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| 1 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 2 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 3 | Analysis of Tianchi volcano activity in Changbai Mountain,NE China显示文摘Changbaishan volcano is the largest potential eruptive volcano in China.In this paper,seismic activity,horizontal displacement,vertical displacement and the fluid geochemistry data acquiring from Changbaishan Tianchi Volcano Observatory(TVO) in recent years are analyzed.The authors discussed the ability for the Changbaishan volcanic seismic monitoring and active level of Changbaishan volcano in recent years based on the fundamental monitoring results.The results show that Changbaishan volcano has experienced an unrest episode from 2002 to 2005,but its active level recovers to the background now. | LIU Guoming YANG Jingkui WANG Lijuan SUN Jicai | 2011 | Global Geology2011，14，1： | 7 |
| 4 | Application and future perspective of CRISPR/Cas9 genome editing in fruit crops显示文摘Fruit crops, including apple, orange, grape,banana, strawberry, watermelon, kiwifruit and tomato, not only provide essential nutrients for human life but also contribute to the major agricultural output and economic growth of many countries and regions in the world. Recent advancements in genome editing provides an unprecedented opportunity for the genetic improvement of these agronomically important fruit crops. Here, we summarize recent reports of applying CRISPR/Cas9 to fruit crops,including efforts to reduce disease susceptibility, change plant architecture or flower morphology, improve fruit quality traits, and increase fruit yield. We discuss challenges facing fruit crops as well as new improvements and platforms that could be used to facilitate genome editing in fruit crops, including d Cas9-base-editing to introduce desirable alleles and heat treatment to increase editing efficiency. In addition, we highlight what we see as potentially revolutionary development ranging from transgene-free genome editing to de novo domestication of wild relatives. Without doubt, we now see only the beginning of what will eventually be possible with the use of the CRISPR/Cas9 toolkit. Efforts to communicate with the public and an emphasis on the manipulation of consumerfriendly traits will be critical to facilitate public acceptance of genetically engineered fruits with this new technology. | Junhui Zhou Dongdong Li Guoming Wang Fuxi Wang Merixia Kunjal Dirk Joldersma Zhongchi Liu | 2020 | Journal of Integrative Plant Biology2020，62，3： | 7 |
| 5 | Multistring analysis of wellhead movement and uncemented casing strength in offshore oil and gas wells显示文摘This paper presents a theoretical method and a finite element method to describe wellhead movement and uncemented casing strength in offshore oil and gas wells. Parameters considered in the theoretical method include operating load during drilling and completion and the temperature field, pressure field and the end effect of pressure during gas production. The finite element method for multistring analysis is developed to simulate random contact between casings. The relevant finite element analysis scheme is also presented according to the actual procedures of drilling, completion and gas production. Finally, field cases are presented and analyzed using the proposed methods. These are four offshore wells in the South China Sea. The calculated wellhead growths during gas production are compared with measured values. The results show that the wellhead subsides during drilling and completion and grows up during gas production. The theoretical and finite element solutions for wellhead growth are in good agreement with measured values and the deviations of calculation are within 10%. The maximum von Mises stress on the uncemented intermediate casing occurs during the running of the oil tube. The maximum von Mises stress on the uncemented production casing, calculated with the theoretical method occurs at removing the blow-out-preventer(BOP) while that calculated with the finite element method occurs at gas production. Finite element solutions for von Mises stress are recommended and the uncemented casings of four wells satisfy strength requirements. | Liu Xiuquan Chen Guoming Chang Yuanjiang Zhang Lei Zhang Weiguo Xie Hua | 2014 | Petroleum Science2014，11，1： | 7 |
| 6 | Multimodal hyperspectral remote sensing:an overview and perspective显示文摘Since the advent of hyperspectral remote sensing in the 1980 s,it has made important achievements in aerospace and aviation field and been applied in many fields.Conventional hyperspectral imaging spectrometer extends the number of spectral bands to dozens or hundreds,and provides spatial distribution of the reflected solar radiation from the scene of observation at the same time.Nowadays,with the fast development of new technology in the fields of information and photoelectricity sensing,and the popularity of unmanned aerial vehicle,hyperspectral remote sensing imaging presents the new trends of multimodality and acquires integration information while keeping high or very-high spectral resolution,especially,high temporal even real time sensing and stereo sensing.Therefore,three important modes of hyperspectral imaging come into existence:(1)multitemporal hyperspectral imaging,which refers to the observation of same region at different dates;(2)hyperspectral video imaging,which captures full frame spectral images in real-time;(3)hyperspectral stereo imaging,which obtains the full dimension information(including 2D image,elevation,and spectra)of observed scene.Along this perspective,firstly,the current researches on hyperspectral remote sensing and image processing are briefly reviewed,and then,comprehensive descriptions of the aforementioned three main hyperspectral imaging modes are carried out from the following four aspects:fundamental principle of new mode of hyperspectral imaging,corresponding scientific data acquisition,data processing and application,and potential challenges in data representation,feature learning and interpretation.Through the analysis of development trend of hyperspectral imaging and current research situation,we hope to provide a direction for future research on multimodal hyperspectral remote sensing. | Yanfeng GU Tianzhu LIU Guoming GAO Guangbo REN Yi MA Jocelyn CHANUSSOT Xiuping JIA | 2021 | Science China(Information Sciences)2021，64，2： | 6 |
| 7 | Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis显示文摘Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis,intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8?T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8?T cells are involved in the pathogenesis of RE. | Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan | 2018 | Virologica Sinica2018，33，5： | 4 |
| 8 | Removal of perchlorate from aqueous solution by cross-linked Fe(Ⅲ)-chitosan complex显示文摘Cross-linked Fe(III)-chitosan composite(Fe-CB) was used as the adsorbent for removing perchlorate from the aqueous solution. The adsorption experiments were carried out by varying contact time, initial concentrations, temperatures, pH, and the presence of co-existing anions. The morphology of the adsorbent was discussed using FT-IR and SEM with X-EDS analysis. The pH ranging from 3.0–10.2 exhibited very little effect on the adsorption capability. The perchlorate uptake onto Fe-CB obeyed Langmuir isotherm model. The adsorption process was rapid and the kinetics data obeyed the pseudo second-order model well. The eluent of 2.5%(W/V) NaCl could regenerate the exhausted adsorbent efficiently. The adsorption mechanism was also discussed. | Long Lv Yanhua Xie Guoming Liu Guo Liu Jing Yu | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 9 | Deep feature extraction and motion representation for satellite video scene classification显示文摘Satellite video scene classification(SVSC)is an advanced topic in the remote sensing field,which refers to determine the video scene categories from satellite videos.SVSC is an important and fundamental step for satellite video analysis and understanding,which provides priors for the presence of objects and dynamic events.In this paper,a two-stage framework is proposed to extract spatial features and motion features for SVSC.More specifically,the first stage is designed to extract spatial features for satellite videos.Representative frames are firstly selected based on the blur detection and spatial activity of satellite videos.Then the fine-tuned visual geometry group network(VGG-Net)is transferred to extract spatial features based on spatial content.The second stage is designed to build motion representation for satellite videos.The motion representation of moving targets in satellite videos is first built by the second temporal principal component of principal component analysis(PCA).Second,features from the first fully connected layer of VGG-Net are used as high-level spatial representation for moving targets.Third,a small network of long and short term memory(LSTM)is further designed for encoding temporal information.Two-stage features respectively characterize spatial and temporal patterns of satellite scenes,which are finally fused for SVSC.A satellite video dataset is built for video scene classification,including 7209 video segments and covering 8 scene categories.These satellite videos are from Jilin-1 satellites and Urthecast.The experimental results show the efficiency of our proposed framework for SVSC. | Yanfeng GU Huan LIU Tengfei WANG Shengyang LI Guoming GAO | 2020 | Science China(Information Sciences)2020，63，4： | 4 |
| 10 | Elevated expression of EBV and TLRs in the brain is associated with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare pediatric neurological disorder, the etiology of which remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor in triggering RE immunopathogenesis. In this study, we analyzed the expression of Epstein-Barr virus(EBV) antigens as well as of Toll-like receptor 3(TLR3), TLR9, and downstream adapter TIRdomain-containing adapter-inducing interferon-β(TRIF) in the brain tissues of 26 patients with RE and 16 control individuals using immunohistochemistry(IHC). In the RE group, EBV antigens were detected in 53% of individuals at various expression levels. In contrast, there was no detectable EBV antigen expression in control brain tissues. Moreover, we found marked increases in the expression of TLR3, TLR9, and TRIF in the brain tissues of RE patients compared with levels in the control group. Furthermore, among RE cases, EBV expression and high TLR3 expression were associated with more severe brain atrophy. Our results suggest that the elevated expression of EBV and TLRs may be involved in RE occurrence through the activation of downstream molecules. | Xin Wang Yisong Wang Dong Liu Peigang Wang Dongying Fan Yuguang Guan Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，5： | 3 |
| 11 | Transforming the Loess Plateau of China显示文摘This paper aims to show the importance of land consolidation in transforming the Loess Plateau of China. The paper comprehensively analyzes how over recent decades the Grain for Green Project and Gully Land Consolidation Project jointly transformed the ecology and landscape of the Loess Plateau and the livelihood of its residents. The findings show that these two projects have achieved a balance between green protection, new land creation, and improved food security and livelihood of local people in the hilly areas of China. The paper points out that the successful transformation of the Plateau lies in a holistic approach incorporating various components of the human and natural systems. Finally, the paper highlights the necessity of retaining these two land consolidation projects as part of an ongoing policy in the mountain and hilly areas of China, changing agricultural management to suit the new relationship between humans and the land. | Yuheng LI Guoming DU Yansui LIU | 2016 | Frontiers of Agricultural Science and Engineering2016，3，3： | 3 |
| 12 | Experimental investigation of a Portevin-Le Chatelier band in Ni–Co-based superalloys in relation toγ’precipitates at 500℃显示文摘The macroscopically localized deformation behaviors of Ni–Co-based superalloys with differentγ’precipitate content were investigated at 500?C and 1×10-4 s-1 via an in situ method namely,digital image correlation(DIC).The DIC results showed that the serrated flow of the stress–strain curves was accompanied by localized deformation of the specimens.The fracture morphology was characterized mainly by transgranular fracture with numerous dimples in the lowγ’content alloy,and intergranular fracture with large fracture section in the highγ’content alloy.The Portevin–Le Chatelier(PLC)effect occurred in the investigated Ni–Co-based superalloys.Furthermore,the localized deformation of the highγ’content alloy was more severe than that of the lowγ’content alloy,and the band width was slightly larger.Moreover,for the first-time ever,a special propagation feature,namely±60?zigzag bands characterized by head-to-tail connections,was observed in the highγ’content alloy. | Yanke Liu Yulong Cai Chenggang Tian Guoliang Zhang Guoming Han Shihua Fu Chuanyong Cui Qingchuan Zhang | 2020 | Journal of Materials Science & Technology2020，47，14： | 2 |
| 13 | Review of flash sintering with strong electric field显示文摘Flash sintering is a novel field‐assisted sintering technology for ceramics that allows a dramatic reduction in processing time and temperature.Since 2010,when flash sintering was first reported,it has been a focus of research interest in the field of materials science.Recent study results have confirmed that the sintering temperature decreases with the strength of the applied electric field;for some ceramics,the sintering temperature can be lowered even to room temperature.This represents an innovative breakthrough for ceramic sintering at ultra‐low temperatures.However,once the electric field strength in flash sintering is increased,new questions and challenges arise,such as whether or not partial discharge occurs in the green body if under electro‐thermal coupling stress,how to quantitatively analyse the impact of discharge on sintering,and,moreover,whether the sintering mechanism under a strong electric field is consistent with that under a weak electric field.These research questions require knowledge of partial discharge detection,dielectric theory,and other topics that are beyond the scope of materials science.To address this need,this review summarises the work carried out in flash sintering with a strong electric field from the perspective of high voltage and insulation technology.First,the flash sintering process and mechanism are briefly introduced.Then,the published literature on flash sintering with a strong electric field for various ceramic materials is summarised in depth.In addition,experimental phenomena that are observed in flash sintering with a strong electric field,such as flash and blackening,are discussed.Finally,some suggestions for future work are presented.It is anticipated that the knowledge gap between different areas of study can be filled by this review. | Hongyang Zhou Xiang Li Yuchen Zhu Jieming Liu Angxuan Wu Guoming Ma Xilin Wang Zhidong Jia Liming Wang | 2022 | High Voltage2022，7，1： | 2 |
| 14 | An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro显示文摘The destruction of proteins via the ubiquitin-proteasome system is amulti-step,complex process involving polyubiquitination of substrate proteins,follow ed by proteolytic degradation by the m acrom olecular 26S proteasome complex.Inhibitors of the proteasome prom ote the accum ulation of proteins that are deleterious to cell survival and are prom ising anticancer agents.Oprozomib(OPZ),an oral second-generation proteasome inhibitor,has been shown to inhibit the grow th of several cancers in preclinical and clinical trials,including m ultiple m yelom a and head and neck cancers,but its effects on lung cancer has not yet been determ ined.In this study,we evaluated the inhibitory effects of OPZ on lung cancer cell lines in vitro.The results showed that OPZ significantly suppressed cell proliferation and strongly induced apoptosis in both tested lung cancer cells independent of p53 expression.OPZ was able to cause obvious caspase 3 and PARP cleavages and stabilize p53 and its transcriptional targets p21,PUMA,and Noxa.Moreover,OPZ was capable of sensitizing lung cancer cells to the conventional chem otherapeutic drug cisplatin.Our study provides preclinical data and sheds light on the potential applications of proteasome inhibitor OPZ in lung cancer treatment. | Hongge Zhu Tianhai Wang Zhou Xin Yiyi Zhan Guoming Gu Xiaoqin Li Xiuli Wang Shune Yang Chunling Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 2 |
| 15 | Correlation of miscibility and mechanical properties of polypropylene/olefin block copolymers:Effect of chain composition显示文摘 | Guoming Liu Xiuqin Zhang Xiuhong Li | 2012 | Journal of Applied Polymer Science2012，152，1： | 1 |
| 16 | al,A simple hydrophilicpalladium ( II) complex as a highly efficient catalyst forroom temperature aerobic Suzuki coupling reactions in a-queous media显示文摘 | GuoM P Liu S W Zhou X L et | 2014 | Molecules2014，19，5： | 1 |
| 17 | Comparison of different detoxification methods for corn cob hemicelluose hydrolysate to improve ethanol production by Candida shehatae ACCC 20335显示文摘 | Ge Jingping Cai Baiyan Liu Guoming | 2011 | African Journal of Microbiology Research2011，5，10： | 1 |
| 18 | Preparation and antimicrobial activity of rosin- based carbamate group- containing quaternary ammonium salt derivatives 显示文摘 | Liu Guifeng Chen Caifeng Wu Guoming | 2013 | Bioresources2013，8，3： | 1 |
| 19 | miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL - 3显示文摘 | Zhengrong Li Yi Cao Zhigang Jie Yi Liu Yingliang Li Junhe Li Guoming Zhu Zhengren Liu Yi Tu Gen Peng Dong-woo Lee Sung-soo Park | 2012 | Cancer Letters2012，，1： | 1 |
| 20 | FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release显示文摘The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and sensitivity.In this work,we report a p H-responsive theranostic nanoplatform based on Fe OOH clusters loaded mesoporous silica nanoparticles(Fe@MSNs).The as-synthesized Fe@MSNs possess activatable T_1magnetic resonance imaging(MRI)performance that can respond to the acidic microenvironment of solid tumor to turn on T_1singals by releasing paramagnetic Fe^(3+)ions.The Fe@MSNs are biocompatible without appreciable cytotoxicity.Moreover,the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid tumor.We believe that this novel p H-responsive theranostic nanoplatform holds great promise in cancer treatment. | Guoming Huang Rui Liu Yuehua Hu Shi-Hua Li Ying Wu Yuan Qiu Jingying Li Huang-Hao Yang | 2018 | Science China Chemistry2018，61，7： | 1 |
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