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| 1 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 2 | Failure laws of narrow pillar and asymmetric control technique of gob-side entry driving in island coal face显示文摘In allusion to the problems of complex stress distribution in the surrounding rock and deformation failure laws, as well as the difficulty in roadway supporting of the gob-side entry driving in the island coal face, 2107 face in Chengjiao Colliery is researched as an engineering case. Through physical mechanical test of rock, theoretical and numerical simulation analyses of rock, the analysis model of the roadway overlying strata structure was established, and its parameters quantified. To reveal the deformation law of the surrounding rock, the stability of the overlying strata structure was studied before, during and after the roadway driving. According to the field conditions, the stress distribution in coal pillar was quantified, and the surrounding rock deformation feature studied with different widths of the pillars in gob-side entry driving. Finally, the pillar width of 4 m was considered as the most reasonable. The research results show that there is great difference in support conditions among roadway roof, entity coal side and narrow pillar side. Besides, the asymmetric control technique for support of the surrounding rock was proposed. The asymmetric control technique was proved to be reasonable by field monitoring, support by bolt-net, steel ladder and steel wire truss used in narrow pillar side. | Yang Jiping Cao Shenggen Li Xuehua | 2013 | International Journal of Mining Science and Technology2013，23，2： | 16 |
| 3 | Factors associated with fatigue in acquired immunodeficiency syndrome patients with antiretroviral drug adverse reactions: a retrospective study显示文摘OBJECTIVE: To retrospectively study the prevalence of fatigue and factors associated with fatigue among acquired immunodeficiency syndrome (AIDS) patients with antiretroviral drug adverse re-ctions. METHODS: Data were collected from case reportforms (CRFs) for a project funded by the 11th National 5-year Special Science and Technology Program on Major Infectious Diseases. Fatigue was defined by patient self-report. The outcomes were the prevalence of fatigue and the potential risk factors of fatigue. Univariate and multivariate logistic regression analyses were conducted to identify the factors associated with fatigue. RESULTS: Among the 228 subjects, the prevalence of fatigue was 86.8%. In univariate analysis, the significant differences in demographic characteristics between patients with and without fatigue were: gender [OR=2.29; 95% CI (1.05-4.98)], education level [OR=0.40; 95% CI (0.18-0.85)], anemia [OR=3.80; 95% CI (1.27-11.31)], time of HIV diagnosis [OR= 0.29; 95% CI (0.13-0.65)], and route of infection [OR= 0.14; 95% CI (0.06-0.32)]. Abnormal taste and rapid pulse were more commonly seen in patients with fatigue (P<0.05), while abdominal distension and lumbar soreness were encountered less often in patients with fatigue (P<0.05). Multivariate analysis showed that the four main factors associated with fatigue were anemia [OR=3.50; 95% CI (1.01-12.15)], route of infection [OR=3.40; 95% CI (1.21-9.58); P= 0.02<0.05], lumbar soreness [OR=0.06; 95% CI (0.02-0.18); P=0.000<0.05], and rapid pulse [OR= 10.58; 95% CI (2.16-51.75); P=0.004<0.05]. CONCLUSION: This study demonstrated that fa- tigue is common (86.8% prevalence) in AIDS patients with antiretroviral drug adverse reactions, and that anemia, route of infection (i.e., non-commercial blood donation) and rapid pulse were risk factors, while lumbar soreness was a protective factor related to fatigue. More attention should bepaid to fatigue and more efforts should be made to find ways to prevent, control and eliminate this symptom in AIDS patients with antiretroviral drug adverse reactions. | Zhibin Liu Jiping Yang Huijuan Liu Yantao Jin | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 12 |
| 4 | Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding显示文摘 | Jiping Yang Jingyi Li Keiichiro Suzuki Xiaomeng Liu Jun Wu Weiqi Zhang Ruotong Ren Weizhou Zhang Piu Chan Juan Carlos Izpisua Belmonte Jing Qu Fuchou Tang Guang-Hui Liu | 2017 | Cell Research2017，27，9： | 12 |
| 5 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 6 | Towards reliable Arctic sea ice prediction using multivariate data assimilation显示文摘Rapid declines in Arctic sea ice have captured attention and pose significant challenges to a variety of stakeholders. There is a rising demand for Arctic sea ice prediction at daily to seasonal time scales, which is partly a sea ice initial condition problem. Thus, a multivariate data assimilation that integrates sea ice observations to generate realistic and skillful model initialization is needed to improve predictive skill of Arctic sea ice. Sea ice data assimilation is a relatively new research area. In this review paper, we focus on two challenges for implementing multivariate data assimilation systems for sea ice forecast. First, to address the challenge of limited spatiotemporal coverage and large uncertainties of observations, we discuss sea ice parameters derived from satellite remote sensing that(1) have been utilized for improved model initialization, including concentration, thickness and drift, and(2) are currently under development with the potential for enhancing the predictability of Arctic sea ice, including melt ponds and sea ice leads. Second, to strive to generate the ‘‘best' estimate of sea ice initial conditions by combining model simulations/forecasts and observations, we review capabilities and limitations of different data assimilation techniques that have been developed and used to assimilate observed sea ice parameters in dynamical models. | Jiping Liu Zhiqiang Chen Yongyun Hu Yuanyuan Zhang Yifan Ding Xiao Cheng Qinghua Yang Lars Nerger Gunnar Spreen Radley Horton Jun Inoue Chaoyuan Yang Ming Li Mirong Song | 2019 | Science Bulletin2019，64，1： | 10 |
| 7 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 8 | Differences in acquired immune deficiency syndrome treatment and evaluation strategies between Chinese and Western Medicine显示文摘Complementary and alternative medicine, including Chinese medicine(CM), has been used to treat acquired immune deficiency syndrome(AIDS) for almost 30 years. We aimed to compare the main differences between AIDS treatment and evaluation strategies between CM and Western Medicine(WM), and analyze advantages and disadvantages.The characteristics of integrative medicine(IM),based on CM and WM, include a patient-centered mode of medicine based on evidence. IM focuses on complex intervention and management with systemic and individual treatment. The evaluation indexes of IM might consist of objective indicators and subjective indexes. IM might be a more valuable method for treating AIDS in the future instead of WM or CM alone. | Liu Zhibin Li Xia Yang Jiping Xu Liran Guo Huijun | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 8 |
| 9 | Survival rate:an indicator of the management of acquired immune deficiency syndrome using Traditional Chinese Medicine显示文摘Complementary and alternative medicine,including Traditional Chinese Medicine(TCM),has been used as therapy against acquired immune deficiency syndrome(AIDS) for almost 30 years. Based on evaluation indicators for AIDS treatment using TCM,we discuss why the survival rate(which has been used widely in Western Medicine) should be adopted as a new important indicator of TCM treatment for AIDS. We advise that further prospective or retrospective cohort studies should be carried out to confirm this hypothesis. | Liu Zhibin Meng Changhai Yang Jiping Chen Xiumin Jin Yantao | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 7 |
| 10 | Albedo of Coastal Landfast Sea Ice in Prydz Bay,Antarctica:Observations and Parameterization显示文摘The snow/sea-ice albedo was measured over coastal landfast sea ice in Prydz Bay, East Antarctica(off Zhongshan Station)during the austral spring and summer of 2010 and 2011. The variation of the observed albedo was a combination of a gradual seasonal transition from spring to summer and abrupt changes resulting from synoptic events, including snowfall, blowing snow, and overcast skies. The measured albedo ranged from 0.94 over thick fresh snow to 0.36 over melting sea ice. It was found that snow thickness was the most important factor influencing the albedo variation, while synoptic events and overcast skies could increase the albedo by about 0.18 and 0.06, respectively. The in-situ measured albedo and related physical parameters(e.g., snow thickness, ice thickness, surface temperature, and air temperature) were then used to evaluate four different snow/ice albedo parameterizations used in a variety of climate models. The parameterized albedos showed substantial discrepancies compared to the observed albedo, particularly during the summer melt period, even though more complex parameterizations yielded more realistic variations than simple ones. A modified parameterization was developed,which further considered synoptic events, cloud cover, and the local landfast sea-ice surface characteristics. The resulting parameterized albedo showed very good agreement with the observed albedo. | Qinghua YANG Jiping LIU Matti LEPPRANTA Qizhen SUN Rongbin LI Lin ZHANG Thomas JUNG Ruibo LEI Zhanhai ZHANG Ming LI Jiechen ZHAO Jingjing CHENG | 2016 | Advances in Atmospheric Sciences2016，33，5： | 7 |
| 11 | Mechanism and characteristics of thermal action of HMX explosive mixture containing high-efficiency fuel显示文摘In this study, the thermal stability and detonation properties of three types of explosives were investigated. Results indicated that nanoaluminum powder improved the detonation properties of HMX by increasing the specific surface area of HMX, which substantially increased the explosion heat and power. The decomposition temperatures of the three explosives containing aluminum hydride, ammonia borane, and nanoaluminum powder during slow cook-off at heating rates of 1.5 and 10°C min–1 were measured as 246°C and 241°C, 256°C and 261°C, and 238°C and 264°C, respectively. The explosives containing hydrogen storage materials swelled; however, the nanoaluminum powder was only slightly peeled off at the edge of the grains during cookoff. Differential scanning calorimetry(DSC) curves of the explosives containing hydrogen storage materials exhibited endothermic and exothermic peaks before the major exothermic reaction peak during the cook-off tests. In contrast, only one weak peak was observed in the DSC curve of the explosive containing nanoaluminum powder before the major exothermic reaction. In addition, the additives and adhesives catalyzed the slow cook-off decomposition, which caused the transformation of HMX crystals and accelerated the thermal decomposition reaction of HMX. The addition of high-density hydrogen storage materials to HMX resulted in detonation heats and explosion powers much greater than cure HMX. This improved performance was attributed to the hydrogen storage materials in the explosives participating in a secondary reaction in the reaction zone at the instant of the explosion, effectively realizing complementary lossless energy and thus greatly improving the explosive power of the explosives. | LIU JiPing YANG WeiWei LIU Ying LIU XiaoBo | 2019 | Science China(Technological Sciences)2019，62，4： | 6 |
| 12 | Comment on the intervention of Traditional Chinese Medicine on survival rates of patients living with human immunodeficiency virus and acquired immune deficiency syndrome显示文摘Despite many differences between Traditional Chinese Medicine(TCM) and conventional medicine,the use of TCM in the treatment of human immunodeficiency virus and acquired immune deficiency syndrome(HIV/AIDS) is increasingly recognized and accepted by patients. Recent research findings on the benefits of Chinese herbal medicine on long-term survival in patients with HIV/AIDS are encouraging and hopeful, but inconclusive. More research is needed. | Li Qiang Liu Zhibin Yang Jiping Guo Huijun Xu Liran | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 5 |
| 13 | Sensitivity of the Arctic sea ice concentration forecasts to different atmospheric forcing: a case study显示文摘A regional Arctic configuration of the Massachusetts Institute of Technology general circulation model(MITgcm) is used as the coupled ice-ocean model for forecasting sea ice conditions in the Arctic Ocean at the National Marine Environmental Forecasting Center of China(NMEFC), and the numerical weather prediction from the National Center for Environmental Prediction Global Forecast System(NCEP GFS) is used as the atmospheric forcing. To improve the sea ice forecasting, a recently developed Polar Weather Research and Forecasting model(Polar WRF) model prediction is also tested as the atmospheric forcing. Their forecasting performances are evaluated with two different satellite-derived sea ice concentration products as initializations:(1) the Special Sensor Microwave Imager/Sounder(SSMIS) and(2) the Advanced Microwave Scanning Radiometer for EOS(AMSR-E). Three synoptic cases, which represent the typical atmospheric circulations over the Arctic Ocean in summer 2010, are selected to carry out the Arctic sea ice numerical forecasting experiments. The evaluations suggest that the forecasts of sea ice concentrations using the Polar WRF atmospheric forcing show some improvements as compared with that of the NCEP GFS. | YANG Qinghua LIU Jiping ZHANG Zhanhai SUI Cuijuan XING Jianyong LI Ming LI Chunhua ZHAO Jiechen ZHANG Lin | 2014 | Acta Oceanologica Sinica2014，33，12： | 5 |
| 14 | MOF-derived ZnCo_2O_4/C wrapped on carbon fiber as anode materials for structural lithium-ion batteries显示文摘To meet the requirements for the mechanical and electrochemical performance for carbon fiber-based (CF-based) composites in the structural lithium ion batteries (SLIBs) application, better CF-Based composites are urgently needed. Herein, we report a novel composite metal organic framework (MOF)-derived ZnCo_2 O_4/C@carbon fiber via a facile method and subsequent annealing treatment. In this anode,the nano ZnCo_2 O_4/C coatings wrapped on the surface of CF provide more active sites for electrode reactions and the thin carbon layers give the additional protection. For this material, after 100 cycles, it exhibits excellent cycling stability including high reversible capacity of 463 mAh/g at 50 mA/g, which increases 201% than that of the CF. Thus, this structural anode material exhibits enhanced capacity, high initial columbic efficiency. | Huagen Li Shubin Wang Mengjie Feng Jiping Yang Boming Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 15 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 16 | Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy显示文摘Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy. | Xiaofeng Yang Yifeng Xu Naiwu Lu Yibin Zhang Hongmei Wang Xin Lu Jiping Cui JinxuZhou Hong Shan Yanxiang Wu Xinping Liu | 2011 | Neural Regeneration Research2011，6，10： | 4 |
| 17 | Asymptomatic stage of human immunodeficiency virus infection is the optimal timing for its management with Traditional Chinese Medicine显示文摘Acquired immune deficiency syndrome(AIDS) is a worldwide public health problem and an incurable disease.The roles of Traditional Chinese Medicine(TCM) on AIDS had been recognized and accepted by more and more people.Being a relatively long period,to initiate combination antiretroviral therapy(cART) for the asymptomatic human immunodeficiency virus(HIV) infection patient is not consensus.According to TCM theory,not only the imbalance of Yin and Yang but also the disharmony of internal body function and external natural environment had occurred in the body of the patient,the imbalance and the disharmony should be adjusted by the means of the treatment based on the patters identified among the symptoms in terms of TCM.We aimed to analyze the feature of patients with asymptomatic infection,and compare the advantages and disadvantages of the usage of cART for asymptomatic infection,explored the possible mechanism underlying TCM treatment of the asymptomatic infection,by reviewing the TCM treatment progress on asymptomatic HIV infection. | Chen Xiumin Yuan Qingting Liu Zhibin Yang Jiping Xu Liran Guo Huijun | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 3 |
| 18 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 19 | Flexible Triboelectric Nanogenerator from Micro-nano Structured Polydimethylsiloxane显示文摘 | XIAO Xinze Lü Chao WANG Gong XU Ying WANG Jiping YANG Hai | 2015 | Chemical Research in Chinese Universities2015，31，3： | 3 |
| 20 | Health related quality of life:is it another comprehensive evaluation indicator of Chinese medicine on acquired immune deficiency syndrome treatment?显示文摘Health related quality of life(HRQOL) can better reflect changes in acquired immune deficiency syndrome(AIDS) patients and inform economic evaluation of AIDS treatment services,and the assessment of HRQOL can help us to detect problems that may influence the progression of the disease,hence HRQOL has become a particularly important assessment indictor for HIV comprehensive interventions.Being a multi-angle,multi-level,and diversified complex intervention,roles of Chinese medicine(CM) in AIDS treatment have been recognized and accepted by more and more patients,and HRQOL has been widely used to evaluate the comprehensive management effects of CM on AIDS.In this article,the authors analyze the definition and measurement of HRQOL,measurement of HRQOL of HIV/AIDS patients and effects of CM on AIDS,and give some reasonable advices for the usage of the scale of HRQOL.The authors hold that some new HRQOL instruments specific for CM treatment of AIDS should be developed and further prospective studies should be carried out to demonstrate the practicality,reliability and validity of HRQOL as an evaluation indictor for CM treatment of AIDS. | Liu Zhibin Yang Jiping | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 3 |
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