off-tumor toxicities restrict ICB therapy.Herein,cellular vesicles displaying anti-programmed cell death-1(PD-1)single-chain variable fragment antibody(aPD-1-scFv)were prepared to reinvigorate T cell immunity to counteract cancer.The nanovesicles displaying aPD-1-scFv(aPD-1-scFv NVs)could enhance the anti-tumor activation of T cells through PD-1 blockade.Furthermore,NVs loading the A_(2a)adenosine receptor(A_(2a)R)antagonist CPI-444 assisted T cells to antagonize adenosine,an immunosuppressive metabolite produced by cancer cells.Hence,CPI-444 loaded aPD-1-scFv NVs could intensively increase the density and activity of tumor infiltrating T cells,directly restraining tumor progress and metastasis. | Tianyuan Xue Zhirang Zhang Tianliang Fang Baoqi Li Yuan Li Liyan Li Yanghua Jiang Fangfang Duan Fanqiang Meng Xin Liang Xudong Zhang | 2022 | Nano Research2022，15，6： | 1 |
| 13 | Advances in cyclodextrin polymers adsorbents for separation and enrichment:Classification,mechanism and applications显示文摘Over the past few decades,supramolecular chemistry has entered the field of scientific research and attracted extensive attention.Among supramolecular macrocycles,cyclodextrins(CDs)are widely applied in the field of adsorption due to their unique structure and properties.This review focuses on the important role of cyclodextrin polymers(CDPs)as adsorbents in the adsorption of different substances.It covers the category of CDPs adsorbents(including crosslinked CDPs,grafted CDPs,CD-based polyrotaxanes/pseudopolyrotaxanes,and imprinted CDPs),their adsorption mechanism and applications in the adsorption of inorganic metal ions,organic pollutants,and biomacromolecules.Finally,the challenges and future perspectives in relative research fields are discussed. | Binfen Zhao Liyan Jiang Qiong Jia | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 14 | High-entropy(Sm_(0.2)Eu_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2))_(2)Hf_(2)O_(7) ceramic with superb resistance to radiation-induced amorphization显示文摘Nuclear engineering materials are required to possess outstanding extreme environmental tolerance and irradiation resistance.A promising novel pyrochlore-type of(Sm_(0.2)Eu_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2))2 Hf_(2)O_(7)high-entropy ceramic(HE-RE2 Hf_(2)O_(7))for control rod was prepared by solid-state reaction method.The ion irradiation of HE-RE_(2) Hf_(2)O_(7)with 400 keV Kr+at 400℃was investigated using a 400 kV ion implanter and compared with single-component pyrochlore Gd2 Hf_(2)O_(7)to evaluate the irradiation resistance.For HE-RE2 Hf_(2)O_(7),the phase transition from pyrochlore to defective fluorite is revealed after irradiation at 60 dpa.After irradiation at 120 dpa,it maintained crystalline,which is comparable to Gd2 Hf_(2)O_(7)but superior to the titanate pyrochlores previously studied.Moreover,the lattice expansion of HE-RE2 Hf_(2)O_(7)(_(0.2)2%)is much lower than that of Gd2 Hf_(2)O_(7)(0.62%),indicating excellent irradiation damage resistance.Nanoindentation tests displayed an irradiation-induced increase in hardness and a decrease in elastic modulus by about 2.6%.Irradiation-induced segregation of elements is observed on the surface of irradiated samples.In addition,HE-RE2 Hf_(2)O_(7)demonstrates a more sluggish grain growth rate than Gd2 Hf_(2)O_(7)at 1200℃,suggesting better high-temperature stability.The linear thermal expansion coefficient of HE-RE2 Hf_(2)O_(7)is 10.7×10-6 K-1 at 298–1273 K.In general,it provides a new strategy for the design of the next advanced nuclear engineering materials. | Jingxin Wu Meng Zhang Zhanqiang Li Minzhong Huang Huiming Xiang Liyan Xue Zhengming Jiang Zhigang Zhao Lianfeng Wei Yong Zheng Fan Yang Guang Ran Yanchun Zhou Heng Chen | 2023 | Journal of Materials Science & Technology2023，，24： | 1 |
| 15 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 16 | Sericin for Resistance Switching Device with Multilevel Nonvolatile Memory显示文摘 | Hong Wang Fanben Meng Yurong Cai Liyan Zheng Yuangang Li Yuanjun Liu Yueyue Jiang Xiaotian Wang Xiaodong Chen | 2013 | Adv Mater2013，，38： | 1 |
| 17 | The effects of CES1A2 A(?816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease显示文摘 | Cheng Xie Xiaoliang Ding Jie Gao Haipeng Wang Yongfu Hang Hua Zhang Jingjing Zhang Bin Jiang Liyan Miao | 2014 | Pharmacogenetics and Genomics2014，，4： | 1 |
| 18 | A method for improving dispersion of starch nanocrystals in water through cr0sslinking modification with sodium hexametaphosphate显示文摘 | REN Liti JIANG Man WANG Liyan | 2012 | Carbohydrate Polymers2012，87，2： | 1 |
| 19 | Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E显示文摘Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from soil in southern China in the 1970s,but the chemical nature of its antiviral substance(s)has remained unknown until now.We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.The antibiotics and Secondary Metabolite Analysis Shell(antiSMASH)analysis of its genome sequence revealed 38 biosynthetic gene clusters(BGCs)for secondary metabolites,and the target BGCs possibly responsible for the production of antiviral components were narrowed down to three BGCs by bioactivity-guided comparative transcriptomics analysis.Through bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene,cluster 36 was identified as the BGC responsible for the biosynthesis of the antiviral compounds.Bioactivity-based molecular networking analysis of mass spectrometric data from different recombinant strains illustrated that the antiviral compounds were a class of structural analogues.Finally,18 pseudo-tetrapeptides with an internal ureido linkage,omicsynins A1–A6,B1–B6,and C1–C6,were identified and/or isolated from fermentation broth.Among them,11 compounds(omicsynins A1,A2,A6,B1–B3,B5,B6,C1,C2,and C6)are new compounds.Omicsynins B1–B4 exhibited potent antiviral activity against IAV with the 50%inhibitory concentration(IC_(50))of approximately 1μmol·L^(-1)and a selectivity index(SI)ranging from 100 to 300.Omicsynins B1–B4 also showed significant antiviral activity against human coronavirus HCoV-229E.By integrating multi-omics data,we discovered a number of novel antiviral pseudo-tetrapeptides produced by Streptomyces sp.1647,indicating that the secondary metabolites of microorganisms are a valuable source of novel antivirals. | Hongmin Sun Xingxing Li Minghua Chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu Yuanyuan Shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong Shuyi Si | 2022 | Engineering2022，，9： | 0 |
| 20 | Molecular modeling of human APOBEC3G to predict the binding modes of the inhibitor compounds IMB26 and IMB35显示文摘APOBEC3G(A3G)is a host cytidine deaminase that incorporates into HIV-1 virions and efficiently inhibits viral replication.The virally encoded protein Vif binds to A3G and induces its degradation,thereby counteracting the antiviral activity of A3G.Vif-mediated A3G degradation clearly represents a potential target for anti-HIV drug development.Currently,there is an urgent need for understanding the three dimensional structure of full-length A3G.In this work,we use a homology modeling approach to propose a structure for A3G based on the crystal structure of APOBEC2(APO2)and the catalytic domain structure of A3G.Two compounds,IMB26 and IMB35,which have been shown to bind to A3G and block degradation by Vif,were docked into the A3G model and the binding modes were generated for further analysis.The results may be used to design or optimize molecules targeting Vif–A3G interaction,and lead to the development of novel anti-HIV drugs. | Zhixin Zhang Congjie Zhai Zeyun Mi Jiwei Ding Yongxin Zhang Xing Shi Xiaoyu Li Liyan Yu Zhuorong Li Jiandong Jiang Jinming Zhou Shan Cen | 2013 | Acta Pharmaceutica Sinica B2013，3，4： | 0 |
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