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| 1 | Distributed cooperative guidance for multiple missiles with fixed and switching communication topologies显示文摘This study investigates cooperative guidance problems for multiple missiles with fixed and switching directed communication topologies. A two-step guidance strategy is proposed to realize the simultaneous attack. In the first step, a distributed cooperative guidance law is designed using local neighboring information for multiple missiles to achieve consensus on range-to-go and leading angle. The second step begins when the consensus of multiple missiles is realized. During the second step, multiple missiles disconnect from each other and hit the target using the proportional navigation guidance law. First, based on the local neighboring communications, a sufficient condition for multiple missiles to realize simultaneous attack with a fixed communication topology is presented, where the topology is only required to have a directed spanning tree. Then,the results are extended to the case of switching communication topologies. Finally, numerical simulations are provided to validate the theoretical results. | Qilun ZHAO Xiwang DONG Zixuan LIANG Chen BAI Jian CHEN Zhang REN | 2017 | Chinese Journal of Aeronautics2017，30，4： | 27 |
| 2 | Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy显示文摘OBJECTIVE:To compare and observe the effects of three kinds of cephalic acupuncture therapies commonly used in the clinic on promoting nerve function rehabilitation in the brain microenvironment of rats with cerebral palsy.METHODS:A negative control group,positive control group,and three cephalic acupuncture groups based on the administration of three cephalic acupuncture therapies were established.Ten experimental rats were selected from each group at 1,2,and 3 weeks after modeling.Neuromotor function after treatment was rated according to the Basso,Beattie,and Bresnahan method.White matter fiber bundles were evaluated by head diffusion tensor imaging.The expression levels of neuron-specific enolase,microtubule-associated protein 2,and myelin basic protein in the brain tissue extract were detected by Western blot analysis and the activities of ATPases were determined using a fixed phosphorus method.RESULTS:The pathological changes in brain tissue were restored and motor function scores were increased in the mice in each cephalic acupuncture group,and the expression of neuronal growth-related proteins in the brain tissue extract was significantly increased.Additionally,the activities of ATPases in the lesion area were significant enhanced(P<0.05).Diffusion tensor imaging revealed that the white matter fiber bundles of mice in each cephalic acupuncture group gradually increased and recovered.The nervous system structure was significantly improved.CONCLUSIONS:All three acupuncture methods promoted the rehabilitation of nerve function damaged by cerebral palsy.These effects are likely related to the improved expression of nerve growth-related proteins,enhancement of ATPase activities,and regulation of the brain microenvironment. | WANG Zixuan FAN Xiangwei CHEN Kaiyun YU Xuefeng GAO Jing | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 8 |
| 3 | Near-surface wind environment in the Yarlung Zangbo River basin,southern Tibetan Plateau显示文摘Aeolian processes have been studied extensively at low elevations,but have been relatively little studied at high elevations.Aeolian sediments are widely distributed in the Yarlung Zangbo River basin,southern Tibetan Plateau,which is characterized by low pressure and low temperature.Here,we comprehensively analyzed the wind regime using data since 1980 from 11 meteorological stations in the study area,and examined the interaction between the near-surface wind and aeolian environment.The wind environment exhibited significant spatial and temporal variation,and mean wind speed has generally decreased on both annual and seasonal bases since 1980,at an average of 0.181 m/(s•10a).This decrease resulted from the reduced contribution of maximum wind speed,and depended strongly on variations of the frequency of sand-driving winds.The drift potential and related parameters also showed obvious spatial and temporal variation,with similar driving forces for the wind environment.The strength of the wind regime affected the formation and development of the aeolian geomorphological pattern,but with variation caused by local topography and sediment sources.The drift potential and resultant drift direction were two key parameters,as they quantify the dynamic conditions and depositional orientation of the aeolian sediments.Wind affected the spatial variation in sediment grain size,but the source material and complex topographic effects on the near-surface wind were the underlying causes for the grain size distribution of aeolian sands.These results will support efforts to control aeolian desertification in the basin and improve our understanding of aeolian processes in high-elevation environments. | YANG Junhuai XIA Dunsheng WANG Shuyuan TIAN Weidong MA Xingyue CHEN Zixuan GAO Fuyuan LING Zhiyong DONG Zhibao | 2020 | Journal of Arid Land2020，12，6： | 5 |
| 4 | Evolution from small molecule to nano-drug delivery systems:An emerging approach for cancer therapy of ursolic acid显示文摘Ursolic acid(UA),a natural pentacyclic triterpenoid,possesses widespread biological and pharmacological activities.However,drawbacks such as low bioavailability,poor targeting and rapid metabolism greatly hinder its further clinical application.Recently,with the development of nanotechnology,various UA nanosystems have emerged as promising strategies for effective cancer therapy.This article reviews various types of UA-based nanodelivery systems,primarily with emphasis placed on novel UA-based carrier-free nanodrugs,which are considered to be innovative methods for cancer therapy.Moreover,this review presents carrier-free nano-drugs that co-assembled of UA and photosensitizers that displayed synergistic antitumor performance.Finally,the article also describes the development and challenges of UA nanosystems for future research in this field.Overall,the information presented in this review will provide new insight into the rational utilization of nano-drugs in cancer therapy. | Jingwei Shao Yifan Fang Ruirui Zhao Fangmin Chen Mingyue Yang Jiali Jiang Zixuan Chen Xiaotian Yuan Lee Jia | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 5 | Comprehensive Assessment of Water Environment Carrying Capacity of Yunnan Province显示文摘Based on the concept and connotation of water environment carrying capacity, taking Yunnan Province as a case, this paper built water environment carrying capacity evaluation system from the perspectives of water resources, water environment carrying capacity and socio-economic development, and applied the index evaluation model to analyze the trends of water environment carrying capacity in Yunnan from 2006 to 2014. The results showed that, during those years, the evaluation value of water environment carrying capacity ranged from 0.23 to 0.46 in Yunnan Province.The minimum value was 0.23 in 2013, the maximum value was 0.46 in 2010. From 2006 to 2014, the evaluation value of water environment carrying capacity was less than 0.5 in general, and the water environment in a fragile state on the whole. | DONG Xuyan LU Ying ZHOU Zixuan CHEN Hao | 2017 | Journal of Landscape Research2017，9，3： | 2 |
| 6 | Low-firing,temperature stable and improved microwave dielectric properties of ZnO-TiO_(2)-Nb_(2)O_(5) composite ceramics显示文摘This article presents low-firing,low-loss and temperature stable ZnO-TiO_(2)-Nb_(2)O_(5) microwave dielectric composite ceramics with the assistance of lithium borosilicate(LBS)and zinc borosilicate(ZBS)glass frits.There is a liquid phase(eutectic mixture)generated by LBS(ZBS)glass,and solid particles could be wetted and dissolved.Therefore,the migrations and rearrangements of particles could be performed.Besides,compared with ceramics undoped with glass frits,lower activation energies(E_(a))of ceramics doped with LBS and ZBS glass suggest that the low-temperature sintering behavior is easier to carry out.The results indicated that LBS and ZBS glass both are effective sintering aids to accelerate the sintering process and improve the microwave dielectric properties of composite ceramics by controlling the phase compositions under low temperature.Combination great properties of ZnO-TiO_(2)-Nb_(2)O_(5) ceramics were obtained when sintered at 900℃ for 4 h:ε_(r)=36.7,Q×f=20,000 GHz,τ_(f)=7 ppm/℃. | Hongyu Yang Shuren Zhang Yawei Chen Hongcheng Yang Zixuan Fang Ying Yuan Enzhu Li | 2019 | Journal of Materiomics2019，5，3： | 2 |
| 7 | Wearable and flexible electrochemical sensors for sweat analysis:a review显示文摘Flexible wearable sweat sensors allow continuous,real-time,noninvasive detection of sweat analytes,provide insight into human physiology at the molecular level,and have received significant attention for their promising applications in personalized health monitoring.Electrochemical sensors are the best choice for wearable sweat sensors due to their high performance,low cost,miniaturization,and wide applicability.Recent developments in soft microfluidics,multiplexed biosensing,energy harvesting devices,and materials have advanced the compatibility of wearable electrochemical sweat-sensing platforms.In this review,we summarize the potential of sweat for medical detection and methods for sweat stimulation and collection.This paper provides an overview of the components of wearable sweat sensors and recent developments in materials and power supply technologies and highlights some typical sensing platforms for different types of analytes.Finally,the paper ends with a discussion of the challenges and a view of the prospective development of this exciting field. | Fupeng Gao Chunxiu Liu Lichao Zhang Tiezhu Liu Zheng Wang Zixuan Song Haoyuan Cai Zhen Fang Jiamin Chen Junbo Wang Mengdi Han Jun Wang Kai Lin Ruoyong Wang Mingxiao Li Qian Mei Xibo Ma Shuli Liang Guangyang Gou Ning Xue | 2023 | Microsystems & Nanoengineering2023，9，1： | 2 |
| 8 | Development of an In-House Multiplex Nested RT-PCR Method for Detecting Acute HIV-1 Infection in High Risk Populations显示文摘 | Zhiying Liu Wei Li Meng Xu Bo Sheng Zixuan Yang Yanmei Jiao Tong Zhang Danlei Mou Dexi Chen Hao Wu | 2015 | Current HIV Research2015，，： | 1 |
| 9 | Research Advance on Carbon Storage of Artificial Grassland in China显示文摘As an essential part of the grassland ecological system,study on the carbon storage has great significances to the carbon reduction in grassland ecological system.The carbon storage in biomass,carbon storage in soil and soil respiration are summarized in this paper to provide scientific reference for the evaluation of carbon storage in artificial grassland. | Fuping TIAN Yongjie SHI Yu HU Zixuan CHEN Yuan LU Xiaofu ZHANG Runlin LI | 2013 | Asian Agricultural Research2013，5，9： | 1 |
| 10 | Event-Triggered-Backstepping-Based Parallel Approaching Guidance Method for Maneuvering Target Interception显示文摘In order to achieve a straight ballistic trajectory of missile and reduce the update frequency of the missile normal acceleration for the interception of maneuvering target,a backstepping-based parallel approaching guidance method is designed with nonlinear disturbance observer(NDO)technique and event-triggered(ET)mechanism in this paper.In order to suppress the adverse e®ect of target maneuver,the NDO is designed to estimate the target maneuvering acceleration.Then,the NDO-based backstepping method is used to obtain the normal acceleration of missile and realize the parallel approaching guidance.In order to reduce the update frequency of missile normal acceleration,the ET mechanism is employed in the parallel approaching guidance method.If the missile trajectory is relatively straight,the normal acceleration of missile remains unchanged.On the contrary,if the missile trajectory is not straight,the normal acceleration of missile is updated to make the missile trajectory straight.In this way,the ET-based parallel approaching guidance can be obtained.Furthermore,a determined method for the initial missile°ight-path angle is proposed to keep the normal acceleration of missile at zero in the initial stage of interception.Besides,Lyapunov stability analysis method is used to prove that all signals in the closed-loop guidance system are uniformly ultimately bounded.Finally,simulation results show the e®ectiveness of the proposed guidance method. | Yaohua Shen Mou Chen Zixuan Zheng Hongzhen Guo | 2022 | Guidance, Navigation and Control2022，2，1： | 1 |
| 11 | Energy transfer kinetics of phycoerythrocyanins (PECs) from the cyanobacteriumAnabaena variabilis (I)显示文摘 | Jingmin Zhang Jianping Zhang Zixuan Yang Jingquan Zhao Lijin Jiang Jianxin Chen Tong Ye Qiyuan Zhang | 1997 | Science in China Series B: Chemistry1997，，3： | 1 |
| 12 | Semisupervised Encrypted Traffic Identification Based on Auxiliary Classification Generative Adversarial Network显示文摘The rapidly increasing popularity of mobile devices has changed the methods with which people access various network services and increased net-work traffic markedly.Over the past few decades,network traffic identification has been a research hotspot in the field of network management and security mon-itoring.However,as more network services use encryption technology,network traffic identification faces many challenges.Although classic machine learning methods can solve many problems that cannot be solved by port-and payload-based methods,manually extract features that are frequently updated is time-consuming and labor-intensive.Deep learning has good automatic feature learning capabilities and is an ideal method for network traffic identification,particularly encrypted traffic identification;Existing recognition methods based on deep learning primarily use supervised learning methods and rely on many labeled samples.However,in real scenarios,labeled samples are often difficult to obtain.This paper adjusts the structure of the auxiliary classification generation adversarial network(ACGAN)so that it can use unlabeled samples for training,and use the wasserstein distance instead of the original cross entropy as the loss function to achieve semisupervised learning.Experimental results show that the identification accuracy of ISCX and USTC data sets using the proposed method yields markedly better performance when the number of labeled samples is small compared to that of convolutional neural network(CNN)based classifier. | Jiaming Mao Mingming Zhang Mu Chen Lu Chen Fei Xia Lei Fan ZiXuan Wang Wenbing Zhao | 2021 | Computer Systems Science & Engineering2021，39，12： | 1 |
| 13 | A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration显示文摘Articular cartilage damage is a universal health problem.Despite recent progress,chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.Loss-of-function changes are frequently observed in chondrocyte expansion and other pathological conditions,but the characteristics and intermediate molecular mechanisms remain unclear.In this study,we demonstrate a time-lapse atlas of chondrocyte dedifferentiation to provide molecular details and informative biomarkers associated with clinical chondrocyte evaluation.We performed various assays,such as single-cell RNA sequencing(scRNA-seq),live-cell metabolic assays,and assays for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq),to develop a biphasic dedifferentiation model consisting of early and late dedifferentiation stages.Early-stage chondrocytes exhibited a glycolytic phenotype with increased expression of genes involved in metabolism and antioxidation,whereas late-stage chondrocytes exhibited ultrastructural changes involving mitochondrial damage and stress-associated chromatin remodeling.Using the chemical inhibitor BTB06584,we revealed that early and late dedifferentiated chondrocytes possessed distinct recovery potentials from functional phenotype loss.Notably,this two-stage transition was also validated in human chondrocytes.An image-based approach was established for clinical use to efficiently predict chondrocyte plasticity using stage-specific biomarkers.Overall,this study lays a foundation to improve the quality of chondrocytes in clinical use and provides deep insights into chondrocyte dedifferentiation. | Yishan Chen Yeke Yu Ya Wen Juan Chen Junxin Lin Zixuan Sheng Wenyan Zhou Heng Sun Chengrui An Jiansong Chen Weiliang Wu Chong Teng Wei Wei Hongwei Ouyang | 2022 | Bone Research2022，10，3： | 1 |
| 14 | High drug loading and pH-responsive nanomedicines driven by dynamic boronate covalent chemistry for potent cancer immunotherapy显示文摘Tumor cells undergoing immunogenic cell death (ICD) have emerged as an in situ therapeutic vaccine helping to activate a persistent anti-tumor response. Several chemotherapeutic agents have been demonstrated to induce ICD, however accompanied with severe adverse effects in the clinic, weakening its immune responses. Herein, to elicit an intensive ICD while minimizing the systemic toxicity, we introduce a tumor targeting peptide modified bortezomib (BTZ) loading nanomedicine (i-NPBTZ) for the efficient delivery and controlled release of BTZ in tumors. This system is constructed by conjugating BTZ to PEGylated polyphenols via a pH-sensitive covalent boronate-phenol bond that allows them to self-assemble into nanovesicles in neutral condition with high drug loading efficiency. Once accumulated in acidic environment, BTZ-phenolic network is disassembled and thereby accelerates the release of BTZ from nanocarriers. The released BTZ selectively kill tumor cells with a concomitant evocation of tumor-specific cytotoxic T cells by triggering ICD in vivo. This can finally lead to an extended tumor ablation and prevention of distant metastasis in a syngeneic tumor mouse model, while reducing the systemic toxicity of BTZ. In general, our system offers a novel concept with clinical potential to exploit ICD for potentiating tumor immunotherapy and also provides an excellent example of the application of polymer-drug interaction for efficient drug delivery and controllable release. | Wei Jiang Han Zhou Qin Wang Ziqi Chen Wang Dong Zixuan Guo Yong Li Wei Zhao Meixiao Zhan Yucai Wang Ligong Lu | 2021 | Nano Research2021，14，11： | 1 |
| 15 | Epicatechin gallate prevents the de novo synthesis of fatty acid and the migration of prostate cancer cells显示文摘Lipid metabolism disorder caused by the upregulation of lipogenic genes is a typical feature of prostate cancer.The synthesis of fatty acids is enhanced to accelerate the development of prostate cancer and is considered as a potential therapeutic target.Epicatechin gallate,an active compound of green tea,has been reported to modulate lipid metabolism.In this research,the potential role of epicatechin gallate in prostate cancer cells was evaluated.The results indicated that epicatechin gallate downregulates the expression of acetyl-CoA carboxylase,ATP citrate lyase,and fatty acid synthase in prostate cancer cells and prostate xenograft tissues,suggesting that epicatechin gallate can inhibit de novo fatty acid synthesis.Moreover,epicatechin gallate significantly restrains the migration rather than the viability of prostate cancer cells.PI3K/AKT/mTOR signaling pathway,which exhibits regulatory effect on lipogenesis,is also inhibited under epicatechin gallate treatment,while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.In conclusion,this study revealed that epicatechin gallate impairs the synthesis of fatty acids via inhibition PI3K/AKT/mTOR signaling pathway and then attenuates the migration of prostate cancer cells. | Luyao Chen Yaping Guo Zixuan Wu Shuwu Zhao Zhaiyi Zhang Fang Zheng Likang Sun Zheng Hao Chen Xu Tao Wang Yanfei Peng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 16 | 3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction显示文摘At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction. | Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang | 2023 | Bio-Design and Manufacturing2023，6，4： | 0 |
| 17 | Analysis on the Wear Performances of Cemented Carbide Tools Containing Ti in the Coatings When Machining Ti⁃6Al⁃4V Alloys显示文摘Because of the high affinity of the same element Ti,cemented carbide tools containing Ti seem to be non⁃optimal in machining titanium alloys.However,in practice,cemented carbide tools containing Ti are still widely used in machining titanium alloys.Cutting experiments were conducted in order to systematically explain the contradictions between the practice and theory.The diffusion process between titanium alloys and the cemented carbide tools was analyzed by auger electron spectroscopy detecting the cutting regions.It was also analyzed by Ti/Co diffusion behavior simulated by molecular thermodynamics.The experimental results and the simulation results showed that the mutual diffusion of Ti/Co atoms was the major reason for the diffusion wear.The dissolution⁃diffusion wear was one of the main wear mechanisms for the cemented carbide tools containing Ti in the coatings.Moreover,four types of cemented carbide tools and two other types of cermet tools were used to machine the Ti⁃6Al⁃4V alloys at different cutting speeds to further verify the high affinity of cutting tools containing Ti in the substrate/coating.The verification experiments results showed that the cemented carbide tools containing Ti generally cannot be used for machining titanium alloys,but could show less affinity in the cutting regions with reasonable cutting conditions. | Jianfei Sun Daxi Du Zixuan Ding Kai Wang Dashan Bai Wuyi Chen | 2021 | Journal of Harbin Institute of Technology(New Series)2021，28，6： | 0 |
| 18 | A purely green approach to low-cost mass production of zeolitic imidazolate frameworks显示文摘Although zeolitic imidazolate frameworks(ZIFs)have bright prospects in wide fields like gas storage/separation,catalysis and medicine,etc.,their large-scale applications are bottlenecked by the absence of their low-cost commercial production technique.Here,we report an uncon ventional method suitable for environmentally friendly and low-cost mass-production of ZIFs.In this method,taking the synthesis of ZIF-8 as an example,ZnO was used instead of Zn(NO_(3))_(2) in traditional solvent synthesis methods and CO_(2) was introduced to dissolve ZnO in aqueous solution of 2-methylimidazole(HMeim)and form water soluble salt([ZnMeim]^(+)[MeimCOO]^(-))at room temperature.Then,by removing CO_(2) through heating or vacuuming,Meim-ions are produced and instantaneously assemble with[ZnMeim]^(+)s to generate ZIF-8 without any by product.Due to the absence of strong acid anions(such as NO^(-)_(3) and Cl^(-) et al.)in solution,the washing of filter cake required in the conventional approaches could be omitted and the filtrate containing only water and HMeim could be reused completely.This method is really green as no waste gas or liquid generates because CO_(2) and water could be recycled perfectly.It overcomes almost all bottlenecks occurred in commercial production of ZIF-8 when using traditional methods.A pilot plant was established for mass-production of ZIF-8 and hundreds kilograms of ZIF-8 was produced,which indicates that the new method is not only environmentally friendly but also low cost and commercial accessibility.It is expected that the new method would open an avenue for commercial applications of ZIFs. | Hai Li Wan Chen Bei Liu Mingke Yang Zixuan Huang Changyu Sun Chun Deng Dapeng Cao Guangjin Chen | 2023 | Green Energy & Environment2023，8，3： | 0 |
| 19 | Oxygen potentiates antiviral ability of zebrafish in response to SVCV infection显示文摘Oxygen(O_(2))profoundly influences the physiological processes of aerobic organisms through a range of mechanisms.Recently,increasing evidence has revealed the relationship between viral infection and oxygen levels.However,due to a lack of feasible methods and in vivo models,how oxygen directly affects antiviral capability remains largely unknown.In contrast to terrestrial animals,fish live in water for life,where oxygen levels change more frequently than on land in areas with similar altitude.Therefore,fish appear to be ideal organisms for elucidating the effect of oxygen levels on antiviral responses.In this study,we report that zebrafish under low oxygen conditions are more susceptible to SVCV infection.Further assays indicate that low oxygen tension not only suppresses SVCV-induced IFN activation but also promotes SVCV replication in both zebrafish cell lines and zebrafish.This study provides novel insights into the effect of oxygen on antiviral responses and virus replication. | Zixuan Wang Chunchun Zhu Xiaoyun Chen Hongyan Deng Xueyi Sun Qian Liao Shuke Jia Wen Liu Yao Bai Wuhan Xiao Xing Liu | 2023 | Water Biology and Security2023，2，4： | 0 |
| 20 | Identification of two pIgR-like molecules in teleost fish with opposite roles in mucosal immunity against bacterial infection显示文摘Polymeric immunoglobulin(Ig)receptor-like(pIgRL)molecules have been identified in teleost fish.However,compared to functional studies of their related genes(e.g.,mammalian CD300 family)in eliminating pathogen invasion while preserving homeostasis,the roles of pIgRL in teleost fish remain unclear.In this study,we demonstrated that a pair of pIgRL molecules in zebrafish,pIgRL3.5 and pIgRL4.2,were highly expressed in the intestine and immune cells.Moreover,we constructed an Edwardsiella piscicida infection model,which induced strong inflammatory responses in the zebrafish intestine.Interestingly,pIgRL3.5 and pIgRL4.2 exhibited opposite inducible expression patterns in response to bacterial infection,suggesting that they perform different roles.More importantly,by conducting overexpression and knockdown experiments,our findings demonstrated that zebrafish pIgRL3.5 played a protective role in host defense against E.piscicida infection by inhibiting excessive inflammatory responses.In contrast,pIgRL4.2 facilitated pathogen growth and dissemination in zebrafish intestine.Collectively,our findings are the first to demonstrate that a pair of pIgRL molecules in teleost fish play opposite roles in mucosal immune response to bacterial infection.Therefore,our results provide crucial insights into the conserved role of pIgRL molecules in immune regulatory functions throughout vertebrate evolution. | Haoyue Xu Zixuan Wang Zhenyu Huang Xiaoyun Chen Ruiqi Lin Yongyao Yu Zhen Xu | 2023 | Water Biology and Security2023，2，4： | 0 |
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