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| 1 | RegCM3对东亚环流和中国气候模拟能力的检验显示文摘使用RegCM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年(1987~2001年)时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式对东亚平均环流的特征和中国地区降水、地面气温的年、季地理分布和季节变化特征均具有一定的模拟能力,对气温和降水年际变率的模拟也较好。此外模式模拟在测站稀少地区,可以提供局地如降水分布更可靠的信息。模式对气温的模拟存在1-3℃的系统性冷偏差;对中国地区降水地理分布的模拟也存在一定偏差,如对年平均降水的模拟中,降水最大值位置与观测有一定差距,特别是对冬季降水中心的模拟存在较大偏差。模式模拟的夏季降水,在中国北方地区总体偏大100-200 mm,南方总体偏小100-200 mm。模式对地面气温的模拟效果好于降水。 | 张冬峰 欧阳里程 高学杰 赵宗慈 PAL Jeremy S GIORGI Filippo | 2007 | 热带气象学报2007，23，5： | 70 |
| 2 | Pancreatic cancer and its stroma: A conspiracy theory显示文摘Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. | Zhihong Xu Srinivasa P Pothula Jeremy S Wilson Minoti V Apte | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 3 | Noninvasive In Vivo Liver Fibrosis Evaluation Using Supersonic Shear Imaging: A Clinical Study on 113 Hepatitis C Virus Patients显示文摘 | éric Bavu Jean-Luc Gennisson Mathieu Couade Jeremy Bercoff Vincent Mallet Mathias Fink Anne Badel Ana?s Vallet-Pichard Bertrand Nalpas Micka?l Tanter Stanislas Pol | 2011 | Ultrasound in Medicine & Biology2011，，9： | 3 |
| 4 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 5 | Arterial Stiffness Is Regulated by Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor During Changes in Blood Flow in Humans显示文摘 | Jeremy Bellien Julie Favre Michele Iacob Ji Gao Christian Thuillez Vincent Richard Robinson Joannidès | 2010 | Hypertension2010，，3： | 2 |
| 6 | Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures显示文摘AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ hybridization.RESULTS: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c tumors.CONCLUSION: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness. | Parastoo B Dahi Komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman | 2012 | World Journal of Clinical Oncology2012，3，3： | 2 |
| 7 | Corpus design criteria 显示文摘 | Atkins S Jeremy C Ostler N | 1992 | Literary and Linguistic Computing1992，7，： | 1 |
| 8 | The effect of superoxide dismutase on nitric oxide-mediated and electrical field-stimulated diabetic rabbit cavernosal smooth muscle relaxation显示文摘 | Khan M A Thompson C S Jeremy J Y | 2001 | BJU Int2001，87，： | 1 |
| 9 | Modeling Predator-Prey Dynamics in a Fluctuating Environment 显示文摘 | S Jeremy Collie D Paul Spencer | 1994 | Can J Fish Aquat Sci1994，，51： | 1 |
| 10 | Magnetic manipulation of copper-tin nanowires capped with nickel ends显示文摘 | ANNE K B JEREMY S T ARTHUR B E WENDY C C | 2004 | Nano Letters2004，4，3： | 1 |
| 11 | Species variation in the fecal mctabolome gives insight into differential gastrointestinal function 显示文摘 | Jasmina S Wang Y L Jeremy K N | 2008 | J Proteome Res2008，7，1： | 1 |
| 12 | Alternative procedures for conver- ting qualitative response data to quantitative expecta- tions: an application to Australian manufacturing 显示文摘 | Jeremy S Mcaleer M | 1995 | Journal of Applied Econometric1995，10，2： | 1 |
| 13 | Tapestry:A resilient global scale overlay for service deployment显示文摘 | Zhao B Huang L Jeremy S | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 14 | Molecular mecha- nisms of pancreatitis : Current opinion 显示文摘 | Alain V Jeremy S W Minoti V A | 2008 | 2I Gastroen- terol Hepatol2008，23，9： | 1 |
| 15 | Comparison of acquisition costs of surgical supplies in different health care systems for cataract and glaucomaprocedures显示文摘 | Jeremy Valentine David Zurakowski Ramesh S Ayyala | 2014 | J Glaucoma2014，23，6： | 1 |
| 16 | The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells显示文摘 | Jeremy A Ross Zsuzsanna S Nagy and Robert A Kirken | 2008 | J Biol Chem2008，283，8： | 1 |
| 17 | 显示文摘 | Lara Wilfredo C Jeremy S Lewis Rodney P | 1998 | Journal of Long-Term Effects of Medical Implants1998，8，1： | 1 |
| 18 | Ferrate( VI) oxidationof hydrogen sulfide显示文摘 | Virender K S Jeremy O S Frank J M | 1997 | Environmental Science & Technology1997，31，9： | 1 |
| 19 | Hogness, Isolation and nucleotide sequence of the gene encoding human rhodopsin Cell显示文摘 | Jeremy Nathans and David S | 2000 | Biology2000，81，： | 1 |
| 20 | Ferrate(VI) oxidation ofaqueous cyanide显示文摘 | Virender K S Wayne R Jeremy O S’ | 1998 | Environmental Science & Technology1998，32，17： | 1 |
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