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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Treatment of cervical dislocation with locked facets显示文摘有锁的方面的背景更低的颈的脱臼在颈的损害是普通的。锁的方面包括单方、双边的类型。不同成功的关上的减小率被使用快速的颅骨拖拉在单方、双边的类型之间完成了,它通常被用来减少颈的脱臼。由于快速的颅骨拖拉对待的颈的损害与锁的方面与颈的脱臼与 38 个病人全部的颈的锁的 facets.Methods A 的不同类型调查对病人特定的一个合适的管理是重要的,从 1988 ~ 2005 的操作被考察。快速的颅骨拖拉在所有病人被使用。成功的关上的减小率在有双边的颈的锁的方面的病人是 88.0% ,那在有单方的颈的锁的方面的那些是 15.4% 。这些数据然后被 Chi 平方测试统计上比较。成功地被减少的病人在受伤水平经历了前面的颈的 discectomy 和熔化,并且在关上的减小失败了的那些在这个系列收到了以后的开的减小和 fixation.Results ,处于在单方、双边的锁的方面脱臼之间的成功的关上的颅骨拖拉减小的率有统计上重要的差别( P0.05 )。单方的颈的锁的方面脱臼没被对双边的颈的锁的方面脱臼的减小合适的颅骨拖拉容易减少。然而,单方的颈的锁的方面脱臼能被以后的开的 reduction.Conclusions 减少单方的颈的锁的方面脱臼应该与以后的开的减小和乐器学立即被对待。双边的颈的锁的方面脱臼能被快速的颅骨拖拉第一减少并且前面的颈的 discectomy 和 interbody 熔化以后。 | YU Ze-sheng James J.Yue WEI Feng LIU Zhong-jun CHEN Zhong-qiang DANG Geng-ting | 2007 | Chinese Medical Journal2007，，3： | 24 |
| 3 | Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke显示文摘Stroke is a leading cause of disability and death,yet effective treatments for acute stroke has been very limited.Thus far,tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients,yet its application is only applicable to less than 4–5% of stroke patients due to the narrow therapeutic window(< 4.5 hours after the onset of stroke) and the high risk of hemorrhagic transformation.Emerging evidence from basic and clinical studies has shown that therapeutic hypothermia,also known as targeted temperature management,can be a promising therapy for patients with different types of stroke.Moreover,the success in animal models using pharmacologically induced hypothermia(PIH) has gained increasing momentum for clinical translation of hypothermic therapy.This review provides an updated overview of the mechanisms and protective effects of therapeutic hypothermia,as well as the recent development and findings behind PIH treatment.It is expected that a safe and effective hypothermic therapy has a high translational potential for clinical treatment of patients with stroke and other CNS injuries. | Jin Hwan Lee James Zhang Shan Ping Yu | 2017 | Neural Regeneration Research2017，12，3： | 19 |
| 4 | Effects of salt stress on rice growth, development characteristics, and the regulating ways: A review显示文摘Rice(Oryza sativa L.) is highly susceptible to the rhizosphere salinity than other cereals.High sensitivity has been observed,mainly at vegetative and reproductive stages in rice.It is the duty of plant physiologists to comprehend the growth,development,and physiological processes of rice plants under stress.This paper includes the overview of rice growth and developmental processes influenced by salt stress and the regulation pathways involved in these processes.It also includes the promising salt tolerance strategies,i.e.,genetic modification techniques,agronomic practices to improve rice growth,yield,and role of phytohormones and their management,especially inhibition of ethylene biosynthesis by using inhibitors 1-methylcyclopropene(1-MCP).Rice cultivation may be a first choice for improvement of salt tolerance through plant growth regulators and improved cultivation techniques.This study will significantly improve the understanding toward low rice grain yield and poor rice resistance under salt stress and will also stream scientific knowledge for effective utilization of salt affected soils by using different regulating ways. | Sajid Hussain ZHANG Jun-hua ZHONG Chu ZHU Lian-feng CAO Xiao-chuang YU Sheng-miao Allen Bohr James HU Ji-jie JIN Qian-yu | 2017 | Journal of Integrative Agriculture2017，16，11： | 19 |
| 5 | Combined treatment of non-small cell lung cancer using radiotherapy and immunotherapy: challenges and updates显示文摘The efficacy of immunotherapy for advanced non-small cell lung cancer(NSCLC)remains unsatisfactory,as the majority of patients either do not experience an objective response or acquire secondary resistance.As a result,several methods to enhance the systemic efficacy of immunotherapy have been investigated,including a large area of active research by combining immunotherapy with radiation therapy(RT).Given the rapidly burgeoning concept of combining immunotherapy and RT for increasing therapeutic benefit,we review the progress in this field thus far and explore further avenues for enhancing this combination.This review commences with a discussion of the only two existing randomized trials(and a pooled analysis)showing that the addition of RT to immunotherapy improves the abscopal response rate,progression-free survival,and overall survival in metastatic NSCLC patients.We then discussed factors and biomarkers that may be associated with a proportionally greater benefit to additional RT,such as low programmed cell death protein ligand 1(PD-L1)status,tumor mutational burden(TMB),and patient’s immune function.Next,the implementation of RT to overcome immunotherapy resistance is discussed,including a mechanistic discussion and methods with which these mechanisms could be exploited.Lastly,the emerging role of low-dose RT is discussed,which may help to overcome inhibitory signals in the tumor stroma that limit T-cell infiltration.Taken together,given the current state of this rapidly expanding realm,these futuristic strategies may be reflected upon to further enhance the efficacy of immunotherapy for a wider group of patients. | Shijie Shang Jie Liu Vivek Verma Meng Wu James Welsh Jinming Yu Dawei Chen | 2021 | Cancer Communications2021，41，11： | 10 |
| 6 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 7 | Thickness-dependent patterning of MoS2 sheets with well-oriented triangular pits by heating in air显示文摘自从 MoS2 表的性质对边结构敏感,有常规边或可控制的形状的 Patterning ultrathin MoS2 层正在呼吁。在这个工作,我们介绍了一种简单、有效、控制得好的技术由简单地在空中加热样品与面向井的等边的三角形的坑蚀刻分层的 MoS2 表。各向异性的氧化蚀刻被包围温度和 MoS2 层的数字极大地影响,坑由此随包围温度和 MoS2 层的数字的增加缩放增加。第一原则的计算被执行了解释三角形的坑的形成机制。这种技术把一条其他的大街提供给设计 MoS2 表的结构。 | Haiqing Zhou Fang Yu Yuanyue Liu Xiaolong Zou Chunxiao Cong Caiyu Qiu Ting Yu Zheng Yan Xiaonan Shen Lianfeng Sun Boris I. Yakobson James M. Tour | 2013 | Nano Research2013，6，10： | 9 |
| 8 | High thermal conductivity of suspended few-layer hexagonal boron nitride sheets显示文摘推迟的很少层的热传导六角形的硼氮化物(h-BN ) 表试验性地用一个 noncontact micro-Raman 光谱学方法被调查。为单层(1L ) 的一阶的温度系数, bilayer (2L ) 并且九层(9L ) h-BN 表被测量是(当时, electrospinning 准备的 3.41 xide nanofibers 被期望减少了热电导率与体积样品相比。自从它包含复杂样品准备方法,热电导率正在质问的 nanofibers 的大小。在这个工作,我们在场对单个 nanofiber 的热电导率的大小合适的一个新奇方法。一 microelectro 机械(MEMS ) 设备被设计了并且制作了在单个 nanofiber 上执行热传导性大小。一个特殊 Si 模板被设计收集并且转单个 nanofibers 到 MEMS 设备名上吗? | Haiqing Zhou Jixin Zhu Zheng Liu Zheng Yan Xiujun Fan Jian Lin Gunuk Wang Qingyu Yan Ting Yu Pulickel M. Ajayan James M. Tour | 2014 | Nano Research2014，7，8： | 9 |
| 9 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 10 | 成都市男男性工作者艾滋病性病知信行定性研究显示文摘目的旨在了解成都市男男性工作者艾滋病性病的知信行情况,并为相关健康教育策略制定提供参考。方法运用半结构式访谈法,对访谈对象进行一对一的访谈。结果共调查21名男男性工作者(MB),年龄中位数为23岁。访谈对象普遍知道的HIV主要传播途径包括血液传播和性传播;普遍认为在同志圈和MB圈内艾滋病性病的感染率较高。21名MB中,16人报告与顾客发生肛交行为时坚持每次使用安全套,5人有时使用。联系客人的方式包括会所老板、MB朋友、常客、网络聊天室、QQ和微信等交友软件。结论 MB人群对于艾滋病性病的一般知识有一定的了解,但仍旧存在一些错误认识,如认为高危行为后及时清洗消毒可以避免HIV感染,肛交中的插入方可以不使用安全套,口交不会传染艾滋病性病等,且存在不坚持使用安全套的现象。应注意消除认识上的误区以及意识与行为间的不一致。 | 彭琳 张菊英 黎瀚东 陈瑾 马骁 James Blanchard Rob Lorway Bob Nancy Yu | 2014 | 中国健康教育2014，30，9： | 8 |
| 11 | Combinatorial Complexity in a Transcriptionally Centered Signaling Hub in Arabidopsis显示文摘四 Phytochrome (phy ) 的一个亚科交往的 bHLH 抄写因素(程序信息文件) 一起在黑暗成年的幼苗支持 skotomorphogenic 开发。这项活动在暴露之上被颠倒到光,由导致程序信息文件的降级的用光使敏化的 phy 分子,从而触发驾驶转变到 photomorphogenesis 的 transcriptional 变化。程序信息文件冗余地并且部分工作在在这进程的 morphogenic 水平的差别。识别程序信息文件 transcriptional 规定的直接目标染色体宽,我们由 ChIP-seq 分析为所有四个程序信息文件分析了 DNA 有约束力的地点,并且定义每个程序信息文件 transcriptionally 调整的基因,用 pif 异种的 RNA-seq 分析。尽管有在在程序信息文件之间的 DNA-binding-motif 识别的可检测的差别的缺席,数据表演规章的模式的一个系列,从单个程序信息文件优势在所有四等于贡献。同样,倡导者体系结构的一个宽广数组被发现,从单个程序信息文件绑定地点,包含单个顺序主题,通过多重程序信息文件绑定地点,各包含至少一个主题,与一个优先地占据到多重程序信息文件的每个地点。每个程序信息文件导致的倡导者占有和表示水平的定量分析揭示了一个吸引人的模式。尽管越过目标基因人口广泛地没有柔韧的关联,是多重程序信息文件的分享的目标的单个基因的检查在关联显示出一个阶段从强烈积极通过 uncorrelated,到否定。这发现建议 transcriptional 规定的双分层的机制,两个都包括由每个程序信息文件和扮演每个程序信息文件上的差别的本地规定的附加的层的有约束力地点的占有的连续统,到在每个地点调制它的内在的 transcriptional 激活能力,在一个量的模式,那从基因在单个程序信息文件之间变化到基因。这些调查结果为探查有重叠直接目标的基因的抄写因素由集成的机制提供一个框架并且有选择地, transduce 发信号到他们的目标网络。 | Anne Pfeiffer | 2014 | Molecular Plant2014，7，11： | 8 |
| 12 | Erratum to: Sn^(4+) precursor enables 12.4% efficient kesterite solar cell from DMSO solution with open circuit voltage deficit below 0.30 V (vol 64, issue 1, page 52, 2021)显示文摘In the version of the article originally published in volume 64,issue 1,2021 of Sci China Mater(2021,64(1):52–60,http://gffzzd3cc09b8251d45dfsfkuv5pqvn6vx6b5w.ffgz.tsg.suse.edu.cn/10.1007/s40843-020-1408-x),the chemical formula of Sn(DMSO)_(4)Cl_(4)(page 54,8^(th) line in the left column;page 56,4^(th) and 6^(th) lines from the bottom of left column and in Equations(6 and 7)in the right column)was miswritten.The correct formula should be as below:SN(DMSO)_(2)CL_(4). | Yuancai Gong Yifan Zhang Erin Jedlicka Rajiv Giridharagopal James A.Clark Weibo Yan Chuanyou Niu Ruichan Qiu Jingjing Jiang Shaotang Yu Sanping Wu Hugh W.Hillhouse David S.Ginger Wei Huang Hao Xin | 2021 | Science China Materials2021，64，5： | 7 |
| 13 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 14 | Optical conductivity-based ultrasensitive mid-infrared biosensing on a hybrid metasurface显示文摘Optical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular structures.Unfortunately,typical refractive index-based optical sensors do not have sufficient sensitivity to probe the binding of low-molecular-weight analytes.Non-optical devices such as field-effect transistors can be more sensitive but do not offer some of the significant features of optical devices,particularly molecular fingerprinting.We present optical conductivity-based mid-infrared(mid-IR)biosensors that allow for sensitive and quantitative measurements of low-molecular-weight analytes as well as the enhancement of spectral fingerprints.The sensors employ a hybrid metasurface consisting of monolayer graphene and metallic nano-antennas and combine individual advantages of plasmonic,electronic and spectroscopic approaches.First,the hybrid metasurface sensors can optically detect target molecule-induced carrier doping to graphene,allowing highly sensitive detection of low-molecular-weight analytes despite their small sizes.Second,the resonance shifts caused by changes in graphene optical conductivity is a well-defined function of graphene carrier density,thereby allowing for quantification of the binding of molecules.Third,the sensor performance is highly stable and consistent thanks to its insensitivity to graphene carrier mobility degradation.Finally,the sensors can also act as substrates for surfaceenhanced infrared spectroscopy.We demonstrated the measurement of monolayers of sub-nanometer-sized molecules or particles and affinity binding-based quantitative detection of glucose down to 200 pM(36 pg/mL).We also demonstrated enhanced fingerprinting of minute quantities of glucose and polymer molecules. | Yibo Zhu Zhaoyi Li Zhuang Hao Christopher DiMarco Panita Maturavongsadit Yufeng Hao Ming Lu Aaron Stein Qian Wang James Hone Nanfang Yu Qiao Lin | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 15 | 胸腺瘤放疗的相关定义和报告指南显示文摘放疗在胸腺肿瘤的治疗中仍然占有重要地位,但是很多细节没有明确的定义。例如,如何放疗、如何确定放疗范围、哪些患者需要放疗和如何报告放疗结果都没有统一的标准。ITMIG的成立,给解决这些问题创造了机会。但是先决条件是制定统一的定义和方法,使不同结果能被理解和比较,这也是本文的主旨。文献和形成初步建议,再提交给下一个扩展工作组(Charles hTomas, Lynn Wilson, Gregory Videtic. James Metz, Harun Badakhshi, Clifton Fuller, Franc-oie Mornex, Conrad Falkson, David Ball, and Ken Rosenzweig)审议,之后将建议提交给ITMIG多学科组进一步讨论,形成初稿(包含推荐方法和标准操作流程)后分发给所有ITMIG成员更进一步讨论并反馈意见,最终版本经ITMIG批准并被采用。 | 付浩 中国胸腺瘤协作组全体成员 Daniel Gomez Ritsuko Komaki James Yu Hitoshi Ikushima Andrea Bezjak | 2014 | 中国肺癌杂志2014，17，2： | 6 |
| 16 | Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘 | Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding | 2014 | Cell Research2014，24，1： | 6 |
| 17 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 18 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 19 | 富血小板血浆注射:慢性盘源性腰痛的新疗法显示文摘研究表明,自体富血小板血浆(platelet-rich Plasma, PRP)注射是治疗包括退行性腰椎间盘疾病在内的多种肌肉骨骼疾病的一种新方法。虽然医师越来越关注PRP,但其临床疗效只有对膝骨性关节炎和肱骨上髁炎的报道。尽管PRP在退行性椎间盘疾病中应用普遍,但仍然需要可靠的临床证据证明其实用性和有效性。该文回顾了现有PRP疗法的文献及其治疗慢性椎间盘源性腰痛(简称盘源性腰痛)的潜在用途,并重点关注其临床试验的证据。 | Suja Mohammed James Yu 汤洋 万丽 | 2019 | 中国疼痛医学杂志2019，25，10： | 4 |
| 20 | Astronomical time scale for the lower Doushantuo Formation of early Ediacaran,South China显示文摘Nearly 90% of the Ediacaran Period(635–541 Ma) of the Neoproterozoic is represented by the Doushantuo Formation(DST Fm) in South China.Its lowest Member I is a 3.7 m-thick cap carbonate deposited at the termination of the Cryogenian Marinoan glaciation.The DST Fm consists of alternating organic-rich black shale and thinly bedded dolostone, and it contains some of the oldest records of multicellular life and three pronounced negative carbon isotope excursions.The Jiulongwan(JLW) section is a well-studied reference section for these Ediacaran events.Spectral analysis of geochemical data through the lower DST Fm(22.3 m) shows 27 predominant ~90 cm sedimentary cycles that correspond to 405-ka long eccentricity cycles.The power spectra of the 405-ka tuned Ca and Fe/Ti series show significant peaks at ~1.2-Ma, 405-ka, 133-ka, 128-ka, 100-ka, 82-ka, ~31-ka and 29-ka periods, respectively.A 11.16 Malong astronomical time scale has been constructed for the lower DST Fm and provide a duration of 1.6 Ma for the cap carbonate(Member Ⅰ) based on the 405-ka long eccentricity cycle tuning.Using the U-Pb age of 635.2 ± 0.6 Ma for the volcanic ash bed at the Member Ⅰ/Ⅱboundary, we proposed a 636.8 Ma age for the base of the DST Fm.These ages and astronomical timescale provide important new constraints on the subdivision of Ediacaran strata, and have implications for understanding the character of the first negative δ^(13)C excursion(EN1).Orbital forcing may have been played an important role for the climate changes and the evolution of Ediacaran multi-cellular life and the carbon cycle variations. | Yu Sui Chunju Huang Rui Zhang Zhixiang Wang James Ogg David B.Kemp | 2018 | Science Bulletin2018，63，22： | 4 |
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