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| 1 | 农户金融需求影响因素及其差异性——基于Probit模型和陕西286户农户调查数据的分析显示文摘以陕西省铜川市286户农户调查数据为基础,运用Probit计量经济模型,对农户金融需求的影响因素及其差异性进行了实证分析。结果显示:户主特征、家庭特征、生产经营特征、收支情况及农村金融供给市场特征等因素对农户的金融需求都有不同程度的影响,不同特征组农户金融需求的影响因素差异性显著。论文认为:应鼓励社会资本向农村金融市场转移,充分调动正规金融机构和非正规金融的积极性;在农村金融供给上,要针对不同特征农户金融需求特点,优化供给资源,提高农村金融市场效率。 | 王芳 罗剑朝 Yvon Martel | 2012 | 西北农林科技大学学报(社会科学版)2012，12，6： | 36 |
| 2 | Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations显示文摘AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. | Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，1： | 16 |
| 3 | Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease显示文摘AIM To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease.METHODS Systematic searches were performed( January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high(> 3 L) or low-volume(2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-torepeat the procedure and side effects/complications.RESULTS Out of 439 citations, 4 trials fulfilled our inclusion criteria(n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol(PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84(0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11(1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-torepeat. Further additional research is urgently required to compare contemporary products in this population. | Sophie Restellini Omar Kherad Talat Bessissow Charles Ménard Myriam Martel Maryam Taheri Tanjani Peter L Lakatos Alan N Barkun | 2017 | World Journal of Gastroenterology2017，23，32： | 16 |
| 4 | Physiopathology of splanchnic vasodilation in portal hypertension显示文摘In liver cirrhosis, the circulatory hemodynamic alterations of portal hypertension signifi cantly contribute to many of the clinical manifestations of the disease. In the physiopathology of this vascular alteration, mesen- teric splanchnic vasodilation plays an essential role by initiating the hemodynamic process. Numerous studies performed in cirrhotic patients and animal models have shown that this splanchnic vasodilation is the result of an important increase in local and systemic vasodilators and the presence of a splanchnic vascular hyporesponsiveness to vasoconstrictors. Among the molecules and factors known to be potentially involved in this arterial vasodilation, nitric oxide seems to have a crucial role in the physiopathology of this vascular alteration. However, none of the wide variety of mediators can be described as solely responsible, since this phenomenon is multifactorial in origin. Moreover, angiogenesis and vascular remodeling processes alsoseem to play a role. Finally, the sympathetic nervous system is thought to be involved in the pathogenesis of the hyperdynamic circulation associated with portal hypertension, although the nature and extent of its role is not completely understood. In this review, we discuss the different mechanisms known to contribute to this complex phenomenon. | María Martell Mar Coll Nahia Ezkurdia Imma Raurell Joan Genescà | 2010 | World Journal of Hepatology2010，2，6： | 13 |
| 5 | Gastric Cancer显示文摘 | Catherine de Martel David Forman Martyn Plummer | 2013 | Gastroenterology Clinics of North America2013，，2： | 7 |
| 6 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 7 | Global burden of cancers attributable to infections in 2008: a review and synthetic analysis显示文摘 | Catherine de Martel Jacques Ferlay Silvia Franceschi Jér?me Vignat Freddie Bray David Forman Martyn Plummer | 2012 | Lancet Oncology2012，，6： | 3 |
| 8 | 听觉躯体感觉双刺激模式通过减少大脑神经同步活动减轻豚鼠和患者的耳鸣程度显示文摘耳鸣是指患者没有受到外界声源或电刺激时,主观上耳内或颅内有声音感觉,是耳科较为常见的一种临床症状。据报道,在美国有15%的人口受到耳鸣的影响。耳鸣会严重地影响患者的生活质量,造成抑郁、焦虑、睡眠障碍和注意力不集中等困扰。然而,目前已有的耳鸣治疗方法仅能缓解患者的耳鸣反应,而不能完全治愈耳鸣。背侧耳蜗核是哺乳动物听觉通路上第一个多感官融合的位点,其主要的输出神经元细胞是梭形细胞。在耳鸣的中枢化机制中,耳鸣是由于神经活动节律失常引起的,其中神经自发活动和同步活动增加是其两个重要的病理生理特征。因此背侧耳蜗核被认为是耳鸣神经活动异常节律的起点。 | 吴旭 黄治物 Marks KL Martel DT Wu C | 2018 | 听力学及言语疾病杂志2018，26，5： | 3 |
| 9 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 10 | Predictors of High-grade Esophagitis After Definitive Three-dimensional Conformal Therapy, Intensity-modulated Radiation Therapy, or Proton Beam Therapy for Non-small cell Lung Cancer显示文摘 | Daniel R. Gomez Susan L. Tucker Mary K. Martel Radhe Mohan Peter A. Balter Jose Luis Lopez Guerra Hongmei Liu Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 2 |
| 11 | Global Burden of Human Papillomavirus and Related Diseases显示文摘 | David Forman Catherine de Martel Charles J. Lacey Isabelle Soerjomataram Joannie Lortet-Tieulent Laia Bruni Jerome Vignat Jacques Ferlay Freddie Bray Martyn Plummer Silvia Franceschi | 2012 | Vaccine2012，，： | 2 |
| 12 | High glucose concentration inhibits the expression of membrane type metalloproteinase by mesangial cells: possible role in mesangium accumulation显示文摘 | Mlennan SV Martell SY Yue DK | 2000 | Diabetologia2000，43，5： | 2 |
| 13 | Baseline carcinoembryonic antigen (CEA) serum levels predict bevacizumab‐based treatment response in metastatic colorectal cancer显示文摘 | Gerald W. Prager Kira H. Braemswig Alexandra Martel Matthias Unseld Georg Heinze Thomas Brodowicz Werner Scheithauer Gabriela Kornek Christoph C. Zielinski | 2014 | Cancer Sci2014，，8： | 2 |
| 14 | The Synthesis of a New Macrocyclic Dinucleating Ligand,3,6,9,17,20,23-Hexaaza-29,30-Dihydroxy-13,27-Dimethyl-Tricyclo[23,3,1,1^(11,15)]Triaconta-1(28),11,13, 15(30),25,26-Hexaene显示文摘A new dinucleating 24-membered hexaazadiphenol macrocyclic ligand, 3,6,9,17,20, 23-hexaaza-29,30- dihydroxy-13,27-dimethyl-tricycl [23, 3, 1, 1 11,15] triaconta -1(28), 11,13,15(30),25, 26-hexaene, BDBPH, was synthesized by the NaBH4 reduction of the Schiff-base obtained from the [2+2] condensation between diethylenetriamine and diformyl -p-cresol. The structure was characterized by elemental analysis, 1HNMR and FAB-MS. The synthetic method was also discussed. | Guo Qiang SHANGGUAN Arthur E. MARTELL Zhong Ren ZHANG (Department of Chemistry, Jining Medical College, Jining 272013Department of Chemistry, Texas A&M University, College Station, Texas 77842 USA) | 2000 | Chinese Chemical Letters2000，11，7： | 2 |
| 15 | Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis显示文摘 | Sara El Ouali Alan N. Barkun Jonathan Wyse Joseph Romagnuolo Joseph J.Y. Sung Ian M. Gralnek Marc Bardou Myriam Martel | 2012 | Gastrointestinal Endoscopy2012，，2： | 2 |
| 16 | Two-weight norm inequalities for maximal operators and fractionals on non-homogeneous spaces显示文摘 | Garcia-Cuerva J Martell J M | 2001 | Indiana Univ Math J2001，50，： | 2 |
| 17 | Future directions in myoma research显示文摘 | Brahma P K Martel K M Christman G M | 2006 | Obstet Gynecol Clin North Am2006，33，1： | 1 |
| 18 | Absorption Spectra of Para-substituted Tetraphenylporphines显示文摘 | Arthur E Martell | 1956 | J Am Chem Soc1956，78，7： | 1 |
| 19 | Distribution of the erm (B) gene, tetracycline resistance genes, and Tn1545 -- like transposons in macrolide- and lincosamide- resistant Enterococci from pigs and humans 显示文摘 | De Leener E Martel A Decostere A | 2004 | Microb Drug Resist2004，10，： | 1 |
| 20 | Advanced radiation treatment planning and delivery approaches for treatment of lung cancer 显示文摘 | Martel MK | 2004 | Hematol Oncol Clin North Am2004，18，1： | 1 |
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