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| 1 | State of the Art and Prospects in Metal-Organic Framework-Derived Microwave Absorption Materials显示文摘Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed. | Shuning Ren Haojie Yu Li Wang Zhikun Huang Tengfei Lin Yudi Huang Jian Yang Yichuan Hong Jinyi Liu | 2022 | Nano-Micro Letters2022，14，4： | 6 |
| 2 | A triple-RBD-based mucosal vaccine provides broad protectionagainst SARS-CoV-2 variants of concern显示文摘The rapid mutation and spread of SARS-CoV-2 variants urge the development of effective mucosal vaccines to provide broadspectrum protection against the initial infection and thereby curb the transmission potential.Here,we designed a chimeric tripleRBD immunogen,3Ro-NC,harboring one Delta RBD and two Omicron RBDs within a novel protein scaffold.3Ro-NC elicits potent and broad RBD-specific neutralizing immunity against SARS-CoV-2 variants of concern.Notably,intranasal immunization with 3RoNC plus the mucosal adjuvant KFD(3Ro-NC+KFDi.n)elicits coordinated mucosal IgA and higher neutralizing antibody specificity(closer antigenic distance)against the Omicron variant.In Omicron-challenged human ACE2 transgenic mice,3Ro-NC+KFDi.n immunization significantly reduces the tissue pathology in the lung and lowers the viral RNA copy numbers in both the lung(85.7-fold)and the nasal turbinate(13.6-fold).Nasal virologic control is highly correlated with RBD-specific secretory IgA antibodies.Our data show that 3Ro-NC plus KFD is a promising mucosal vaccine candidate for protection against SARS-CoV-2 Omicron infection,pathology and transmission potential. | Jingyi Yang Mei-Qin Liu Lin Liu Xian Li Mengxin Xu Haofeng Lin Shuning Liu Yunqi Hu Bei Li Bowen Liu Min Li Ying Sun Yao-Qing Chen Zheng-Li Shi Huimin Yan | 2022 | Cellular & Molecular Immunology2022，19，11： | 3 |
| 3 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 4 | An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro显示文摘The destruction of proteins via the ubiquitin-proteasome system is amulti-step,complex process involving polyubiquitination of substrate proteins,follow ed by proteolytic degradation by the m acrom olecular 26S proteasome complex.Inhibitors of the proteasome prom ote the accum ulation of proteins that are deleterious to cell survival and are prom ising anticancer agents.Oprozomib(OPZ),an oral second-generation proteasome inhibitor,has been shown to inhibit the grow th of several cancers in preclinical and clinical trials,including m ultiple m yelom a and head and neck cancers,but its effects on lung cancer has not yet been determ ined.In this study,we evaluated the inhibitory effects of OPZ on lung cancer cell lines in vitro.The results showed that OPZ significantly suppressed cell proliferation and strongly induced apoptosis in both tested lung cancer cells independent of p53 expression.OPZ was able to cause obvious caspase 3 and PARP cleavages and stabilize p53 and its transcriptional targets p21,PUMA,and Noxa.Moreover,OPZ was capable of sensitizing lung cancer cells to the conventional chem otherapeutic drug cisplatin.Our study provides preclinical data and sheds light on the potential applications of proteasome inhibitor OPZ in lung cancer treatment. | Hongge Zhu Tianhai Wang Zhou Xin Yiyi Zhan Guoming Gu Xiaoqin Li Xiuli Wang Shune Yang Chunling Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 2 |
| 5 | Downregulation of MANCR inhibits cancer cell proliferation in mantle cell lymphoma possibly by interacting with RUNX2显示文摘The mitotically associated lncRNA(MANCR)participates in breast cancer cell proliferation,while its involvement in other cancers is still unknown.In this study,we therefore studied the role of MANCR in mantle cell lymphoma(MCL).We found that serum MANCR and Runt-related transcription factor 2(RUNX2)were upregulated in MCL patients when compared with those in healthy controls.A positive correlation between serum MANCR and RUNX2 was found in MCL patients but not in controls.Upregulation of serum MANCR distinguished MCL patients from controls.MANCR overexpression promoted RUNX2 expression in MCL cells,while RUNX2 overexpression failed to significantly change the expression levels of MANCR.MANCR overexpression promoted the proliferation of MCL cells,while MANCR silencing inhibited the proliferation of MCL cells.In addition,RUNX2 overexpression attenuated the inhibitory effects of MANCR silencing on cell proliferation.However,MANCR overexpression and silencing had no significant effects on cell migration and invasion.Further bioinformatics analysis showed that MANCR may sponge miR-218 to upregulate RUNX2.Therefore,we conclude that downregulation of MANCR may inhibit cancer cell proliferation in MCL possibly by interacting with RUNX2. | Shujuan Wen Min Zeng Yan Li Xin Hu Shan Li Xiao Liang Lin Zhu Shune Yang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 1 |
| 6 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 7 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
| 8 | Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis显示文摘DearEditor,Indole-3-carboxaldehyde(ICA)is a gut microbe-derived tryptophan metabolite.Here,we explored the role of ICA in atherosclerosis.Plasma tryptophan metabolites were measured in healthy individuals and patients with atherosclerosis(Supplementary Table S1).The latter group showed disturbed tryptophan metabolism,while no difference was observed in tryptophan levels between the two groups(Fig.1a).ICA concentration is lower in the patients group(Fig.1b),consistent with previous clinical studies.1 The concentration of other metabolites of kynurenine or serotonin pathway showed no variations between the control and the patients(Supplementary Fig.1a). | Yijing Lu Wenlong Yang Zhiyong Qi Rifeng Gao Jing Tong Tingwen Gao Yin Zhang Aijun Sun Shuning Zhang Junbo Ge | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 9 | Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors显示文摘Cell metabolism plays vital roles in organismal development,but it has been much less studied than transcriptional and epigenetic control of developmental programs.The difficulty might be largely attributed to the lack of in situ metabolite assays.Genetically encoded fluorescent sensors are powerful tools for noninvasive metabolic monitoring in living cells and in vivo by highly spatiotemporal visualization.Among all living organisms,the NAD(H)and NADP(H)pools are essential for maintaining redox homeostasis and for modulating cellular metabolism.Here,we introduce NAD(H)and NADP(H)biosensors,present example assays in developing organisms,and describe promising prospects for how sensors contribute to developmental biology research. | Ting Li Yejun Zou Shuning Liu Yi Yang Zhuo Zhang Yuzheng Zhao | 2022 | Cell Regeneration2022，11，1： | 0 |
| 10 | An all-in-one FeO_(x)-rGO sponge fabricated by solid-phase microwave thermal shock for water evaporation and purification显示文摘Developing high-efficiency photothermal seawater desalination devices is of significant importance in addressing the shortage of freshwater.Despite much effort made into photothermal materials,there is an urgent need to design a rapidly synthesized photothermal evaporator for the comprehensive purification of complex seawater.Therefore,we report on all-in-one FeOx-rGO photothermal sponges synthesized via solid-phase microwave thermal shock.The narrow band gap of the semiconductor material Fe_(3)O_(4) greatly reduces the recombination of electron-hole pairs,enhancing non-radiative relaxation light absorption.The abundantπorbitals in rGO promote electron excitation and thermal vibration between the lattices.Control of the surface hydrophilicity and hydrophobicity promotes salt resistance while simultaneously achieving the purification of various complex polluted waters.The optimized GFM-3 sponge exhibitedan enhanced photothermal conversion rate of 97.3% and a water evaporation rate of 2.04 kg/(m^(2)·hr),showing promising synergistic water purification properties.These findings provide a highly efficient photothermal sponge for practical applicationsof seawater desalination and purification,as well as develop a super-rapid processing methodology for evaporation devices. | Youkun Sun Xiuwen Zhao Xueling Song Jinchen Fan Junhe Yang Yingchun Miao Shuning Xiao | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 11 | Learning Single-Shot Detector with Mask Prediction and Gate Mechanism显示文摘Detection efficiency plays an increasingly important role in object detection tasks.One-stage methods are widely adopted in real life because of their high efficiency especially in some real-time detection tasks such as face recognition and self-driving cars.RetinaMask achieves significant progress in the field of one-stage detectors by adding a semantic segmentation branch,but it has limitation in detecting multi-scale objects.To solve this problem,this paper proposes RetinaMask with Gate(RMG)model,consisting of four main modules.It develops RetinaMask with a gate mechanism,which extracts and combines features at different levels more effectively according to the size of objects.It firstly extracted multi-level features from input image by ResNet.Secondly,it constructed a fused feature pyramid through feature pyramid network,then gate mechanism was employed to adaptively enhance and integrate features at various scales with the respect to the size of object.Finally,three prediction heads were added for classification,localization and mask prediction,driving the model to learn with mask prediction.The predictions of all levels were integrated during the post-processing.The augment network shows better performance in object detection without the increase of computation cost and inference time,especially for small objects. | Jingyi Chen Haiwei Pan Qianna Cui Yang Dong Shuning He | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
| 12 | Reduced ABO blood group antibody titers in patients after CD19 CAR-T cell therapy显示文摘1.INTRODUCTION With rapid developments in genetic engineering,tumor immunology,and cellular engineering,chimeric antigen receptor T cell(CAR-T)cell therapy has become a novel immunotherapy for oncology and other medical fields.1 The promising results of CD19 CAR-T treating B-cell malignancies were reported.2,3 Simultaneously,there existed many adverse events,the most reported of which including B-cell aplasia,hematological toxicity,cytokine release syndrome(CRS),and immune effector-cell–associated neurotoxicity syndrome(ICANS),3,4 but there is still lack of reports demonstrating the impact of CD19 CAR-T on the ABO blood group potency of patient’s serum. | Qiang Li Zhihuan Yang Kuo Fang Shuning Wei Jiali Sun Wei Liu Xiaojuan Chen Wenyang Huang Guangji Zhang Yin Shi Yuntao Liu Xiaoyuan Gong Fang Liu Xueli Zhou Jianxiang Wang Ying Wang | 2023 | Blood Science2023，5，1： | 0 |
| 13 | Micromechanical interlocking structure at the filler/resin interface for dental composites: a review显示文摘Dental resin composites(DRCs)are popular materials for repairing caries or dental defect,requiring excellent properties to cope with the complex oral environment.Filler/resin interface interaction has a significant impact on the physicochemical/biological properties and service life of DRCs. | Shuning Zhang Xiao Wang Jiawei Yang Hongyan Chen Xinquan Jiang | 2023 | International Journal of Oral Science2023，15，2： | 0 |
| 14 | Effect of Na^(+)and Sr^(2+)Substitution on the Formation of the Oxygen Vacancies in Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+)Phosphor显示文摘The low-valence cations Na^(+)and Sr^(2+)were selected as the co-dopants to increase the vacancies concentration in the Y_(2.982)Ce_(0.018)Al_(2)Ga_(3)O_(12)phosphor.The successful incorporation of Na^(+)and Sr^(2+)was confirmed by the X-Ray Difiraction(XRD)results.All the samples show 5d-4f green persistent luminescence of Ce^(3+)after 450 nm excitation.The decay curves demonstrate that the persistent luminescence is efiectively enhanced with Na+and Sr2+doping.The thermoluminescence glow curves also show not only does the trap concentration increase,but also the distribution of trap depths is broadened.In addition,the air-and H_(2)/Ar-annealing treatments were conducted on every as-made sample.The experimental results prove that the increased traps after the Na^(+)/Sr^(2+)doping are mainly attributed to the oxygen vacancies,and the traps have a continuous and broad distribution of trap depths.We hope this work could give new inspiration for designing a high-performance persistent phosphor. | YANG Ting JIANG Hongyi DONG Ye GAO Shuai LIU Shuning | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，5： | 0 |
| 15 | Ultra-lightweight ceramic scaffolds with simultaneous improvement of pore interconnectivity and mechanical strength显示文摘The high porosity and interconnectivity of scaffolds are critical for nutrient transmission in bone tis-sue engineering but usually lead to poor mechanical properties.Herein,a novel method that combines acid etching(AE)with selective laser sintering(SLS)and reaction bonding(RB)of Al particles is pro-posed to realize highly improved porosity,interconnectivity,mechanical strength,and in vitro bioactivity in 3D Al_(2)O_(3) scaffolds.By controlling the oxidation and etching behaviors of Al particles,a tunable hol-low spherical feature can be obtained,which brings about the distinction in compressive response and fracture path.The prevention of microcrack propagation on the in situ formed hollow spheres results in unique near elastic buckling rather than traditional brittle fracture,allowing an unparalleled compressive strength of 3.72±0.17 MPa at a high porosity of 87.7%±0.4%and pore interconnectivity of 94.7%±0.4%.Furthermore,scaffolds with an optimized pore structure and superhydrophilic surface show excellent cell proliferation and adhesion properties.Our findings offer a promising strategy for the coexistence of out-standing mechanical and biological properties,with great potential for tissue engineering applications. | Ye Dong Annan Chen Ting Yang Shuai Gao Shuning Liu Hongyi Jiang Yusheng Shi Chenglong Hu | 2023 | Journal of Materials Science & Technology2023，，6： | 0 |
| 16 | Applying the Theory of Similarity in Distributed Knowledge-Based Systems | DAI Jianshe HUANG Yong YANG Xiaoyin WANG Shuning(Department of Automation Control Engineering)Huazhong(University of Science and Technology, Woman 430074, China) | 1996 | Systems Science and Systems Engineering1996，6，2： | 0 |
| 17 | The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma显示文摘Osteosarcoma(OS)patients have a poor prognosis due to its high degree of heterogeneity and high rate of metastasis.Magnetic hyperthermia therapy(MHT)combined with immunotherapy is an effective strategy to treat solid and metastatic tumors.Here,we combined biodegradable magnesium(Mg)macroscale rods,which acted as an eddy thermo-magnetic agent under a low external alternating magnetic field,and immunotherapy to achieve a radical cure for OS.The eddy thermal effect(ETE)of the Mg rods(MgR)showed outstanding cytotoxic effects and enhanced the maturation of dendritic cells(DCs),and the mild MHT induced the immunogenic cell death(ICD)in the OS cells.Combined with immune checkpoint blockade(ICB)therapy,we obtained an excellent curative effect against OS,and a further evaluation demonstrated that the local MHT induced by the MgR increased T cells infiltration and the polarization of M1 macrophages.Interestingly,the biodegradable MgR also promoted bone osteogenesis.Our work highlighted the uneven ETE mediated by the biodegradable MgR induced a comprehensive immunologic activation in the OS tumor microenvironment(TME),which would inspire the application of MHT for the effective treatment of OS. | Jun Ge Nailin Yang Yuqi Yang Hao Yu Xiaoyuan Yang Yingjie Wang Tianyi Wang Shuning Cheng Yuanjie Wang Zhihui Han Yun Teng Jun Zou Huilin Yang Liang Cheng | 2023 | Bioactive Materials2023，，7： | 0 |
| 18 | Exact Boundary Controllability of Fifth-order KdV Equation Posed on the Periodic Domain显示文摘In this paper,we show by Hilbert Uniqueness Method that the boundary value problem of fifth-order KdV equation{y_(t)-y_(5x)=0,(x,t)∈(0,2π)×(0,T),y(t,2π)-y(t,0)=h_(0)(t),y_(x)(t,2π)-y_(x)(t,0)=h_(1)(t),y_(2x)(t,2π)-y_(2x)(t,0)=h_(2)(t),y_(3x)(t,2π)-y_(3x)(t,0)=h_(3)(t),y_(4x)(t,2π)-y_(4x)(t,0)=h_(4)(t),(with boundary data as control inputs)is exact controllability. | YANG Shuning ZHAO Xiangqing | 2022 | Journal of Partial Differential Equations2022，35，2： | 0 |
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