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| 1 | Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient显示文摘Dear Editor,SARS-CoV-2,a novel coronavirus and causing COVID-19,has given rise to a worldwide pandemic.1,2 So far,tens of thousands of COVID-19 patients have been clinically cured and discharged,but multiple COVID-19 cases showed SARS-CoV-2 positive again in discharged patients,3 which raises an attention for the discharged patients.Also,there is an urgent need to understand the pathogenesis of SARS-CoV-2 infection.Here,we conducted postmortem pathologic study in a ready-fordischarge COVID-19 patient who succumbed to sudden cardiovascular accident.Pathological examination revealed SARSCoV-2-viruses remaining in pneumocytes and virus-caused pathological changes in the lungs.Our study provided new insights into SARS-CoV-2 pathogenesis and might facilitate the improvement of clinical guideline for virus containment and disease management. | Xiao-Hong Yao Zhi-Cheng He Ting-Yuan Li Hua-Rong Zhang Yan Wang Huaming Mou Qiaonan Guo Shi-Cang Yu Yanqing Ding Xindong Liu Yi-Fang Ping Xiu-Wu Bian | 2020 | Cell Research2020，30，6： | 35 |
| 2 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edskpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edskpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edskpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 3 | Standardized training for resident doctors in China显示文摘Medical graduates are not fully trained physicians when they leave medical school.Currently,standardized training for resident doctors in most hospitals in China is carried out according to the Ministry of Health guidelines.However,these guidelines provide only outline guidance,and specific resident training is managed independently by and varies with individual institutions.Therefore,it is important to study training demand to learn about the content and emphasis of training. | Tonglin Sun Yanqing Wang | 2014 | The Journal of Biomedical Research2014，28，3： | 23 |
| 4 | Optimal time to use low molecular weight heparin on prethrombotic state of rat chronic obstructive pulmonary disease model显示文摘 | Wang Yanqing Sun Nina Cheng Zhaozhong Tong Li | 2014 | Chinese Medical Journal2014，，3： | 19 |
| 5 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 6 | Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons显示文摘 | Xiangyu LI Lu SU Yujue WANG Yanqing YU Chengwen WANG Xiaoliang LI Zhihua WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 14 |
| 7 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddhkpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3hkpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 8 | Gray bootstrap method for estimating frequency-varying random vibration signals with small samples显示文摘During environment testing, the estimation of random vibration signals(RVS) is an important technique for the airborne platform safety and reliability. However, the available methods including extreme value envelope method(EVEM), statistical tolerances method(STM) and improved statistical tolerance method(ISTM) require large samples and typical probability distribution. Moreover, the frequency-varying characteristic of RVS is usually not taken into account. Gray bootstrap method(GBM) is proposed to solve the problem of estimating frequency-varying RVS with small samples. Firstly, the estimated indexes are obtained including the estimated interval, the estimated uncertainty, the estimated value, the estimated error and estimated reliability. In addition, GBM is applied to estimating the single flight testing of certain aircraft. At last, in order to evaluate the estimated performance, GBM is compared with bootstrap method(BM) and gray method(GM) in testing analysis. The result shows that GBM has superiority for estimating dynamic signals with small samples and estimated reliability is proved to be 100% at the given confidence level. | Wang Yanqing Wang Zhongyu Sun Jianyong Zhang Jianjun Zissimos Mourelato | 2014 | Chinese Journal of Aeronautics2014，27，2： | 12 |
| 9 | Effect of allogeneic umbilical cord mesenchymal stem cell transplantation in a rat model of hepatic cirrhosis显示文摘OBJECTIVE: To determine the effects of human umbilical cord mesenchymal stem cell(UCMSC) transplantation, alone or in combination with tanshinone IIA(Tan IIA) on hepatic cirrhosis in rats.METHODS: A rat model of cirrhosis was established. Rats were divided into control, UCMSC, and UCSMC plus Tan IIA groups. Rats in the UCMSC group were injected via the tail vein with 0.2 m L Di I-labeled UCMSC suspension. Intraperitoneal Tan IIA injections(20 mg/kg) were started on the day ofUCMSC transplantation in the UCMSC plus Tan IIA group, and continued for 7 consecutive days thereafter. Rats were sacrificed 1 day, 3 days, 1 month,and 3 months after transplantation and the numbers of Di I-labeled UCMSCs colonizing the liver were determined. Albumin(ALB) and alanine aminotransferase(ALT) levels were measured in venous blood, and m RNA and protein expression levels of human ALB and cytokeratin(CK)-18 in liver tissues were determined by reverse transcription-polymerase chain reaction and western blotting, respectively.RESULTS: Serum ALT levels were significantly lower and serum ALB levels significantly higher in rats in the UCMSC group compared with the control group(P < 0.05). Hepatic CK-18 and ALB m RNA and protein expression levels increased after transplantation, and were significantly higher in the UCMSC plus Tan IIA group compared with the UCMSC group(P < 0.05).CONCLUSION: Human UCMSCs transplanted into rats with liver cirrhosis can grow and differentiate into hepatocyte-like cells resulting in improved liver function in vivo. Tan IIA further influenced transplantation outcomes. | Yang Lihua Wang Yun Wang Xiaohua Liu Yanqing | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 12 |
| 10 | Agricultural information dissemination using ICTs:A review and analysis of information dissemination models in China显示文摘Over the last three decades,China’s agriculture sector has been transformed from the traditional to modern practice through the effective deployment of Information and Communication Technologies(ICTs).Information processing and dissemination have played a critical role in this transformation process.Many studies in relation to agriculture information services have been conducted in China,but few of them have attempted to provide a comprehensive review and analysis of different information dissemination models and their applications.This paper aims to review and identify the ICT based information dissemination models in China and to share the knowledge and experience in applying emerging ICTs in disseminating agriculture information to farmers and farm communities to improve productivity and economic,social and environmental sustainability.The paper reviews and analyzes the development stages of China’s agricultural information dissemination systems and different mechanisms for agricultural information service development and operations.Seven ICT-based information dissemination models are identified and discussed.Success cases are presented.The findings provide a useful direction for researchers and practitioners in developing future ICT based information dissemination systems.It is hoped that this paper will also help other developing countries to learn from China’s experience and best practice in their endeavor of applying emerging ICTs in agriculture information dissemination and knowledge transfer. | Yun Zhang Lei Wang Yanqing Duan | 2016 | Information Processing in Agriculture2016，3，1： | 12 |
| 11 | Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway显示文摘OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 pathway.METHODS: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation assay.RESULTS: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and STAT3.CONCLUSION: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis. | Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan Hou Mengmeng Zhang Yulian Kang Liyuan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 11 |
| 12 | Strengthening FCC-CoCrFeMnNi high entropy alloys by Mo addition显示文摘In order to strengthen the face-centered-cubic(FCC) type CoCrFeMnNi high entropy alloys(HEAs), different contents of Mo(0–16 at.%, similarly hereinafter) were alloyed. Phase evolution, microstructure,mechanical properties and related mechanism of these HEAs were systematically studied. The results show that sigma phase is appeared with addition of Mo, and the volume fraction of it increases gradually from 0 to 66% with increasing Mo content. It is found that Mo is enriched in sigma phase, which indicates that Mo element is beneficial to form sigma phase. Compressive testing shows that the yield strength of the alloys increases gradually from 216 to 765 MPa, while the fracture strain decreases from 50%(no fracture) to 19% with increasing of Mo. The alloy exhibits the best compressive performance when Mo content reaches 11%, the yield strength, fracture strength and fracture strain are 547 MPa, 2672 MPa and44% respectively. The increased volume fraction of sigma phase plays an important role in improving the compressive strength of(CoCrFeMnNi)_(100-x)Mo_xHEAs. | Gang Qin Ruirun Chen Huiting Zheng Hongze Fang Liang Wang Yanqing Su Jingjie Guo Hengzhi Fu | 2019 | Journal of Materials Science & Technology2019，35，4： | 11 |
| 13 | Biomimetic Corrugated Silicon Nanocone Arrays for Self-Cleaning Antireflection Coatings显示文摘Corrugated silicon nanocone(SiNC)arrays have been fabricated on a silicon wafer by two polystyrene-sphere-monolayer-masked etching steps in order to create high-performance antireflective coatings.The reflectance was reduced from above 35%to less than 0.7%in the range 400-1050 nm,and it remained below 0.5%at incidence angles up to 70°at 632.8 nm for both s-and p-polarized light.The fluorinated corrugated SiNC array surface exhibits superhydrophobic properties with a water contact angle of 164°. | Yandong Wang Nan Lu Hongbo Xu Gang Shi Miaojun Xu Xiaowen Lin Haibo Li Wentao Wang Dianpeng Qi Yanqing Lu Lifeng Chi | 2010 | Nano Research2010，3，7： | 8 |
| 14 | Microstructures and mechanical properties of Nb-alloyed CoCrCuFeNi high-entropy alloys显示文摘Nb has a positive effect on improving the mechanical properties of metal materials, and it is expected to strengthen CoCrCuFeNi high-entropy alloys(HEAs) with outstanding ductility and relatively weak strength. In this paper, the alloying effects of Nb on the microstructural evolution and the mechanical properties of the(CoCrCuFeNi)_(100-x)Nb_xHEA were investigated systematically. The result shows that Nb promotes the phase transition from FCC(face-centered cubic) to Laves phase, and the volume fractions of Laves phase increase from 0% to 58.2% as the Nb content increases. Compressive testing shows that the addition of Nb has a positive effect on improving the strength of CoCrCuFeNi HEA. The compressive yield strength of(CoCrCuFeNi)_(100-x)Nb_xHEAs increases from 338 MPa to 1322 MPa and the fracture strain gradually reduces from 60.0%(no fracture) to 8.1% as the Nb content increases from 0 to 16 at.%. The volume fraction increase of hard Laves phase is the key factor for the strength increase, and the reduction of the VEC(valence electron concentration) value induced by the addition of Nb is beneficial for the increase of the Laves phase content in these alloys. | Gang Qin Shu Wang Ruirun Chen Xue Gong Liang Wang Yanqing Su Jingjie Guo Hengzhi Fu | 2018 | Journal of Materials Science & Technology2018，34，2： | 8 |
| 15 | Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization显示文摘This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of recombinant DNA(pCCMp24) and recombinant attenuated vaccinia virus Tian Tan(rddVTT-CCMp24).Intramuscular immunization was performed on days 0(prime) and 21(boost).The immunogenicity of the vaccine schedules was determined by measuring human immunodeficiency virus(HIV)-specific binding antibody levels and cytokine(interleukin-2 and interleukin-4) concentrations in peripheral blood,analyzing lymphocyte proliferation capacity against HIV epitopes and CD4 + /CD8 + cell ratio,and monitoring interferon-gamma levels at different times post-immunization.The results showed that pCCMp24,rddVTT-CCMp24 and their prime-boost immunization induced humoral and cellular immune responses.The pCCMp24/rddVTT-CCMp24 immunization strategy increased CD8 + T cells and induced more IFN-γ-secreting cells compared with single-shot rDNA.The prime-boost immunization strategy also induced the generation of cellular immunological memory to HIV epitope peptides.These results demonstrated that prime-boost immunization with rDNA and rddVTT-CCMp24 had a tendency to induce greater cellular immune response than single-shot vaccinations,especially IFN-γ response,providing a basis for further studies. | LIU CunXia DU ShouWen LI Chang WANG YuHang WANG MaoPeng LI Yi YIN RongLan LI Xiao REN DaYong QIN YanQing REN JingQiang JIN NingYi | 2013 | Science China(Life Sciences)2013，56，6： | 7 |
| 16 | A meta-analysis of Chinese herbal medicines for vascular dementia显示文摘OBJECTIVE: To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL: We retrieved publications from Cochrane Library (2004 to July 2011), PubMed (1966 to July 2011), the Chinese Science and Technique Journals Database (1977 to July 2011), the China National Knowledge Infrastructure (1979 to July 2011), Google Scholar (July 2011), and the Chinese Biomedical Database (1977 to July 2011) using the'Chinese medicine OR Chinese herbal medicine' and 'vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia'. SELECTION CRITERIA: Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherché et l'Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers' Handbook 5.0. MAIN OUTCOME MEASURES: Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS: We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants (1 605 patients took Chinese medicine decoctions (treatment group); 1 263 patients took western medicine or placebo). The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention (relative risk (RR)=1.27; 95% confidence interval (CI): 1.18-1.38, P<0.01). Mini-Mental State Examination scores were higher in patients taking Chinese herbal medicines than in those in the control group (weighted mean difference (WMD)=2.83; 95%CI: 2.55-3.12, P<0.01). Patients in the treatment group showed better disease amelioration than those in the control group (Hasegawa Dementia Scale scores; WMD=2.41, 95%CI: 1.48-3.34, P<0.01). There were also considerably fewer adverse reactions among those in the treatment group compared with those in the control group (RR=0.20, 95%CI: 0.08-0.47, P<0.01). CONCLUSION: Chinese herbal medicine appears to be safer and more effective than control measures in the treatment of vascular dementia. However, the included trials were generally low in quality. More well-designed, high-quality trials are needed to provide better evidence for the assessment of the efficacy and safety of Chinese medicines for vascular dementia. | Xiude Qin Yu Liu Yanqing Wu Shuo Wang Dandan Wang Jinqiang Zhu Qiaofeng Ye Wei Mou Liyuan Kang | 2013 | Neural Regeneration Research2013，8，18： | 7 |
| 17 | Fuzzy norm method for evaluating random vibration of airborne platform from limited PSD data显示文摘For random vibration of airborne platform, the accurate evaluation is a key indicator to ensure normal operation of airborne equipment in flight. However, only limited power spectral density(PSD) data can be obtained at the stage of flight test. Thus, those conventional evaluation methods cannot be employed when the distribution characteristics and priori information are unknown. In this paper, the fuzzy norm method(FNM) is proposed which combines the advantages of fuzzy theory and norm theory. The proposed method can deeply dig system information from limited data, which probability distribution is not taken into account. Firstly, the FNM is employed to evaluate variable interval and expanded uncertainty from limited PSD data, and the performance of FNM is demonstrated by confidence level, reliability and computing accuracy of expanded uncertainty. In addition, the optimal fuzzy parameters are discussed to meet the requirements of aviation standards and metrological practice. Finally, computer simulation is used to prove the adaptability of FNM. Compared with statistical methods, FNM has superiority for evaluating expanded uncertainty from limited data. The results show that the reliability of calculation and evaluation is superior to 95%. | Wang Zhongyu Wang Yanqing Wang Qian Zhang Jianjun | 2014 | Chinese Journal of Aeronautics2014，27，6： | 6 |
| 18 | Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination显示文摘The differentiation and maturation of oligodendrocyte precursor cells(OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1 L(myelin transcription factor 1-like), mainly expressed in neurons,has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1 L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1 L in neuron/glia antigen 2-positive(NG^(2+))OPCs was significantly higher than that in mature CC1^+ oligodendrocytes. In primary cultured OPCs,overexpression of Myt1 L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1 L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. Ch IP assays showed that Myt1 L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1 L is an essential regulator of OPC differentiation, thereby supporting Myt1 L as a potential therapeutic target for demyelinating diseases. | Yanqing Shi Qi Shao Zhenghao Li Ginez A. Gonzalez Fengfeng Lu Dan Wang Yingyan Pu Aijun Huang Chao Zhao Cheng He Li Cao | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 19 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 20 | Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation显示文摘象 bystin 一样(BYSL ) 基因以前被描绘为参予早胚胎培植的房间粘附编码附件蛋白质。它也涉及 40S ribosomal 子单元生物的续生说并且被发现在很快种胚胎和癌症房间线被表示。以便在癌症房间增长和生长探索 BYSL 的角色,我们把 hepatocellular 癌(HCC ) 用作一个模型。这里,我们报导 BYSL 在 vitro 并且在 vivo 为 HCC 房间生长是关键的。在人的 HCC 标本的 BYSL mRNA 和蛋白质的表示层次显著地与在邻近的非癌的织物看见的那些相比被增加。在 vitro,由短发卡 RNA 的 BYSL 的抑制减少了 HCC 房间增长,导致了 apoptosis 并且部分在 G2/M 阶段逮捕了房间周期。在 vivo,与 BYSL siRNA 对待的 HCC 房间没能在下的培植以后在裸体老鼠形成肿瘤。为了为 BYSL 导致 RNAi 的细胞生长决定细胞的基础,逮捕, BYSL subcellular 本地化在有丝分裂并且分裂期间 HepG2 细胞被检验。BYSL 在 nucleologenesis 期间在多重阶段是在场的,在导出核的 foci (NDF ) 包括, perichromosomal 区域和 prenucleolar 身体(PNB ) 在有丝分裂期间。BYSL 弄空显著地压制了 NDF 和 PNB 形成,并且在有丝分裂以后破坏了 nucleoli 汇编,导致增加的 apoptosis 和到浆液饥饿的 HCC 房间的减少的忍耐。一起拿,我们的研究显示那 upregulated BYSL 表情在 hepatocarcinogenesis 起一个作用。 | Hanzhi Wang Wei Xiao Qinbo Zhou Yun Chen Shuo Yang Jiansong Sheng Yanqing Yin Jia Fan Jiawei Zhou | 2009 | Cell Research2009，19，10： | 5 |
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