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| 1 | Photocatalytic degradation of methyl orange over ITO/CdS/ZnO interface composite films显示文摘ITO/CdS/ZnO interface composite films were successfully prepared by subsequent electrodeposition of CdS and ZnO onto indium tin oxide (ITO) glass substrates. The obtained ITO/CdS/ZnO composite films were characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-Vis spectroscopy. The photocatalytic activity of ITO/CdS/ZnO composite films were investigated using methyl orange (MO) as a model organic compound under UV light irradiation. The influence of operating parameters on MO degradation including initial concentration of MO, pH value of solution, and inorganic anion species over the composite films were examined. A blue shift of absorption threshold was observed for the ITO/CdS/ZnO film in comparison with ITO/ZnO film. ITO/CdS/ZnO composite films prepared under specific conditions showed a higher photocatalytic activity than that of ITO/ZnO films. It was also found that the photocatalytic degradation of MO on the composite films followed pseudo-first order kinetics. | WEI Shouqiang, SHAO Zhongcai, LU Xudong, LIU Ying, CAO Linlin, HE Yan School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang 110168, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 4 |
| 2 | Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?显示文摘The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has infected millions of people and caused tremendous morbidity and mortality worldwide. Effective treatment for coronavirus disease 2019(COVID-19) due to SARSCoV-2 infection is lacking, and different therapeutic strategies are under testing. Host humoral and cellular immunity to SARSCoV-2 infection is a critical determinant for patients’ outcomes. SARS-CoV-2 infection results in seroconversion and production of anti-SARS-CoV-2 antibodies. The antibodies may suppress viral replication through neutralization but might also participate in COVID-19 pathogenesis through a process termed antibody-dependent enhancement. Rapid progress has been made in the research of antibody response and therapy in COVID-19 patients, including characterization of the clinical features of antibody responses in different populations infected by SARS-CoV-2, treatment of COVID-19 patients with convalescent plasma and intravenous immunoglobin products, isolation and characterization of a large panel of monoclonal neutralizing antibodies and early clinical testing, as well as clinical results from several COVID-19 vaccine candidates. In this review, we summarize the recent progress and discuss the implications of these findings in vaccine development. | Ligong Lu Hui Zhang Meixiao Zhan Jun Jiang Hua Yin Danielle JDauphars Shi-You Li Yong Li You-Wen He | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 3 | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China显示文摘Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor prognosis.Almost 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor prognosis.Thus,global institutions have been working to develop mIDH2 inhibitors.SH1573 is a novel mIDH2 inhibitor that we independently designed and synthesised.We have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and safety.First,SH1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal model.It could also promote the differentiation of mutant AML cell lines and granulocytes in PDX models.Then,it was confirmed that SH1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue distribution.Finally,toxicological data showed that SH1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically safe.This research successfully promoted the approval of SH1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,SH1573 was effective and safe. | Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu Du Xian Zhang Luwei Han Liwen Zhao Ligong Lu Hongzhi Du Shengtao Yuan Meixiao Zhan | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 3 |
| 4 | Photosensitizer conjugate-functionalized poly(hexamethylene guanidine) for potentiated broad-spectrum bacterial inhibition and enhanced biocompatibility显示文摘Pathogen infection is the main cause of human morbidity and death.Traditional antibiotics usually sterilize bacteria in chemical ways,which tends to develop serious antibiotic resistance.Cationic polymers exhibit good bacterial inhibition with less resistance,but often face severe cytotoxicity toward normal cells.The optimization of polymeric antimicrobials for enhanced bactericidal capacity and improved biocompatibility is quite meaningful.In addition,photodynamic therapy(PDT) is a therapeutic modality with less susceptibility to develop resistance.Herein,a typical commercial polymeric antimicrobial,polyhexamethylene guanidine(PHMG) was selected for current proof-of-concept optimization due to its excellent bactericidal capacity but moderate biocompatibility.Eosin-Y(EoS)was copolymerized to afford EoS-labeled polymer conjugates,poly(2-(dimethylamino) ethyl methacrylate-co-eosin),P(DMAEMA-co-EoS),which was conjugated with PHMG to afford a novel polymeric antimicrobial,P(DMAEMA-co-EoS)-b-PHMG-b-P(DMAEMA-co-EoS),noted as PEoS-PHMG.It could efficiently kill broad-spectrum bacteria by physical damage and photodynamic therapy.Compared with PHMG,the bacterial inhibition of PEoS-PHMG was potentiated after the functionalization.Furthermore,PEoS-PHMG exhibited low cytotoxicity and minimal hemolysis,which was demonstrated by cell viability assays toward LO2 cells and RAW 264.7 cells as well as hemolytic assays against red blood cells.These results confirmed that the resultant PEoS-PHMG could act as promising alternative antibacterial materials with excellent broad-spectrum bacterial inhibition and favorable biocompatibility. | Fengfeng Xiao Bing Cao Liewei Wen Yanhong Su Meixiao Zhan Ligong Lu Xianglong Hu | 2020 | Chinese Chemical Letters2020，31，9： | 2 |
| 5 | The Gravitational-wave physics Ⅱ: Progress显示文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project 'Physics associated with the gravitational waves' supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit. | Ligong Bian Rong-Gen Cai Shuo Cao Zhoujian Cao He Gao Zong-Kuan Guo Kejia Lee Di Li Jing Liu Youjun Lu Shi Pi Jian-Min Wang Shao-Jiang Wang Yan Wang Tao Yang Xing-Yu Yang Shenghua Yu Xin Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 2 |
| 6 | Detection of Salmonella enterica serovar Dublin by polymerase chain reaction in multiplex format显示文摘 | Ligong Zhai Xiaohan Kong Zhaoxin Lu Fengxia Lv Chong Zhang Xiaomei Bie | 2014 | Journal of Microbiological Methods2014，，： | 1 |
| 7 | Improving welded valve quality by vibratory weld conditioning 显示文摘 | Qinghua Lu Ligong Chen Chunzhen Ni | 2007 | Materials Science and Engineering: A2007，457，12： | 1 |
| 8 | Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial显示文摘 | Masatoshi Kudo Guohong Han Richard S. Finn Ronnie T.P. Poon Jean‐Frederic Blanc Lunan Yan Jijin Yang Ligong Lu Won‐Young Tak Xiaoping Yu Joon‐Hyeok Lee Shi‐Ming Lin Changping Wu Tawesak Tanwandee Guoliang Shao Ian B. Walters Christine Dela Cruz Valerie Po | 2014 | Hepatology2014，，5： | 1 |
| 9 | High drug loading and pH-responsive nanomedicines driven by dynamic boronate covalent chemistry for potent cancer immunotherapy显示文摘Tumor cells undergoing immunogenic cell death (ICD) have emerged as an in situ therapeutic vaccine helping to activate a persistent anti-tumor response. Several chemotherapeutic agents have been demonstrated to induce ICD, however accompanied with severe adverse effects in the clinic, weakening its immune responses. Herein, to elicit an intensive ICD while minimizing the systemic toxicity, we introduce a tumor targeting peptide modified bortezomib (BTZ) loading nanomedicine (i-NPBTZ) for the efficient delivery and controlled release of BTZ in tumors. This system is constructed by conjugating BTZ to PEGylated polyphenols via a pH-sensitive covalent boronate-phenol bond that allows them to self-assemble into nanovesicles in neutral condition with high drug loading efficiency. Once accumulated in acidic environment, BTZ-phenolic network is disassembled and thereby accelerates the release of BTZ from nanocarriers. The released BTZ selectively kill tumor cells with a concomitant evocation of tumor-specific cytotoxic T cells by triggering ICD in vivo. This can finally lead to an extended tumor ablation and prevention of distant metastasis in a syngeneic tumor mouse model, while reducing the systemic toxicity of BTZ. In general, our system offers a novel concept with clinical potential to exploit ICD for potentiating tumor immunotherapy and also provides an excellent example of the application of polymer-drug interaction for efficient drug delivery and controllable release. | Wei Jiang Han Zhou Qin Wang Ziqi Chen Wang Dong Zixuan Guo Yong Li Wei Zhao Meixiao Zhan Yucai Wang Ligong Lu | 2021 | Nano Research2021，14，11： | 1 |
| 10 | The Signless Laplacian Spectral Radius of Tricyclic Graphs with a Given Girth显示文摘A tricyclic graph G =(V(G), E(G)) is a connected and simple graph such that|E(G)| = |V(G)|+2. Let Tg nbe the set of all tricyclic graphs on n vertices with girth g. In this paper, we will show that there exists the unique graph which has the largest signless Laplacian spectral radius among all tricyclic graphs with girth g containing exactly three(resp., four)cycles. And at the same time, we also give an upper bound of the signless Laplacian spectral radius and the extremal graph having the largest signless Laplacian spectral radius in Tg n,where g is even. | Lu QIAO Ligong WANG | 2014 | Journal of Mathematical Research with Applications2014，34，4： | 0 |
| 11 | Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant显示文摘Dear Editor,Emerging epidemiology data indicate that the Omicron BA.2 sublineage is expected to become the dominant strain owing to its enhanced transmissibility.1 The BA.1 sublineage reduced the efficacy of neutralizing antibodies.2,3 The BA.2 sublineage may possess similar neutralizing antibody evasion.3 However,booster(3rd dose)vaccination strategies,or three exposures to the SARS-CoV2 spike protein through natural infection elicits strong neutralizing antibody responses.This raises the question of whether booster doses also elicit neutralizing antibody responses against BA.2.We present in this study the neutralization activity of serum from human recipients of homologous booster(three doses of CoronaVac inactivated vaccine)or heterologous booster(inactivated vaccine priming dose with BnT162b2 third dose)vaccine regimens against pseudovirus containing the Omicron BA.2 spike protein.We also evaluated the neutralizing activities of 6 monoclonal antibodies,and serum from monkeys vaccinated with a recombinant RBD protein vaccine.Finally,we also evaluated cell entry mediated by the Omicron BA.2 spike protein. | Gen Li Zhongcheng Zhou Peng Du Meixiao Zhan Ning Li Xinxin Xiong Shengjun Tang Miao Man Daniel T.Baptista-Hon Ligong Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 12 | γδT cells:origin and fate,subsets,diseases and immunotherapy显示文摘The intricacy of diseases,shaped by intrinsic processes like immune system exhaustion and hyperactivation,highlights the potential of immune renormalization as a promising strategy in disease treatment.In recent years,our primary focus has centered onγδT cell-based immunotherapy,particularly pioneering the use of allogeneic Vδ2+γδT cells for treating late-stage solid tumors and tuberculosis patients.However,we recognize untapped potential and optimization opportunities to fully harnessγδT cell effector functions in immunotherapy.This review aims to thoroughly examineγδT cell immunology and its role in diseases.Initially,we elucidate functional differences betweenγδT cells and theirαβT cell counterparts.We also provide an overview of major milestones inγδT cell research since their discovery in 1984.Furthermore,we delve into the intricate biological processes governing their origin,development,fate decisions,and T cell receptor(TCR)rearrangement within the thymus.By examining the mechanisms underlying the anti-tumor functions of distinctγδT cell subtypes based onγδTCR structure or cytokine release,we emphasize the importance of accurate subtyping in understandingγδT cell function.We also explore the microenvironment-dependent functions ofγδT cell subsets,particularly in infectious diseases,autoimmune conditions,hematological malignancies,and solid tumors.Finally,we propose future strategies for utilizing allogeneicγδT cells in tumor immunotherapy.Through this comprehensive review,we aim to provide readers with a holistic understanding of the molecular fundamentals and translational research frontiers ofγδT cells,ultimately contributing to further advancements in harnessing the therapeutic potential ofγδT cells. | Yi Hu Qinglin Hu Yongsheng Li Ligong Lu Zheng Xiang Zhinan Yin Dieter Kabelitz Yangzhe Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 13 | Surface Oxidation and Subsurface Microstructure Evolution of Alloy 690TT Induced by Partial Slip Fretting Corrosion in High-Temperature Pure Water显示文摘The surface oxidation and subsurface microstructure evolution of Alloy 690 TT can occur during partial slip fretting corrosion in high-temperature pure water.Detailed characterization methods such as laser scanning confocal microscopy,scanning electron microscopy,electron probe micro-analyzer,and transmission electron microscopy were used to reveal the related mechanism.The results showed that Cr_(2)O_(3) oxides together with a small number of spinel oxides were formed in sticking region since a small quantity of high-temperature water could pass through the gaps between the asperities to oxidize the materials.Widespread distribution of oxides in microslip region consisted of(Ni,Fe)Cr_(2)O_(4),because Ni^(2+)and Fe^(2+) ions could react with Cr_(2)O_(3) to generate a small amount of non-stoichiometric spinel oxides.The oxides around micropitting in microslip region consisted of double-layer structure.The outermost layer contained(Fe,Cr)-rich oxides due to the effect of fretting leading to mechanical mixing between Cr_(2)O_(3) and(Ni,Fe)(Fe,Cr)_(2)O_(4).The inner layer consisted of(Fe,Ni)-rich oxides owing to the consumption of Cr_(2)O_(3) by the reaction with Ni^(2+)and Fe^(2+) ions.The reciprocating motion of oxide particles in microslip region resulted in the stress-strain supporting the recrystallization for the formation and development of a tribologically transformed structure in subsurface and plowing effect by fretting in surface. | Long Xin Yongming Han Ligong Ling Yonghao Lu Tetsuo Shoji | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 0 |
| 14 | Maxima of the Q-Index for Halin Graphs显示文摘The Q-index of a graph G is the largest eigenvalue q(G) of its signless Laplacian matrix Q(G). In this paper, we prove that the wheel graph W_n = K_1 ∨C_(n-1)is the unique graph with maximal Q-index among all Halin graphs of order n. Also we obtain the unique graph with second maximal Q-index among all Halin graphs of order n. | Qi KONG Ligong WANG Yong LU | 2017 | Journal of Mathematical Research with Applications2017，37，3： | 0 |
| 15 | Analysis on electrical transport characteristic of 8-hydroquinoline aluminum film显示文摘The current_voltage and capacitance_voltage characteristic of the organic single_layered electroluminescent diode utilizing 8_hydroquinoline aluminum as active layer have been measured under bias ranging from -5 V to 28 V in this work. A simple model for charge transport process of 8_hydroquinoline aluminum layer is proposed to illuminate the conductivity characteristic of the diode. | Ligong Zhang Dapeng Jiang Xinguang Ren Xueyan Liu Yajun Li Ande Lu Jinshan Yuan | 1998 | Chinese Science Bulletin1998，43，2： | 0 |
| 16 | m^(6)A mRNA modification potentiates Th17 functions to inflame autoimmunity显示文摘N6-methyladenosine(m^(6)A),the most common and abundant epigenetic RNA modification,governs mRNA metabolism to determine cell differentiation,proliferation and response to stimulation.m^(6)A methyltransferase METTL3 has been reported to control T cell homeostasis and sustain the suppressive function of regulatory T cells(Tregs).However,the role of m^(6)A methyltransferase in other subtypes of T cells remains unknown.T helper cells 17(Th17)play a pivotal role in host defense and autoimmunity.Here,we found that the loss of METTL3 in T cells caused serious defect of Th17 cell differentiation,and impeded the development of experimental autoimmune encephalomyelitis(EAE).We generated Mettl3f/fIl17aCre mice and observed that METTL3 deficiency in Th17 cells significantly suppressed the development of EAE and displayed less Th17 cell infiltration into central nervous system(CNS).Importantly,we demonstrated that depletion of METTL3 attenuated IL-17A and CCR5 expression by facilitating SOCS3 mRNA stability in Th17 cells,leading to disrupted Th17 cell differentiation and infiltration,and eventually attenuating the process of EAE.Collectively,our results highlight that m^(6)A modification sustains Th17 cell function,which provides new insights into the regulatory network of Th17 cells,and also implies a potential therapeutic target for Th17 cell mediated autoimmune disease. | Xuefei Wang Chen Chen Hongwei Sun Kaiqiong Mao Jiameng Yao Weiqiao Zhang Meixiao Zhan Hua-Bing Li Zhiren Zhang Shu Zhu Ligong Lu | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
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