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5篇 您的检索式：作者名="Yakun Wan"

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		题名	作者	年代	出处	被引量
	1	Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology.	Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu	2022	Research2022，，2：	2
	2	Application of radiofrequency ablation for splenic preservation显示文摘	Yakun Wu Lili Wan Peizhi Li Yinglin Zhang Min Li Jianping Gong Wei Zhang	2014	Journal of Surgical Research2014，，：	1
	3	Effects of temperature and atmosphere component on quality of stored jujube fruit显示文摘	LIN Li TIAN Shiping WAN Yakun et at	2004	Acta Botanica Sinica2004，46，8：	1
	4	Induction of defense responses against Alternaria rot by different elicitors in harvested pear fruit显示文摘	Tian Shiping Wan Yakun Qin Guozheng	2006	Applied Microbiology and Biotechnology2006，70，6：	1
	5	Effects of temperature and atmosphere component on quality of stored Jujube fruit显示文摘	LI LIN TIAN SHIPING WAN YAKUN	2004	Acta Botanica Sinica2004，46，8：	1

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