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| 1 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 2 | Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study显示文摘Attention deficit hyperactivity disorder(ADHD)is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor(DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity(Re Ho) and functional connectivity(FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD44-repeat/4-repeat(4 R/4 R) allele(n = 30) or the DRD42-repeat(2 R) allele(n = 19). The results showed that participants with the DRD4 2 R allele had decreased Re Ho bilaterally in the posterior lobes of the cerebellum, while Re Ho was increased in the left angular gyrus. Compared with participants carrying the DRD4 4 R/4 R allele, those with the DRD4 2 R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children. | ANDan Qian Xin Wang Huiru Liu Jiejie Tao Jiejie Zhou Qiong Ye Jiance Li Chuang Yang Jingliang Cheng Ke Zhao Meihao Wang | 2018 | Neuroscience Bulletin2018，34，3： | 10 |
| 3 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 4 | External fixation is more suitable for intra-articular fractures of the distal radius in elderly patients显示文摘The purpose of this study was to compare the functional outcomes,psychological impact,and complication rates associated with external fixation and volar or dorsal plating in relation to the functional parameters following treatment of intra-articular fractures of the distal radius(IFDR) in patients older than 65 years.We hypothesized that using volar or dorsal plating would improve functional outcomes,but that it would be associated with more complications and equivalent functional outcomes when compared with the external fixation group.A total of 123 consecutive patients suffering from IFDR were recruited into the study.The patients were measured for clinical,radiological,and psychosocial functioning outcomes and were followed up after 1 week and 3,6 and 12 months.After 3 months,the plating group had better pronation(P=0.001),supination,(P=0.047) and extension(P=0.043) scores.These differences were somewhat attenuated by6 months and disappeared at 1 year.The plating group had a greater occurrence of wound infection(P=0.043),tendonitis,(P=0.024) and additional surgery compared with the external fixation group.The only TNO-AZL Adult Quality of Life scores in the plating group that were lower than those in the external fixation group were in the 'gross motor' category(walking upstairs,bending over,walking 500 yards; P=0.023).Internal fixation was more advantageous than external fixation in the early rehabilitation period; after 1 year the outcomes were similar.The plating group showed significantly higher levels of wound infection and tendonitis and had a greater need for additional surgeries. | Chuang Ma Qiang Deng Hongwei Pu Xinchun Cheng Yuhua Kan Jing Yang Aihemaitijiang Yusufu Li Cao | 2016 | Bone Research2016，4，1： | 7 |
| 5 | Theoretical and numerical research of wire array Z-pinch and dynamic hohlraum at IAPCM显示文摘Dense Z-pinch plasmas are powerful and energy-efficient laboratory sources of X-rays,and show the possibility to drive inertial confinement fusion(ICF).Recent advances in wire-array Z-pinch and Z-pinch dynamic hohlraum(ZPDH)researches at the Institute of Applied Physics and Computational Mathematics are presented in this paper.Models are setup to study different physical processes.A full circuit model(FCM)was used to study the coupling between Z-pinch implosion and generator discharge.A mass injection model with azimuthal modulation was setup to simulate the wire-array plasma initiation,and the two-dimensional MHD code MARED was developed to investigate the Z-pinch implosion,MRT instability,stagnation and radiation.Implosions of nested and quasi-spherical wire arrays were also investigated theoretically and numerically.Key processes of ZPDH,such as the arrayefoam interaction,formation of the hohlraum radiation,as well as the following capsule ablation and implosion,were analyzed with different radiation magneto-hydrodynamics(RMHD)codes.An integrated 2D RMHD simulation of dynamic hohlraum driven capsule implosion provides us the physical insights of wire-array plasma acceleration,shock generation and propagation,hohlraum formation,radiation ablation,and fuel compression. | Ning Ding Yang Zhang Delong Xiao Jiming Wu Zihuan Dai Li Yin Zhiming Gao Shunkai Sun Chuang Xue Cheng Ning Xiaojian Shu Jianguo Wang | 2016 | Matter and Radiation at Extremes2016，1，3： | 7 |
| 6 | Correlation-weighted least squares residual algorithm for RAIM显示文摘The Least Squares Residual(LSR)algorithm,one of the classical Receiver Autonomous Integrity Monitoring(RAIM)algorithms for Global Navigation Satellite System(GNSS),presents a high Missed Detection Risk(MDR)for a large-slope faulty satellite and a high False Alarm Risk(FAR)for a small-slope faulty satellite.From the theoretical analysis of the high MDR and FAR cause,the optimal slope is determined,and thereby the optimal test statistic for fault detection is conceived,which can minimize the FAR with the MDR not exceeding its allowable value.To construct a test statistic approximate to the optimal one,the CorrelationWeighted LSR(CW-LSR)algorithm is proposed.The CW-LSR test statistic remains the sum of pseudorange residual squares,but the square for the most potentially faulty satellite,judged by correlation analysis between the pseudorange residual and observation error,is weighted with an optimal-slope-based factor.It does not obey the same distribution but has the same noncentral parameter with the optimal test statistic.The superior performance of the CW-LSR algorithm is verified via simulation,both reducing the FAR for a small-slope faulty satellite with the MDR not exceeding its allowable value and reducing the MDR for a large-slope faulty satellite at the expense of FAR addition. | Dan SONG Chuang SHI Zhipeng WANG Cheng WANG Guifei JING | 2020 | Chinese Journal of Aeronautics2020，33，5： | 6 |
| 7 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 8 | 中国海相黏土的压缩指数的EPR-RCGA回归模型和RMSE-AIC-BIC模型选择及其工程应用(英文)显示文摘目的:压缩指数是软土工程领域的关键参数。本文旨在提出一个基于进化多项式回归和实编码遗传算法(EPR-RCGA)的回归分析方法,将压缩指数与物理特性建立相关关系并应用于工程实践。创新点:结合EPR和RCGA方法,将中国沿海21个不同区域的黏土的压缩性指数与天然含水率和液塑限之间建立相关关系,并采用均方根误差(RMSE)、赤池信息量准则(AIC)和贝叶斯信息准则(BIC)对所建立的不同回归模型进行优选。方法:1.从文献中收集中国沿海21个地区的黏土的压缩指数和常见的基本物理性质,并对数据进行整理和分类。2.进行压缩指数和天然含水量及液塑限之间的EPR回归关系分析,并采用新近提出的RCGA优化方法来提高回归关系的精度。3.采用RMSE、AIC和BIC对不同组合下的回归关系进行优选,并确定最佳回归关系。4.将得到的关系式应用到有限元路堤计算来验证所得关系式的实用性和准确性。结论:1.本文提出的压缩指数关系式比现有的经验公式更好,预测得到的压缩指数更为精确。2.采用所提出的压缩指数回归模型预测了东南沿海一路堤下不同土层的压缩指数,并应用所得数据和有限元方法对路堤的沉降进行了模拟分析,验证了所提方法的可靠性。3.所有结果表明,结合基于EPR和RCGA的回归分析方法以及基于RMSE、AIC和BIC的模型选择方法对分析压缩指数与黏土的物理性质的相关关系是切实可行的,可以更好地服务于中国沿海地区的工程设计。 | Ze-xiang WU Hui JI Chuang YU Cheng ZHOU | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，3： | 3 |
| 9 | Fe-B-Y-Nb bulk metallic glasses in relation to clusters显示文摘Bulk metallic glass formations in the Fe-B-Y-Nb quaternary alloy system were in-vestigated by using the cluster line rule in combination with the minor alloying principle. The Fe-B-Y ternary system was selected as the basic system and the intersections of cluster lines were taken as the basic ternary compositions. The basic compositions were further alloyed with minor amounts of Nb. After 3-5 at.% Nb was added,the basic composition Fe68.6B25.7Y5.7,which was developed from the most densely packed cluster Fe8B3,formed 3 mm bulk metallic glasses. These quaternary bulk metallic glasses (Fe68.6B25.7Y5.7)100-xNbx (x=3-5 at.%) are expressed approximately with a unified simple composition formula: (Fe8B3)1(Y,Nb)1. The (Fe68.6B25.7Y5.7)97Nb3 bulk metallic glass has the largest glass forming ability with the following characteristic parameters Tg=907 K,Tx=1006 K,Tg/Tl=0.644,γ=0.434,and longness t=22 mm. The combination of the cluster line rule and the minor-alloying principle is a promising new route towards the quantitative composition design of multi-component metallic glasses. | CHENG Xu WANG Qing CHEN WeiRong DONG Chuang | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 3 |
| 10 | Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells显示文摘AIM: To investigate the effect of metformin on silibinin-induced apoptosis in human colorectal cancer(COLO 205) cells.METHODS: MTT assays were performed to quantify cell viability.Western blot assays were applied to identify the expression of signaling proteins.RESULTS: The combined treatment of COLO 205 cells with metformin and silibinin decreased cell survival at a dose insufficient to influence the non-malignant cells [Human colonic epithelial cells(HCo Epi C)].Silibinin and metformin increased phosphatase and tensin homolog and 5'-adenosine monophosphate-activated protein kinase expression in COLO 205 cells and inhibited the phosphorylation of mammol/Lalian target of rapamycin.This combined treatment resulted in an increase in the expression of activated caspase 3 and apoptosis inducing factor, indicating apoptosis.CONCLUSION: The combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect HCo Epi C.This finding reveals a potential therapeutic strategy for the treatment of colorectal cancer. | Cheng-Chia Tsai Tang-Wei Chuang Li-Jen Chen Ho-Shan Niu Kun-Ming Chung Juei-Tang Cheng Kao-Chang Lin | 2015 | World Journal of Gastroenterology2015，21，14： | 3 |
| 11 | Improvement of stability and solid-state battery performances of annealed 70Li_(2)S–30P_(2)S_(5) electrolytes by additives显示文摘The replacement of liquid electrolyte with solid electrolyte can significantly improve the safety and power/energy density of lithium batteries.70Li_(2)S–30P_(2)S_(5) is one of the most promising solid electrolytes with high conductivity for solid–state batteries.In this work,the ionic conductivity and stability toward moisture and lithium metal of 70Li_(2)S–30P_(2)S_(5) were enhanced by introducing the different amounts of Li_(2)O additives.65Li_(2)S–30P_(2)S_(5)–1%Li_(2)O delivered the highest conductivity,while 65Li_(2)S–30P_(2)S_(5)–5%Li_(2)O showed the best moisture stability and improved lithium compatibility.Solid-state batteries using 65Li_(2)S–30P_(2)S_(5)–5%Li_(2)O electrolyte and high-voltage LiNi_(0.6)Mn_(0.2)Co_(0.2)O_(2) cathode exhibited low initial discharge capacity(100 mAh·g^(-1))and Coulombic efficiency(69%).Li_(3)InCl_(6) electrolytes were introduced both in the cathode mixture to replace sulfide electrolyte and in the interface layer to improve the cathode compatibility for the solid-state batteries,showing enhanced discharge capacity(175 mAh·g^(-1))and improved initial Coulombic efficiency(86%).Moreover,it also exhibited good performance at-20℃. | Hao-Tian Ren Zi-Qi Zhang Jun-Zhao Zhang Lin-Feng Peng Zhen-Yuan He Ming Yu Chuang Yu Long Zhang Jia Xie Shi-Jie Cheng | 2022 | Rare Metals2022，41，1： | 3 |
| 12 | The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation显示文摘The role of the vascularized bone marrow component as a continuous source of donor-derived hematopoietic stem cells that facilitate tolerance induction of vascularized composite allografts is not completely understood.In this study,vascularized composite tissue allograft transplantation outcomes between recipients receiving either conventional bone marrow transplantation(CBMT)or vascularized bone marrow(VBM)transplantation from Balb/c(H2d)to C57BL/6(H2b)mice were compared.Either high-or low-dose CBMT(1.5×10^(8)or 3×10^(7)bone marrow cells,respectively)was applied.In addition,recipients were treated with costimulation blockade(1 mg anti-CD154 and 0.5 mg CTLA4Ig on postoperative days 0 and 2,respectively)and short-term rapamycin(3 mg/kg/day for the first posttransplant week and then every other day for another 3 weeks).Similar to high-dose conventional bone marrow transplantation,5/6 animals in the vascularized bone marrow group demonstrated long-term allograft survival(>120 days).In contrast,significantly shorter median survival was noted in the low-dose CBMT group(~64 days).Consistently high chimerism levels were observed in the VBM transplantation group.Notably,low levels of circulating CD4^(+)and CD8^(+)T cells and a higher ratio of Treg to Teff cells were maintained in VBM transplantation and high-dose CBMT recipients(>30 days)but not in low-dose VBM transplant recipients.Donor-specific hyporesponsiveness was shown in tolerant recipients in vitro.Removal of the vascularized bone marrow component after secondary donor-specific skin transplantation did not affect either primary allograft or secondary skin graft survival. | Cheng-Hung Lin Madonna R.Anggelia Hui-Yun Cheng Aline Yen Ling Wang Wen-Yu Chuang Chih-Hung Lin W.P.Andrew Lee Fu-Chan Wei Gerald Brandacher | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 13 | Decrease in DNA methylation 1(DDM1) is required for the formation of ~mCHH islands in maize显示文摘DNA methylation plays a crucial role in suppressing mobilization of transposable elements and regulation of gene expression. A number of studies have indicated that DNA methylation pathways and patterns exhibit distinct properties in different species, including Arabidopsis, rice, and maize.Here, we characterized the function of DDM1 in regulating genome-wide DNA methylation in maize. Two homologs of Zm DDM1 are abundantly expressed in the embryo and their simultaneous disruption caused embryo lethality with abnormalities in cell proliferation from the early stage of kernel development. We establish that Zm DDM1 is critical for DNA methylation, at CHG sites, and to a lesser extent at CG sites, inheterochromatic regions, and unexpectedly, it is required for the formation ofmCHH islands. In addition, Zm DDM1 is indispensable for the presence of 24-nt si RNA, suggesting its involvement in the Rd DM pathway. Our results provide novel insight into the role of Zm DDM1 in regulating the formation of mCHH islands, via the Rd DM pathway maize, suggesting that,in comparison to Arabidopsis, maize may have adopted distinct mechanisms for regulating ~mCHH. | Jin Cheng Long Ai Ai Xia Jing Han Liu Ju Li Jing Ya Zhong Wang Chuang Ye Qi Yan He | 2019 | Journal of Integrative Plant Biology2019，61，6： | 2 |
| 14 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 15 | Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes显示文摘 | Wen-Liang Yu Wen-Chien Ko Kuo-Chen Cheng Ching-Chien Lee Chien-Cherng Lai Yin-Ching Chuang | 2008 | Diagnostic Microbiology & Infectious Disease2008，，1： | 2 |
| 16 | Light induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidore-ductase in vivo 显示文摘 | Chen ST Chuang Jf Cheng CL | 2005 | Neuroscience2005，130，2： | 1 |
| 17 | Solvent Effects on Molecular Packing and Tribological Properties of Octadecyhrichloosilane Films on Silicon 显示文摘 | Cheng Y Zheng B Chuang P | 2010 | Langmuir2010，26，11： | 1 |
| 18 | Local radiotherapy with or without transcathere arteriale chemoembolization for patients with unresectable hepatocellular carcinoma 显示文摘 | Chuang VP Cheng SH | 2000 | Int J Radiat Oncol Biol Phys2000，47，： | 1 |
| 19 | Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma 显示文摘 | Cheng JC Chuang VP Cheng SH | 2000 | Int J Radia Oncol Biol Phys2000，47，： | 1 |
| 20 | A pilot study of threedimensional conformal radiotherapy in unresectabl hepatocellular carcinsioma显示文摘 | Lin YM Chuang VP | 1999 | J Gastroenterol Hepatol1999，14，： | 1 |
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