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| 1 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 2 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 3 | Application and future perspective of CRISPR/Cas9 genome editing in fruit crops显示文摘Fruit crops, including apple, orange, grape,banana, strawberry, watermelon, kiwifruit and tomato, not only provide essential nutrients for human life but also contribute to the major agricultural output and economic growth of many countries and regions in the world. Recent advancements in genome editing provides an unprecedented opportunity for the genetic improvement of these agronomically important fruit crops. Here, we summarize recent reports of applying CRISPR/Cas9 to fruit crops,including efforts to reduce disease susceptibility, change plant architecture or flower morphology, improve fruit quality traits, and increase fruit yield. We discuss challenges facing fruit crops as well as new improvements and platforms that could be used to facilitate genome editing in fruit crops, including d Cas9-base-editing to introduce desirable alleles and heat treatment to increase editing efficiency. In addition, we highlight what we see as potentially revolutionary development ranging from transgene-free genome editing to de novo domestication of wild relatives. Without doubt, we now see only the beginning of what will eventually be possible with the use of the CRISPR/Cas9 toolkit. Efforts to communicate with the public and an emphasis on the manipulation of consumerfriendly traits will be critical to facilitate public acceptance of genetically engineered fruits with this new technology. | Junhui Zhou Dongdong Li Guoming Wang Fuxi Wang Merixia Kunjal Dirk Joldersma Zhongchi Liu | 2020 | Journal of Integrative Plant Biology2020，62，3： | 7 |
| 4 | Direct Reduction of Solid Fe_2O_3 in Molten CaCl_2 by Potentially Green Process显示文摘Sintered (300°C) porous pellets of Fe2O3 were electrolyzed to Fe in molten CaCl2 (800–900°C) under argon at 1.8–3.2 V for 2–20 h. The laboratory scale experiments show that it was a potentially direct green method to produce Fe powder. At lower electrolysis voltage (<2.2 V), higher current efficiency (>90%) and smaller energy consumption (~3.0 kWh/kg) can be obtained. When the electrolysis voltage was above 2.4 V, the deposition of metal Ca from the salt lowered the current efficiency and increased the energy consumption. The electrolysis voltage also had effects on the micrographs of the reduced powder. The cubic particles can be seen in the products at the voltage lower than 2.2 V; when the voltage was higher than 2.2 V, it was nodular. The reduction proceeds at the cathode in two steps, i.e., from Fe2O3 to FeO and then to Fe. The oxygen emits at the anode. The process is potentially free of carbon emission and produces two useful products at both cathode and anode, promising a zero-emission technology for the extractive metallurgical industry. | Guoming Li Dihua Wang Zhen Chen | 2009 | Journal of Materials Science & Technology2009，25，6： | 5 |
| 5 | An Outbreak of Multidrug-Resistant Tuberculosis in a Secondary School --Hubei Province, 2019显示文摘What is already known about this topic?Multidrug-resistant tuberculosis(MDR-TB)is a type of tuberculosis with resistance to common treatments such as isoniazid and rifampicin.MDR-TB is a major global health challenge and needs to be controlled tightly through prevention measures,early diagnosis,and full treatment and management.What is added by this report?This outbreak was the first MDR-TB related public health emergency in Hubei Province.In total,five MDR-TB cases and nine clinically diagnosed cases were identified within one class in a secondary school.Students and teachers from other classes were monitored,but no other cases were found.What are the implications for public health practice?The implementation of TB prevention and control measures in schools is important to increase knowledge on TB and to raise awareness on protecting personal wellbeing.The Automatic Early Warning Information System alerted the local health department and allowed for a timely response to prevent further disease spread. | Mengxian Zhang Tang Wang Shuangyi Hou Jianjun Ye Liping Zhou Zhong Zhang Zhiqiang Deng Qin Da Guoming Li Shiyue Li | 2019 | China CDC weekly2019，1，5： | 5 |
| 6 | Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis显示文摘Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis,intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8?T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8?T cells are involved in the pathogenesis of RE. | Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan | 2018 | Virologica Sinica2018，33，5： | 4 |
| 7 | Deep feature extraction and motion representation for satellite video scene classification显示文摘Satellite video scene classification(SVSC)is an advanced topic in the remote sensing field,which refers to determine the video scene categories from satellite videos.SVSC is an important and fundamental step for satellite video analysis and understanding,which provides priors for the presence of objects and dynamic events.In this paper,a two-stage framework is proposed to extract spatial features and motion features for SVSC.More specifically,the first stage is designed to extract spatial features for satellite videos.Representative frames are firstly selected based on the blur detection and spatial activity of satellite videos.Then the fine-tuned visual geometry group network(VGG-Net)is transferred to extract spatial features based on spatial content.The second stage is designed to build motion representation for satellite videos.The motion representation of moving targets in satellite videos is first built by the second temporal principal component of principal component analysis(PCA).Second,features from the first fully connected layer of VGG-Net are used as high-level spatial representation for moving targets.Third,a small network of long and short term memory(LSTM)is further designed for encoding temporal information.Two-stage features respectively characterize spatial and temporal patterns of satellite scenes,which are finally fused for SVSC.A satellite video dataset is built for video scene classification,including 7209 video segments and covering 8 scene categories.These satellite videos are from Jilin-1 satellites and Urthecast.The experimental results show the efficiency of our proposed framework for SVSC. | Yanfeng GU Huan LIU Tengfei WANG Shengyang LI Guoming GAO | 2020 | Science China(Information Sciences)2020，63，4： | 4 |
| 8 | On the γ' precipitates of the normal and inverse Portevin-Le Chatelier effect in a wrought Ni-base superalloy显示文摘The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy. | Xinguang Wang Guoming Han Chuanyong Cui Shuai Guan Jinguo Li Guichen Hou Yizhou Zhou Xiaofeng Sun | 2019 | Journal of Materials Science & Technology2019，35，1： | 3 |
| 9 | Laminar Distribution of Neurochemically-Identified Interneurons and Cellular Co-expression of Molecular Markers in Epileptic Human Cortex显示文摘Inhibitory GABAergic interneurons are fundamental elements of cortical circuits and play critical roles in shaping network activity. Dysfunction of interneurons can lead to various brain disorders, including epilepsy,schizophrenia, and anxiety. Based on the electrophysiological properties, cell morphology, and molecular identity,interneurons could be classified into various subgroups. In this study, we investigated the density and laminar distribution of different interneuron types and the coexpression of molecular markers in epileptic human cortex.We found that parvalbumin(PV) and somatostatin(SST)neurons were distributed in all cortical layers except layer I, while tyrosine hydroxylase(TH) and neuropeptide Y(NPY) were abundant in the deep layers and white matter.Cholecystokinin(CCK) neurons showed a high density in layers IV and VI. Neurons with these markers constituted*7.2%(PV), 2.6%(SST), 0.5%(TH), 0.5%(NPY), and4.4%(CCK) of the gray-matter neuron population. Doubleand triple-labeling revealed that NPY neurons were also SST-immunoreactive(97.7%), and TH neurons were more likely to express SST(34.2%) than PV(14.6%). A subpopulation of CCK neurons(28.0%) also expressed PV, but none contained SST. Together, these results revealed the density and distribution patterns of different interneuron populations and the overlap between molecular markers in epileptic human cortex. | Qiyu Zhu Wei Ke Quansheng He Xiongfei Wang Rui Zheng Tianfu Li Guoming Luan Yue-Sheng Long Wei-Ping Lia Yousheng Shu | 2018 | Neuroscience Bulletin2018，34，6： | 3 |
| 10 | Elevated expression of EBV and TLRs in the brain is associated with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare pediatric neurological disorder, the etiology of which remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor in triggering RE immunopathogenesis. In this study, we analyzed the expression of Epstein-Barr virus(EBV) antigens as well as of Toll-like receptor 3(TLR3), TLR9, and downstream adapter TIRdomain-containing adapter-inducing interferon-β(TRIF) in the brain tissues of 26 patients with RE and 16 control individuals using immunohistochemistry(IHC). In the RE group, EBV antigens were detected in 53% of individuals at various expression levels. In contrast, there was no detectable EBV antigen expression in control brain tissues. Moreover, we found marked increases in the expression of TLR3, TLR9, and TRIF in the brain tissues of RE patients compared with levels in the control group. Furthermore, among RE cases, EBV expression and high TLR3 expression were associated with more severe brain atrophy. Our results suggest that the elevated expression of EBV and TLRs may be involved in RE occurrence through the activation of downstream molecules. | Xin Wang Yisong Wang Dong Liu Peigang Wang Dongying Fan Yuguang Guan Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，5： | 3 |
| 11 | Transforming the Loess Plateau of China显示文摘This paper aims to show the importance of land consolidation in transforming the Loess Plateau of China. The paper comprehensively analyzes how over recent decades the Grain for Green Project and Gully Land Consolidation Project jointly transformed the ecology and landscape of the Loess Plateau and the livelihood of its residents. The findings show that these two projects have achieved a balance between green protection, new land creation, and improved food security and livelihood of local people in the hilly areas of China. The paper points out that the successful transformation of the Plateau lies in a holistic approach incorporating various components of the human and natural systems. Finally, the paper highlights the necessity of retaining these two land consolidation projects as part of an ongoing policy in the mountain and hilly areas of China, changing agricultural management to suit the new relationship between humans and the land. | Yuheng LI Guoming DU Yansui LIU | 2016 | Frontiers of Agricultural Science and Engineering2016，3，3： | 3 |
| 12 | Circular BANP knockdown inhibits the malignant progression of residual hepatocellular carcinoma after insufficient radiofrequency ablation显示文摘Background:Circular RNAs(circRNAs)are endogenous non-coding RNAs,some of which have pathological roles.The current study aimed to explore the role of circRNA BTG3-associated nuclear protein(circ-BANP)binding with let-7f-5p and its regulation of the toll-like receptor 4(TLR4)/signal transducer and activator of transcription 3(STAT3)signaling pathway in residual hepatocellular carcinoma(HCC)after insufficient radiofrequency ablation(RFA).Methods:Circ-BANP,let-7f-5p,and TLR4 expressions in HCC samples were assessed using reverse transcription-quantitative polymerase chain reaction(RT-qPCR)and Western blotting.Bioinformatics prediction,RNA pull-down assay,and dual luciferase reporter gene assay were used to analyze the relationships among circ-BANP,let-7f-5p,and TLR4.Huh7 cells were used to generate an in vitro model of residual HCC,defined as Huh7-H cells,which were transfected with either a plasmid or the sequence of circ-BANP,let-7f-5p,or TLR4.Expression of circ-BANP,let-7f-5p,and TLR4 mRNA was determined by RT-qPCR.TLR4,STAT3,p-STAT3,vascular endothelial growth factor A,vascular endothelial growth factor receptor-2,and epithelialmesenchymal transformation(EMT)-related factors proteins were determined by Western blotting.Cell proliferation was determined by cell counting kit-8 and 5-Ethynyl-2’-deoxyuridine(EdU)assay and cell migration and invasion by Transwell assay.Animal studies were performed by inducing xenograft tumors in nude mice.Results:Circ-BANP and TLR4 mRNAs were upregulated in HCC tissues(the fold change for circ-BANP was 1.958 and that for TLR4 was 1.736 relative to para-tumors)and expression further increased following insufficient RFA(fold change for circBANP was 2.407 and that of TLR4 was 2.224 relative to para-tumors).Expression of let-7f-5p showed an opposite tendency(fold change for let-7f-5p in HCC tissues was 0.491 and that in tumors after insufficient RFA was 0.300 relative to paratumors).Competitive binding of circ-BANP to let-7f-5p was demonstrated and TLR4 was identified as a target of let-7f-5p(P<0.01).Knockdown of circ-BANP or elevation of let-7f-5p expression inhibited the TLR4/STAT3 signaling pathway,proliferation,invasion,migration,angiogenesis,and EMT in Huh7 and Huh7-H cells(P<0.01).The effects induced by circBANP knockdown were reversed by let-7f-5p inhibition.Overexpression of TLR4 reversed the impact of let-7f-5p upregulation on the cells(P<0.01).Silencing of circ-BANP inhibited the in vivo growth of residual HCC cells after insufficient RFA(P<0.01).Conclusions:Knockdown of circ-BANP upregulated let-7f-5p to inhibit proliferation,migration,and EMT formation in residual HCC remaining after insufficient RFA.Effects occur via regulation of the TLR4/STAT3 signaling pathway. | Guoming Li Jian Kong Shuying Dong Haigang Niu Shilun Wu Wenbing Sun | 2022 | Chinese Medical Journal2022，，13： | 2 |
| 13 | Flashover Behavior of Cone-type Spacers with Inhomogeneous Temperature Distribution in SF_(6)/N_(2)-filled DC-GIL Under Lightning Impulse with DC Voltage Superimposed显示文摘Before designing DC gas insulated transmission lines(GIL),the insulation characteristics of spacers under a lightning impulse(LI)voltage with a superimposed DC voltage must be clarified.Many experiments have been performed to guide the development of the DC spacer.However,the impacts of thermal stresses on their insulation performance under combined voltage are always neglected,and little attention has been given to the insulation characteristics of spacers in an eco-friendly gas filled DC-GIL.To solve these problems,an experiment setup with the abilities to load the thermal field and the DC voltage with LI voltage superimposed on the cone-type spacer are built.After that,the insulation characteristics of spacers under the combined voltage of DC with lightning impulse at 0.1 MPa SF_(6)/N_(2) gas mixtures are investigated,under different thermal stress conditions.The experiment’s results indicate that:1)The flashover voltage of spacers under the same polarity superimposed voltages is slightly higher than that under LI alone.Conversely,the flashover voltage under reverse polarity superimposed voltages is lower than that under LI alone.2)The longer the duration of the foregoing DC voltage,the differences between the flashover voltage under superposed voltage and that under LI alone are larger.3)The combined flashover voltages are reduced under thermal stress.To ensure the insulation performance of newly designed DC spacers,the insulation test is suggested to be applied under thermal stress and combined voltage of the DC with lightning impulse,especially for superimposed reverse polarity. | Guoming Ma Hongyang Zhou Yuan Wang Hanchi Zhang Shijie Lu Youping Tu Jian Wang Chengrong Li | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 2 |
| 14 | Feasibility of C_(3)F_(7)CN/CO_(2)gas mixtures in high-voltage DC GIL:a review on recent advances显示文摘With the rise of renewable energy resources,especially offshore wind power plant,the DC transmission concept has attracted more and more attention.The selection of eco-friendly insulating gas,as most critical insulating part of gas-insulated equipment is top priority for developing highly reliable system.Moreover,it is acknowledged that eco-friendly C_(3)F_(7)CN/CO_(2) gas mixtures have become a potential alternative to SF_(6) gas due to its excellent performance.This study reviews the basic physical properties of C_(3)F_(7)CN gas/gas mixtures and insulation properties including the gas gap breakdown and surface flashover performance at DC,as well as lightning impulse voltage.Investigation about the gas stability is presented,including the compatibility of gas with solid materials in gas-insulated transmission line(GIL),and the decomposition characteristics under long-term electrical and thermal stresses.The important progress on the charge accumulation characteristics of gas-solid interface in the novel gas environment under DC voltage stress is analysed.Finally,the key issues that need to be paid attention to and further followed through regarding the application of this novel gas in GIL are summarised and put forward.This study hopefully can provide a complete reference for the development of eco-friendly DC gas insulation equipment with C_(3)F_(7)CN/CO_(2) gas mixtures. | Youping Tu Geng Chen Cong Wang Yuming Shao Yujing Tong Chuanyang Li Guoming Ma Tohid Shahsavarian | 2020 | High Voltage2020，5，4： | 2 |
| 15 | The value of bone scintigraphy on the determination of the full extent of tumor involvement in jaw bones显示文摘目的将有希望地在在颌骨决定肿瘤参与的最大程度上调查骨头 scintigraphy 的价值并且估计转移的存在。这研究有本地道德的委员会赞同的方法,和所有病人给了写的知情同意。有在颌骨的主要恶性瘤的三十七个连续病人为学习被招募。骨头 scintigraphy 在外科前在所有病人被执行测量多骨的参与的最大程度,它与 histologic 调查结果相比。结果全部身体扫描与多重多骨的转移揭示了一个案例。36 个骨头瘤的切除术标本病理地被分析识别每个肿瘤的类型和尺寸。在骨头 scintigraphy 和病理定义的颌骨的肿瘤参与的长度是 5.62 ± 1.58 厘米, 4.48 ± 1.57 厘米,分别地(P <
0.05 ) 。从移开的标本的肿瘤 negative 边缘病理地根据骨头 scintigraphy 被证实。与是的 histologic 调查结果参考的标准,骨头 scintigraphy 的精确性在在颌骨决定肿瘤参与的最大程度是 100%(36 个病人中的 36 个) 。当完全清除肿瘤房间并且每当可能时,保存功能时,结论骨头 scintigraphy 趋于在决定骨头切除术的适当程度提供特定的指南并且在建立多骨的转移。 | Jiawei Xie Chao Ma Guoming Wang Shuyao Zuo Ningyi Li Muyun Jia | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 2 |
| 16 | Capacitive Imaging Technique for the Inspection of Composite Sucker Rod显示文摘Composite sucker rod has been extensively used due to its high strength, light weight and corrosion resistive nature. However, such composite sucker rod is diffcult for conventional non-destructive evaluation(NDE) techniques to inspect because of its complex material and/or structure. It is thus useful to embark research on developing novel NDE technique to comply the inspection requirement. This work demonstrates the feasibility of using the capacitive imaging(CI) technique for the inspection of composite sucker rod. Finite element(FE) models were constructed in COMSOL to simulate the detection of defects in the glass-fiber layer and on the carbon core surface. An FE Model based inversion method is proposed to obtain the profile of the carbon core. Preliminary CI experimental results are then presented, including the detection of surface wearing defect in the glass-fiber layer, and obtaining the profile of the carbon core. A set of accelerated aging experiments were also carried out and the results indicate that the CI technique is potentially useful in evaluating the ageing status of such composite sucker rod. The CI technique described in this work shows great potential to target some challenging tasks faced in the non-destructive evaluation of composite sucker rod, including quality control, defect detection and ageing assessment. | Kefan Wang Xiaokang Yin Chen Li Wei Li Guoming Chen | 2019 | Chinese Journal of Mechanical Engineering2019，32，6： | 2 |
| 17 | Review of flash sintering with strong electric field显示文摘Flash sintering is a novel field‐assisted sintering technology for ceramics that allows a dramatic reduction in processing time and temperature.Since 2010,when flash sintering was first reported,it has been a focus of research interest in the field of materials science.Recent study results have confirmed that the sintering temperature decreases with the strength of the applied electric field;for some ceramics,the sintering temperature can be lowered even to room temperature.This represents an innovative breakthrough for ceramic sintering at ultra‐low temperatures.However,once the electric field strength in flash sintering is increased,new questions and challenges arise,such as whether or not partial discharge occurs in the green body if under electro‐thermal coupling stress,how to quantitatively analyse the impact of discharge on sintering,and,moreover,whether the sintering mechanism under a strong electric field is consistent with that under a weak electric field.These research questions require knowledge of partial discharge detection,dielectric theory,and other topics that are beyond the scope of materials science.To address this need,this review summarises the work carried out in flash sintering with a strong electric field from the perspective of high voltage and insulation technology.First,the flash sintering process and mechanism are briefly introduced.Then,the published literature on flash sintering with a strong electric field for various ceramic materials is summarised in depth.In addition,experimental phenomena that are observed in flash sintering with a strong electric field,such as flash and blackening,are discussed.Finally,some suggestions for future work are presented.It is anticipated that the knowledge gap between different areas of study can be filled by this review. | Hongyang Zhou Xiang Li Yuchen Zhu Jieming Liu Angxuan Wu Guoming Ma Xilin Wang Zhidong Jia Liming Wang | 2022 | High Voltage2022，7，1： | 2 |
| 18 | An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro显示文摘The destruction of proteins via the ubiquitin-proteasome system is amulti-step,complex process involving polyubiquitination of substrate proteins,follow ed by proteolytic degradation by the m acrom olecular 26S proteasome complex.Inhibitors of the proteasome prom ote the accum ulation of proteins that are deleterious to cell survival and are prom ising anticancer agents.Oprozomib(OPZ),an oral second-generation proteasome inhibitor,has been shown to inhibit the grow th of several cancers in preclinical and clinical trials,including m ultiple m yelom a and head and neck cancers,but its effects on lung cancer has not yet been determ ined.In this study,we evaluated the inhibitory effects of OPZ on lung cancer cell lines in vitro.The results showed that OPZ significantly suppressed cell proliferation and strongly induced apoptosis in both tested lung cancer cells independent of p53 expression.OPZ was able to cause obvious caspase 3 and PARP cleavages and stabilize p53 and its transcriptional targets p21,PUMA,and Noxa.Moreover,OPZ was capable of sensitizing lung cancer cells to the conventional chem otherapeutic drug cisplatin.Our study provides preclinical data and sheds light on the potential applications of proteasome inhibitor OPZ in lung cancer treatment. | Hongge Zhu Tianhai Wang Zhou Xin Yiyi Zhan Guoming Gu Xiaoqin Li Xiuli Wang Shune Yang Chunling Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 2 |
| 19 | Correlation of miscibility and mechanical properties of polypropylene/olefin block copolymers:Effect of chain composition显示文摘 | Guoming Liu Xiuqin Zhang Xiuhong Li | 2012 | Journal of Applied Polymer Science2012，152，1： | 1 |
| 20 | Structural optimization of 2-D array probe for ACFM显示文摘 | CHEN Guoming LI Wei WANG Zexin | 2007 | NDT&E International2007，40，6： | 1 |
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