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| 1 | Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions显示文摘AIM: To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA-induced erosions and ulcers of the stomach.METHODS: In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients (415 women, 196 men, average age 60.5 years) with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSAID-induced lesions whenever necroses of the ischemic type were found. Together with the histological report, we endosed a questionnaire to investigate the use of medication.The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings.RESULTS: At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years (43.9%) or months (29.5%). The most common indication for the use of these drugs was pain (64.3%),and the most common indication for colonoscopy was bleeding (55.5%). Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon (79.9%). A separate analysis of age and sex distribution,endoscopic and histological findings for NSAIDs alone,ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups.CONCLUSION: This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective controlled study. | Manfred Stolte Diana Karimi Michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 2 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 3 | Renal Cell Carcinoma With Tumor Thrombus Extension Into the Vena Cava: Prospective Long-Term Followup显示文摘 | Axel Haferkamp Patrick J. Bastian Hildegard Jakobi Maria Pritsch Jesco Pfitzenmaier Peter Albers Peter Hallscheidt Stefan C. Müller Markus Hohenfellner | 2007 | The Journal of Urology2007，，5： | 2 |
| 4 | Single training session for first time pelvic C-clamp users: Correct pin placement and frame assembly显示文摘 | I Hildegard K Zsoh J Balogh M | 2011 | Injury2011，15，4： | 1 |
| 5 | Synthesis and structure-activity relationships of cis-tetrahydro-phthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents显示文摘 | Margaretha V M Kirsten M B Hildegard B | 2008 | J Meal Chem2008，46，10： | 1 |
| 6 | Beyond the Search Process - Exploring Group Mem- bers' Information 显示文摘 | Hildegard J | 2009 | Information Processing & Management2009，45，1： | 1 |
| 7 | Perception of fruity and vegetative aromas in red wine显示文摘 | KAREN H SUSAN E E HILDEGARDE H | 2009 | Journal of Sensory Studies2009，24，： | 1 |
| 8 | Perception of Atrial Fibrillation Before and After Radiofrequency Catheter Ablation: Relevance of Asymptomatic Arrhythmia Recurrence显示文摘 | Gerhard Hindricks Christopher Piorkowski Hildegard Tanner Richard Kobza Jin-Hong Gerds-Li Corrado Carbucicchio Hans Kottkamp | 2005 | Circulation2005，，3： | 1 |
| 9 | Das spannungsri β korrosionverhalfen derAlZnMg-legierungen显示文摘 | Gruhl W Hildegard Cordier bonn | 1968 | Alum1968，44，7： | 1 |
| 10 | Evidence for intestinal se- cretion as an additional clearance pathway of talinolol enati- omers: concentration- and dose-dependent absorption in vitro and in vivo 显示文摘 | Ulrike W Hildegard SL Ernst M | 1996 | Pharmaceutic Res1996，13，4： | 1 |
| 11 | Sustainability issues for start-up entrepreneurs 显示文摘 | Hildegard S Sandra M Jurgen F | 2002 | Greener Management International2002，，38： | 1 |
| 12 | Inspiratory Muscle Training in Patients With COPD显示文摘 | Hildegard Sánchez Riera Teodoro Montemayor Rubio Francisco Ortega Ruiz Pilar Cejudo Ramos Daniel Del Castillo Otero Teresa Elias Hernandez Jose Castillo Gomez | 2001 | Chest2001，，3： | 1 |
| 13 | Collaborative information behavior:Exploring Kuhlthau's information search process model in a group- based educational setting显示文摘 | Hildegard J | 2006 | Information Processing & Management2006，42，1： | 1 |
| 14 | 显示文摘 | Volker Wacheck Elisabeth Heere-Ress Julius Halaschek-Wiener Trevor Lucas Hildegard Meyer Hans-Georg Eichler Burkhard Jansen | 2001 | Journal of Molecular Medicine2001，，10： | 1 |
| 15 | Beyond the search process-Exploring group members' information 显示文摘 | Hildegard J | 2009 | Information Processing & Man- agement2009，45，1： | 1 |
| 16 | Combining welfare mix and New Public Management: The case of long‐term care insurance in Germany显示文摘 | Hildegard Theobald | 2012 | International Journal of Social Welfare2012，，： | 1 |
| 17 | How to organize the digital library: reergineering and change management in the Bayerische Staatsbibliodtek, Mimic 显示文摘 | Schaffler Hildegard | 2004 | Library Hi Tech2004，22，4： | 1 |
| 18 | The effect of temperature and of dietary restriction on lifespan and reproduction in the rotifer Asplanchna brightwelli显示文摘 | CAROLE V-S HILDEGARD E E | 1982 | Experimental Gerontology1982，17，： | 1 |
| 19 | Nutrition, physical growth, and bone density in treated phenylketonuria显示文摘 | Hildegard P Hans-Joachim B | 2000 | Eur J Pediatr2000，，： | 1 |
| 20 | Effects of uranium and phosphate concentrations on ox- idative stress related responses induced in Arabidopsis thali- ana 显示文摘 | Nathalie Vanhoudt Hildegarde Vandenhove Karen Smeets | 2008 | Plant Physiology and Biochemistry2008，46，： | 1 |
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