|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased postoperative complications after protective ileostomy closure delay: An institutional study显示文摘AIM: To study the morbidity and complications as-sociated to ileostomy reversal in colorectal surgery pa-tients, and if these are related to the time of closure. METHODS: A retrospective analysis of 93 patients, who had undergone elective ileostomy closure between 2009 and 2013 was performed. Demographic, clinical and surgical variables were reviewed for analysis. All complications were recorded, and classified according to the Clavien-Dindo Classification. Statistical univariate and multivariate analysis was performed, setting a P value of 0.05 for significance.RESULTS: The patients had a mean age of 60.3 years, 58% male. The main procedure for ileostomy cre-ation was rectal cancer(56%), and 37% had received preoperative chemo-radiotherapy. The average delay from creation to closure of the ileostomy was 10.3 mo. Postoperative complications occurred in 40% of the pa-tients, with 1% mortality. The most frequent were ileus(13%) and wound infection(13%). Pseudomembra-nous colitis appeared in 4%. Increased postoperative complications were associated with delay in ileostomyclosure(P = 0.041). Male patients had more complica-tions(P = 0.042), mainly wound infections(P = 0.007). Pseudomembranous colitis was also associated with the delay in ileostomy closure(P = 0.003). End-to-end in-testinal anastomosis without resection was significantly associated with postoperative ileus(P = 0.037). CONCLUSION: Although closure of a protective il-eostomy is a fairly common surgical procedure, it has a high rate of complications, and this must be taken into account when the indication is made. The delay in stoma closure can increase the rate of complications in general, and specifically wound infections and colitis. | Ines Rubio-Perez Miguel Leon Daniel Pastor Joaquin Diaz Dominguez Ramon Cantero | 2014 | World Journal of Gastrointestinal Surgery2014，6，9： | 11 |
| 2 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 3 | Selenium alters miRNA profile in an intestinal cell line: Evidence that miR‐185 regulates expression of GPX2 and SEPSH2显示文摘 | Anabel Maciel‐Dominguez Daniel Swan Dianne Ford John Hesketh | 2013 | Mol. Nutr. Food Res2013，，12： | 1 |
| 4 | A high-resolution transcriptome map of cell cycle reveals novel connections between periodic genes and cancer显示文摘通过房间周期的前进大部分依赖于周期的基因表示的波浪,并且为这些 transcriptome 动力学的规章的网络在肿瘤生物学的各种各样的方面作为危险的批评的点出现了。在二个连续房间期间通过人的房间的定序 RNA 骑车(> 23 亿配对读) ,我们与周期的表示识别了超过 1 000 mRNAs,非编码的 RNA 和 pseudogenes。周期的抄本在与 DNA 新陈代谢,有丝分裂,和 DNA 损坏反应有关的功能被充实,显示这些基因多半代表通常认为的房间周期管理者。用我们周期的基因的集合,我们开发了一条新途径称为的 “有丝分裂的 trait”那能由他们的 transcriptome 类似分类主要肿瘤和正常纸巾到不同房间周期阶段。由分析 >在癌症染色体地图集(TCGA ) 和数据设置的另外的表示的 4 000 件肿瘤样品,我们发现那个有丝分裂的特点显著地与基因改变,肿瘤子类型和,尤其是耐心的幸存相关。我们进一步在多重房间类型与柔韧的周期的表示定义 67 基因的一个核心集合。蛋白质作为蛋白质蛋白质相互作用的主要中心由这些基因功能编码了并且主要为房间周期前进被要求。核心基因也包括有约束力的 CTCF/RAD21 和 H3K36me3 的增加的层次有唯一的染色质特征。这些特征在的损失子宫并且肾癌症与核心的改变的表示被联系 67 基因。我们的学习为周期的基因规定建议新联系染色质的机制并且提供癌症病人结果的一个预言者。 | Daniel Dominguez Yi-Hsuan Tsai Nicholas Gomez Deepak Kumar Jha Ian Davis Zefeng Wang | 2016 | Cell Research2016，26，8： | 1 |
| 5 | Selenium alters miRNA profile in an intestinal cell line: Evidence that miR‐185 regulates expression of GPX2 and SEPSH2显示文摘 | Anabel Maciel‐Dominguez Daniel Swan Dianne Ford John Hesketh | 2013 | Mol Nutr Food Res2013，，12： | 1 |
| 6 | 伊森伯格管理学院商业创新中心显示文摘这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的扩建和部分翻新使伊森伯格管理学院现有的空间扩大了近一倍. | Alice Cladet Amina Blacksher Barbara Stallone Beat Schenk Cheyenne Vandevoorde Daniel Kidd Davide Maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna Mydlak Kai-Uwe Bergmann Kristoffer Negendahl Ku Hun Chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa Khan Nicolas Gustin Pei Pei Yang Peter Lee Seoyoung Shin Simon Lee Terrence Chew Tianqi Zhang Tore Banke Yehezkiel Wiliardy Yixin Li Max Touhey Laurian Ghinitoiu 曲鸿(译) | 2019 | 城市环境设计2019，0，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员