|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | National cancer incidence and mortality in China, 2012显示文摘Background: Population-based cancer registration data in 2012 from all available cancer registries were collected by the National Central Cancer Registry(NCCR). NCCR estimated the numbers of new cancer cases and cancer deaths in China with compiled cancer incidence and mortality rates.Methods: In 2015, there were 261 cancer registries submitted cancer incidence and deaths occurred in 2012. All the data were checked and evaluated based on the NCCR criteria of data quality. Qualified data from 193 registries were used for cancer statistics analysis as national estimation. The pooled data were stratified by area(urban/rural), gender, age group [0, 1–4, 5–9, 10–14, …, 85+] and cancer type. New cancer cases and deaths were estimated using age-specific rates and corresponding national population in 2012. The Chinese census data in 2000 and Segi's population were applied for age-standardized rates. All the rates were expressed per 100,000 person-year.Results: Qualified 193 cancer registries(74 urban and 119 rural registries) covered 198,060,406 populations(100,450,109 in urban and 97,610,297 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 69.13% and 2.38%, respectively, and the mortality to incidence rate ratio(M/I) was 0.62. A total of 3,586,200 new cancer cases and 2,186,600 cancer deaths were estimated in China in 2012. The incidence rate was 264.85/100,000(289.30/100,000 in males, 239.15/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 191.89/100,000 and 187.83/100,000 with the cumulative incidence rate(0–74 age years old) of 21.82%. The cancer incidence, ASIRC and ASIRW in urban areas were 277.17/100,000, 195.56/100,000 and 190.88/100,000 compared to 251.20/100,000, 187.10/100,000 and 183.91/100,000 in rural areas, respectively. The cancer mortality was 161.49/100,000(198.99/100,000 in males, 122.06/100,000 in females), the age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 112.34/100,000 and 111.25/100,000, and the cumulative mortality rate(0–74 years old) was 12.61%. The cancer mortality, ASMRC and ASMRW were 159.00/100,000, 107.231/100,000 and 106.13/100,000 in urban areas, 164.24/100,000, 118.22/100,000 and 117.06/100,000 in rural areas, respectively. Cancers of lung, stomach, liver, colorectum, esophagus, female breast, thyroid cervix, brain tumor and pancreas were the most common cancers, accounting for about 77.4% of all cancer new cases. Lung cancer, liver cancer, stomach cancer, esophageal cancer, colorectal cancer, pancreatic cancer, female breast cancer, brain tumor, leukemia and lymphoma were the leading causes of cancer death, accounting for about 84.5% of all cancer deaths. The cancer spectrum showed difference between urban and rural, males and females both in incidence and mortality rates.Conclusions: Cancer surveillance information in China is making great progress with the increasing number of cancer registries, population coverage and the improving data quality. Cancer registration plays a fundamental role in cancer control by providing basic information on population-based cancer incidence, mortality, survival and time trend. The disease burden of cancer is serious in China, so that, cancer prevention and control, including health education, health promotion, cancer screening and cancer care services in China, should be enhanced. | Wanqing Chen Rongshou Zheng Tingting Zuo Hongmei Zeng Siwei Zhang Jie He | 2016 | Chinese Journal of Cancer Research2016，28，1： | 238 |
| 2 | Cancer incidence and mortality in China in 2013:an analysis based on urbanization level显示文摘Objective: To explore the cancer patterns in areas with different urbanization rates(URR) in China with data from 255 population-based cancer registries in 2013, collected by the National Central Cancer Registry(NCCR).Methods: There were 347 cancer registries submitted cancer incidence and deaths occurred in 2013 to NCCR.All those data were checked and evaluated based on the NCCR criteria of data quality, and qualified data from 255 registries were used for this analysis. According to the proportion of non-agricultural population, we divided cities/counties into 3 levels: high level, with URR equal to 70% and higher; median level, with URR between 30%and 70%; and low level, with URR equal to 30% and less. Cancer incidences and mortalities were calculated,stratified by gender and age groups in different areas. The national population of Fifth Census in 2000 and Segi's population were applied for age-standardized rates.Results: Qualified 255 cancer registries covered 226,494,490 populations. The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 68.04% and 1.74%, respectively,and the mortality to incidence rate ratio(M/I) was 0.62. A total of 644,487 new cancer cases and 399,275 cancer deaths from the 255 cancer registries were submitted to NCCR in 2013. The incidence rate was 284.55/100,000(314.06/100,000 in males, 254.19/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 190.10/100,000 and 186.24/100,000 with the cumulative incidence rate(0–74 age years old) of 21.60%. The cancer mortality was 176.28/100,000(219.03/100,000 in males, 132.30/100,000 in females), and the age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 110.91/100,000 and 109.92/100,000, and the cumulative mortality rate(0–74 age years old) was 12.43%. Low urbanization areas were high in crude cancer incidence and mortality rates, middle urbanization areas came next to it followed by high urbanization areas. After adjusted by age, there was a U-shaped association between age-standardized incidence(ASIRC and ASIRW) and the urbanized ratio with the middle urbanization areas having the lowest ASIRC and ASIRW. Unlike with the agestandardized incidence, the sort order of age-standardized mortality(ASMRC and ASMRW) among three urbanization areas was reversed completely from the crude mortality. Lung cancer was the most common cancer in all areas of 255 cancer registries, followed by stomach cancer, liver cancer, colorectal cancer and esophageal cancer with new cases of 130,700, 76,200, 63,800, 60,900 and 50,200 respectively. Lung cancer was also the leading cause of cancer death in all areas of 255 cancer registries for both males and females with the number of deaths of 72,200 and 34,100, respectively. Other cancer types with high mortality in males were liver cancer, stomach cancer,esophageal cancer and colorectal cancer. In females, stomach cancer was the second cause of cancer death, followed by liver cancer, colorectal cancer and breast cancer.Conclusions: Along with the development of socioeconomics associated with urbanization, as well as the agingpopulation, the incidence and mortality keep increasing in China. Cancer burden and patterns are different in each urbanization level. Cancer control strategies should be implemented referring to local urbanization status. | Wanqing Chen Rongshou Zheng Siwei Zhang Hongmei Zeng Tingting Zuo Changfa Xia Zhixun Yang Jie He | 2017 | Chinese Journal of Cancer Research2017，29，1： | 305 |
| 3 | In vitro derivation of functional insulin-producing cells from human embryonic stem cells显示文摘为人的胚胎的茎(ES ) 的自强和区别的能力细胞为对待类型 Idiabetes mellitus 为胰腺的贝它细胞的产生使他们成为潜在的来源。这里,我们报导一最新发展了并且有效方法,在aserum免费的系统执行了,区分进生产胰岛素的 cells.Activin A 的导致的人的 ES 房间它在起始的阶段被使用从人的 EScells 导致权威的内胚叶区别,是由权威的内胚叶标记 Sox17 和 Brachyury.Further 的表示检测了, all-trans retinoic 酸( RA )被用来支持胰腺的区别,由早胰腺的抄写因素 pdx1 和 hlxb9 的表示显示了。在成熟 inDMEM/F12 以后有 bFGF 和菸碱的没有浆液的媒介,区分的房间表示了小岛特定的标记象 C 肽,胰岛素,胰高血糖素和 glut2 那样。百分比 ofC-peptide-positive 房间超过了 15% 。由这些房间的胰岛素和 C 肽的分泌物在葡萄糖层次对应于变化。当移植了进肾的囊时, ofStreptozotocin (STZ ) 对待裸体老鼠,这些区分的人的 ES 房间熬过并且维持贝它房间标记基因的表示包括 C 肽, pdx1, glucokinase, nkx6.1, IAPP, pax6and Tcf1。百分之三十只移植裸体老鼠展出了 stableeuglycemia 的明显的恢复;并且改正的显型被支撑超过六个星期。我们的新方法为学习人的胰开发的机制提供一个有希望的试管内区别模特儿并且说明为类型 Idiabetes mellitus 的处理使用人的 ES 房间的潜力。 | Wei Jiang Yan Shi Dongxin Zhao Song Chen Jun Yong Jing Zhang Tingting Qing Xiaoning Sun Peng Zhang Mingxiao Ding Dongsheng Li Hongkui Deng | 2007 | Cell Research2007，17，4： | 38 |
| 4 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 5 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edscfw06nubko5v6bfp.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edscfw06nubko5v6bfp.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edscfw06nubko5v6bfp.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 6 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 7 | Feeding of Riptortus pedestris on soybean plants, the primary cause of soybean staygreen syndrome in the Huang-Huai-Hai river basin显示文摘Staygreen syndrome or Zhengqing in soybean has recently become a major issue for Chinese growers in the Huang-Huai-Hai river basin.Although previous studies revealed that staygreen can be induced when pods/seeds are damaged, it is unknown whether virus infection or insect infestation causes staygreen.To determine whether viral infection causes staygreen, a survey of soybean staygreen incidence in the Huang-Huai-Hai river basin was conducted in 2016 and 2017.Diseased samples were collected and analyzed using DAS-ELISA for Soybean mosaic virus, Watermelon mosaic virus, Bean pod mottle virus, Cucumber mosaic virus, and Bean common mosaic virus.The survey showed that the severity of soybean staygreen syndrome was most prevalent in Beijing, Henan, Shaanxi, and some parts of Shandong provinces, with yield losses from 0 to nearly 100%, but only a small fraction of samples were positive for the tested viruses.A field cage experiment and an insecticide treatment field trial were conducted to determine the contribution of the bean bug, Riptortus pedestris, to staygreen incidence.The field cage experiment showed that R.pedestris treatment resulted in shorter plants, more empty pods, increased numbers of abnormal seeds, and decreased yields.The field experiment showed that there were fewer R.pedestris and less soybean staygreen incidence in fields treated with insecticide than in untreated control fields.Together, these results suggest that R.pedestris infestation rather than virus infection induces staygreen syndrome and that growers in this region can mitigate staygreen syndrome via bean bug control. | Kai Li Xinxin Zhang Jianqiu Guo Hannah Penn Tingting Wu Lin Li Hong Jiang Lidan Chang Cunxiang Wu Tianfu Han | 2019 | The Crop Journal2019，7，3： | 30 |
| 8 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 9 | Key technologies and the implementation of wind,PV and storage co-generation monitoring system显示文摘The coordinated control of multiple-sources including wind,photovoltaic(PV)and storage brings new challenges to traditional dispatch and control technologies.This paper firstly introduces a framework of wind,PV and storage co-generation monitoring system.Then,key technologies of co-generation monitoring system including day-ahead optimal dispatching,active power coordinated control and reactive power and voltage control are proposed.The framework and the techniques described in this paper have been applied in the National Wind,Photovoltaic,Storage and Transmission Demonstration Project of China,and their validity have been tested and verified. | Xianliang TENG Zonghe GAO Yingyuan ZHANG Hua HUANG Lili LI Tingting LIANG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 25 |
| 10 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 11 | Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer显示文摘Objective:MicroRNAs(miRNAs) have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer(CRC) has not been reported.Methods:We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC(OM-CRC).Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC(L-CRC),72 synchronous liver-metastatic CRC(SLM-CRC) and 36 other OM-CRC by quantitative real-time PCR.Results:Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR-141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic(ROC) curve showed serum miR-126 had a cut-off [log 10 relative quantity(log 10 RQ)=–0.2005] with 77.78% sensitivity and 68.97% specificity with an area under curve(AUC) of 0.7564,miR-141 had a cut-off(log 10 RQ=–0.2285) with 86.11% sensitivity and 76.11% specificity with an AUC of 0.8279,and miR-21 had a cut-off(log 10 RQ=–0.1310) with 73.61% sensitivity and 66.38% specificity with an AUC of 0.7479.Conclusions:We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC. | Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang Weirong Li Zhongtao Zhang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 22 |
| 12 | Role of secondary aerosols in haze formation in summer in the Megacity Beijing显示文摘A field experiment from 18 August to 8 September 2006 in Beijing, China, was carried out. A hazy day was defined as visibility < 10 km and RH(relative humidity) < 90%. Four haze episodes, which accounted for ~ 60% of the time during the whole campaign, were characterized by increases of SNA(sulfate, nitrate, and ammonium) and SOA(secondary organic aerosol) concentrations. The average values with standard deviation of SO2-+4, NO-3, NH4 and SOA were 49.8(± 31.6), 31.4(±22.3), 25.8(±16.6) and 8.9(±4.1) μg/m3, respectively, during the haze episodes, which were 4.3, 3.4, 4.1, and 1.7 times those in the non-haze days. The SO2-4,NO-3, NH+4, and SOA accounted for 15.8%, 8.8%, 7.3%, and 6.0% of the total mass concentration of PM10 during the non-haze days. The respective contributions of SNA species to PM10 rose to about27.2%, 15.9%, and 13.9% during the haze days, while the contributions of SOA maintained the same level with a slight decrease to about 4.9%. The observed mass concentrations of SNA and SOA increased with the increase of PM10 mass concentration, however, the rate of increase of SNA was much faster than that of the SOA. The SOR(sulfur oxidation ratio) and NOR(nitrogen oxidation ratio) increased from non-haze days to hazy days, and increased with the increase of RH. High concentrations of aerosols and water vapor favored the conversion of SO2 to SO2-4and NO2 to NO-3, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing. | Tingting Han Xingang Liu Yuanhang Zhang Yu Qu Limin Zeng Min Hu Tong Zhu | 2015 | Journal of Environmental Sciences2015，27，5： | 22 |
| 13 | Physiological and molecular studies of staygreen caused by pod removal and seed injury in soybean显示文摘Leaves provide substances and signals for pod and seed development in soybean.However,the regulatory feedbacks of pod and seed to leaf development remain unclear.We investigated the effects of pod and seed on leaf senescence by conducting pod removal and seed injury experiments.Pod removal and seed injury delayed leaf senescence and caused the staygreen phenotype of leaves.There were dosage effects of pod number on the extent of staygreen in depodded plants.The concentrations of chlorophyll(SPAD value,an index of relative chlorophyll content),soluble protein,and soluble sugar in the leaves of depodded plants were higher than those of intact plants.During seed development,the content of IAA decreased,while that of ABA increased.This trend was more pronounced in intact than in depodded and seed-injured plants.The GA3/ABA ratio decreased gradually in all treatments.The content of GA3 was relatively stable and was higher in intact than in depodded plants.The expression levels of four senescence-related genes,Gm SARK,Gm SGR1,Gm CYN1,and Gm NAC,declined in depodded or seed-injured treatments and were positively correlated with the number of leaves retained on plants.Gm FT2 a,the major flowering-promoting gene,was expressed at a higher level while E1,a key flowering inhibitory gene,was expressed at a lower level in depodded than in intact plants.We propose that the pod or seed can regulate leaf development.When the seed is aborted owing to disease infection or pest attack,the leaves stay green because of the absence of the seed signals for senescence. | Xinxin Zhang Min Wang Tingting Wu Cunxiang Wu Bingjun Jiang Changhong Guo Tianfu Han | 2016 | The Crop Journal2016，4，6： | 23 |
| 14 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 15 | ADMM-based Distributed State Estimation for Integrated Energy System显示文摘In order to have an accurate knowledge of system-wide operation states,it is necessary to perform state estimation for the integrated energy system(IES)as the basis of energy man-agement and control.Centralized state estimation is practically infeasible for IES due to the unreliability of communication,the barrier on privacy,and the large scale of integrated systems.This paper proposes a distributed state estimation algorithm based on the alternating direction method of multipliers(ADMM)for IES containing electricity,heat,and natural gas.Various coupling units are taken into full consideration in modeling of IES state estimation to reflect the harmonization of multi energy.On the basis of bilinear measurement model,the state estimation considering nonlinear measurements can be replaced by an equivalent three-stage problem containing two linear state estimations and an intermediate transformation to avoid non-convex optimization.The three-stage procedure for IES state estimation can be further decoupled over three sub-systems with coordination on coupling units,yielding a fully distributed scheme based on ADMM.A modified ADMM with the self-adjusting penalty parameter is also adopted to enhance the convergence.Simulation results demonstrate the validity and superiority of the proposed algorithm. | Yaxin Du Wen Zhang Tingting Zhang | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 20 |
| 16 | Healthy function and high valued utilization of edible fungi显示文摘Edible fungi are large fungi with high added value that can be utilized as resources.They are rich in high-quality protein,carbohydrate,various vitamins,mineral elements and other nutrients,and are characterized by high protein,low sugar,low fat and low cholesterol.In addition,edible fungi contain a variety of bioactive substances,such as polysaccharides,dietary fiber,steroids,polyphenols,and most of these compounds have antioxidant,anti-tumor and other physiological functions.This review comprehensively discusses the bioactive components and functional characteristics of edible fungi(such as antioxidant,anti-aging,hypolipidemic activities,etc.).Then the recent developments and prospect in the high-valued utilization of edible fungi are discussed and summarized.The objective of this review is to improve the understanding of health-promoting properties of edible fungi,and provide reference for the industrial production of edible fungi-based health products. | Yanrong Zhang Dawei Wang Yuetong Chen Tingting Liu Shanshan Zhang Hongxiu Fan Hongcheng Liu Yu Li | 2021 | Food Science and Human Wellness2021，10，4： | 20 |
| 17 | Structure, evolution and regional tectonic implications of the Queshan metamorphic core complex in eastern Jiaodong Peninsula of China显示文摘The Queshan MCC is an important example of a crustal extensional structure in the eastern Jiaodong Peninsula along the southeastern margin of the NCC in the Early Cretaceous. The MCC is a typical Cordilleran-type core complex with a three-layered structure:(1) the upper plate is constituted by the Cretaceous supradetachment basin and Paleoproterozoic basement;(2) the lower plate comprises the Neoarchean high-grade metamorphic complexes and late Mesozoic granitic intrusions; and(3) the two plates are separated by a master detachment fault. A series of late NEN-oriented brittle faults superimposed on and destructed the early MCC. Petrology, geometry, kinematics, macro- and micro-structures and quartz c-axis fabrics imply that the MCC has a progressive exhumation history from middle-lower to subsurface level(via middle-upper crustal level) under the nearly WNW-ESE regional extensional regime. We present structural and geochronological evidence to constrain the exhumation of the Queshan MCC from ca. 135 to 113 Ma. Based on the comprehensive analysis of the different patterns of extensional structures in the Jiaodong and Liaodong Peninsula, we have defined the Jiao-Liao Early Cretaceou extensional province and further divided the crustal extension of it into two stages: the first stage was the intense flow of the middle-lower crust and the second stage was the extension of the middle-upper crust. Combining the tectonic setting, the lithosphere thinning in the Jiao-Liao Early Cretaceous extensional province can be considered a typical model for the response of crust-mantle detachment faulting under regional extension in East Asia. | XIA ZengMing LIU JunLai NI JinLong ZHANG TingTing SHI XingMing WU Yun | 2016 | Science China Earth Sciences2016，59，5： | 17 |
| 18 | Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics显示文摘SI RT6 is an important histone modifying protein that regulates DNA repair,telomere maintenance,energy me-tabolism,and target gene expression.Recently SIRT6 has been identifi ed as a tumor suppressor and is down-regulated in certain cancer types,but not in other can-cers.From deposited gene profi ling studies we found that SIRT6 was overexpressed in prostate tumors,compared with normal or paratumor prostate tissues.Tissue micro-array studies confi rmed the higher levels of SIRT6 in both prostate tumor tissues and prostate cancer cells than in their normal counterparts.Knockdown of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cy-cle,increased apoptosis,elevated DNA damage level and decrease in BCL2 gene expression.Moreover,SIRT6-de-fi ciency reduced cell viability and enhanced chemothera-peutics sensitivity.Taken together,this study provides the fi rst evidence of SIRT6 overexpression in human prostate cancer,and SIRT6 regulation could be exploited for pros-tate cancer therapy. | Yewei Liu Qian Reuben Xie Boshi Wang Jiaxiang Shao Tingting Zhang Tengyuan Liu Gang Huang Weiliang Xia | 2013 | Protein & Cell2013，4，9： | 17 |
| 19 | High-speed femtosecond laser plasmonic lithography and reduction of graphene oxide for anisotropic photoresponse显示文摘Micro/nanoprocessing of graphene surfaces has attracted significant interest for both science and applications due to its effective modulation of material properties,which,however,is usually restricted by the disadvantages of the current fabrication methods.Here,by exploiting cylindrical focusing of a femtosecond laser on graphene oxide(GO)films,we successfully produce uniform subwavelength grating structures at high speed along with a simultaneous in situ photoreduction process.Strikingly,the well-defined structures feature orientations parallel to the laser polarization and significant robustness against distinct perturbations.The proposed model and simulations reveal that the structure formation is based on the transverse electric(TE)surface plasmons triggered by the gradient reduction of the GO film from its surface to the interior,which eventually results in interference intensity fringes and spatially periodic interactions.Further experiments prove that such a regular structured surface can cause enhanced optical absorption(>20%)and an anisotropic photoresponse(~0.46 ratio)for the reduced GO film.Our work not only provides new insights into understanding the laser-GO interaction but also lays a solid foundation for practical usage of femtosecond laser plasmonic lithography,with the prospect of expansion to other two-dimensional materials for novel device applications. | Tingting Zou Bo Zhao Wei Xin Ye Wang Bin Wang Xin Zheng Hongbo Xie Zhiyu Zhang Jianjun Yang Chunlei Guo | 2020 | Light(Science & Applications)2020，9，1： | 17 |
| 20 | SEUSS and PIF4 Coordinately Regulate Light and Temperature Signaling Pathways to Control Plant Growth显示文摘 | Junling Huai Xinyu Zhang dialong Li Tingting Ma Ping Zha Yanjun Jing Rongcheng Lin | 2018 | Molecular Plant2018，11，7： | 15 |
您所在的机构暂未开通此部分的功能，请联系管理员