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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | IRES-mediated cap-independent translation,a path leading to hidden proteome显示文摘Most eukaryotic mRNAs are translated in a cap-dependent fashion;however,under stress conditions,the cap-independent translation driven by internal ribosomal entry sites(IRESs)can serve as an alternative mechanism for protein production.Many IRESs have been discovered from viral or cellular mRNAs to promote ribosome assembly and initiate translation by recruiting different trons-acting factors.Although the mechanisms of translation initiation driven by viral IRESs are relatively well understood,the existence of cellular IRESs is still under debate due to the limitations of translation reporter systems used to assay IRES activities.A recent screen identified>1000 putative IRESs from viral and human mRNAs,expanding the scope and mechanism for capindependent translation.Additionally,a large number of circular RNAs lacking free ends were identified in eukaryotic cells,many of which are found to be translated through IRESs.These findings suggest that IRESs may play a previously unappreciated role in driving translation of the new type of mRNA,implying a hidden proteome produced from cap-independent translation. | Yun Yang Zefeng Wang | 2019 | Journal of Molecular Cell Biology2019，11，10： | 16 |
| 3 | Mixing state of individual carbonaceous particles during a severe haze episode in January 2013,Nanjing,China显示文摘Chemical composition,hourly counts,and sizes of atmospheric carbonaceous particles were measured to investigate their mixing state on clear and hazy days.623,122 carbonaceous particles with sizes0.2-2.0 μm was analyzed using a single-particle aerosol mass spectrometer from 1st to 17 th January2013.Particle types included biomass/biofuel burning particles(biomass),element carbon(EC-dominant)particles that were also mixed with biomass/biofuel burning species(EC-biomass) or secondary species(EC-secondary),organic carbon(OC),internally mixed OC and EC(OCEC),ammonium-containing(ammonium) and sodium-containing(sodium) particles.On clear days the top ranked carbonaceous particle types were biomass(48.2%),EC-biomass(15.7%),OCEC(11.1%),and sodium(9.6%),while on hazy days they were biomass(37.3%),EC-biomass(17.6%),EC-secondary(16.6%),and sodium(12.7%).The fractions of EC-secondary,ammonium(10%),and sodium particle types were elevated on hazy days.Numbers of EC-secondary particles were more than four times those on clear days(4.1%).Thus,carbonaceous particles mixed with ammonium,nitrate and sulfate during aging and transport,enhancing their light extinction effects and hygroscopic growth under high relative humidity on hazy days,further reducing visibility.Our real-time single-particle data showed that changes to mixing state had a significant impact on light extinction during haze events in Nanjing. | Honglei Wang Bin Zhu Zefeng Zhang Junlin An Lijuan Shen | 2015 | Particuology2015，13，3： | 12 |
| 4 | Effective suppression of stimulated Raman scattering in half 10 kW tandem pumping fiber lasers using chirped and tilted fiber Bragg gratings显示文摘The average power of fiber lasers has been scaled deeply into the kW regime in the past years. However, stimulated Raman scattering(SRS) is still a major factor limiting further power scaling. Here, we have demonstrated for the first time, to the best of our knowledge, the suppression of SRS in a half 10 kW tandem pumping fiber amplifier using chirped and tilted fiber Bragg gratings(CTFBGs). With specially self-designed and manufactured CTFBGs inserted between the seed laser and the amplifier stage, a maximum SRS suppression ratio of >15 dB in spectrum is observed with no reduction in laser efficiency. With one CTFBG, the effective output power is improved to3.9 kW with a beam quality M2 factor of ~1.7 from <3.5 k W with an M2 factor of >2; with two CTFBGs, the effective laser power reaches 4.2 kW with an increasing ratio of 20% and an M2 factor of ~1.8, and further power improvement is limited by the power and performance of the 1018 nm pump sources. This work provides an effective SRS suppression method for high-power all-fiber lasers, which is useful for further power scaling of these systems. | MENG WANG ZEFENG WANG LE LIU QIHAO HU HU XIAO XIAOJUN XU | 2019 | Photonics Research2019，7，2： | 11 |
| 5 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 6 | Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China):results from a prospective double-blind randomised clinical trial显示文摘Aim The role of clopidogrel in treating patients with acute ischaemic stroke is unclear.We have conducted the clinical trial in order to evaluate the efficacy and safety of clopidogrel with a loading dose in treating patients with non-cardiogenic acute ischaemic stroke.Method Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China)was a prospective,randomised,double-blind and placebo-controlled clinical trial in China.Patients with acute ischaemic stroke of non-cardiogenic origin within 48 hours of onset were enrolled and those received thrombolysis were excluded.Enrolled patients were divided into two treatment groups:loading dose and routine dose.The primary outcome was the incidence of stroke recurrence or progression within 7 days.Primary safety outcome was measured by life-threatening haemorrhage.An intent-to-treat analysis was used for the statistical analysis.results From March 2008 to March 2010,a total of 303 patients from 16 centres were recruited into this study;six were excluded because of lack of basic information.Since the enrolment was slow and the study drug expired in March 2010,this clinical trial was stopped earlier than planned.No significant baseline and demographic differences were seen between the two groups.There was no difference in primary outcome between the loading dosage group 16.1%(24/149)and control group 14.9%(22/148),respectively(p=0.782).The mortality and disability rate within 90 days in loading dose group(19.6%)was slightly lower than that in controlled group(23.4%),p=0.444.Loading dose group had two(1.3%)cases of fatal haemorrhage and control group had four(2.7%)within 90 days,p=0.674.No significant difference was detected in other adverse events between the groups.conclusion In our study stopped early due to slow enrolment,loading dose of clopidogrel does not reduce the risk of recurrent stroke.Future trials with sufficient number of patients enrolled are needed to re-examine this hypothesis. | Ying Zhao Wanyong Yang Zefeng Tan Wenmin Wang Weimin Xiao Jinsheng Zeng Anding Xu | 2017 | Stroke & Vascular Neurology2017，2，3： | 7 |
| 7 | Mitigation of stimulated Raman scattering in kilowatt-level diode-pumped fiber amplifiers with chirped and tilted fiber Bragg gratings显示文摘The average power of diode-pumped fiber lasers has been developed deeply into the kW regime in the past years.However, stimulated Raman scattering(SRS) is still a major factor limiting the further power scaling. Here, we have demonstrated the mitigation of SRS in kilowatt-level diode-pumped fiber amplifiers using a chirped and tilted fiber Bragg grating(CTFBG) for the first time. The CTFBG is designed and inscribed in large-mode-area(LMA) fibers, matching with the operating wavelength of the fiber amplifier. With the CTFBG inserted between the seed laser and the amplifier stage, an SRS suppression ratio of ~10 dB is achieved in spectrum at the maximum output laser power of 2.35 kW,and there is no reduction in laser slope efficiency and degradation in beam quality. This work proves the feasibility and practicability of CTFBGs for SRS suppression in high-power fiber lasers, which is very useful for the further power scaling. | Meng Wang Le Liu Zefeng Wang Xiaoming Xi Xiaojun Xu | 2019 | High Power Laser Science and Engineering2019，7，1： | 7 |
| 8 | Genomic selection: A breakthrough technology in rice breeding显示文摘Rice(Oryza sativa)provides a staple food source for more than half the world population.However,the current pace of rice breeding in yield growth is insufficient to meet the food demand of the everincreasing global population.Genomic selection(GS)holds a great potential to accelerate breeding progress and is cost-effective via early selection before phenotypes are measured.Previous simulation and experimental studies have demonstrated the usefulness of GS in rice breeding.However,several affecting factors and limitations require careful consideration when performing GS.In this review,we summarize the major genetics and statistical factors affecting predictive performance as well as current progress in the application of GS to rice breeding.We also highlight effective strategies to increase the predictive ability of various models,including GS models incorporating functional markers,genotype by environment interactions,multiple traits,selection index,and multiple omic data.Finally,we envision that integrating GS with other advanced breeding technologies such as unmanned aerial vehicles and open-source breeding platforms will further improve the efficiency and reduce the cost of breeding. | Yang Xu Kexin Ma Yue Zhao Xin Wang Kai Zhou Guangning Yu Cheng Li Pengcheng Li Zefeng Yang Chenwu Xu Shizhong Xu | 2021 | The Crop Journal2021，9，3： | 7 |
| 9 | Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets显示文摘RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates that splicing defects resulting from splicing dysregulation play critical roles in cancer pathogenesis and can serve as new biomarkers and therapeutic targets for cancer intervention. These findings have greatly deepened the mechanistic understandings of the regulation of alternative splicing in cancer cells, leading to rapidly growing interests in targeting cancer-related splicing defects as new therapies. Here we summarize the current research progress on splicing dysregulation in cancer and highlight the strategies available or under development for targeting RNA splicing defects in cancer. | Yongbo Wang Yufang Bao Sirui Zhang Zefeng Wang | 2020 | Science China(Life Sciences)2020，63，4： | 5 |
| 10 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 11 | Enhancing light-matter interaction in 2D materials by optical micro/nano architectures for high-performance optoelectronic devices显示文摘Two-dimensional materials are a promising solution for next-generation electronic and optoelectronic devices due to their unique properties.Owing to the atomic thickness of 2D materials,the light-matter interaction length in 2D materials is much shorter than that in bulk materials,which limits the performance of optoelectronic devices composed of 2D materials.To improve the light-matter interactions,optical micro/nano architectures have been introduced into 2D material optoelectronic devices.In this review,we present a concise introduction and discussion of various strategies for the enhancement of lightmatter interaction in 2D materials,namely,the plasmonic effect,waveguide,optical cavity,and reflection architecture.We have outlined the current advances in high-performance 2D material optoelectronic devices(eg,photodetectors,electrooptic modulators,light-emitting diodes,and molecular sensors)assisted by these enhancement strategies.Finally,we have discussed the future challenges and opportunities of micro/nano photonic structure designs in 2D material devices. | Li Tao Zefeng Chen Zhiyong Li Jiaqi Wang Xin Xu Jian-Bin Xu | 2021 | InfoMat2021，3，1： | 5 |
| 12 | Not just a sponge: new functions of circular RNAs discovered显示文摘One of the most exciting findings in RNA biology is the discovery of numerous circular RNAs(circ RNA)in mammalian genome.Once being considered as low abundance splicing byproducts,circ RNAs are surprisingly | WANG ZeFeng | 2015 | Science China(Life Sciences)2015，58，4： | 4 |
| 13 | Study of Krypton Laser-Induced Choroidal Neovascularization in a Guinea Pig Model of High Anisometropia显示文摘Purpose:To investigate the association between high anisometropia and the area of choroidal neovascularization (CNV) induced by krypton laser in guinea pigs and better understand the pathogenesis and prevention of myopic CNV. Methods:.Nine 3-week old male guinea pigs with anisometropia > 6.00D were randomly assigned to three groups according to examination date after laser photocoagulation (7d, 14d and 28d). All animals underwent refraction. The eye with higher myopia was used as the experimental eye, and the other as the control eye..All eyes received repeated multi-wavelength krypton laser photocoagulation treatments (wavelength: 532 nm; laser power: 400 mW; spot diameter: 50 μm; exposure time: 0.1s). Fundus photography and indocyanine green angiography (ICGA) were performed. Afterwards, the animals were sacrificed immediately,.and the eyes were enucleated and processed for histopathologic examination and flat mounts. Results: CNV appeared at 7d after laser treatment. The area of CNV peaked at 14d, and decrease in area and the presence of scarring was noted at 28 d..CNV was present in 66.7% of eyes by ICGA at 14 d..CNV could be observed under light microscopy at all three time points..At 14 d,.flat mount showed the neovascular plexus around the lesion. Semi-quantitative analysis revealed that the area of CNV in treated eyes was greater than that of control eyes. Conclusion:.Since the mechanism of CNV in this study resembles that of CNV in pathological myopia, this model can be used to investigate the etiology, pathogenesis and treatment of CNV in pathological myopia. | Jianghui Wang Wei Jiang Zefeng Kang Lina Liang Xiaoman Liu Nannan Tian Qing Zhang | 2012 | Eye Science2012，27，2： | 4 |
| 14 | Classification of Imagined Speech EEG Signals with DWT and SVM显示文摘With the development of human-computer interaction technology,brain-computer interface(BCI)has been widely used in medical,entertainment,military,and other fields.Imagined speech is the latest paradigm of BCI and represents the mental process of imagining a word without making a sound or making clear facial movements.Imagined speech allows patients with physical disabilities to communicate with the outside world and use smart devices through imagination.Imagined speech can meet the needs of more complex manipulative tasks considering its more intuitive features.This study proposes a classification method of imagined speech Electroencephalogram(EEG)signals with discrete wavelet transform(DWT)and support vector machine(SVM).An open dataset that consists of 15 subjects imagining speaking six different words,namely,up,down,left,right,backward,and forward,is used.The objective is to improve the classification accuracy of imagined speech BCI system.The features of EEG signals are first extracted by DWT,and the imagined words are clas-sified by SVM with the above features.Experimental results show that the proposed method achieves an average accuracy of 61.69%,which is better than those of existing methods for classifying imagined speech tasks. | ZHANG Lingwei ZHOU Zhengdong XU Yunfei JI Wentao WANG Jiawen SONG Zefeng | 2022 | Instrumentation2022，9，2： | 4 |
| 15 | Force/Moment Isotropy of 8/4-4 Parallel Six-Axis Force Sensor Based on Performance Atlases显示文摘A six-axis force sensor with parallel 8/4-4 structure is introduced and its measurement principle is analyzed.Based on condition numbers of Jacobian matrix spectral norm of the sensor,the relationship between the force and moment isotropy and some structural parameters is deduced.Orthogonal test methods are used to determine the degree of primary and secondary factors that have significant effect on sensor characteristics.Furthermore,the relationship between each performance index and the structural parameters of the sensor is analyzed by the method of the atlas,which lays a foundation for structural optimization design of the force sensor. | Song Weishan Li Chenggang Wang Chunming Song Yong Wu Zefeng Rajnathsing Hemant | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，6： | 3 |
| 16 | A New Cleaner Power Generation System Based on Self-Sustaining Supercritical Water Gasification of Coal显示文摘A new cleaner power generation system(IPGS) is proposed and investigated in this paper. Integrating combined cycle with supercritical water gasification of coal, the thermodynamic energy of the produced syngas is cascade utilized according to its temperature and pressure, both sensible and latent heat of the syngas can be recycled into the system, and thereby the net power efficiency can be about 6.4 percentage points higher than that of the traditional GE gasification based power plant(GEPP). The exergy analysis results show that the exergy efficiency of the proposed system reaches 52.45%, which is 13.94% higher than that of the GEPP, and the improvement in exergy efficiency of the proposed system mainly comes from the exergy destruction decline in the syngas energy recovery process, the condensation process and the syngas purification process. The syngas combustion process is the highest exergy destruction process with a value of 157.84 MW in the proposed system. Further performance improvement of the proposed system lies in the utilization process of syngas. Furthermore, system operation parameters have been examined on the coal mass fraction in the supercritical water gasifier(GF), the gasification temperature, and the gasification pressure. The parametric analysis shows that changes in coal concentration in the GF exert more influence on the exergy efficiency of the system compared with the other two parameters. | LIU Changchun HAN Wei WANG Zefeng ZHANG Na | 2022 | Journal of Thermal Science2022，31，5： | 3 |
| 17 | Electrochemical corrosion behavior of steel wires in a coalmine with a corrosive medium显示文摘6 脳升起电报的 19 点接触被用作我们的研究目标在一个实验室检验钢电线的腐蚀的进步,在 coalmine 模仿实际工作条件。一个电气化学的方法被用来与腐蚀剂酸溶液的不同表面处理调查钢电线的腐蚀行为。在当,赤裸的钢电线的阳极激活过程最快的地方,结果证明钢电线的阳极激活主要发生在腐蚀前期间是他们的相应腐蚀速度,当涂的钢电线和他们的相应腐蚀加速的油的阳极激活过程最低时。在中间、迟了的沉浸时期期间,一部被动电影在钢电线的表面上被产生,它逐渐地与时间的推移被损坏。本地 pitting 腐蚀与一个高极化的潜力在钢电线的表面上容易发生。合适的相等的电路被选择在各种各样的腐蚀剂时间和不同表面处理适合钢电线的电气化学的阻抗光谱学(EIS ) ,它显示好恰当的结果。双电的层费用转移抵抗在顺序增加:赤裸的钢电线,未经治疗的钢电线和油涂的钢电线和他们的腐蚀抵抗接着减少,它与他们的极化曲线一致。油层在未经治疗的钢电线上提供某个保护的效果,但是它的效果不是完全清楚的。 | Wang Songquan Zhang Dekun Wang Dagang Zhang Zefeng | 2011 | Mining Science and Technology2011，21，1： | 3 |
| 18 | Towards high-power mid-IR light source tunable from 3.8 to 4.5 µm by HBr-filled hollow-core silica fibres显示文摘Fibre lasers operating at the mid-IR have attracted enormous interest due to the plethora of applications in defence,security,medicine,and so on.However,no continuous-wave(CW)fibre lasers beyond 4μm based on rare-earth-doped fibres have been demonstrated thus far.Here,we report efficient mid-IR laser emission from HBr-filled silica hollow-core fibres(HCFs)for the first time.By pumping with a self-developed thulium-doped fibre amplifier seeded by several diode lasers over the range of 1940–1983 nm,narrow linewidth mid-IR emission from 3810 to 4496 nm has been achieved with a maximum laser power of about 500 mW and a slope efficiency of approximately 18%.To the best of our knowledge,the wavelength of 4496 nm with strong absorption in silica-based fibres is the longest emission wavelength from a CW fibre laser,and the span of 686 nm is also the largest tuning range achieved to date for any CW fibre laser.By further reducing the HCF transmission loss,increasing the pump power,improving the coupling efficiency,and optimizing the fibre length together with the pressure,the laser efficiency and output power are expected to increase significantly.This work opens new opportunities for broadly tunable high-power mid-IR fibre lasers,especially beyond 4μm. | Zhiyue Zhou Zefeng Wang Wei Huang Yulong Cui Hao Li Meng Wang Xiaoming Xi Shoufei Gao Yingying Wang | 2022 | Light(Science & Applications)2022，11，1： | 3 |
| 19 | Effect of various kinematic parameters of mine hoist on fretting parameters of hoisting rope and a new fretting fatigue test apparatus of steel wires显示文摘 | Dagang Wang Dekun Zhang Zefeng Zhang Shirong Ge | 2012 | Engineering Failure Analysis2012，，： | 2 |
| 20 | Multi-Cluster Feature Selection Based on Isometric Mapping显示文摘Dear editor,This letter presents an unsupervised feature selection method based on machine learning.Feature selection is an important component of artificial intelligence,machine learning,which can effectively solve the curse of dimensionality problem.Since most of the labeled data is expensive to obtain. | Yadi Wang Zefeng Zhang Yinghao Lin | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，3： | 2 |
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