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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Electrically driven, phosphor-free, white light-emitting diodes using gallium nitride-based double concentric truncated pyramid structures显示文摘White light-emitting diodes(LEDs)are becoming an alternative general light source,with huge energy savings compared to conventional lighting.However,white LEDs using phosphor(s)suffer from unavoidable Stokes energy converting losses,higher manufacturing cost,and reduced thermal stability.Here,we demonstrate electrically driven,phosphor-free,white LEDs based on three-dimensional gallium nitride structures with double concentric truncated hexagonal pyramids.The electroluminescence spectra are stable with varying current.The origin of the emission wavelength is studied by cathodoluminescence and high-angle annular dark field scanning transmission electron microscopy experiments.Spatial variation of the carrier injection efficiency is also investigated by a comparative analysis between spatially resolved photoluminescence and electroluminescence. | Seung-Hyuk Lim Young-Ho Ko Christophe Rodriguez Su-Hyun Gong Yong-Hoon Cho | 2016 | Light(Science & Applications)2016，5，1： | 6 |
| 3 | New Virologic Tools for Management of Chronic Hepatitis B and C显示文摘 | Stéphane Chevaliez Christophe Rodriguez Jean–Michel Pawlotsky | 2012 | Gastroenterology2012，，6： | 4 |
| 4 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 5 | Long-chain omega6 polyunsaturated fatty acids in erythrocyte phospholipids are associated with insulin resistance in non-obese type 2 diabetics 显示文摘 | Rodriguez Y Christophe AB | 2005 | Clin Chim Acta2005，354，12： | 1 |
| 6 | Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal显示文摘 | Deqiang Sun Min Luo Mira Jeong Benjamin Rodriguez Zheng Xia Rebecca Hannah Hui Wang Thuc Le Kym F. Faull Rui Chen Hongcang Gu Christoph Bock Alex Meissner Berthold G?ttgens Gretchen J. Darlington Wei Li Margaret A. Goodell | 2014 | Cell Stem Cell2014，，： | 1 |
| 7 | Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum显示文摘 | Christopher M Dekaney JM Rodriguez M | 2005 | Gastroenterology2005，129，： | 1 |
| 8 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 9 | VMeteic Spare Parts Optimization Model Validation 显示文摘 | Christopher M Rodriguez Kevin Downer | 1997 | The National Technical Information Service1997，，： | 1 |
| 10 | Cerebral Oxygen Desaturation Predicts Cognitive Decline and Longer Hospital Stay After Cardiac Surgery显示文摘 | James P. Slater Theresa Guarino Jessica Stack Kateki Vinod Rami T. Bustami John M. Brown Alejandro L. Rodriguez Christopher J. Magovern Thomas Zaubler Kenneth Freundlich Grant V.S. Parr | 2009 | The Annals of Thoracic Surgery2009，，1： | 1 |
| 11 | Restructuring proteomics through verification显示文摘 | Emily Boja Robert Rivers Christopher Kinsinger Mehdi Mesri Tara Hiltke Amir Rahbar Henry Rodriguez | 2010 | Biomarkers Med2010，，6： | 1 |
| 12 | Intermittent Hypoxia Induces Hyperlipidemia in Lean Mice显示文摘 | Jianguo Li Laura N. Thorne Naresh M. Punjabi Cheuk-Kwan Sun Alan R. Schwartz Philip L. Smith Rafael L. Marino Annabelle Rodriguez Walter C. Hubbard Christopher P. O’Donnell Vsevolod Y. Polotsky | 2005 | Circulation Research2005，，7： | 1 |
| 13 | 波罗的海河流养分运输模拟:一种大尺度途径显示文摘我们首次开发了一个集水区模型,对波罗的海流域内所有105个主要集水区的陆地-海洋养分通量同时进行了模拟。对所有这些主要集水区进行一致模拟的方法,即水通量(水文模拟)和负荷功能(排放数据)的一致处理,将促进波罗的海差别巨大的子流域之间河流养分运输的比较。河流排放的热点,如维斯瓦河、奥得河、道加瓦河或丹麦海岸,可以很容易地被展示;并且这些热点及北部集水区中相对未被干扰的河流之间的比较可为决策者指明:1)要改善波罗的海环境状况,在哪里采取补救措施最有效。2)河流养分负荷可能削减的百分比是多少。验证期内实测通量与模拟通量之间的相对差异通常很小。监测水体流量和养分通量的累积偏差(即相对偏差)[∑(模拟-实测)/∑实测×100(%)]总计为径流+8.2%,可溶性无机氮-2.4%,总氮+5.1%,可溶性无机磷+13%,总磷+19%。并且,该模型认为,现存的污染负荷汇编资料中低估了总磷点源,因为在市政府的排放负荷计算中存在着矛盾。 | Carl-Magnus Mrth Christoph Humborg Hanna Eriksson sa Danielsson Miguel Rodriguez Medina Stefan Lfgren Dennis P.Swaney Lars Rahm 王胜 | 2007 | AMBIO-人类环境杂志2007，36，2： | 1 |
| 14 | New Virologic Tools for Management of Chronic Hepatitis B and C显示文摘 | Stéphane Chevaliez Christophe Rodriguez Jean–Michel Pawlotsky | 2012 | Gastroenterology2012，，6： | 1 |
| 15 | Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma显示文摘 | Frank T. Kolligs Jose I. Bilbao Tobias Jakobs Mercedes I?arrairaegui Jutta M. Nagel Macarena Rodriguez Alexander Haug Delia D’Avola Mark op den Winkel Antonio Martinez‐Cuesta Christoph Trumm Alberto Benito Klaus Tatsch Christoph J. Zech Ralf‐Thorsten Hoff | 2015 | Liver Int2015，，6： | 1 |
| 16 | Long‐term results of weekly/daily cisplatin‐based chemoradiation for locally advanced squamous cell carcinoma of the anal canal显示文摘 | Cathy Eng George J. Chang Y. Nancy You Prajnan Das Yan Xing Marc Delclos Robert A. Wolff Miguel A. Rodriguez‐Bigas John Skibber Aki Ohinata Spencer Gould Jonathan Phillips Christopher H. Crane | 2013 | Cancer2013，，21： | 1 |
| 17 | Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal显示文摘 | Deqiang Sun Min Luo Mira Jeong Benjamin Rodriguez Zheng Xia Rebecca Hannah Hui Wang Thuc Le Kym F. Faull Rui Chen Hongcang Gu Christoph Bock Alex Meissner Berthold G?ttgens Gretchen J. Darlington Wei Li Margaret A. Goodell | 2014 | Cell Stem Cell2014，，： | 1 |
| 18 | Mutations in foregut SOX2^+ cells induce efficient proliferation via CXCR2 pathway显示文摘Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics. | Tomoaki Hishida Eric Vazquez-Ferrer Yuriko Hishida-Nozaki Ignacio Sancho-Martinez Yuta Takahashi Fumiyuki Hatanaka Jun Wu Alejandro Ocampo Pradeep Reddy Min-Zu Wu Laurie Gerken Reuben J. Shaw Concepcion Rodriguez Esteban Christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni Castells Josep M. Campistol Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2019 | Protein & Cell2019，10，7： | 1 |
| 19 | 髋关节异响:陶瓷-陶瓷全髋关节置换的一种现象显示文摘背景:现代陶瓷一陶瓷全髋置换术的早期临床应用报告显示其具有优异的临床和影像学结果。只有极少数病例由于早期设计缺陷而出现了灾难性的失败,多表现为假体断裂。有几篇文献报道涉及了术后可以闻及的“嘎吱”声。本文旨在研究陶瓷一陶瓷全髋关节置换术后“嘎吱”作响的髋关节(以下简称“嘎吱”髋,译者注)的发生率。方法:2003年3月至2005年5月,3位医生对143例患者(159髋)行陶瓷一陶瓷全髋关节置换。149髋(131例)随访1年以上。以改良的HSS评分及患者主控调查问卷进行前瞻性评估。以60髋(48例)金属一聚乙烯全髋关节置换作为对照组,在年龄、性别、体重指数与陶瓷一陶瓷组病例匹配的基础上,对比“嘎吱”声或其他声音的发生率,并按事前确定的标准进行影像学评估。 | Christopher A. Jarrett, MD Amar S. Ranawat, MD Matteo Bruzzone, MD Yossef C. Blum, MD Jose A. Rodriguez, MD Chitranjan S. Ranawat, MD 朱跃良(译) 徐永清(译) | 2010 | 中华骨科杂志2010，30，3： | 0 |
| 20 | Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes显示文摘与定义文化协议,人的胚胎的干细胞(hESCs ) 能在 vitro 产生 cardiomyocytes,因此为人的心开发提供一个伟大的模型,并且保持为心脏病治疗的大潜力。在这研究,我们成功地产生了人的 cardiomyocytes (hCMs ) 的一张高度纯的人口(>95%cTnT+) 从 hESC,在基因表示和 DNA methylation 的线,使我们能识别并且描绘 hCM 特定的签名,铺平。这些充实 hCM 的基因的基因功能的协会网络和基因疾病网络分析提供新卓见进 hCM transcriptional 规定的机制,并且为调查心脏的基因函数和疾病机制作为一个增进知识、富有的资源站。而且,我们证明心脏结构的基因和心脏抄写的因素有不同 epigenetic 机制调整他们的基因表示,提供 epigenetic 机械怎么协调在不同房间调整基因表示的更好的理解打字。 | Ying Gut Guang-Hui Liu Nongluk Plongthongkum' Christopher Benner Fei Yi Jing Qu Keiichiro Suzuki Jiping Yang Weiqi Zhang Mo Li Nuria Montserrat Isaac Crespo Antonio del Sol Concepcion Rodriguez Esteban Kun Zhang Juan Carlos Izpisua Belmonte | 2014 | Protein & Cell2014，5，1： | 0 |
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