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| 1 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 2 | 胸腺瘤放疗的相关定义和报告指南显示文摘放疗在胸腺肿瘤的治疗中仍然占有重要地位,但是很多细节没有明确的定义。例如,如何放疗、如何确定放疗范围、哪些患者需要放疗和如何报告放疗结果都没有统一的标准。ITMIG的成立,给解决这些问题创造了机会。但是先决条件是制定统一的定义和方法,使不同结果能被理解和比较,这也是本文的主旨。文献和形成初步建议,再提交给下一个扩展工作组(Charles hTomas, Lynn Wilson, Gregory Videtic. James Metz, Harun Badakhshi, Clifton Fuller, Franc-oie Mornex, Conrad Falkson, David Ball, and Ken Rosenzweig)审议,之后将建议提交给ITMIG多学科组进一步讨论,形成初稿(包含推荐方法和标准操作流程)后分发给所有ITMIG成员更进一步讨论并反馈意见,最终版本经ITMIG批准并被采用。 | 付浩 中国胸腺瘤协作组全体成员 Daniel Gomez Ritsuko Komaki James Yu Hitoshi Ikushima Andrea Bezjak | 2014 | 中国肺癌杂志2014，17，2： | 6 |
| 3 | Demographic Origins of the Great Recession:Implications for China显示文摘The demographic dividend,that is,the growth of the working age population aged 16years relative to younger and older age dependents,has often been cited as a crucial component of the accelerated economic growth experienced by disparate countries and regions at different points in time.Generally less emphasized are the ramifications of this process when it occurs in reverse;that is,when the relative size of the working age population begins to shrink.Related to this is the more subtle effect of changes to the age structure of the overall working age population,which can have compounding or offsetting effects in relation to the demographic dividend noted above.This paper explores how these age-related phenomena were instrumental to both the Great Depression and the Great Recession of2008.We explore how the generational composition of economic actors and the aging of the baby-boom worker may have played a role in provoking these remarkable recessionary periods.The reversal of the demographic dividend and the aging of the working age population are factors now contributing to the propagation of the global economic downturn,as witnessed in the example of Japan over the past half-century.This paper applies the lessons of the Great Depression,the Great Recession and Japan to offer a forward-looking analysis of the Chinese economy.China is on the precipice of a significant demographic shift whose implications for economic growth are explored. | Rafael Gomez Danielle Lamb | 2013 | China & World Economy2013，21，2： | 4 |
| 4 | Predictors of High-grade Esophagitis After Definitive Three-dimensional Conformal Therapy, Intensity-modulated Radiation Therapy, or Proton Beam Therapy for Non-small cell Lung Cancer显示文摘 | Daniel R. Gomez Susan L. Tucker Mary K. Martel Radhe Mohan Peter A. Balter Jose Luis Lopez Guerra Hongmei Liu Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 2 |
| 5 | Lymphopenia Association With Gross Tumor Volume and Lung V5 and Its Effects on Non-Small-Cell Lung Cancer Patient Outcomes显示文摘 | Chad Tang Zhongxing Liao Daniel Gomez Lawrence Levy Yan Zhuang Rediet A. Gebremichael David S. Hong Ritsuko Komaki James W. Welsh | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 2 |
| 6 | Technical Advances of Radiation Therapy for Thymic Malignancies显示文摘 | Daniel Gomez Ritsuko Komaki | 2010 | Journal of Thoracic Oncology ( Suppl Mali)2010，，10： | 1 |
| 7 | Thermophoretic Effects on Particles in Counterflow Laminar Diffusion Flames显示文摘 | Alessandro Gomez Daniel E. Rosner | 1993 | Combustion Science and Technology (-)1993，，5： | 1 |
| 8 | Influence of resistance-temperature models of thermistors on the behaviour of linearizing circuits显示文摘 | Slomovitz Daniel Gomez Daniel | 1990 | International Journal of Electronics1990，69，5： | 1 |
| 9 | Incidental Receipt of Cardiac Medications and Survival Outcomes Among Patients With Stage III Non–Small-Cell Lung Cancer After Definitive Radiotherapy显示文摘 | Hongmei Wang Zhongxing Liao Yan Zhuang Ying Liu Lawrence B. Levy Ting Xu Syed Wamique Yusuf Daniel R. Gomez | 2014 | Clinical Lung Cancer2014，，： | 1 |
| 10 | Inspiratory Muscle Training in Patients With COPD显示文摘 | Hildegard Sánchez Riera Teodoro Montemayor Rubio Francisco Ortega Ruiz Pilar Cejudo Ramos Daniel Del Castillo Otero Teresa Elias Hernandez Jose Castillo Gomez | 2001 | Chest2001，，3： | 1 |
| 11 | Changes in Pulmonary Function After Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, or Proton Beam Therapy for Non-Small-Cell Lung Cancer显示文摘 | Jose L. Lopez Guerra Daniel R. Gomez Yan Zhuang Lawrence B. Levy George Eapen Hongmei Liu Radhe Mohan Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 12 | A Fuzzy Language显示文摘 | Daniel Sanchez Alvarez Antonio F Gomez Skarme ta | 2004 | Fuzzy Sets and Systems2004，141，： | 1 |
| 13 | A fuzzy language显示文摘 | Daniel Sanchez Alvarez Antonio F Gomez Skarmeta | 2004 | Fuzzy Sets and Systems2004，141，： | 1 |
| 14 | Developmental changes in Ca2+ currents from newborn rat cardiomyocytes in primary culture显示文摘 | Jean -Pierre Gomez Daniel Potreau Jean -Eric Branka Guy Raymond | 1994 | Pflügers Archiv European Journal of Physiology (-)1994，，3： | 1 |
| 15 | An object-ori- ented architecture for sensorless cutting force feedback for CNC milling process monitoring and control 显示文摘 | Roberto Augusto Gomez Loenzo Pedro Daniel Alaniz Lum- breras Rene de Jesus Romero Troncoso etc | 2010 | Advances in Engineering Software2010，，41： | 1 |
| 16 | Low rate of thoracic toxicity in palliative paraspinal single-fraction stereotactic body radiation therapy显示文摘 | Daniel R. Gomez Margie A. Hunt Andrew Jackson William P. O’Meara Elena N. Bukanova Michael J. Zelefsky Yoshiya Yamada Kenneth E. Rosenzweig | 2009 | Radiotherapy and Oncology2009，，3： | 1 |
| 17 | A high-resolution transcriptome map of cell cycle reveals novel connections between periodic genes and cancer显示文摘通过房间周期的前进大部分依赖于周期的基因表示的波浪,并且为这些 transcriptome 动力学的规章的网络在肿瘤生物学的各种各样的方面作为危险的批评的点出现了。在二个连续房间期间通过人的房间的定序 RNA 骑车(> 23 亿配对读) ,我们与周期的表示识别了超过 1 000 mRNAs,非编码的 RNA 和 pseudogenes。周期的抄本在与 DNA 新陈代谢,有丝分裂,和 DNA 损坏反应有关的功能被充实,显示这些基因多半代表通常认为的房间周期管理者。用我们周期的基因的集合,我们开发了一条新途径称为的 “有丝分裂的 trait”那能由他们的 transcriptome 类似分类主要肿瘤和正常纸巾到不同房间周期阶段。由分析 >在癌症染色体地图集(TCGA ) 和数据设置的另外的表示的 4 000 件肿瘤样品,我们发现那个有丝分裂的特点显著地与基因改变,肿瘤子类型和,尤其是耐心的幸存相关。我们进一步在多重房间类型与柔韧的周期的表示定义 67 基因的一个核心集合。蛋白质作为蛋白质蛋白质相互作用的主要中心由这些基因功能编码了并且主要为房间周期前进被要求。核心基因也包括有约束力的 CTCF/RAD21 和 H3K36me3 的增加的层次有唯一的染色质特征。这些特征在的损失子宫并且肾癌症与核心的改变的表示被联系 67 基因。我们的学习为周期的基因规定建议新联系染色质的机制并且提供癌症病人结果的一个预言者。 | Daniel Dominguez Yi-Hsuan Tsai Nicholas Gomez Deepak Kumar Jha Ian Davis Zefeng Wang | 2016 | Cell Research2016，26，8： | 1 |
| 18 | Changes in Pulmonary Function After Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, or Proton Beam Therapy for Non-Small-Cell Lung Cancer显示文摘 | Jose L. Lopez Guerra Daniel R. Gomez Yan Zhuang Lawrence B. Levy George Eapen Hongmei Liu Radhe Mohan Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 19 | Seed predation and dispersal in relict Scots pine forests in southern Spain显示文摘 | JORGE C GOMEZ J M DANIEL G | 1999 | Plant Ecology1999，145，： | 1 |
| 20 | Esophageal Cancer Dose Escalation Using a Simultaneous Integrated Boost Technique显示文摘 | James Welsh Matthew B. Palmer Jaffer A. Ajani Zhongxing Liao Steven G. Swisher Wayne L. Hofstetter Pamela K. Allen Steven H. Settle Daniel Gomez Anna Likhacheva James D. Cox Ritsuko Komaki | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
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