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| 1 | Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy显示文摘瞄准:在部分肝切除术以后在肝新生上学习妨碍的黄疸的效果。方法: Hepatocyte 生长因素( HGF ),它的受体, 遇见c ,脉管的内皮生长因素( VEGF )和转变生长在肝织物和孤立的肝细胞的 factor-beta1 ( TGF-beta1 ) mRNA 表示被量的反向抄写的聚合酶链反应( RT-PCR )用 LightCycler 在胆汁的阻塞( BO )以后调查。为 desmin 和 alpha 光滑的肌肉肌动朊(alpha-SMA ) 染色的 Immunohistochemical 也被学习。标记的原子抗原(PCNA ) 索引的再生肝重量和增殖的房间,和生长因素表示然后与伴随物在 70% 肝切除术以后被评估在 BO 老鼠或假冒操作老鼠的内部胆汁的排水。结果:肝的 TGF-beta1 mRNA 层次显著地在 BO 以后增加了 14 天,并且进一步与胆汁郁积的持续时间增加了。同时, HGF 和 VEGF 趋于增加,但是不是重要的。在房间孤立, TGF-beta1 mRNA 主要在肝的星形的房间(HSC ) 被发现部分。Immunohistochemical 研究揭示了 HSC (desmin 积极的房间) 的一个增加的数字并且在 BO 以后在门区域激活 HSC (alpha-SMA-positive 房间) 。在一个肝切除术模型,肝新生在 BO 老鼠被推迟,作为与假冒操作老鼠相比。在肝切除术,和更早的 HGF mRNA 山峰沉醉于 BO 老鼠以后, TGF-beta1 mRNA 是显著地起来调整的直到 48 h。结论:BO 导致 HSC 增长和激活,导致 TGF-beta1 mRNA 的起来规定和在肝的 HGF mRNA 的抑制。这些改变的表示模式可以强烈与妨碍的黄疸在肝切除术以后涉及推迟的肝新生。 | Hironobu Makino Hiroaki Shimizu Hiroshi Ito Fumio Kimura Satoshi Ambiru Akira Togawa Masayuki Ohtsuka Hiroyuki Yoshidome Atsushi Kato Hideyuki Yoshitomi Shigeaki Sawada Masaru Miyazaki | 2006 | World Journal of Gastroenterology2006，12，13： | 32 |
| 2 | An overview of the “Three-North” Shelterbelt project in China显示文摘The 'Three-North' Shelterbelt is the largest and most distinctive artificial ecological engineering project in China.It has been conducted since November 25,1978 in the 'Three-North' (i.e.,Northeast China,North China and Northwest China) regions.In this study,the background and the essential benefits of the 'Three-North' Shelterbelt project are summarized.The basic status and future development of the 'Three-North' Shelterbelt project are also studied.As well,we tried to discuss the problems existing in the current shelterbelt system and the strategies to conduct this ecological project rationally. | LI Miao-miao LIU An-tian ZOU Chun-jing XU Wen-duo Hideyuki SHIMIZU WANG Kai-yun | 2012 | Forestry Studies in China2012，14，1： | 12 |
| 3 | Peripheral portal vein-oriented non-dilated bile duct puncture for percutaneous transhepatic biliary drainage显示文摘AIM: To evaluate the efficacy of peripheral portal vein(PV)-oriented non-dilated bile duct(BD) puncture for percutaneous transhepatic biliary drainage(PTBD).METHODS: Thirty-five patients with non-dilated BDs underwent PTBD for the management of various biliary disorders, including benign bilioenteric anastomotic stricture(n = 24), BD stricture(n = 5) associated with iatrogenic BD injury, and postoperative biliary leakage(n = 6). Under ultrasonographic guidance, percutaneous transhepatic puncture using a 21-G needle was performed along the running course of the peripheral targeted non-dilated BD(preferably B6 for right-sided approach, and B3 for left-sided approach) or along the accompanying PV when the BD was not well visualized. This technique could provide an appropriate insertion angle of less than 30° between the puncture needle and BD running course. The puncture needle was then advanced slightly beyond the accompanying PV. The needle tip was moved slightly backward while injecting a small amount of contrast agent to obtain the BD image, followed by insertion of a 0.018-inch guide wire(GW). A drainage catheter was then placed usinga two-step GW method. RESULTS: PTBD was successful in 33(94.3%) of the 35 patients with non-dilated intrahepatic BDs. A rightsided approach was performed in 25 cases, while a left-sided approach was performed in 10 cases. In 31 patients, the first PTBD attempt proved successful. Four cases required a second attempt a few days later to place a drainage catheter. PTBD was successful in two cases, but the second attempt also failed in the other two cases, probably due to poor breath-holding ability. Although most patients(n = 26) had been experiencing cholangitis with fever(including septic condition in 8 cases) before PTBD, only 5(14.3%) patients encountered PTBD procedure-related complications, such as transient hemobilia and cholangitis. No major complications such as bilioarterial fistula or portal thrombosis were observed. There was no mortality in our series.CONCLUSION: Peripheral PV-oriented BD puncture for PTBD in patients with non-dilated BDs is a safe and effective procedure for BD stricture and postoperative bile leakage. | Hiroaki Shimizu Atsushi Kato Tsukasa Takayashiki Satoshi Kuboki Masayuki Ohtsuka Hideyuki Yoshitomi Katsunori Furukawa Masaru Miyazaki | 2015 | World Journal of Gastroenterology2015，21，44： | 10 |
| 4 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 5 | Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma显示文摘Pseudomembranous colitis (PMC) usually manifests asfever and diarrhea in hospitalized patients treated withsystemic antibiotics. We described a case of PMC withintestinal obstruction but without diarrhea. A 60-yearold man was hospitalized for chemotherapy for the treatment of Burkitt lymphoma of the stomach. The patient became febrile and complained of crampy abdominal pain during the post-chemotherapy nadir. Plain abdominal radiography showed some intestinal gas and niveau. Because stool cytotoxin assay for clostridium difficile was positive and colon fiberscopic examination showed a pseudomembrane at the left side of the colon,and a diagnosis of PMC was made. Treatment with intracolonic vancomycin administration by colonoscopy and nasoileus tube was successful. Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases. | Kenichi Nomura Kohei Fukumoto Daisuke Shimizu Takashi Okuda Naohisa Yoshida Yuri Kamitsuji Yosuke Matsumoto Hideyuki Konishi Yuji Ueda Shigeo Horiike Takeshi Okanoue Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，17： | 5 |
| 6 | 内蒙古松树山的植物区系与沙地油松林群落特征显示文摘根据多次对内蒙古松树山地区的植物调查资料和沙地油松林群落学的研究,结果表明:(1)松树山在植物区系上,正处在蒙古植物区系、华北植物区系、长白植物区系和达乌里植物区系的交汇地区。植物种类比较丰富,种子植物达394种。松树山植物的科、属、种分别占科尔沁沙地的61.1%、58.1%和41.1%;(2)松树山植物区系地理成分以温带性质成分占绝对优势,占本地区的90.61%,其中以温带亚洲成分、旧世界温带成分和中国-日本成分最多,分别占本地区的16.8%、14.0%和13.7%;(3)沙地油松林是松树山地区和科尔沁沙地唯一的针阔叶混交林类型,群落生活型谱以地面芽植物种类最丰富,占40.7%,其次为高位芽植物(22.2%)和地下芽植物(25.5%)。(4)沙地油松林可划分为沙地胡枝子蒙古栎油松林和沙地山杏油松林2个类型,前者主要分布在石质沙丘上,后者多分布在固定沙丘的阴坡。群落演替进程为沙地先锋植物群落阶段→根茎禾草杂类草群落阶段→沙地灌丛群落阶段→沙地油松林阶段。 | 邹春静 周园 徐文铎 SHIMIZU Hideyuki | 2009 | 生态学杂志2009，28，2： | 4 |
| 7 | Intraspecific diversity: adaptive differentiation of Picea mongolica W. D. Xu ecotypes显示文摘Picea mongolica W. D. Xu is an endemic and endangered species which is only found in semi-arid areas of northern China. It has been widely used as an afforestation tree in the establishment of the Three-North Shelterbelt System for its adaptation to arid soils and as a virescent tree in urban gardens and streets for its beautiful shape. Due to different microenvironments, P. mongolica populations may differentiate into many ecological groups with different adaptive abilities. Long-term adaptation to a dry environment makes P. mongolica differentiate into different ecotypes. Typical ecotypes are P. mongolica f. purpurea (Fp), P. mongolica f. rubra (Fr) and P. mongolica f. viridis (Fv). Our results show that cone size is clearly not uniform among different ecotypes; the largest cones are found in the Fv ecotype and the smallest in Fp. There were also distinct differences between these ecotypes in terms of height and length of squama. At the molecular level, the zymograms of peroxidase and lipase prove the existence of different ecotypes in P. mongolica. The results are useful for investigating and managing this rare spruce species in China. | LIU An-tian ZOU Chun-jing ZHANG Chao ZHENG Yuan-run Hideyuki SHIMIZU XU Wen-duo | 2011 | Forestry Studies in China2011，13，3： | 3 |
| 8 | Utilization of theγ-glutamyltranspeptidase reaction for glutathione synthesis 显示文摘 | Hidehiko Kumagai Hideyuki Suzuki Miho Shimizu | 1989 | Journal of Biotechnology1989，9，： | 1 |
| 9 | Yellowing of disease? Or differentiating for adaptation? Study on Cinnamomum camphora ecotypes显示文摘Cinnamomum camphora (L.) Presl is an evergreen broad-leaved tree of the Lauraceae family, widely distributed in the sub-tropical areas in the south of China and used as a virescent tree in urban gardens and streets in Shanghai for its beautiful shape and intensive stress-resistance. However, yellowing of C. camphora in recent years casts doubt about its significance. We believe the green-leaved and yellow-leaved C. camphora might be two different ecotypes, and tentatively refer to the green-leaved C. camphora as C. camphora f. viridis f. nov (CCV) and the yellow-leaved as C. camphora f. flavus f. nov (CCF). We studied their differences and arrived at the following conclusions: 1) compared with CCF, the area of lamina of CCV is significantly larger and the amount of chlorophyll (Chl) significantly higher; 2) the lamina and palisade tissues of CCV are significantly thicker than those of CCF, but its cuticle is significantly thinner; 3) the shape of the stomata of CCV is different from that of the CCF; the stomatal density and stomatal index of CCV are significantly lower than those of CCF. These results show that C. camphora might evolve adaptive differentiation in some aspects which can be used in virescence in urban streets and gardens. | LI Qing ZOU Chun-jing XU Ying Shimizu HIDEYUKI | 2010 | Forestry Studies in China2010，12，2： | 1 |
| 10 | Surgical Resection after Downsizing Chemotherapy for Initially Unresectable Locally Advanced Biliary Tract Cancer: A Retrospective Single-center Study显示文摘 | Atsushi Kato Hiroaki Shimizu Masayuki Ohtsuka Hiroyuki Yoshidome Hideyuki Yoshitomi Katsunori Furukawa Dan Takeuchi Tsukasa Takayashiki Fumio Kimura Masaru Miyazaki | 2013 | Annals of Surgical Oncology2013，，1： | 1 |
| 11 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，5： | 1 |
| 12 | Aggressive surgical approaches to hilar cholangiocarcinoma: Hepatic or local resection?显示文摘 | Masaru Miyazaki Hiroshi Ito Koji Nakagawa Satoshi Ambiru Hiroaki Shimizu Yoshiaki Shimizu Atsushi Kato Shunta Nakamura Hideyuki Omoto Nobuyuki Nakajima Fumio Kimura Toshikazu Suwa | 1998 | Surgery1998，，2： | 1 |
| 13 | High-Pressure Elastic Properties of Solid Argon to 70 Gpa 显示文摘 | Hiroyasu Shimizu Hideyuki Tashiro Tetsji Kume | 2001 | Phys Rev Lett2001，86，： | 1 |
| 14 | Combined vascular resection in operative resection for hilar cholangiocarcinoma: Does it work or not?显示文摘 | Masaru Miyazaki Atsushi Kato Hiroshi Ito Fumio Kimura Hiroaki Shimizu Masayuki Ohtsuka Hiroyuki Yoshidome Hideyuki Yoshitomi Katsunori Furukawa Satoshi Nozawa | 2007 | Surgery2007，，5： | 1 |
| 15 | Interval Period Tumor Progression: Does Delayed Hepatectomy Detect Occult Metastases in Synchronous Colorectal Liver Metastases?显示文摘 | Hiroyuki Yoshidome Fumio Kimura Hiroaki Shimizu Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Ayako Iida Masaru Miyazaki | 2008 | Journal of Gastrointestinal Surgery2008，，： | 1 |
| 16 | Surgical strategy for mucin-producing bile duct tumor显示文摘 | Masayuki Ohtsuka Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Tsukasa Takayashiki Kosuke Suda Masaru Miyazaki | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，3： | 1 |
| 17 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，5： | 1 |
| 18 | Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T cell differentiation in patients undergoing pancreaticoduodenectomy显示文摘 | Toshiaki Aida Katsunori Furukawa Daisuke Suzuki Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Masaru Miyazaki | 2013 | Surgery2013，，： | 1 |
| 19 | Principles of sand dune fixation with straw-checkerboard technology and its effects on the environment显示文摘 | Guo Yu Qiu In-Bok Lee Hideyuki Shimizu | 2004 | Joumal of Arid Environments2004，56，： | 1 |
| 20 | Sj?gren’s Syndrome with Multiple Bullae Caused by Lymphocytic Interstitial Pneumonia显示文摘 | Hirokazu Tokuyasu Etsuko Watanabe Ryota Okazaki Yuji Kawasaki Ryutaro Kikuchi Noritaka Isowa Hideyuki Ohnuma Hiroshi Miura Eiji Shimizu Yoichiro Kobashi | 2007 | Lung2007，，3： | 1 |
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