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	题名	作者	年代	出处	被引量
1	Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD.	Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao	2012	World Journal of Gastroenterology2012，18，13：	8
2	Differential effects of selective and non- selective musearinie antagonists on gastrointestinal transit and bowel function in healthy women 显示文摘	Bharucha AE Isowa H Hiro S	2013	Neurogastroenterol Motil2013，25，01：	1
3	O6-Methylguanine-DNA-methyltransferase activity in human liver tumors显示文摘	Isowa G Ishizaki K Sadamoto T	1991	Carcinogenesis1991，12，7：	1
4	Total synthesis of ferrichrome 显示文摘	Ohmori M Kurita H	1974	Bull ChemSoc Jpn1974，47，1：	1
5	Mediastinal seminoma difficult to differentiate from thymoma through preoperative biopsy:report of a case显示文摘	Ito S Isowa N Kikuchi R	2004	Kyobu Geka2004，57，11：	1
6	Three Cases of ResectedPleomorphic Carcinoma显示文摘	Kikuchi R Isowa N Tokuyasu H	2010	Ann Thorac Cardiovasc Surg2010，16，4：	1
7	Effects ofcryopreservation on sperm structure in Japanese pearl oyster Pinctadafucata martensii显示文摘	Narita T Kawamoto K Isowa K	2008	Fisheries Science2008，74，5：	1
8	Large cell neuroendocrine carcinoma arising from the left main bronchus 显示文摘	Tokuyasu H Sakaguchi Y Isowa N	2011	Intern Med2011，50，18：	1
9	Successful thoracoscopic debridement of descending necrotizing mediastinitis 显示文摘	Isowa N Yamada T Kijima T	2004	Ann Thorac Surg2004，77，5：	1
10	Role of microtubules in LPS- induced macrophage inflammatory protein-2 production from rat pneumocytes显示文摘	Isowa N Keshavjee SH Liu M	2000	Am J Physiol Lung Cell Mol Physiol2000，279，6：	1
11	PTHrP regulates angiogenesis and bone resorption via VEGF expression显示文摘	Isowa S Shimo T Ibaragi S		0，，：	1
12	The inadvisability of thoracoscopic lung biopsy on patients with pulmonaryhypertension显示文摘	Hasegawa S Isowa N Bando T	2002	Chest2002，122，3：	1
13	Production of tumor necrosis factor-α from primary cultured rat alveolar epithelial cells显示文摘	McRitchie DI Isowa N Edelson JD	2000	Cytokine2000，12，：	1
14	Human thioredoxin attenuates hypoxia-reoxygenation injury of murine endothelial cells in a thiolfree condition显示文摘	Isowa N Yoshimura T Kosaka S	2000	J Cell Physiol2000，182，1：	1
15	Sj?gren’s Syndrome with Multiple Bullae Caused by Lymphocytic Interstitial Pneumonia显示文摘	Hirokazu Tokuyasu Etsuko Watanabe Ryota Okazaki Yuji Kawasaki Ryutaro Kikuchi Noritaka Isowa Hideyuki Ohnuma Hiroshi Miura Eiji Shimizu Yoichiro Kobashi	2007	Lung2007，，3：	1
16	Association of polymorphism in the human μ-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception 显示文摘	Matsunaga M Isowa T Murakami H	2009	Brain Behav Immun2009，23，7：	1
17	Effects of cryopreservation methods on poet-thaw motility of spermatozoa from the Japanese pearl oyster,Pinctada fucata martensii显示文摘	Kawamoto T Narita T Isowa K	2007	Cryobiology2007，54，1：	1
18	Effects of cryopreservation methods on post-thaw motility of spermatozoa from the Japanese pearl oyster,Pinctada fucata martensii显示文摘	Kawamoto T Narita T Isowa K	2007	Cryobiology2007，54，1：	1
19	Morphologic examination of rabbit nasal mucosa after the nasal administration of insulin peanut oil suspension and a powder dosage form with soybean-derived sterylglucoside显示文摘	Maitani Y Isowa K Naqai T	1995	Biological & pharmaceutical bulletin1995，18，6：	1
20	The use of cardiopulmonary bypass during extended resection of non-small cell lung cancer显示文摘	Seiki Hasegawa Toru Bando Noritaka Isowa	2003	Interactive Cardiovasc Thorac Surgery2003，2，：	1

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