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| 1 | Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice显示文摘 | Liu,L Zhang,X Qian,B Min,XY Gao,X Li,CF Cheng,YL Huang,J | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 15 |
| 2 | 具有极性反转的乳头状肾肿瘤:形态学、免疫组化和分子学研究显示文摘作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP 2级,4例WHO/ISUP 1级,肿瘤分期均为pT1期。这类肿瘤具有细小纤维血管轴心的分支状乳头,被覆立方/柱状细胞,胞质颗粒状嗜酸性,管腔边缘光滑,核规则且多位于细胞顶端,偶尔核仁明显或不明显。5例形成小管状结构,9例有明显的胞质空泡,10例具有假包膜。18例肿瘤均无砂粒体、坏死、核分裂象和细胞内含铁血黄素沉积。相比之下,1型乳头状肾细胞癌具有纤细的乳头状结构,被覆单层细胞,胞质稀少,细胞核通常位于乳头状结构基底部呈单层排列,而2型乳头状肾细胞癌具有较宽的乳头状结构,表面被覆细胞呈假复层排列,胞质嗜酸性,核无规则分布。1型和2型乳头状肾细胞癌可见砂粒体、泡沫样巨噬细胞以及细胞内含铁血黄素沉积。免疫组化结果显示,18例肿瘤中CK(AE1/AE3)、EMA、MUC1、CD10、GATA3和L1CAM均阳性。 | 魏建国(摘译) 方三高(审校) Al-Obaidy K I Eble J N Cheng L | 2019 | 临床与实验病理学杂志2019，35，8： | 15 |
| 3 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 4 | Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity显示文摘One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach. | Leo K Cheng Rie Komuro Travis M Austin Martin L Buist Andrew J Pullan | 2007 | World Journal of Gastroenterology2007，13，9： | 3 |
| 5 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 6 | Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Bas/Raf-1/ERK1/2 pathway显示文摘 | Lo L W Cheng J J Chiu J J | 2001 | J Cell Physiol2001，188，3： | 2 |
| 7 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 8 | 收缩压和舒张压变异性对脑卒中患者血管事件的不同影响显示文摘较高的血压变异性(blood pressure variability,BPV)是心血管病的危险因素。然而,在引发不同的血管事件时,收缩压变异性(systolic blood pressure variability,SBPV)和舒张压变异性(diastolic blood pressure variability,DBPV)是否存在不同作用仍不清楚。本研究旨在探讨SBPV或DBPV对急性缺血性脑卒中(acute ischaemic stroke,IS)或短暂性脑缺血发作(transient ischaemic attack,TIA)患者血管事件的作用是否存在区别。 | 周卫(译) 袁源(摘) 叶鹏(审校) Dai L Cheng A Hao X Xu J Zuo Y Wang A Meng X Li H Wang Y Zhao X Wang Y | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 9 | Nutrient removal from swine lagoon liquid by Lemna minor 8627显示文摘 | CHENG J LANDESMAN L BERGMANN B A | 2002 | Trahsaction of the ASAE2002，45，4： | 1 |
| 10 | Effects of supplementing with single or multiple trace minerals on growth performance,fecal mineral excretion and nutrient utilization in pullets from 1 to 18 weeks of age显示文摘 | Zhong L L Yao J H Cheng N | 2007 | Asian-Australasian Journal of Animal Science2007，20，： | 1 |
| 11 | Influence of chemical potential on the computer simulation of hydrogen storage in single - walled carbon nanotube array 显示文摘 | Cheng J R Zhang L B Ding R | 2008 | Comp Mater Sci2008，44，： | 1 |
| 12 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 13 | 显示文摘 | Cheng Y L Dai J M Wu DJ | 2010 | J Magn Magn Mater2010，322，： | 1 |
| 14 | Immobilizationof RGD peptide on HA coating through a chemical bondingapproach显示文摘 | YANG C L CHENG K WENG W J | 2009 | Journal of Materials Science:Materials in Medi-cine2009，20，11： | 1 |
| 15 | Structure and attribute index for ap- proximate graph matching in large graphs 显示文摘 | ZHU L NG W K CHENG J | 2011 | Information Systems2011，36，6： | 1 |
| 16 | On quadratic Lyapunov functions显示文摘 | CHENG D GUO L HUANG J | 2003 | IEEE Trans on Automatic Control2003，48，5： | 1 |
| 17 | Growth of(100) -oriented LaNiO3 thin films directly on Si substrates by a simple metalorganic decomposition technique for the highly oriented PZT thin films显示文摘 | Meng X J Cheng J G Sun J L | 2000 | J Cryst Growth2000，220，： | 1 |
| 18 | Continuous extremal optimization for Lennard-Jones clusters 显示文摘 | Zhou T Bai W J Cheng L J | 2005 | Physical Review E2005，72，1： | 1 |
| 19 | The holocene asian monsoon: links to solar changes and North Atlantic climate 显示文摘 | Wang Y J Cheng H Edwards R L | 2005 | Science2005，308，： | 1 |
| 20 | Accurate error- rate performance analysis of OFDM on frequency-se- lective Nakagami-m fading channels显示文摘 | DU Z CHENG J L BEAULIEU N C | 2006 | IEEE Trans Commun2006，54，2： | 1 |
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