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| 1 | Distributed cooperative guidance for multiple missiles with fixed and switching communication topologies显示文摘This study investigates cooperative guidance problems for multiple missiles with fixed and switching directed communication topologies. A two-step guidance strategy is proposed to realize the simultaneous attack. In the first step, a distributed cooperative guidance law is designed using local neighboring information for multiple missiles to achieve consensus on range-to-go and leading angle. The second step begins when the consensus of multiple missiles is realized. During the second step, multiple missiles disconnect from each other and hit the target using the proportional navigation guidance law. First, based on the local neighboring communications, a sufficient condition for multiple missiles to realize simultaneous attack with a fixed communication topology is presented, where the topology is only required to have a directed spanning tree. Then,the results are extended to the case of switching communication topologies. Finally, numerical simulations are provided to validate the theoretical results. | Qilun ZHAO Xiwang DONG Zixuan LIANG Chen BAI Jian CHEN Zhang REN | 2017 | Chinese Journal of Aeronautics2017，30，4： | 27 |
| 2 | An-2 Encodes a Cytokinin Synthesis Enzyme that Regulates Awn Length and Grain Production in Rice显示文摘大量词法、生理的特点在驯服下面在栽培米饭 Oryza sativa 和野米饭 Oryza rufipogon 之间变化了。这里,我们报导 An-2 基因克隆,编码象蛋白质 6 一样的孤独的盖伊(OsLOGL6 ) ,它在 O 催化细胞激动素合成的最后的步。rufipogon。在 theawnless indica Guangluai 4 的基因背景怀有 An-2 的野等位基因的 near-isogenic 线证明 An-2 由由每植物每圆锥花序和 tillers 减少谷物提高房间分割,而是减少谷物生产支持芒延伸。我们表明在 An-2 地点的一个基因变化在减少芒长度并且在驯养的米饭增加 tiller 和谷物数字上有大影响。基因 expressionpatterns 的分析建议 An-1 调整芒的形成初发,并且 An-2 支持芒延伸。在栽培米饭的 theAn-2 地点的核苷酸差异被发现显著地与野米饭的相比被减少,建议 An-2 地点受到人工的选择。我们因此在 An-2 的基因变化的选择由于减少的芒长度并且增加的 proposethat 在栽培米饭的谷物产量。 | Benguo Gu Taoying Zhou Jianghong Luo Hui Liu Yongchun Wang Yingying Shangguan Jingjie Zhu Yan Li Tao Sang Zixuan Wang Bin Han | 2015 | Molecular Plant2015，8，11： | 22 |
| 3 | Computed tomography-based radiomics for prediction of neoadjuvant chemotherapy outcomes in locally advanced gastric cancer: A pilot study显示文摘Objective: The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography(CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy.Methods: Thirty consecutive patients with CT-staged II/III gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017. All patients underwent upper abdominal CT during the unenhanced, late arterial phase(AP) and portal venous phase(PP) before the administration of neoadjuvant chemotherapy. In total, 19,985 radiomics features were extracted in the AP and PP for each patient.Four methods were adopted during feature selection and eight methods were used in the process of building the classifier model. Thirty-two combinations of feature selection and classification methods were examined. Receiver operating characteristic(ROC) curves were used to evaluate the capability of each combination of feature selection and classification method to predict a non-good response(non-GR) based on tumor regression grade(TRG).Results: The mean area under the curve(AUC) ranged from 0.194 to 0.621 in the AP, and from 0.455 to 0.722 in the PP, according to different combinations of feature selection and the classification methods. There was only one cross-combination machine-learning method indicating a relatively higher AUC(>0.600) in the AP, while 12 cross-combination machine-learning methods presented relatively higher AUCs(all >0.600) in the PP. The feature selection method adopted by a filter based on linear discriminant analysis + classifier of random forest achieved a significantly prognostic performance in the PP(AUC, 0.722±0.108; accuracy, 0.793; sensitivity, 0.636; specificity,0.889; Z=2.039; P=0.041).Conclusions: It is possible to predict non-GR after neoadjuvant chemotherapy in locally advanced gastric cancers based on the radiomics of CT. | Zhenhui Li Dafu Zhang Youguo Dai Jian Dong Lin Wu Yajun Li Zixuan Cheng Yingying Ding Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，4： | 18 |
| 4 | Progress in wearable electronics/photonics—Moving toward the era of artificial intelligence and internet of things显示文摘The past few years have witnessed the significant impacts of wearable electronics/photonics on various aspects of our daily life,for example,healthcare monitoring and treatment,ambient monitoring,soft robotics,prosthetics,flexible display,communication,human-machine interactions,and so on.According to the development in recent years,the next-generation wearable electronics and photonics are advancing rapidly toward the era of artificial intelligence(AI)and internet of things(IoT),to achieve a higher level of comfort,convenience,connection,and intelligence.Herein,this review provides an opportune overview of the recent progress in wearable electronics,photonics,and systems,in terms of emerging materials,transducing mechanisms,structural configurations,applications,and their further integration with other technologies.First,development of general wearable electronics and photonics is summarized for the applications of physical sensing,chemical sensing,humanmachine interaction,display,communication,and so on.Then self-sustainable wearable electronics/photonics and systems are discussed based on system integration with energy harvesting and storage technologies.Next,technology fusion of wearable systems and AI is reviewed,showing the emergence and rapid development of intelligent/smart systems.In the last section of this review,perspectives about the future development trends of the next-generation wearable electronics/photonics are provided,that is,toward multifunctional,self-sustainable,and intelligent wearable systems in the AI/IoT era. | Qiongfeng Shi Bowei Dong Tianyiyi He Zhongda Sun Jianxiong Zhu Zixuan Zhang Chengkuo Lee | 2020 | InfoMat2020，2，6： | 17 |
| 5 | Experimental study of an aircraft fuel tank inerting system显示文摘In this work, a simulated aircraft fuel tank inerting system has been successfully established based on a model tank. Experiments were conducted to investigate the influences of different operating parameters on the inerting effectiveness of the system, including flow rate of the inert gas(nitrogen-enriched air), inert gas concentration, fuel load of the tank and different inerting approaches. The experimental results show that under the same operating conditions, the time span of a complete inerting process decreased as the flow rate of inert gas was increased; the time span using the inert gas with 5% oxygen concentration was much longer than that using pure nitrogen;when the fuel tank was inerted using the ullage washing approach, the time span increased as the fuel load was decreased; the ullage washing approach showed the best inerting performance when the time span of a complete inerting process was the evaluation criterion, but when the decrease of dissolved oxygen concentration in the fuel was also considered to characterize the inerting effectiveness, the approach of ullage washing and fuel scrubbing at the same time was the most effective. | Cai Yan Bu Xueqin Lin Guiping Sun Bing Zeng Yu Li Zixuan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 15 |
| 6 | Radiomics approach for preoperative identification of stages Ⅰ-Ⅱand Ⅲ-Ⅳ of esophageal cancer显示文摘Objective: To predict preoperative staging using a radiomics approach based on computed tomography(CT)images of patients with esophageal squamous cell carcinoma(ESCC).Methods: This retrospective study included 154 patients(primary cohort: n=114; validation cohort: n=40) with pathologically confirmed ESCC. All patients underwent a preoperative CT scan from the neck to abdomen. High throughput and quantitative radiomics features were extracted from the CT images for each patient. A radiomics signature was constructed using the least absolute shrinkage and selection operator(Lasso). Associations between radiomics signature, tumor volume and ESCC staging were explored. Diagnostic performance of radiomics approach and tumor volume for discriminating between stages Ⅰ-Ⅱ and Ⅲ-Ⅳ was evaluated and compared using the receiver operating characteristics(ROC) curves and net reclassification improvement(NRI).Results: A total of 9,790 radiomics features were extracted. Ten features were selected to build a radiomics signature after feature dimension reduction. The radiomics signature was significantly associated with ESCC staging(P<0.001), and yielded a better performance for discrimination of early and advanced stage ESCC compared to tumor volume in both the primary [area under the receiver operating characteristic curve(AUC): 0.795 vs. 0.694,P=0.003; NRI=0.424)] and validation cohorts(AUC: 0.762 vs. 0.624, P=0.035; NRI=0.834).Conclusions: The quantitative approach has the potential to identify stage Ⅰ-Ⅱ and Ⅲ-Ⅳ ESCC before treatment. | Lei WU Cong Wang Xianzheng Tan Zixuan Cheng Ke Zhao Lifen Yan Yanli Liang Zaiyi Liu Changhong Liang | 2018 | Chinese Journal of Cancer Research2018，30，4： | 14 |
| 7 | Understanding primary and secondary sources of ambient oxygenated volatile organic compounds in Shenzhen utilizing photochemical age-based parameterization method显示文摘Oxygenated volatile organic compounds(OVOCs) are key intermediates in the atmospheric photooxidation process. To further study the primary and secondary sources of OVOCs,their ambient levels were monitored using a proton-transfer reaction mass spectrometer(PTR-MS) at an urban site in the Pearl River Delta of China. Continuous monitoring campaigns were conducted in the spring, summer, fall, and winter of 2016. Among the six types of OVOC species, the mean concentrations of methanol were the highest in each season(up to 13–20 ppbv), followed by those of acetone, acetaldehyde and acetic acid(approximately 2–4 ppbv), while those of formic acid and methyl ethyl ketone(MEK) were the lowest(approximately 1–2 ppbv). As observed from a diurnal variation chart, the OVOCs observed in Shenzhen may have been affected by numerous factors such as their primary and secondary sources and photochemical consumption. The photochemical age-based parameterization method was used to apportion the sources of ambient OVOCs. Methanol had significant anthropogenic primary sources but negligible anthropogenic secondary sources during all of the seasons. Acetone, MEK and acetic acid were mostly attributed to anthropogenic primary sources during each season with smaller contributions from anthropogenic secondary sources. Acetaldehyde had similar contributions from both anthropogenic secondary and anthropogenic primary sources throughout the year.Meanwhile, anthropogenic primary sources contributed the most to formic acid. | Bo Zhu Yu Han Chuan Wang Xiaofeng Huang Shiyong Xia Yingbo Niu Zixuan Yin Lingyan He | 2019 | Journal of Environmental Sciences2019，31，1： | 13 |
| 8 | Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy显示文摘OBJECTIVE:To compare and observe the effects of three kinds of cephalic acupuncture therapies commonly used in the clinic on promoting nerve function rehabilitation in the brain microenvironment of rats with cerebral palsy.METHODS:A negative control group,positive control group,and three cephalic acupuncture groups based on the administration of three cephalic acupuncture therapies were established.Ten experimental rats were selected from each group at 1,2,and 3 weeks after modeling.Neuromotor function after treatment was rated according to the Basso,Beattie,and Bresnahan method.White matter fiber bundles were evaluated by head diffusion tensor imaging.The expression levels of neuron-specific enolase,microtubule-associated protein 2,and myelin basic protein in the brain tissue extract were detected by Western blot analysis and the activities of ATPases were determined using a fixed phosphorus method.RESULTS:The pathological changes in brain tissue were restored and motor function scores were increased in the mice in each cephalic acupuncture group,and the expression of neuronal growth-related proteins in the brain tissue extract was significantly increased.Additionally,the activities of ATPases in the lesion area were significant enhanced(P<0.05).Diffusion tensor imaging revealed that the white matter fiber bundles of mice in each cephalic acupuncture group gradually increased and recovered.The nervous system structure was significantly improved.CONCLUSIONS:All three acupuncture methods promoted the rehabilitation of nerve function damaged by cerebral palsy.These effects are likely related to the improved expression of nerve growth-related proteins,enhancement of ATPase activities,and regulation of the brain microenvironment. | WANG Zixuan FAN Xiangwei CHEN Kaiyun YU Xuefeng GAO Jing | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 8 |
| 9 | Insights into Pore Structure and Fractal Characteristics of the Lower Cambrian Niutitang Formation Shale on the Yangtze Platform,South China显示文摘Shales from the Lower Cambrian Niutitang Formation of Yangtze Platform have been widely investigated due to its shale gas potential.To better illustrate the pore structure and fractal characteristics of shale,a series of experiments were conducted on outcrop samples from the Lower Cambrian Niutitang Formation on Yangtze Platform,including X-ray diffraction(XRD),field-emission scanning electron microscopy(FE-SEM) and low-temperature nitrogen adsorption.Frenkel-Halsey-Hill(FHH) model was adopted to calculate the fractal dimensions.Furthermore,the relationships between fractal dimensions and pore structure parameters and mineral composition are discussed.FE-SEM observation results show that interparticle pores are most developed in shale,followed by intraparticle pores.This study identified the fractal dimensions D1(ranging from 2.558 0 to 2.710 2) and D2(ranging from 2.541 5 to 2.765 2).The pore structure of the Niutitang Formation shale is primarily controlled by quartz and clay content.Fractal dimensions are able to characterize the pore structure complexity of Niutitang Formation shale because D1 and D2 correlate well with average pore diameter and quartz content. | Zixuan Liu Detian Yan Xing Niu | 2020 | Journal of Earth Science2020，31，1： | 7 |
| 10 | Developing potent PROTACs tools for selective degradation of HDAC6 protein显示文摘Dear Editor, Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups on histone and non-histone proteins, thereby playing a vital role in the modulation of gene expression and protein activity. Eighteen HDACs have been identified in human and subdivided into four classes including I, II (Ila, lib), III and IV (Seto et al., 2014). Among them, HDAC6 is a unique lib HD AC with dominant cytoplasmic localization and two functional catalytic domains. Besides the functions for deacetylation of histone, and modulation of a-tubulin, HSP90 and cortactin, HDAC6 also participates in protein trafficking and degradation, cell shape and migration (Valenzuela-Fernandez et al., 2008). The deregulation of HDAC6 is related to various diseases, such as neurodegenerative diseases, cancer and pathological autoimmune response (Batchu et al., 2016). Hence, it is especially important for directly controlling cellular HDAC6 protein levels to achieve therapeutic purposes. The traditional approaches of red u ci ng cellular protein levels mainly rely on genetic modifications, such as RNA interference, transcription activator-like effector nucleases, recombination-based gene knockout and clustered regularly interspaced short palindromic repeats (CRISPR-Cas9)(Boettcher et al., 2015). However, these approaches have failed to a certain degree to achieve acute and reversible changes of gene function. Furthermore, the complications of potential genetic compensation and/or spontaneous mutations arising in geneknockout models may lead to misinterpretations (Davisson etal., 2012;El-Brolosy etal., 2017). Therefore, it is urgent for developing a rapid, robust, and reversible approach to directly modulate HDAC6 protein levels. | Zixuan An Wenxing Lv Shang Su Wei Wu Yu Rao | 2019 | Protein & Cell2019，10，8： | 7 |
| 11 | Triboelectric Nanogenerators and Hybridized Systems for Enabling Next-Generation IoT Applications显示文摘In the past few years,triboelectric nanogenerator-based(TENG-based)hybrid generators and systems have experienced a widespread and flourishing development,ranging among almost every aspect of our lives,e.g.,from industry to consumer,outdoor to indoor,and wearable to implantable applications.Although TENG technology has been extensively investigated for mechanical energy harvesting,most developed TENGs still have limitations of small output current,unstable power generation,and low energy utilization rate of multisource energies.To harvest the ubiquitous/coexisted energy forms including mechanical,thermal,and solar energy simultaneously,a promising direction is to integrate TENG with other transducing mechanisms,e.g.,electromagnetic generator,piezoelectric nanogenerator,pyroelectric nanogenerator,thermoelectric generator,and solar cell,forming the hybrid generator for synergetic single-source and multisource energy harvesting.The resultant TENG-based hybrid generators utilizing integrated transducing mechanisms are able to compensate for the shortcomings of each mechanism and overcome the above limitations,toward achieving a maximum,reliable,and stable output generation.Hence,in this review,we systematically introduce the key technologies of the TENG-based hybrid generators and hybridized systems,in the aspects of operation principles,structure designs,optimization strategies,power management,and system integration.The recent progress of TENG-based hybrid generators and hybridized systems for the outdoor,indoor,wearable,and implantable applications is also provided.Lastly,we discuss our perspectives on the future development trend of hybrid generators and hybridized systems in environmental monitoring,human activity sensation,human-machine interaction,smart home,healthcare,wearables,implants,robotics,Internet of things(IoT),and many other fields. | Qiongfeng Shi Zhongda Sun Zixuan Zhang Chengkuo Lee | 2021 | Research2021，，1： | 7 |
| 12 | Active Power Reserve Photovoltaic Virtual Synchronization Control Technology显示文摘The photovoltaic virtual synchronous generator(PV-VSG)solves the problem of lack of inertia in the PV power-generation system.The existing PV plants without energy storage are required to participate in the power grid’s frequency modulation(FM),but existing PV-VSGs with energy storage have high requirements for coordinated control.Therefore,the active power reserve PV-VSG(APR-PV-VSG)is studied.Based on the different methods to obtain the maximum power point(MPP),the peer-to-peer and master-slave APR-PV-VSG strategies are proposed.The PV inverters are deviated from the MPP to reserve active power,which is used as the virtual inertia and primary FM power.These methods equip the PV power station with FM capability.The effectiveness of the proposed control strategies is verified by simulation results. | Xing Zhang Qian Gao Yuhua Hu Haizheng Zhang Zixuan Guo | 2020 | Chinese Journal of Electrical Engineering2020，6，2： | 6 |
| 13 | Effect of SBS and crumb rubber on asphalt modification:A review of the properties and practical application显示文摘Owing to the environmental protection potential and the desirable high performance capabilities,asphalt rubber(AR)and styrene-butadiene-styrene(SBS)modified asphalt have been widely used.However,the poor construction workability and segregation issues of AR,along with the exorbitant cost of SBS modified asphalt,are of the serious problems that plague their application scope.Moreover,SBS/crumb rubber(CR)modified asphalt is gradually becoming widespread and it therefore becomes incumbent to find appropriate ways to mitigate the issues that may limit its use.As a consequence,it becomes crucial to analyze the interaction between CR and SBS modifiers in the composite mixture,as well as evaluate the influence of modifier dosage on the performance of the modified asphalt.This study presents a comprehensive review of the effects of SBS modifier,CR modifier and composite SBS/CR on the performance of modified asphalts.Macro analysis and micro analysis,including analysis on the conventional physical properties,are carried out.It can uncover the interaction between modifier and asphalt,which reveals how the modifiers influence the properties of modified asphalts.This study will serve as a source of invaluable information to researchers,engineers,and designers,informing them the development,potential and challenges of the CR,SBS and SBS/CR modified asphalts,the optimum contents to attain the best performance along with the mechanism involved. | Haibin Li Canyang Cui Ahmed Abdulakeem Temitope Zixuan Feng Guijuan Zhao Ping Guo | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，5： | 6 |
| 14 | Self-Healing,Self-Adhesive and Stable Organohydrogel-Based Stretchable Oxygen Sensor with High Performance at Room Temperature显示文摘With the advent of the 5G era and the rise of the Internet of Things,various sensors have received unprecedented attention,especially wearable and stretchable sensors in the healthcare field.Here,a stretchable,self-healable,self-adhesive,and room-temperature oxygen sensor with excellent repeatability,a full concentration detection range(0-100%),low theoretical limit of detection(5.7 ppm),high sensitivity(0.2%/ppm),good linearity,excellent temperature,and humidity tolerances is fabricated by using polyacrylamide-chitosan(PAM-CS)double network(DN)organohydrogel as a novel transducing material.The PAM-CS DN organohydrogel is transformed from the PAM-CS composite hydrogel using a facile soaking and solvent replacement strategy.Compared with the pristine hydrogel,the DN organohydrogel displays greatly enhanced mechanical strength,moisture retention,freezing resistance,and sensitivity to oxygen.Notably,applying the tensile strain improves both the sensitivity and response speed of the organohydrogel-based oxygen sensor.Furthermore,the response to the same concentration of oxygen before and after self-healing is basically the same.Importantly,we propose an electrochemical reaction mechanism to explain the positive current shift of the oxygen sensor and corroborate this sensing mechanism through rationally designed experiments.The organohydrogel oxygen sensor is used to monitor human respiration in real-time,verifying the feasibility of its practical application.This work provides ideas for fabricating more stretchable,self-healable,self-adhesive,and high-performance gas sensors using ion-conducting organohydrogels. | Yuning Liang Zixuan Wu Yaoming Wei Qiongling Ding Meital Zilberman Kai Tao Xi Xie Jin Wu | 2022 | Nano-Micro Letters2022，14，3： | 5 |
| 15 | Humidity Sensing of Stretchable and Transparent Hydrogel Films for Wireless Respiration Monitoring显示文摘Respiratory monitoring plays a pivotal role in health assessment and provides an important application prospect for flexible humidity sensors.However,traditional humidity sensors suffer from a trade-off between deformability,sensitivity,and transparency,and thus the development of high-performance,stretchable,and low-cost humidity sensors is urgently needed as wearable electronics.Here,ultrasensitive,highly deformable,and transparent humidity sensors are fabricated based on cost-effective polyacrylamide-based double network hydrogels.Concomitantly,a general method for preparing hydrogel films with controllable thickness is proposed to boost the sensitivity of hydrogel-based sensors due to the extensively increased specific surface area,which can be applied to different polymer networks and facilitate the development of flexible integrated electronics.In addition,sustainable tapioca rich in hydrophilic polar groups is introduced for the first time as a second cross-linked network,exhibiting excellent water adsorption capacity.Through the synergistic optimization of structure and composition,the obtained hydrogel film exhibits an ultrahigh sensitivity of 13,462.1%/%RH,which is unprecedented.Moreover,the hydrogel film-based sensor exhibits excellent repeatability and the ability to work normally under stretching with even enhanced sensitivity.As a proof of concept,we integrate the stretchable sensor with a specially designed wireless circuit and mask to fabricate a wireless respiratory interruption detection system with Bluetooth transmission,enabling real-time monitoring of human health status.This work provides a general strategy to construct high-performance,stretchable,and miniaturized hydrogel-based sensors as next-generation wearable devices for real-time monitoring of various physiological signals. | Yuning Liang Qiongling Ding Hao Wang Zixuan Wu Jianye Li Zhenyi Li Kai Tao Xuchun Gui Jin Wu | 2022 | Nano-Micro Letters2022，14，11： | 5 |
| 16 | Near-surface wind environment in the Yarlung Zangbo River basin,southern Tibetan Plateau显示文摘Aeolian processes have been studied extensively at low elevations,but have been relatively little studied at high elevations.Aeolian sediments are widely distributed in the Yarlung Zangbo River basin,southern Tibetan Plateau,which is characterized by low pressure and low temperature.Here,we comprehensively analyzed the wind regime using data since 1980 from 11 meteorological stations in the study area,and examined the interaction between the near-surface wind and aeolian environment.The wind environment exhibited significant spatial and temporal variation,and mean wind speed has generally decreased on both annual and seasonal bases since 1980,at an average of 0.181 m/(s•10a).This decrease resulted from the reduced contribution of maximum wind speed,and depended strongly on variations of the frequency of sand-driving winds.The drift potential and related parameters also showed obvious spatial and temporal variation,with similar driving forces for the wind environment.The strength of the wind regime affected the formation and development of the aeolian geomorphological pattern,but with variation caused by local topography and sediment sources.The drift potential and resultant drift direction were two key parameters,as they quantify the dynamic conditions and depositional orientation of the aeolian sediments.Wind affected the spatial variation in sediment grain size,but the source material and complex topographic effects on the near-surface wind were the underlying causes for the grain size distribution of aeolian sands.These results will support efforts to control aeolian desertification in the basin and improve our understanding of aeolian processes in high-elevation environments. | YANG Junhuai XIA Dunsheng WANG Shuyuan TIAN Weidong MA Xingyue CHEN Zixuan GAO Fuyuan LING Zhiyong DONG Zhibao | 2020 | Journal of Arid Land2020，12，6： | 5 |
| 17 | Senegenin promotes in vitro proliferation of human neural progenitor cells显示文摘Senegenin,an effective component of Polygala tenuifolia root extract,promotes proliferation and differentiation of neural progenitor cells in the hippocampus.However,the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood.Cells from a ventral mesencephalon neural progenitor cell line(ReNcell VM) were utilized as models for pharmaceutical screening.The effects of various senegenin concentrations on cell proliferation were analyzed,demonstrating that high senegenin concentrations(5,10,50,and 100 μmo/L),particularly 50 μmol/L,significantly promoted proliferation of ReNcell VM cells.In the mitogen-activated protein kinase signal transduction pathway,senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases.Moreover,cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors.Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase. | Shi, Fang Liang, Zhigang Guo, Zixuan Li, Ran Yu, Fen Zhang, Zhanjun Wang, Xuan Wang, Xiaomin | 2011 | Neural Regeneration Research2011，6，3： | 5 |
| 18 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 19 | UAV flight strategy algorithm based on dynamic programming显示文摘Unmanned aerial vehicles(UAVs) may play an important role in data collection and offloading in vast areas deploying wireless sensor networks, and the UAV's action strategy has a vital influence on achieving applicability and computational complexity. Dynamic programming(DP) has a good application in the path planning of UAV, but there are problems in the applicability of special terrain environment and the complexity of the algorithm.Based on the analysis of DP, this paper proposes a hierarchical directional DP(DDP) algorithm based on direction determination and hierarchical model. We compare our methods with Q-learning and DP algorithm by experiments, and the results show that our method can improve the terrain applicability, meanwhile greatly reduce the computational complexity. | ZHANG Zixuan WU Qinhao ZHANG Bo YI Xiaodong TANG Yuhua | 2018 | Journal of Systems Engineering and Electronics2018，29，6： | 4 |
| 20 | Highlights and new Editorial Advisory Board members of the Journal of Environmental Sciences显示文摘The Journal of Environmental Sciences(JES)is honored to welcome Professors/Drs William A.Mitch,Jiuhui Qu,Susan D.Richardson,Jerald L.Schnoor,Hongxiao Tang,Shu Tao,and Hugh A.Tilson to serve on the Editorial Advisory Board(EAB).Their tremendous experience in scientific publications,leading expertise in topic areas pertinent to JES,diverse international networks/perspectives,and exemplary dedication to scientific excellence will guide and help the continuing healthy growth of JES. | Qingcai Feng Suqin Liu Zhengang Mao Jian Xu Zixuan Wang X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，9： | 4 |
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