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| 1 | Intensity-modulated radiation therapy with concurrent chemotherapy for locally advanced cervical and upper thoracic esophageal cancer显示文摘AIM: To evaluate the dosimetry, efficacy and toxicity of intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy for patients with locally advanced cervical and upper thoracic esophageal cancer. METHODS: A retrospective study was performed on 7 patients who were definitively treated with IMRT and concurrent chemotherapy. Patients who did not receive IMRT radiation and concurrent chemotherapy were not included in this analysis. IMRT plans were evaluated to assess the tumor coverage and normal tissue avoidance. Treatment response was evaluated and toxicities were assessed. RESULTS: Five- to nine-beam IMRT were used to deliver a total dose of 59.4-66 Gy (median: 64.8 Gy) to the primary tumor with 6-MV photons. The minimum dose received by the planning tumor volume (PTV) of the gross tumor volume boost was 91.2%-98.2% of the prescription dose (standard deviation [SD]: 3.7%-5.7%). The minimum dose received by the PTV of the clinical tumor volume was 93.8%-104.8% (SD: 4.3%-11.1%) of the prescribed dose. With a median follow-up of 15 mo (range: 3-21 mo), all 6 evaluable patients achieved complete response. Of them, 2 developed localrecurrences and 2 had distant metastases, 3 survived with no evidence of disease. After treatment, 2 patients developed esophageal stricture requiring frequent dilation and 1 patient developed tracheal-esophageal fi stula. CONCLUSION: Concurrent IMRT and chemotherapy resulted in an excellent early response in patients with locally advanced cervical and upper thoracic esophageal cancer. However, local and distant recurrence and toxicity remain to be a problem. Innovative approaches are needed to improve the outcome. | Shu-Lian Wang Zhongxing Liao Helen Liu( Jaffer Ajani Stephen Swisher James D Cox Ritsuko Komaki | 2006 | World Journal of Gastroenterology2006，12，34： | 27 |
| 2 | 胸腺瘤放疗的相关定义和报告指南显示文摘放疗在胸腺肿瘤的治疗中仍然占有重要地位,但是很多细节没有明确的定义。例如,如何放疗、如何确定放疗范围、哪些患者需要放疗和如何报告放疗结果都没有统一的标准。ITMIG的成立,给解决这些问题创造了机会。但是先决条件是制定统一的定义和方法,使不同结果能被理解和比较,这也是本文的主旨。文献和形成初步建议,再提交给下一个扩展工作组(Charles hTomas, Lynn Wilson, Gregory Videtic. James Metz, Harun Badakhshi, Clifton Fuller, Franc-oie Mornex, Conrad Falkson, David Ball, and Ken Rosenzweig)审议,之后将建议提交给ITMIG多学科组进一步讨论,形成初稿(包含推荐方法和标准操作流程)后分发给所有ITMIG成员更进一步讨论并反馈意见,最终版本经ITMIG批准并被采用。 | 付浩 中国胸腺瘤协作组全体成员 Daniel Gomez Ritsuko Komaki James Yu Hitoshi Ikushima Andrea Bezjak | 2014 | 中国肺癌杂志2014，17，2： | 6 |
| 3 | 应用最大似然率及随机效应模型探讨非小细胞肺癌放化疗中急性放射性食管炎与照射剂量和疗程的关系显示文摘背景与目的:局部晚期非小细胞肺癌的治疗疗效差,增加治疗强度如同期放化疗是提高疗效的方法,但毒性反应较大。本研究探讨非小细胞肺癌同期放化疗的治疗方式中,应用最大似然率及随机效应模型探讨非小细胞肺癌放化疗中急性放射性食管炎的发生率与照射剂量和疗程时间因素的关系。方法:本研究中的39例病例资料来自于1998年3月-2000年11月间在M.D.Anderson癌症治疗中心进入随机临床Ⅲ期的同期放化疗治疗研究不能手术的Ⅱ期和Ⅲ期非小细胞肺癌患者。所有的患者在放疗前均接受顺铂和口服依托泊苷(VP-16)的化疗。放疗方案为每次1.2Gy,bid,前后野对照治疗至肿瘤剂量达40~50Gy后,采用避开脊髓的斜野放疗至总剂量69.6Gy。病例分布为amifostine治疗组,19例;非amifostine治疗组,20例。还原三维治疗计划设计并计算了剂量-体积直方图(DVHs)。治疗开始后每周对急性放射性食管炎程度评估1次,在放疗结束后1个月再随访评估1次。评分的标准是根据美国放射治疗研究组(RTOG)的急性反应的标准。采用了多因素的随机效应模型及最大似然率的分析以研究在这39例病例中急性放射性食管炎的严重程度与照射剂量和疗程时间因素的关系,并考虑了不同病例个体间的敏感性差异。结果:在amifostine治疗组有11%(2/19),非amifostine治疗组有30%(6/20)的患者发生Ⅲ度的急性食管炎。在这两组中,急性食管炎的发生率在开始治疗后第4周(累计剂量为48Gy)达高峰并呈一稳定状态。随治疗后期剂量的进一步增加,急性食管炎发生的危险性并不明显增加。原因可能是食管粘膜上皮组织的修复和在治疗后的上皮细胞加速再增殖。疗程中的周剂量或累计周剂量要比整个疗程的总剂量更好地预测急性食管炎的发生。结论:肿瘤累积剂量和患者的内在敏感性与Ⅲ度急性放射性食管炎的发生率有关。欲将发生急性食管炎的危险性降低至10%以下,需限制第4周的累计剂量在36Gy以下,或9Gy/周。这可能为开展IMRT等新技术的治疗提供有用的参考信息。 | 章真 Helen Liu Zhongxing Liao Ritsuko Komaki James D Cox | 2006 | 中国癌症杂志2006，16，12： | 5 |
| 4 | 非小细胞肺癌术后三维适形放疗与常规放疗的疗效比较显示文摘背景与目的:非小细胞肺癌术后三维适形放疗与常规放疗的疗效比较目前尚缺乏长期随访结果.本研究回顾性分析非小细胞肺癌(NSCLC)术后分别采用三维适形放疗和常规放疗的疗效及放疗反应,比较不同放疗技术对疗效及放疗反应的影响。方法:收集1990年12月-2002年8月美国M.D.安德森癌症研究中心收治的167例Ⅲ.期NSCLC患者的术后放疗资料进行回顾性分析。其中常规放疗组(CV组)90例.三维适形放疗组(CF组)77例。CV组放疗中位剂量为54.3Gy/27次.CF组放疗中位刹龟为53.9Gy/26次.均在5~6周内完成。结果:两组患者病例特征具有可比性。CV组和CF组中位随访时间分别为36个月和24个月,两组无瘤生存率、局部控制率及无远处转移生存率差异无显著性,但两组总生存率差异有显著性(P=0.014)。CF组在肺部纤维化、心脏损伤和血液系统放疔反应发生率显著性上要低于CV组,其余放疗反应差异基本尤最著性。两组死亡原因差异有显著性,CV组有8例患者死于与心脏损伤有关的并发症,而CF组没有。结论:Ⅲ、期NSCLC术后采用改进的三维适形放疗技术不仅可以取得与常规放疗类似的疗效,还可提高总生存率,同时降低了肺部纤维化、心脏损伤和血液系统反应发生率,三维适形放疗的治疗优势值得关注. | 林原 Zhongxing Liao Pamela K.Allen James D.Cox Ritsuko Komaki | 2007 | 中国癌症杂志2007，17，4： | 4 |
| 5 | 应用随机效应模型探讨肺癌放化疗中影响食管炎的剂量和容积因素显示文摘目的 :应用随机效应模型分析非小细胞肺癌同期放化疗中的急性放射性食管炎发生率与食管受到的照射剂量和容积关系。方法 :6 2例不能手术的Ⅱ期和Ⅲ期非小细胞肺癌患者于 1998年 3月至 2 0 0 0年 11月间在M .D .Anderson癌症治疗中心进入随机、临床Ⅲ期的同期放化疗治疗研究 ,比较应用或未用阿米福汀 (amifostine)时对食管毒性反应的作用。对其中 39例有三维治疗计划的病例进行回顾性分析 ,阿米福汀组和非阿米福汀组分别为 19和 2 0例。急性食管炎程度的评估为每周 1次 ,在放疗结束后的 1个月再随访评估 1次。评分的标准根据RTOG急性反应的标准。放疗的方式为 1.2Gy/次 ,2次 /d ,前后野对照治疗至 4 0~ 5 0Gy后采用避开脊髓的斜野放疗 ,至总剂量 6 9.6Gy/ 6周。所有的患者在放疗前均接受顺铂和口服依托泊苷 (VP 16 )的化疗。采用多因素的随机效应模型分析急性食管炎的评分 (严重程度 )与不同的剂量容积因素的关系。结果 :39例中 ,阿米福汀组中 2例(11% ) ,非阿米福汀组 6例 (30 % )患者发生了Ⅲ度的急性食管炎。Ⅲ度急性食管炎最早出现在治疗的第 3周末 ,即累计肿瘤量达 36Gy时。第 4周后 ,呈一平缓的趋势 ,其发生率并不随以后剂量的增加而明显提高。在所有与Ⅲ度食管炎发生有关的剂量和容积因素中 ,以? | 章真 LIU Helen LIAO Zhongxing Ritsuko KOMAKI James DCOX | 2004 | 中国癌症杂志2004，14，6： | 3 |
| 6 | Predictors of High-grade Esophagitis After Definitive Three-dimensional Conformal Therapy, Intensity-modulated Radiation Therapy, or Proton Beam Therapy for Non-small cell Lung Cancer显示文摘 | Daniel R. Gomez Susan L. Tucker Mary K. Martel Radhe Mohan Peter A. Balter Jose Luis Lopez Guerra Hongmei Liu Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 2 |
| 7 | ⅢA期非小细胞肺癌术后三维适形放疗与常规放疗的初步比较显示文摘目的回顾性比较ⅢA期非小细胞肺癌(NSCLC)术后三维适形放疗(3DCRT组)和常规放疗(CRT组)的近期疗效及放疗反应。方法对美国安德森癌症中心收治的114例ⅢA期NSCLC患者的术后放疗资料进行回顾性分析。CRT组63例,3DCRT组51例。CRT组放疗中位剂量为53.5 Gy分27次,3DCRT组的为52.8 Gy分26次,均在5~6周内完成。结果CRT、3DCRT组中位随访时间分别为28、13个月。两组近期放疗反应、局部控制率及无远处转移生存率等无差异。1、2年总生存率CRT组为80%、62%,3DCRT组为93%、70%。1、2年无瘤生存率CRT组为62%、44%,3DCRT组为58%、32%。两组死亡原因有统计学差异,CRT组有4例死于与心脏损伤有关的并发症,而3DCRT组则无。结论ⅢA期NSCLC术后三维适形放疗可取得与常规放疗类似的近期疗效而并不增加局部复发和远处转移的危险性,对心脏的损伤有降低趋势,对生存率影响则有待更长时间的随访结果。 | 林原 LIAOZhong-xing ALLEN Pamela CHANG Joe COX James KOMAKI Ritsuko | 2006 | 中华放射肿瘤学杂志2006，15，4： | 2 |
| 8 | Lymphopenia Association With Gross Tumor Volume and Lung V5 and Its Effects on Non-Small-Cell Lung Cancer Patient Outcomes显示文摘 | Chad Tang Zhongxing Liao Daniel Gomez Lawrence Levy Yan Zhuang Rediet A. Gebremichael David S. Hong Ritsuko Komaki James W. Welsh | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 2 |
| 9 | Technical Advances of Radiation Therapy for Thymic Malignancies显示文摘 | Daniel Gomez Ritsuko Komaki | 2010 | Journal of Thoracic Oncology ( Suppl Mali)2010，，10： | 1 |
| 10 | Influence of Technologic Advances on Outcomes in Patients With Unresectable, Locally Advanced Non–Small-Cell Lung Cancer Receiving Concomitant Chemoradiotherapy显示文摘 | Zhongxing X. Liao Ritsuko R. Komaki Howard D. Thames Helen H. Liu Susan L. Tucker Radhe Mohan Mary K. Martel Xiong Wei Kunyu Yang Edward S. Kim George Blumenschein Waun Ki Hong James D. Cox | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 11 | Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice显示文摘 | Satoshi Itasaka Ritsuko Komaki Roy S. Herbst Keiko Shibuya Tomoaki Shintani Nancy R. Hunter Amir Onn Corazon D. Bucana Luka Milas K. Kian Ang Michael S. O’Reilly | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 1 |
| 12 | Progress in the management of limited‐stage small cell lung cancer显示文摘 | Arya Amini Lauren A. Byers James W. Welsh Ritsuko U. Komaki | 2014 | Cancer2014，，6： | 1 |
| 13 | Changes in Pulmonary Function After Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, or Proton Beam Therapy for Non-Small-Cell Lung Cancer显示文摘 | Jose L. Lopez Guerra Daniel R. Gomez Yan Zhuang Lawrence B. Levy George Eapen Hongmei Liu Radhe Mohan Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 14 | Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery显示文摘 | Shu-lian Wang Zhongxing Liao Ara A. Vaporciyan Susan L. Tucker Helen Liu Xiong Wei Stephen Swisher Jaffer A. Ajani James D. Cox Ritsuko Komaki | 2006 | International Journal of Radiation Oncology Biology Physics2006，，3： | 1 |
| 15 | Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer显示文摘 | Jingya Wang Caimiao Wei Susan L. Tucker Bevan Myles Matthew Palmer Wayne L. Hofstetter Stephen G. Swisher Jaffer A. Ajani James D. Cox Ritsuko Komaki Zhongxing Liao Steven H. Lin | 2013 | International Journal of Radiation Oncology Biology Physics2013，，5： | 1 |
| 16 | Propensity Score-based Comparison of Long-term Outcomes With 3-Dimensional Conformal Radiotherapy vs Intensity-Modulated Radiotherapy for Esophageal Cancer显示文摘 | Steven H. Lin Lu Wang Bevan Myles Peter F. Thall Wayne L. Hofstetter Stephen G. Swisher Jaffer A. Ajani James D. Cox Ritsuko Komaki Zhongxing Liao | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 17 | Targeted Therapy Against VEGFR and EGFR With ZD6474 Enhances the Therapeutic Efficacy of Irradiation in an Orthotopic Model of Human Non-Small-Cell Lung Cancer显示文摘 | Keiko Shibuya Ritsuko Komaki Tomoaki Shintani | 2007 | International Journal of Radiation Oncology Biology Physics2007，69，5： | 1 |
| 18 | Treatment Outcomes of Resected Esophageal Cancer显示文摘 | Wayne Hofstetter Stephen G. Swisher Arlene M. Correa Kenneth Hess Joe B. Putnam Jaffer A. Ajani Marcelo Dolormente Rhodette Francisco Ritsuko R. Komaki Axbal Lara Faye Martin David C. Rice Arcenio J. Sarabia W. Roy Smythe Ara A. Vaporciyan Garrett L. Wals | 2002 | Annals of Surgery2002，，3： | 1 |
| 19 | Quantifying the Interfractional Displacement of the Gastroesophageal Junction During Radiation Therapy for Esophageal Cancer显示文摘 | Jingya Wang Steven H. Lin Lei Dong Peter Balter Radhe Mohan Ritsuko Komaki James D. Cox George Starkschall | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 1 |
| 20 | A Phase II Study of a Paclitaxel-Based Chemoradiation Regimen With Selective Surgical Salvage for Resectable Locoregionally Advanced Esophageal Cancer: Initial Reporting of RTOG 0246显示文摘 | Stephen G. Swisher Kathryn A. Winter Ritsuko U. Komaki Jaffer A. Ajani Tsung T. Wu Wayne L. Hofstetter Andre A. Konski Christopher G. Willett | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
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