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| 1 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 2 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 3 | Modeling and boundary control of a flexible marine riser coupled with internal fluid dynamics显示文摘In this paper, vibration reduction of a flexible marine riser with time-varying internal fluid is studied by using boundary control method and Lyapunov's direct method. To achieve more accurate and practical riser's dynamic behavior, the model of marine riser with time-varying internal fluid is modeled by a distributed parameter system (DPS) with partial differential equations (PDEs) and ordinary differential equations (ODEs) involving functions of space and time. The dynamic responses of riser are completely different if the time-varying internal fluid is considered. Boundary control is designed at the top boundary of the riser based on original infinite dimensionality PDEs model and Lyapunov's direct method to reduce the riser's vibrations. The uniform boundedness and closed-loop stability are proved based on the proposed boundary control. Simulation results verify the effectiveness of the proposed boundary control. | Yu LIU Haowei HUANG Hongxia GAO Xinsheng WU | 2013 | 控制理论与应用(英文版)2013，11，2： | 8 |
| 4 | Different Transcription Profiles of SOCS-3,ob and IGF-I Genes and their Possible Correlations in Obese and Lean Pigs显示文摘猪品种在胖免职和肌肉发展能力有重要差别。然而,在这些差别后面的分子的机制仍然是 unknown.Inthis 学习,三候选人基因的表示模式,压制或表明 3 的 cytokine ( SOCS-3 ),肥胖( ob )和像胰岛素的生长因素我( IGF-I ),它涉及脂肪质的新陈代谢或肌肉开发,被分析。全部的 RNA 从 8-month-old Bamei 的背面的下的脂肪质的组织和 longissimus 被提取, Largewhite pigs.Semiquantitative reversetranscription 聚合酶链反应被用来在肌肉组织在脂肪质的组织,和 SOCS-3 和 IGF-I 基因决定 SOCS-3and ob 基因的表示层次。结果证明在脂肪质的组织, SOCS-3 的表示水平在 Bamei 是显著地更高的(肥胖) 猪比那在 Largewhite (瘦) 猪(P<0.01 ) 。然而,在肌肉组织,它在 Largewhite 猪(P<0.01 ) 比那是显著地更低的 inBamei。而且, SOCS-3 的表示断然在肌肉组织在脂肪质的组织和 IGF-I 的被相关到 ob 的。这些调查结果建议在 SOCS-3 基因表达的差别铺平在脂肪质并且肌肉纸巾,在在肌肉组织的 SOCS-3 和 IGF-I 之间的在在脂肪质的组织的 SOCS-3 和 ob 之间的关系,和那,可能贡献在肥胖、瘦的猪之间的不同胖免职和肌肉发展能力。 | Jiangwei WU Bo WANG Haowei ZHANG Taiyong YU Gongshe YANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 6 |
| 5 | Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly显示文摘Error-free cell division depends on the accurate assembly of the spindle midzone from dynamic spindle microtubules to ensure chromatid segregation during metaphase-anaphase transition.However,the mechanism underlying the key transition from the mitotic spindle to central spindle before anaphase onset remains elusive.Given the prevalence of chromosome instability phenotype in gastric tumorigenesis,we developed a strategy to model context-dependent cell division using a combination of light sheet microscope and 3D gastric organoids.Light sheet microscopic image analyses of 3D organoids showed that CENP-E inhibited cells undergoing aberrant metaphase-anaphase transition and exhibiting chromosome segregation errors during mitosis.Highresolution real-time imaging analyses of 2D cell culture revealed that CENP-E inhibited cells undergoing central spindle splitting and chromosome instability phenotype.Using biotinylated syntelin as an affinity matrix,we found that CENP-E forms a complex with PRC1 in mitotic cells.Chemical inhibition of CENP-E in metaphase by syntelin prevented accurate central spindle assembly by perturbing temporal assembly of PRC1 to the midzone.Thus,CENP-E-mediated PRC1 assembly to the central spindle constitutes a temporal switch to organize dynamic kinetochore microtubules into stable midzone arrays.These findings reveal a previously uncharacterized role of CENP-E in temporal control of central spindle assembly.Since CENP-E is absent from yeast,we reasoned that metazoans evolved an elaborate central spindle organization machinery to ensure accurate sister chromatid segregation during anaphase and cytokinesis. | Xu Liu Leilei Xu Junying Li Phil Y.Yao Wanjuan Wang Hazrat Ismail Haowei Wang Bryce Liao Zhihong Yang Tarsha Ward Ke Ruan Jianchun Zhang Quan Wu Ping He Xia Ding Dongmei Wang Chuanhai Fu Zhen Dou Feng Yan Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，8： | 3 |
| 6 | CaMKIIα-driven,phosphatase-checked postsynaptic plasticity via phase separation显示文摘Ca^(2+)/calmodulin-dependent kinase Ila(CaMKIla)is essential for synaptic plasticity and learning by decoding synaptic Ca^(2+)oscillations.Despite decades of extensive research,new mechanisms underlying CaMKIIa's function in synapses are still being discovered.Here,we discover that Shank3 is a specific binding partner for autoinhibited CaMKIla.We demonstrate that Shank3 and GluN2B,via combined actions of Ca^(2+)and phosphatases,reciprocally bind to CaMKIla.Under basal condition,CaMKIla is recruited to the Shank3 subcompartment of postsynaptic density(PSD)via phase separation.Rise of Ca^(2+)concentration induces GluN2Bmediated recruitment of active CaMKIla and formation of the CaMKIIa/GluN2B/PSD-95 condensates,which are autonomously dispersed upon Ca^(2+)removal.Protein phosphatases control the Ca^(2+)-dependent shuttling of CaMKIla between the two PSD subcompartme nts and PSD condensate formation.Activation of CaMKIla further enlarges the PSD assembly and in duces structural LTP.Thus,Ca^(2+)-induced and phosphatase-checked shuttling of CaMKIla between distinct PSD nano-domains can regulate phase separation-mediated PSD assembly and synaptic plasticity. | Qixu Caic Menglong Zeng Xiandeng Wu Haowei Wu Yumeng Zhan Ruijun Tian Mingjie Zhang | 2021 | Cell Research2021，31，1： | 3 |
| 7 | Porous polyetheretherketone microcarriers fabricated via hydroxylation together with cellderived mineralized extracellular matrix coatings promote cell expansion and bone regeneration显示文摘Porous microcarriers have aroused increasing attention recently by facilitating oxygen and nutrient transfer,supporting cell attachment and growth with sufficient cell seeding density.In this study,porous polyetheretherketone(PEEK)microcarriers coated with mineralized extracellular matrix(mECM),known for their chemical,mechanical and biological superiority,were developed for orthopedic applications.Porous PEEK microcarriers were derived from smooth microcarriers using a simple wet-chemistry strategy involving the reduction of carbonyl groups.This treatment simultaneously modified surface topology and chemical composition.Furthermore,the microstructure,protein absorption,cytotoxicity and bioactivity of the obtained porous microcarriers were investigated.The deposition of mECM through repeated recellularization and decellularization on the surface of porous MCs further promoted cell proliferation and osteogenic activity.Additionally,the mECM coated porous microcarriers exhibited excellent bone regeneration in a rat calvarial defect repair model in vivo,suggesting huge potential applications in bone tissue engineering. | Shuo Sun Zixue Jiao Yu Wang Zhenxu Wu Haowei Wang Qingming Ji Yi Liu Zongliang Wang Peibiao Zhang | 2021 | Regenerative Biomaterials2021，8，2： | 2 |
| 8 | A New In Vivo Animal Model to Create Intervertebral Disc Degeneration Characterized by MRI, Radiography, CT/Discogram, Biochemistry, and Histology显示文摘 | HaoWei Zhou ShuXun Hou WeiLin Shang WenWen Wu Yao Cheng Fang Mei BaoGan Peng | 2007 | Spine2007，，8： | 1 |
| 9 | Interactions between cadmium and multiple precipitates in an Al-Li-Cu alloy:Improving aging kinetics and precipitation hardening显示文摘This work demonstrates significant improvements in both the aging kinetics and precipitation hardening of an Al-Li-Cu alloy with the minor addition of Cd(0.06 at.%).The precipitation hardening effect of T1 precipitates in casting Al-Li-Cu alloys has long been ignored since it is difficult to achieve a high number density of fine precipitates without a large number of dislocations.A detailed transmission electron microscopy investigation shows that the Cd addition has changed the distribution of T1 precipitates from the conventional uneven distribution near dislocations or grain boundaries to a more homogeneous manner.Most of the Cd-rich nanoparticles were observed at the broad face and/or terminal of the T1 platelets.It is highly likely that these nanoparticles act as heterogeneous nucleation sites,which consequently leads to a higher number density of T1 precipitates.Moreover,Cd atoms were preferentially segregated withinδprecipitates,which can be attributed to the strong bonding between Li and Cd.The interactions between Cd and the T1(Al2CuLi)andδ′(Al3Li)precipitates in Al-Li-Cu alloy are first reported.The present study may propose a new mechanism to effectively improve precipitation kinetics and therefore the age-hardening effect of Al-Li-Cu alloys. | Liang Wu Yugang Li Xianfeng Li Naiheng Ma Haowei Wang | 2020 | Journal of Materials Science & Technology2020，42，11： | 1 |
| 10 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 11 | A source-relay se- lection scheme in two-way amplify-and-forward relaying networks 显示文摘 | Li Enyu Yang Shizhong Wu Haowei | 2012 | IEEE Commun Lett2012，16，10： | 1 |
| 12 | A New In Vivo Animal Model to Create Intervertebral Disc Degeneration Characterized by MRI, Radiography, CT/Discogram, Biochemistry, and Histology显示文摘 | HaoWei Zhou ShuXun Hou WeiLin Shang WenWen Wu Yao Cheng Fang Mei BaoGan Peng | 2007 | Spine2007，，8： | 1 |
| 13 | A source-relay selection scheme in two-way amplify-and-forward relaying networks显示文摘 | Li Enyu Yang Shizhong Wu Haowei | 2012 | IEEE Communications Letters2012，16，10： | 1 |
| 14 | Mechanical stress in high-temperature superconducting ring-shaped bulk during the pulsed-field magnetization显示文摘The high-temperature superconducting(HTS)bulk has a higher critical current density and can trap the larger magnetic field.When the high-temperature superconducting bulk is magnetized by the pulsed-field,it will be subjected to electromagnetic stress and thermal stress.Furthermore,the bulk may be damaged under larger mechanical stress or strain during the pulsed-field magnetization.In this paper,the electromagnetic field,the temperature and the mechanical response of the ring-shaped bulk are simulated based on the electromagnetic and mechanical governing equations,and the simulated trapped field is consistent with the experimental results given in the reference.The stress distribution on the top surface of the ring-shaped bulk during pulsedfield magnetization is opposite to the case of field cold magnetization.Moreover,the inner edge on the middle plane of the bulk may be broken more easily than the outer edge during the pulsed-field magnetization.Afterward,the influences of the size of the inner radius,ambient temperature and rise time of the applied field are presented.Finally,the mechanical stress of the bulk with the cooling process is investigated,and the tensile stress on the surface can be enhanced by the cooling process. | WANG Lan WU HaoWei YONG HuaDong | 2023 | Science China(Technological Sciences)2023，66，2： | 1 |
| 15 | Chip-scale spontaneous quasi-phase matched second harmonic generation in a micro-racetrack resonator显示文摘In this paper,we demonstrate efficient spontaneous quasi-phase matched(SQPM)second harmonic generation(SHG)in a microracetrack resonator on X-cut thin film lithium niobate.Our approach does not involve poling,but exploits the anisotropy of the crystals to allow the phase-matching condition to be fulfilled spontaneously as the TE-polarized light circulates in a specifically designed racetrack resonator.In experiment,normalized on-chip conversion efficiencies of 1.01×10-4/W and 0.43×10-4/W are achieved by 37th-order and 111th-order SQPM,respectively.The configurable SQPM will benefit the application of nonlinear frequency conversion and quantum source generation in chip-scale integrated photonics compatible with standard CMOS fabrication processes. | Tingge Yuan Jiangwei Wu Yi'an Liu Xiongshuo Yan Haowei Jiang Hao Li Zhaokang Liang Qiang Lin Yuping Chen Xianfeng Chen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 1 |
| 16 | Hybrid Protocol for Wireless-Powered Untrusted Relay Networks with Imperfect Channel Reciprocity显示文摘This work investigates the security issue of the energy-constrained untrusted relay network with imperfect channel reciprocity,where the relay without the built-in power supply can only scavenge energy from radio-frequency signals radiated by the source and destination.A hybrid power-splitting(PS)-and time-switching(TS)-based relaying(HPTR)protocol is presented to improve the degraded secrecy performance due to the incomplete self-interference cancellation at the destination.To evaluate the secrecy throughput(ST)of the studied system,the analytical expression of the secrecy outage probability under the delay-limited transmission mode and the closed-form lower bound of the ergodic secrecy capacity under delay-tolerant transmission mode are derived.Both linear and nonlinear models for the energy harvester at the relay are compared.The optimal PS and TS ratios are evaluated numerically.The theoretical derivations are validated by numerical results,revealing that the residual jamming has a negative effect on the secrecy performance of untrusted relay networks,which can be alleviated by the HPTR protocol.Besides,we compare the ST performance of the HPTR protocol with that of the PS and TS relaying schemes,and the results show that the HPTR protocol outperforms both PS and TS relaying protocols in terms of the ST. | Rui Ma Haowei Wu Liubin Wang Jinglan Ou Lian Yan | 2021 | China Communications2021，18，9： | 0 |
| 17 | INTERACTION OF PARTICLES WITH A SOLIDIFIED INTERFACE DURING SOLIDIFICATION OF METAL MATRIX COMPOSITE REINFORCED WITH PARTICLES显示文摘INTERACTIONOFPARTICLESWITHASOLIDIFIEDINTERFACEDURINGSOLIDIFICATIONOFMETALMATRIXCOMPOSITEREINFORCEDWITHPARTICLESCHUShuangjie;W... | CHU Shuangjie WANG Haowei WU Renjie LIN Xiaotang(Institute of Composite Materials,Shanghai Jiaotong University,Shanghai 200030,China | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，1： | 0 |
| 18 | Mutations of MSH5 in nonobstructive azoospermia(NOA)and rescued via in vivo gene editing显示文摘Dear Editor,Male infertility is a multifactorial heterogeneous pathological condition affecting∼7%of men.Nonobstructive azoospermia(NOA)is one of the most severe male reproductive diseases and occurs in∼1%of men of reproductive age.1 However,its etiology remains elusive. | Min Chen Chencheng Yao Yingying Qin Xiuhong Cui Peng Li Zhiyong Ji Limei Lin Haowei Wu Zhi Zhou Yaoting Gui Zheng Li Fei Gao | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 19 | Secure polar coding for a joint source-channel model显示文摘This paper investigates a joint source-channel model where Alice, Bob, and Eve, observe components of a discrete memoryless source and communicate over a discrete memoryless wiretap channel which is independent of the source. Alice and Bob wish to agree upon a secret key and simultaneously communicate a secret message, both of which are required to be kept concealed from Eve. An achievable tradeoff region between the secret-key and secret-message rates has been established in the literature. In this paper, we propose an explicit polar coding scheme that achieves the tradeoff region for general sources and channels under the strong secrecy criterion. The encoding scheme is constructed based on a nontrivial combination of(1) encoding scheme for secret-key generation using correlated sources,(2) utilizing the generated key as a one-time pad to encrypt the secret message partially, and(3) a modified form of wiretap channel encoding scheme that incorporates the structure of superposition coding. | Haowei WANG Xiaofeng TAO Huici WU Na LI Jin XU | 2021 | Science China(Information Sciences)2021，64，11： | 0 |
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