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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 3 | Artificial Intelligence Applications in the Development of Autonomous Vehicles:A Survey显示文摘The advancement of artificial intelligence(AI)has truly stimulated the development and deployment of autonomous vehicles(AVs)in the transportation industry.Fueled by big data from various sensing devices and advanced computing resources,AI has become an essential component of AVs for perceiving the surrounding environment and making appropriate decision in motion.To achieve goal of full automation(i.e.,self-driving),it is important to know how AI works in AV systems.Existing research have made great efforts in investigating different aspects of applying AI in AV development.However,few studies have offered the research community a thorough examination of current practices in implementing AI in AVs.Thus,this paper aims to shorten the gap by providing a comprehensive survey of key studies in this research avenue.Specifically,it intends to analyze their use of AIs in supporting the primary applications in AVs:1)perception;2)localization and mapping;and 3)decision making.It investigates the current practices to understand how AI can be used and what are the challenges and issues associated with their implementation.Based on the exploration of current practices and technology advances,this paper further provides insights into potential opportunities regarding the use of AI in conjunction with other emerging technologies:1)high definition maps,big data,and high performance computing;2)augmented reality(AR)/virtual reality(VR)enhanced simulation platform;and 3)5G communication for connected AVs.This paper is expected to offer a quick reference for researchers interested in understanding the use of AI in AV research. | Yifang Ma Zhenyu Wang Hong Yang Lin Yang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 16 |
| 4 | Preparation of colloidal gold immunochromatography strip for detection of methamidophos residue显示文摘Methamidophos (Met) is a broad spectrum organophosphorus insecticide and acaricide.Even a trace of its residue is harmful to humans and many animals.In this study,the synthesis and identification of colloidal gold particles and antibody-colloidal gold conjugates were performed,and the preparation of colloidal gold immunochromatography strip was conducted for detection of Met residue.The size of colloidal gold particles was checked using a transmission electron microscope (TEM).The formation of antibody-colloidal gold conjugates was monitored by UV/Vis spectroscopy.The preparation of colloidal gold immunochromatography strips,analysis of Met standard solutions,and other four pesticides and vegetable samples were operated with common methods and principals.The TEM images showed the average diameter of colloidal gold particles was almost the same size: approximately 40.0 nm in diameter.For the conjugation of colloidal gold and monoclonal antibody (MAb),0.03 mg/ml of MAb was confirmed to be the minimum amount for stabilization of colloidal gold.With the prepared colloidal gold immunochromatography test strip to determine the standard Met solution,the results demonstrated a detection limit of approximately 1.0 μg/ml.Cross-reaction indicated that the strip had a high specificity to Met.The results of 10 green vegetable sample tests confirmed that one sample was positive by HPLC analysis.There was evidence to suggest that colloidal gold particles and antibody-colloidal gold conjugates were synthesized successfully.The prepared colloidal gold immunochromatography strip was applicable for preliminary screening of Met residue. | Shi Chenggang Zhao Suqing Zhang Kun Hong Guobao Zhu Zhenyu | 2008 | Journal of Environmental Sciences2008，20，11： | 15 |
| 5 | Targeting BMI-1-mediated epitheliale-mesenchymal transition to inhibit colorectal cancer liver metastasis显示文摘Liver is the most common metastatic site for colorectal cancer(CRC),there is no satisfied approach to treat CRC liver metastasis(CRCLM).Here,we investigated the role of a polycomb protein BMI-1 in CRCLM.Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage,invasion depth and right-sided primary tumor.Knockdown BMI-1 in high metastatic HCT116 and LOVO cells repressed the migratory/invasive phenotype and reversed epithelialemesenchymal transition(EMT),while BMI-1 overexpression in low metastatic Ls174 T and DLD1 cells enhanced invasiveness and EMT.The effects of BMI-1 in CRC cells were related to upregulating snail via AKT/GSK-3βpathway.Furthermore,knockdown BMI-1 in HCT116 and LOVO cells reduced CRCLM using experimental liver metastasis mice model.Meanwhile,BMI-1 overexpression in Ls174 T and DLD1 significantly increased CRCLM.Moreover,sodium butyrate,a histone deacetylase and BMI-1 inhibitor,reduced HCT116 and LOVO liver metastasis in immunodeficient mice.Our results suggest that BMI-1 is a major regulator of CRCLM and provide a potent molecular target for CRCLM treatment. | Zhiyao Xu Zhuha Zhou Jing Zhang Feichao Xuan Mengjing Fan Difan Zhou Zhenyu Liuyang Ximei Ma Yiyang Hong Yihong Wang Sherven Sharma Qinghua Dong Guanyu Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 6 | Development of nutritious rice with high zinc/selenium and low cadmium in grains through QTL pyramiding显示文摘Enriching zinc(Zn) and selenium(Se) levels,while reducing cadmium(Cd) concentration in rice grains is of great benefit for human diet and health.Large natural variations in grain Zn, Se, and Cd concentrations in different rice accessions enable Zn/Sebiofortification and Cd-minimization through molecular breeding. Here, we report the development of new elite varieties by pyramiding major quantitative trait loci(QTLs) that significantly contribute to high Zn/Se and low Cd accumulation in grains. A chromosome segment substitution line CSSLGCC7 with the PA64s-derived GCC7 allele in the 93-11 background, exhibited steadily higher Mn and lower Cd concentrations in grains than those of 93-11. This elite chromosome segment substitution line(CSSL) was used as the core breeding material to cross with CSSLs harboring other major QTLs for essential mineral elements, especially CSSLGZC6 for grain Zn concentration and CSSLGSC5 for grain Se concentration. The CSSLGCC7+GZC6 and CSSLGCC7+GSC5 exhibited lower Cd concentration with higher Zn and Se concentrations in grains, respectively. Our study thus provides elite materials for rice breeding targeting high Zn/Se and low Cd concentrations in grains. | Chaolei Liu Shilin Ding Anpeng Zhang Kai Hong Hongzhen Jiang Shenglong Yang Banpu Ruan Bin Zhang Guojun Dong Longbiao Guo Dali Zeng Qian Qian Zhenyu Gao | 2020 | Journal of Integrative Plant Biology2020，62，3： | 7 |
| 7 | The liquid phase separation of Bi-Ga hypermonotectic alloy under acoustic levitation condition显示文摘Containerless treatment of Bi-58.5at%Ga hypermonotectic alloy is successfully performed with acous-tic levitation technique. Under acoustic levitation condition,the second phase (Ga) distributes almost homogeneously in solidification sample,opposite to macrosegregation in solidification sample under conventional condition. Stokes motion of the second liquid droplet (Ga) is significantly restrained un-der acoustic levitation condition. The analyses indicate that the melt vibration in the gravity direction forced by acoustic field can induce steady flow around the second liquid droplet,which influences droplet shape during its moving upward and consequently restrains Stokes motion velocity of the second liquid droplet. | HONG ZhenYu LV YongJun XIE WenJun WEI BingBo | 2007 | Chinese Science Bulletin2007，52，11： | 7 |
| 8 | Ternary eutectic growth of Ag-Cu-Sb alloy within ultrasonic field显示文摘The liquid to solid transformation of ternary Ag42.4Cu21.6Sb36 eutectic alloy was ac- complished in an ultrasonic field with a frequency of 35 kHz, and the growth mechanism of this ternary eutectic was examined. Theoretical calculations predict that the sound intensity in the liquid phase at the solidification interface increases gradually as the interface moves up from the sample bottom to its top. The growth mode of (ε + θ + Sb) ternary eutectic exhibits a transition of 'divorced eutectic— mixture of anomalous and regular structures—regular eutectic' along the sample axis due to the inhomogeneity of sound field distribution. In the top zone with the highest sound intensity, the cavitation effect promotes the three eutectic phases to nucleate independently, while the acoustic streaming efficiently suppresses the coupled growth of eutectic phases. In the meantime, the ultrasonic field accelerates the solute transportation at the solid-liquid interface, which reduces the solute solubility of eutectic phases. | ZHAI Wei HONG ZhenYu WEI BingBo | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，4： | 6 |
| 9 | Design of Drilling and Riveting Multi-functional End Effector for CFRP and Aluminum Components in Robotic Aircraft Assembly显示文摘To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength. | Zhang Lin Tian Wei Li Dawei Hong Peng Li Zhenyu Zhou Weixue Liao Wenhe | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 5 |
| 10 | Dynamic solidification of Sn-38.1% Pb eutectic alloy within ultrasonic field显示文摘The dynamic solidification of Sn-38.1% Pb eutectic alloy within an ultrasonic field is investigated at a frequency of 35 kHz.As the sample height H is reduced,the effect of ultrasound on macrosegregation becomes more prominent,and the volume fraction of spherical eutectic cells increases correspondingly.When H equals the wavelength λ in liquid alloy,the introduction of ultrasound enlarges the distribution region of the primary (Sn) phase,but reduces the domains of the Sn-Pb eutectic and primary (Pb) phases.Meanwhile,a 'dendritic-equiaxed' structural transition occurs in the primary (Sn) phase,and its grain size is significantly reduced within the ultrasonic field.Once H decreases to λ/2 and λ/4,the ultrasonic field promotes crystal nucleation and suppresses further undercooling of the bulk liquid alloy.Theoretical analyses indicate that the local high pressure induced by the cavitation effect and the stirring effect due to acoustic streaming are the main factors dominating the eutectic growth mechanism during dynamic solidification. | ZHAI Wei HONG ZhenYu XIE WenJun WEI BingBo | 2011 | Chinese Science Bulletin2011，56，1： | 5 |
| 11 | Flexible memristors as electronic synapses for neuro- inspired computation based on scotch tape-exfoliated mica substrates显示文摘灵活 memristor 设备在便携计算机和集成电路由于他们的应用基于塑料底层吸引了可观的注意。然而,很塑料底层的 memristors 不能工作或在高温度的环境成年。在这研究, scotch-tape-exfoliated 云母被用作灵活 memristor 底层以便解决这些高温度的问题。我们的 TiN/ZHO/IGZO memristor,它被构造用一薄(10 m ) 云母底层,有优异灵活性和 thermostability。在把它弄弯 103 次以后,设备继续展出非凡的电的特征。它能也为在高、低的抵抗状态之间的转变被实现,甚至在多达 300 | Xiaobing Yan Zhenyu Zhou Jianhui Zhao Qi Liu Hong Wang Guoliang Yuan Jingsheng Chen | 2018 | Nano Research2018，11，3： | 5 |
| 12 | Solidification characteristics of Pb-Sb hypereutecticalloy within ultrasonic field显示文摘The solidification of Pb-16%Sb hypereutectic alloy is investigated within ultrasonic field with a fre-quency of 15 kHz. It is found that the ultrasonic field promotes crystal nucleation and terminates the further bulk undercooling of the alloy melt. Theoretical analysis shows that the cavitation effect and the forced bulk vibration are the main factors that reduce the undercooling level. With the increase of ul-trasound intensity, the primary (Sb) phase experiences a growth mode transition from faceted to non-faceted branched growth, and the macrosegregation of primary (Sb) phase is gradually sup-pressed. In addition, the microstructures of Pb-Sb eutectic exhibit a conspicuous coarsening with in-creasing ultrasound intensity, and a structural transition of “lamellar eutectic—anomalous eutectic” occurs when ultrasound intensity rises up to 1.6 W/cm2. The ultrasonic field also changes the solute distribution adjacent to the solidification front, which lowers the Pb contents in primary (Sb) phase. | ZHAI Wei HONG ZhenYu XIE WenJun WEI BingBo | 2007 | Chinese Science Bulletin2007，52，6： | 5 |
| 13 | Effect of rotating magnetic field on the solidification microstructures of Pb-Sn alloys显示文摘The influence of the rotating magnetic field (RMF) on the solidification proc- ess of Pb-Sn binary alloys is studied by comparing the solidification microstructures under the common condition and RMF condition. It is found that the RMF can completely elimi- nate the gravity induced macrosegregation, and result in dendrite fragmentation and promote solute diffusion velocity. These differences are regarded as the effect of compli- cated melt flow caused by RMF. Moreover, when the content of the primary phase is small, many spherical microstructures form under the RMF condition. The analyses indicate that these special microstructures are likely the conjunction action of melt flow and concentra- tion and temperature field uniformity caused by RMF. | MENG Xiaohua CHEN Changle HONG Zhenyu WANG Jianyuan | 2006 | Science China(Technological Sciences)2006，49，3： | 4 |
| 14 | Rapid solidification of acoustically levitated Al-Cu-Si eutectic alloy under laser irradiation显示文摘Al-27%Cu-5.3%Si ternary eutectic alloy was melted using a YAG laser and then solidified while being acoustically levitated. A maximum undercooling to 195 K (0.24 TL) was achieved with a cooling rate of 76 K/s. The solidification microstructure was composed of (Al+θ+Si) ternary eutectics and (Al+θ) pseudobinary eutectics. During acoustic levitation, the (Al+θ+Si) ternary eutectics are refined and the (Al+θ) pseudobinary eutectics have morphological diversity. On the surface of the alloys, surface oscillations and acoustic streaming promote the nucleation of the three eutectic phases and expedite the cooling process. This results in the refinement of the ternary eutectic microstructure. During experiments, the reflector decreases with increasing alloy temperature, and the levitation distance always exceeds the resonant distance. Because of the acoustic radiation pressure, the melted alloy was flattened, and deformation increases with increasing sound pressure. The maximum aspect ratio achieved was 6.64, corresponding to a sound pressure of 1.8×104 Pa. | YAN Na GENG DeLu HONG ZhenYu WEI BingBo | 2011 | Chinese Science Bulletin2011，56，9： | 4 |
| 15 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 16 | The IAA-and ABA-responsive transcription factor CgMYB58 upregulates lignin biosynthesis and triggers juice sac granulation in pummelo显示文摘In citrus,lignin overaccumulation in the juice sac results in granulation and an unpleasant fruit texture and taste.By integrating metabolic phenotyping and transcriptomic analyses,we found 702 differentially expressed genes(DEGs),including 24 transcription factors(TFs),to be significantly correlated with lignin content.CgMYB58 was further identified as a critical R2R3 MYB TF involved in lignin overaccumulation owing to its high transcript levels in Huanong Red-fleshed pummelo(HR,Citrus grandis)fruits.Transient expression of CgMYB58 led to an increase in the lignin content in the pummelo fruit mesocarp,whereas its stable overexpression significantly promoted lignin accumulation and upregulated 19 lignin biosynthetic genes.Among these genes,CgPAL1,CgPAL2,Cg4CL1,and CgC3H were directly modulated by CgMYB58 through interaction with their promoter regions.Moreover,we showed that juice sac granulation in pummelo fruits could be affected by indole-3-acetic acid(IAA)and abscisic acid(ABA)treatments.In HR pummelo,ABA significantly accelerated this granulation,whereas IAA effectively inhibited this process.Taken together,these results provide novel insight into the lignin accumulation mechanism in citrus fruits.We also revealed the theoretical basis via exogenous IAA application,which repressed the expression of CgMYB58 and its target genes,thus alleviating juice sac granulation in orchards. | Meiyan Shi Xiao Liu Haipeng Zhang Zhenyu He Hongbin Yang Jiajing Chen Jia Feng Wenhui Yang Youwu Jiang Jia-Long Yao Cecilia Hong Deng Juan Xu | 2020 | Horticulture Research2020，7，1： | 4 |
| 17 | COLLISION AVOIDANCE DECISION-MAKING MODEL OF MULTI-AGENTS IN VIRTUAL DRIVING ENVIRONMENT WITH ANALYTIC HIERARCHY PROCESS显示文摘Collision avoidance decision-making models of multiple agents in virtual driving environ-ment are studied. Based on the behavioral characteristics and hierarchical structure of the collision avoidance decision-making in real life driving,delphi approach and mathematical statistics method are introduced to construct pair-wise comparison judgment matrix of collision avoidance decision choices to each collision situation. Analytic hierarchy process (AHP) is adopted to establish the agents' collision avoidance decision-making model. To simulate drivers' characteristics,driver factors are added to categorize driving modes into impatient mode,normal mode,and the cautious mode. The results show that this model can simulate human's thinking process,and the agents in the virtual environment can deal with collision situations and make decisions to avoid collisions without intervention. The model can also reflect diversity and uncertainty of real life driving behaviors,and solves the multi-objective,multi-choice ranking priority problem in multi-vehicle collision scenarios. This collision avoidance model of multi-agents model is feasible and effective,and can provide richer and closer-to-life virtual scene for driving simulator,reflecting real-life traffic environment more truly,this model can also promote the practicality of driving simulator. | LU Hong YI Guodong TAN Jianrong LIU Zhenyu | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 4 |
| 18 | Single atom and defect engineering of CuO for efficient electrochemical reduction of CO_(2) to C_(2)H_(4)显示文摘Electrochemical CO_(2) transformation to high‐value ethylene(C_(2)H_(4))at high currents and efficiencies is desired and yet remains a grand challenge.We show for the first time that coupling single Sb atoms and oxygen vacancies of CuO enable synergistic electrocatalytic reduction of CO_(2) to C_(2)H_(4) at low overpotentials.Highly dispersed Sb atoms occupying metal substitutional sites of CuO are synthesized under mild conditions.The overall CO_(2) reduction faradaic efficiency(FE)reaches 89.3±1.1%with an FE toward C_(2)H_(4) exceeding 58.4%at a high‐current density of 500 mA/cm^(2).Addition of the p‐block metal is found to induce transformation of CuO from flakes to nanoribbons rich in nanoholes and oxygen vacancies,greatly enhancing CO_(2) adsorption and activation while suppressing hydrogen evolution.Further density functional theory calculations with in situ X‐ray diffraction reveal that combining Sb sites and oxygen vacancies prominently lessen the dimerization energy of adsorbed CO intermediate,thus boosting the conversion of CO_(2) to produce C_(2)H_(4).This study provides a new perspective for promoting selective C-C coupling for electrochemical CO_(2) reduction. | Senlin Chu Changwoo Kang Woonghyeon Park Yu Han Song Hong Leiduan Hao Hao Zhang Tsz Woon Benedict Lo Alex W.Robertson Yousung Jung Buxing Han Zhenyu Sun | 2022 | SmartMat2022，3，1： | 3 |
| 19 | Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury显示文摘The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used computer simulation of molecular docking to predict that S1P might be a ligand for triggering receptor expressed on myeloid cells 2(TREM2).Next,microscale thermophoresis(MST),surface plasmon resonance(SPR)and liquid chromatography–tandem mass spectrometry(LC–MS/MS)were performed to reveal that S1P was a novel TREM2 ligand.Then,we confirmed the pro-phagocytosis of S1P targeting in Trem2-Dap12 transfected CHO cells and TREM2 knockdown microglia.Point mutation analysis showed that D104 was the critical binding residue.Trem2^(−/−)mice were used to demonstrate the role of S1P-induced phagocytosis targeting on TREM2 in protecting against ischemic brain injury.Finally,further studies revealed that apolipoprotein E(APOE)loaded with S1P was released by microglia and bound to apoptotic neurons via LDL receptor related protein 1B(LRP1B)and thereby induced microglia to phagocytose apoptotic neurons.Overall,the present work reveals for the first time that S1P acts as a novel endogenous ligand of TREM2 to effectively promote microglial phagocytosis.Our findings provide a new lead compound for developing immunomodulator targeting on TREM2. | Tengfei Xue Juan Ji Yuqin Sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng Xiulan Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 20 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
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