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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Preschooler's physical activity levels and associations with lesson context,teacher's behavior,and environment during preschool physical education显示文摘 | Van Cauwenberghe E Valery L Jessica G Ilse D B Greet C | 2012 | Early Childhood Research Quarterly2012，27，2： | 1 |
| 3 | Systematic comparison of perfusion-CT and CT angiography in acute stroke patients显示文摘 | Jessica C T William P D Songling L | 2007 | Ann Neurol2007，61，6： | 1 |
| 4 | A Modified TILL- ING Method for Wheat Breeding 显示文摘 | Dong C M Jessica D M Kate V | 2009 | The Plant Genome2009，2，： | 1 |
| 5 | Market efficiency in the European carbon markets显示文摘 | Amélie C Olivier D Jessica F | 2013 | Energy Policy2013，60，： | 1 |
| 6 | Microbial transformation of cadina-4,10(15)-dien-3-one,aromadendr- 1(10)-en-9-one and methyl ursolate by mucor plumbeus atcc 4740 显示文摘 | Dwight O C Peter L D R Jessica C G | 2002 | Phytochemistry2002，59，5： | 1 |
| 7 | Response of net ecosystem gas exchange to a simulated precipitation pulse in a semi-arld grassland : the role of native versus non-native grasses and soil texture显示文摘 | TRAVIS E H JESSICA M C DANIELLE D I | 2004 | Oecologia2004，141，： | 1 |
| 8 | Association of Cumulatively Low or High Serum Calcium Levels with Mortality in Long-Term Hemodialysis Patients显示文摘 | Miller Jessica E Kovesdy Csaba P Norris Keith C Mehrotra Rajnish Nissenson Allen R Kopple Joel D Kalantar-zadeh Kamyar | 2010 | American Journal of Nephrology2010，，5： | 1 |
| 9 | Controlling the dimensions,reactivity and crystallinity of multiwalled carbon nanotubes using low ethanol concentrations显示文摘 | ANDRE B M JESSICA C D AARON M G | 2008 | Chem Phys Lett2008，453，13： | 1 |
| 10 | Conducting block copolymers of regioregular Poly(3-hexylthiophene) and Poly(methacrylates):Electronic Materials with Variable Conductivities and Degrees of Interfibrillar order显示文摘 | Mihaela C Iovu Rui zhang Jessica R Cooper Detlef M Smilgies Anna E Javier Elena E Sheina Tomasz Kowalewski Richard D Mccullough | 2007 | Macromolecular Rapid Communications2007，28，： | 1 |
| 11 | Response of net ecosystem gas exchange to a simulated precipitation pulse in a semi-arid grassland:the role of native versus non-native grasses and soil texture显示文摘 | Travis E H Jessica M C Danielle D I | 2004 | Oecologia2004，141，： | 1 |
| 12 | Regioregular poly(3-alkylthiophene) conducting block copolymers显示文摘 | Mihaela C Iovu Malika Jeffries-EL Elena E Sheina Jessica R Cooper Richard D Mccullough | 2005 | Polymer2005，46，： | 1 |
| 13 | National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13-17 Years - United States, 2013显示文摘 | Elam-Evans Laurie D Yankey David Jeyarajah Jenny Singleton James A Curtis C Robinette MacNeil Jessica Hariri Susan | 2014 | Morbidity and Mortality Weekly Report2014，，29： | 1 |
| 14 | Genome sequence of the palaeopolyp|oid soybean 显示文摘 | Jeremy S Steven B C Jessica S Ma J X Therese M William N David L H Qijian S Jay J T Cheng J L Xu D Uffe H Gregory D M Yeisoo Y Tetsuya S Taishi U Madan K B Devinder S Babu V Erika L Myron P David G Shu S Q David G Kerrie B Montona F Brian A Du J C Tian Z Zhu L Navdeep G Trupti J Marc L Anand S Zhang X C Kazuo S Henry T N Rod A Perry C James S Jane G Dan R Gary S Randy C S Scott A J | 2010 | Nature2010，463，： | 1 |
| 15 | Modelling how vegetation cover affects climate change impacts on streamflow timing and magnitude in the snowmelt-dominated upper Tuolumne Basin,Sierra Nevada显示文摘 | Nicoleta C Cristea Jessica D Lundquist Steven P Lohei- de | 2014 | Hydrol Process2014，28，12： | 1 |
| 16 | AVP2,a sequence-divergent, K^+-insensitive H^+-translocating inorganic pyrophosphatase from Arabidopsis 显示文摘 | Yolanda M D Jessica C K Philip A R | 2000 | Plant Physiol2000，123，： | 1 |
| 17 | Nestin-expressing neural stem cells identified in the scar following myocardial infraction显示文摘 | Jessica D Viviane E Robert C | 2005 | Cell Physiol2005，204，： | 1 |
| 18 | From Acute Pancreatitis to End - organ injury: mechanisms of acute lung injury 显示文摘 | Tercio De C Jessica D Raul C | 2007 | Surgical Infections2007，8，1： | 1 |
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