|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endocrine role of bone in the regulation of energy metabolism显示文摘Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function.Recently,an increasing number of studies have characterized the significance of bone as an endocrine organ,suggesting that bone-derived factors regulate local bone metabolism and metabolic functions.In addition,these factors can regulate global energy homeostasis by altering insulin sensitivity,feeding behavior,and adipocyte commitment.These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis,treatment,and prevention of metabolic diseases such as osteoporosis,obesity,and diabetes mellitus.In this review,we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research. | Ruoyu Zhou Qiaoyue Guo Ye Xiao Qi Guo Yan Huang Changjun Li Xianghang Luo | 2021 | Bone Research2021，9，4： | 11 |
| 2 | FluxExplorer: A general platform for modeling and analyses of metabolic net-works based on stoichiometry显示文摘Stoichiometry-based analyses of meta- bolic networks have aroused significant interest of systems biology researchers in recent years. It is necessary to develop a more convenient modeling platform on which users can reconstruct their network models using completely graphical operations, and explore them with powerful analyzing modules to get a better understanding of the properties of metabolic systems. Herein, an in silico platform, FluxExplorer, for metabolic modeling and analyses based on stoichiometry has been developed as a publicly available tool for systems biology research. This platform integrates various analytic approaches, in- cluding flux balance analysis, minimization of meta- bolic adjustment, extreme pathways analysis, shadow prices analysis, and singular value decom- position, providing a thorough characterization of the metabolic system. Using a graphic modeling process, metabolic networks can be reconstructed and modi- fied intuitively and conveniently. The inconsistencies of a model with respect to the FBA principles can be proved automatically. In addition, this platform sup- ports systems biology markup language (SBML). FluxExplorer has been applied to rebuild a metabolic network in mammalian mitochondria, producing meaningful results. Generally, it is a powerful and very convenient tool for metabolic network modeling and analysis. | LUO Ruoyu LIAO Sha ZENG Shaoqun LI Yixue LUO Qingming | 2006 | Chinese Science Bulletin2006，51，6： | 6 |
| 3 | Effect of Quercetin on Breeding and Apoptosis of Cervical Cancer HeLa Cell and on Growth of Transplanted Tumor in Nude Mice显示文摘Effect of quercetin on HeLa cell system of cervical cancer was studied by methods of MTT and Annexin V-FITC/PI. The results show that quercetin has functions of inhibiting breeding of HeLa cells and inducing apoptosis of the cells. The total apoptosis rate is positively proportional to reaction duration and concentration of quercetin used. The maximum apoptosis rate being (88.76±2.35)% was obtained when the concentration was 50.0 μmol/L and the cells were treated with quercetin for 72 hours. Based on establishing a model of tumor of cervical cancer transplanted into nude mice,quercetin of different concentrations was injected into abdominal cavity of nude mice and situation of tumor growth was reviewed. The result showed that with quercetin concentration increasing from 0 to 100.0 μmol/L,the transplantation volume and weight of the tumors decreased from (279.59±70.58) mm3 and ( 0.145±0.019) g to (128.72±36.12) mm3 and (0.089± 0.019) g respectively,while apoptosis rate of the transplanted tumor increased from (9.63±1.85)% to (34.98±0.47)%,which proved that quercetin inhibited increment of volume and weight of transplanted tumor in nude mice bodies. | ZHANG Wei XU Xiaoxia CHEN Hong ZHANG Jie ZHANG Xiaobing LUO Ruoyu FANG Furong | 2007 | Wuhan University Journal of Natural Sciences2007，12，3： | 2 |
| 4 | Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration显示文摘Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted by the preformed traditional bone graft substitute. Therefore, the injectable hydrogels have attracted an increasing interest for bone repair because of their fittability and mini-invasivity. However, the uncontrollable spreading or mechanical failures during its manipulation remain a problem to be solved. Moreover, in order to achieve vascularized bone regeneration, alternatives of osteogenic and angiogenic growth factors should be adopted to avoid the problem of immunogenicity and high cost. In this study, a novel injectable self-healing hydrogel system (GMO hydrogel) loaded with KP and QK peptides had been developed for enhancing vascularized regeneration of small irregular bone defect. The dynamic imine bonds between gelatin methacryloyl and oxidized dextran provided the GMO hydrogel with self-healing and shear-thinning abilities, which led to an excellent injectability and fittability. By photopolymerization of the enclosed GelMA, GMO hydrogel was further strengthened and thus more suitable for bone regeneration. Besides, the osteogenic peptide KP and angiogenic peptide QK were tethered to GMO hydrogel by Schiff base reaction, leading to desired releasing profiles. In vitro, this composite hydrogel could significantly improve the osteogenic differentiation of BMSCs and angiogenesis ability of HUVECs. In vivo, KP and QK in the GMO hydrogel demonstrated a significant synergistic effect in promoting new bone formation in rat calvaria. Overall, the KP and QK loaded GMO hydrogel was injectable and self-healing, which can be served as an efficient approach for vascularized bone regeneration via a minimally invasive approach. | Runze Li Chen Zhou Jun Chen Haotian Luo Ruoyu Li Danying Chen Xuenong Zou Weicai Wang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 5 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 6 | p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis显示文摘Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is unclear.Methods: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological phenotypes.The RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease phenotypes.Results: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc^(-/-)WRN^(-/-)p53^(S/S)(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and Hnf1b.Conclusions: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis. | Haili Li Yongjin Zhang Juhua Dan Ruoyu Zhou Cui Li Rong Li Xiaoming Wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 7 | Review on HVDC cable terminations显示文摘With modern power utilities going green by utilising renewable energy technologies and the development of the smart power grid,high-voltage direct current(HVDC)technologies become more and more important in the energy transmission.In particular,HVDC cable systems play a prominent role in undersea power transmission and offshore renewable energy integration.As an essential part of a complete HVDC cable system,the cable termination is one of the most critical components.The mathematical and physical background of HVDC cable systems is discussed and the development of various types of HVDC cable terminations is reviewed.Regarding the non-uniform field distribution,the influence of temperature on the non-linear conductivity is briefly discussed.Furthermore,faults of terminations caused by inappropriate installation and testing of cable systems are discussed. | Hanyu Ye Tobias Fechner Xianzhang Lei Yi Luo Mingyu Zhou Zhengyi Han Haitian Wang Qikai Zhuang Ruoyu Xu Duo Li | 2018 | High Voltage2018，3，2： | 1 |
| 8 | CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity显示文摘Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation.Mechanisms underlying antipsychotics cardiotoxicity remain largely unknown.Herein we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics cardiotoxicity.Pyroptosis-based small-molecule compound screen identified cannabinoid receptor 1(CB1R)as an upstream regulator of the NLRP3 inflammasome.Mechanistically,antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm,where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177–209,rendering stabilization of the inflammasome.Knockout of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and cardiotoxicity.Multi-organ-based investigation revealed no additional toxicity of newer CB1R antagonists.In authentic human cases,the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced cardiotoxicity.These results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and smallmolecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics. | Liliang Li Pan Gao Xinru Tang Zheng Liu Mengying Cao Ruoyu Luo Xiaoqing Li Jing Wang Xinyi Lin Chao Peng Zhihong Li Jianhua Zhang Xian Zhang Zhonglian Cao Yunzeng Zou Li Jin | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 9 | Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway显示文摘 | Jie Li Liying Xue Hongling Hao Ruoyu Li Jianmin Luo | 2014 | Tumor Biology2014，，7： | 1 |
| 10 | Facile defect engineering in ZnIn_(2)S_(4) coupled with carbon dots for rapid diclofenac degradation显示文摘Semiconductor-mediated photocatalysis is a promising photochemical process for harvesting inexhaustible solar energy to address the energy crisis and environmental issues.However,the low solar-light response and poor carrier migration are severe drawbacks that limit its practical application.Herein,we propose a convenient pathway for improving electron-hole separation and solar energy utilisation by engineering defective ZnIn2 S4 with doping of carbon dots.The optimum ZnIn2 S_(4)/CD_(2)00 nanosheet exhibited 100% diclofenac(DCF) degradation within 12 min under visible-light.The estimated photocatalytic efficiency under natural sunlight was 98.2%.Scavenging experiments and electron spin resonance(ESR) analysis indicated that the superoxide radical(O_(2)·-),photoelectron(e^(-)),hole(h^(+)) and hydroxyl radical(·OH) were the predominant contributions in the ZnIn2 S4/CD200/DCF/visible light system.Furthermore,ZnIn2 S4/CD200 exhibited excellent reusability and stability after 4 times recycling.The photodegradation routes mainly involved hydroxylation,decarboxylation,C-N bond cleavage,dechlorination,ring closure,and ring-opening.The ecological risk assessment and total organic carbon(TOC) tests exhibited desirable toxicity reduction and mineralization results.These observations not only offer a facile strategy for the construction of defective ZnIn2 S4,but also pioneer the direct utilisation of natural light for highly efficient environmental remediation. | Dongxu Yang Jialiang Liang Liang Luo Ruoyu Deng Guo Li Qiang He Yi Chen | 2021 | Chinese Chemical Letters2021，32，8： | 0 |
| 11 | Boosting the sodium storage performance of Prussian blue analogues via effective etching显示文摘Prussian blue analogues(PBAs)have gained significant popularity as cathode materials for sodium-ion batteries(SIBs)due to their remarkable features such as high capacity and convenient synthesis.However,PBAs usually suffer from kinetic problems during the electrochemical reactions due to sluggish Na~+diffusion in the large crystals,resulting in low-capacity utilization and inferior rate capability.In this study,we present a facile etching method aiming at activating the sodium storage sites and accelerating the Na~+transport of Na_2NiFe(CN)_6(denoted as NaNiHCF)by precisely controlling its morphologies.A progressive corner passivation phenomenon occurred in NaNiHCF during the etching process,which led to a substantial augmentation of the specific surface area as the morphology transitioned from a standard cube to a dice shape.Notably,by controlling the etching time,the obtained NaNiHCF-3 electrode exhibited boosted electrochemical performance with high reversible capacity of 83.5mAh g~(-1)(98.2%of its theoretical capacity),superior rate capability(71.2 mAh g~(-1)at 10 C),and stable cycling life-span at different temperatures.Both experimental and computational methods reveal the remarkably reversible structural evolution process and improved Na~+diffusion coefficient.We believe that this work can serve as an indispensable reference to tailor the structure of PBAs to obtain improved electrochemical performance. | Yanan Zhao Jian Peng Kean Chen Laibing Luo Hui Chen Hang Zhang Shulei Chou Xiangmin Feng Weihua Chen Ruoyu Cao Xinping Ai Yongjin Fang Yuliang Cao | 2023 | Science China Chemistry2023，66，11： | 0 |
| 12 | A Quasi-Funk's Section Theorem in n-Complex Space显示文摘The Funk's section theorem in the n-complex space Cn is investigated. It turns out that this theorem does not admit an extension for the class of general origin-symmetric star bodies in Cn but for a class of star bodies called generalized complex intersection bodies. A quasi-version of Funk's section theorem in Cn is established then. | LUO Ruoyu | 2015 | Wuhan University Journal of Natural Sciences2015，20，3： | 0 |
| 13 | P311 promotes typeⅡtransforming growth factor-βreceptor mediated fibroblast activation and granulation tissue formation in wound healing显示文摘Background:P311,a highly conserved 8 kDa intracellular protein,has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts.Nevertheless,how P311 regulates the differentiation and function of fibroblasts to affect granulation tissue formation remains unclear.In this work,we studied the underlying mechanisms via which P311 affects fibroblasts and promotes acute skin wound repair.Methods:To explore the role of P311,both in vitro and in vivo wound-healing models were used.Full-thickness skin excisional wounds were made in wild-type and P311−/−C57 adult mice.Wound healing rate,re-epithelialization,granulation tissue formation and collagen deposition were measured at days 3,6 and 9 after skin injury.The biological phenotypes of fibroblasts,the expression of target proteins and relevant signaling pathways were examined both in vitro and in vivo.Results:P311 could promote the proliferation and differentiation of fibroblasts,enhance the ability of myofibroblasts to secrete extracellular matrix and promote cell contraction,and then facilitate the formation of granulation tissue and eventually accelerate skin wound closure.Importantly,we discovered that P311 acts via up-regulating the expression of type II transforming growth factor-βreceptor(TGF-βRII)in fibroblasts and promoting the activation of the TGF-βRII-Smad signaling pathway.Mechanistically,the mammalian target of rapamycin signaling pathway is closely implicated in the regulation of the TGF-βRII-Smad pathway in fibroblasts mediated by P311.Conclusions:P311 plays a critical role in activation of the TGF-βRII-Smad pathway to promote fibroblast proliferation and differentiation as well as granulation tissue formation in the process of skin wound repair. | Jue Wang Ruoyu Shang Jiacai Yang Zhihui Liu Yunxia Chen Cheng Chen Wenxia Zheng Yuanyang Tang Xiaorong Zhang Xiaohong Hu Yong Huang Han-Ming Shen Gaoxing Luo Weifeng He | 2022 | Burns & Trauma2022，10，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员