|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 2 | Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain显示文摘 | Pierre Bouzat Nathalie Sala Tamarah Suys Jean-Baptiste Zerlauth Pedro Marques-Vidal Fran?ois Feihl Jocelyne Bloch Mahmoud Messerer Marc Levivier Reto Meuli Pierre J. Magistretti Mauro Oddo | 2014 | Intensive Care Medicine2014，，3： | 1 |
| 3 | MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain 显示文摘 | Pierre K Magistretti P J Pellerin L | 2002 | Cereb Blood Flow Metab2002，22，5： | 1 |
| 4 | Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation 显示文摘 | Pierre K Debernardi R Magistretti P J | 2003 | J Neurochem2003，86，6： | 1 |
| 5 | Brainenergy metabolism : focus on astrocyte-neuron metaboliccooperation显示文摘 | Mireille Belanger Igor Allaman Pierre J Magistretti | 2011 | Cell Metab2011，14，6： | 1 |
| 6 | Lights at night:does photobiomodulation improve sleep?显示文摘Sleep is a critical part of our daily routine.It impacts every organ and system of our body,from the brain to the heart and from cellular metabolism to immune function.A consistent daily schedule of quality of sleep makes a world of difference to our health and well-being.Despite its importance,so many individuals have trouble sleeping well.Poor quality sleep has such a detrimental impact on many aspects of our lives;it affects our thinking,learning,memory,and movements.Further,and most poignantly,poor quality sleep over time increases the risk of developing a serious medical condition,including neurodegenerative disease.In this review,we focus on a potentially new non-pharmacological treatment that improves the quality of sleep.This treatment,called photobiomodulation,involves the application of very specific wavelengths of light to body tissues.In animal models,these wavelengths,when applied at night,have been reported to stimulate the removal of fluid and toxic waste-products from the brain;that is,they improve the brain’s inbuilt house-keeping function.We suggest that transcranial nocturnal photobiomodulation,by improving brain function at night,will help improve the health and well-being of many individuals,by enhancing the quality of their sleep. | Audrey Valverde Catherine Hamilton Cécile Moro Malvina Billeres Pierre Magistretti John Mitrofanis | 2023 | Neural Regeneration Research2023，18，3： | 1 |
| 7 | MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain 显示文摘 | Pierre K Magistretti P J Pellerin L | 2002 | J Cereb Blood Flow Metab2002，22，5： | 1 |
| 8 | Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation显示文摘 | Mireille Bélanger Igor Allaman Pierre J. Magistretti | 2011 | Cell Metabolism2011，，6： | 1 |
| 9 | Astrocyte–neuron metabolic relationships: for better and for worse显示文摘 | Igor Allaman Mireille Bélanger Pierre J Magistretti | 2010 | Trends in Neurosciences2010，，2： | 1 |
| 10 | MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain 显示文摘 | Pierre K Magistretti PJ Pellerin L | 2002 | J Cereb Blood Flow Metab2002，22，5： | 1 |
| 11 | Do astrocytes respond to light,sound,or electrical stimulation?显示文摘Astrocytes are not only the most populous cell type in the human brain,but they also have the most extensive and dive rse sets of connections,across synapses,axons,blood vessels,as well as having their own internal network.Unsurprisingly,they are associated with many brain functions;from the synaptic transmission to energy metabolism and fluid homeostasis,and from cerebral blood flow and blood-brain barrier maintenance to neuroprotection,memory,immune defenses and detoxification,slee p,and early development.And yet,notwithstanding these key roles,so many current therapeutic approaches to a range of brain disorders have largely neglected their potential involvement.In this review,we consider the role of astrocytes in three brain therapies;two are emerging treatments(photobiomodulation and ultrasound),while the other is well-established(deep brain stimulation).In essence,we explore the issue of whether external sources,such as light,sound,or electricity,can influence the function of astrocytes,as they do neurons.We find that,when taken all together,each of these external sources can influence many,if not,all of the functions associated with astrocytes.These include influencing neuronal activity,prompting neuroprotection,reducing inflammation(astrogliosis) and potentially increasing cerebral blood flow and stimulating the glymphatic system.We suggest that astrocytes,just like neurons,can respond positively to each of these external applications and that their activation co uld each impart many beneficial outcomes on brain function;they are likely to be key playe rs underpinning the mechanisms behind many therapeutic strategies. | Audrey Le Naour Emilien Beziat Jaimie Hoh Kam Pierre Magistretti Alim-Louis Benabid John Mitrofanis | 2023 | Neural Regeneration Research2023，18，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员