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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Characteristics of volatile organic compounds,NO_2,and effects on ozone formation at a site with high ozone level in Chengdu显示文摘Chengdu is a megacity in the southwest of China with high ozone(O_3) mixing ratio.Observation of volatile organic compounds(VOCs), NO_2 and O_3 with high temporal resolution was conducted in Chengdu to investigate the chemical processes and causes of high O_3 levels. The hourly mixing ratios of VOCs, NO2, and O_3 were monitored by an online system from 28 August to 7 October, 2016. According to meteorological conditions,Chengdu, with relative warm weather and low wind speed, is favorable to O_3 formation.Part of the O_3 in Chengdu may be transported from the downtown area. In O_3 episodes,the average mixing ratios of NO_2 and O_3 were 20.20 ppbv and 47.95 ppbv, respectively. In non-O_3 episodes, the average mixing ratios of NO_2 and O_3 were 16.38 ppbv and 35.15 ppbv,respectively. The average mixing ratio of total VOCs(TVOCs) was 40.29 ppbv in non-O_3 episodes, which was lower than that in O_3 episodes(53.19 ppbv). Alkenes comprised51.7% of the total O_3 formation potential(OFP) in Chengdu, followed by aromatics which accounted for 24.2%. Ethylene, trans-pentene, propene, and BTEX(benzene, ethylbenzene,toluene, m/p-xylene, o-xylene) were also major contributors to the OFP in Chengdu. In O_3 episodes, intensive secondary formations were observed during the campaign. Oxygenated VOCs(OVOCs), such as acetone, Methylethylketone(MEK), and Methylvinylketone(MVK)were abundant. Isoprene rapidly converted to MVK and Methacrolein(MACR) during O_3 episodes. Acetone was mainly the oxidant of C3-C5 hydrocarbons. | Yuanyuan Deng Jing Li Yaqi Li Rongrong Wu Shaodong Xie | 2019 | Journal of Environmental Sciences2019，31，1： | 29 |
| 3 | Perfluorooctane sulfonate (PFOS) and other fluorochemicals in viscera and muscle of farmed pigs and chickens in Beijing,China显示文摘Eleven perfluorinated compounds(PFCs) were determined in tissue samples from farmed pigs and chickens(n=143) that were purchased in Beijing in March 2009.The total PFCs mean concentration was the highest in pig liver(3.438 ng g-1 wet weight(ww)),followed by pig kidney(0.508 ng g-1(ww)),pig heart(0.167 ng g-1(ww)),chicken liver(0.098 ng g-1(ww)),chicken heart(0.050 ng g-1(ww)),pork loin(0.018 ng g-1(ww)),and chicken breast(0.012 ng g-1(ww)).Among the PFCs analyzed,perfluorooctane sulfonate(PFOS) was the predominant compound in viscera and muscle of farmed pigs and chickens.In addition,a strong linear correlation(r = 0.932) was observed between the concentrations of PFOS and perfluoroundecanoic acid(PFUnDA) in pig liver.Our preliminary conclusion is that there is little potential risk of exposure to PFCs via the consumption of these products in Beijing. | WANG JieMing SHI YaLi PAN YuanYuan CAI YaQi | 2010 | Chinese Science Bulletin2010，55，31： | 24 |
| 4 | Interactions between HLH and bHLH Factors Modulate Light-Regulated Plant Development显示文摘Phytochromes (Phy ) 和因素(程序信息文件) 抄写因素组成一个主要发信号的交往 phytochrome 响应红和 far-red 光控制植物开发的模块。当由邻居的 shading 种并且导致称为阴影回避症候群(SAS ) 的房间 elongationa 现象,低 red:far 红的比率被解释。PAR1 和它的最靠近的相当或相同的事物 PAR2 是 SAS 的否定管理者;他们属于缺乏要求的典型的基本的域的 HLH 抄写因素家庭因为 DNA 绑定,和他们被相信通过还有待于被识别的 DNA 有约束力的抄写因素调整基因表达式。这里,我们证明那个轻信号稳定 PAR1 蛋白质, PAR1 与 PIF4 交往并且禁止调停 PIF4 的基因激活。DNA 下拉和染色质 immunoprecipitation (薄片) 试金证明 PAR1 禁止在 vitro 并且在 vivo 有约束力的 PIF4 DNA。转基因的植物 overexpressing PAR1 (PAR1OX ) 在胚轴延伸对赤霉素(GA ) 或高温度感觉迟钝,同样到 pifq 异种。除了 PIF4, PAR1 也与 PRE1, brassinosteroid (BR ) 激活的一个 HLH 抄写因素和 GA 交往。PRE1 的 Overexpression 大部分压制了 PAR1OX 的矮子显型。这些结果显示 PAR1PRE1 和 PAR1PIF4 heterodimers 形成响应光和荷尔蒙调整房间延伸和植物开发的一个复杂 HLH/bHLH 网络。 | Yaqi Hao Eunkyoo Oh GUtsu Choi Zongsuo Liang Zhi-Yong Wang | 2012 | Molecular Plant2012，5，3： | 19 |
| 5 | Evaluation of perfluorinated compounds in seven wastewater treatment plants in Beijing urban areas显示文摘The presence of perfluorinated compounds(PFCs)in seven major wastewater treatment plants(WWTPs)in Beijing was investigated in the current study.We detected nine PFCs in all the wastewater and sludge samples.Perfluorooctane acid(PFOA)is the dominant PFCs in influents and effluents,while perfluorooctane sulfonate(PFOS)is the major contaminant in sludge.The highest PFC concentration was found in plants at Qinghe and Jiuxianqiao WWTP,while the lowest was found at Fangzhuang WWTP.The total values of PFC range from 2.88 to 176 ng/L in influents,from 5.48 to 498 ng/L in effluents,and from 1.21 to 32.0 ng/g(dry wt)in sludge.The fact that effluents usually contain higher levels of PFCs than influents suggests that additional PFCs are produced during the wastewater treatment processes.However,PFOS decreases in effluents than in influents in 62%of the water samples.This may be due to the adsorption and removal of the sludge during the active process.Perfluoroalkyl carboxylates(PFCAs)were found significantly correlated with each other in the effluents,which may indicate their similar sources or the existence of their potential precursors in the wastewater or treatment processes.The mass flows of PFC discharges into WWTPs are 0.4–51.4 mg/day,and the mass flows of PFCs in effluents exceed those in influents by 127%.Domestic and commercial wastewaters are suggested to be the major sources of PFC pollution in WWTPs in Beijing. | PAN YuanYuan SHI YaLi WANG JieMing CAI YaQi | 2011 | Science China Chemistry2011，54，3： | 16 |
| 6 | The variation of the estimated GPS instrumental bias and its possible connection with ionospheric variability显示文摘Based on the analysis of the satellite DCB data estimated by our method and the Center for Orbit Determination in Europe(CODE)from 1999 to 2011,the features of the temporal variation of differential code biases(DCB)are studied.Summarily,there are three types of variations in DCB on different time scales.The first one is the day-to-day variation that exhibits more obviously in solar maximum years.The second one is the variation with about one year periodic variation that behaves more obviously from 1999 to 2004.The last one is the monotonously descending tendency from 1999 to 2010.Considering the basic ionospheric approximation in DCB estimation method,the features of the variability of the ionospheric morphology from 1999to 2010 are also displayed based on the ionospheric characteristic parameters.It can be concluded that the day-to-day and annual variation of the estimated global positioning system(GPS).DCB is related to the ionospheric variability.The variation of DCBs on solar cycle time scale includes the real hardware DCBs and pseudo-DCBs induced by ionospheric variation.No doubt,these kinds of'pseudo'variations of DCB will affect the precision of ionospheric total electron content(TEC)derived from the GPS data.In addition,this study is helpful for evaluating the influence of ionospheric weather on TEC derivation and is also useful for developing one estimation method of DCB with more stability and precision through introducing a more practical ionospheric model. | ZHANG DongHe SHI Hao JIN YaQi ZHANG Wei HAO YongQiang XIAO Zuo | 2014 | Science China(Technological Sciences)2014，57，1： | 14 |
| 7 | Degradation of glucosinolates in rapeseed meal by Lactobacillus delbrueckii and Bacillus subtilis显示文摘Lactobacillus delbrueckii and Bacillus subtilis were employed as a new combination of strains to treat rapeseed meal by solid-state fermentation,aiming to efficiently degrade the glucosinolates,which are the main toxin in the meal.Single-factor tests and Response surface methodology(RSM)were used to optimize the fermentation parameters.Under the optimum fermentation parameters of 15%total injection volume of the mixture of Lactobacillus delbrueckii and Bacillus subtilis with a ratio of 2:1,bran content of16%,feed to water ratio of 1:1.5,fermentation temperature of 36°C and fermentation time of 72 h,the content of glucosinolates in rapeseed meal was decreased from 64.558μmol/g to 3.473μmol/g,reaching a high degradation rate(94.62%).The high detoxification rate by a consortium of Lactobacillus delbrueckii and Bacillus subtilis provides a bright application prospect in feed utilization of rapeseed meal. | Zhenyu Zhang Min Wen Yaqi Chang | 2020 | Grain & Oil Science and Technology2020，3，2： | 10 |
| 8 | Comprehensive analysis of NAC transcription factors and their expression during fruit spine development in cucumber (Cucumis sativus L.)显示文摘The cucumber(Cucumis sativus L.)is an important vegetable crop worldwide,and fruit trichomes or spines are an important trait for external fruit quality.The mechanisms underlying spine formation are not well understood,but the plant-specific NAC family of transcription factors may play important roles in fruit spine initiation and development.In this study,we conducted a genome-wide survey and identified 91 NAC gene homologs in the cucumber genome.Clustering analysis classified these genes into six subfamilies;each contained a varying number of NAC family members with a similar intron–exon structure and conserved motifs.Quantitative real-time PCR analysis revealed tissue-specific expression patterns of these genes,including 10 and 12 that exhibited preferential expression in the stem and fruit,respectively.Thirteen of the 91 NAC genes showed higher expression in the wild-type plant than in its near-isogenic trichome mutant,suggesting their important roles in fruit spine development.Exogenous application of four plant hormones promoted spine formation and increased spine density on the cucumber fruits;several NAC genes showed differential expression over time in response to phytohormone treatments on cucumber fruit,implying their essential roles in fruit-trichome development.Among the NAC genes identified,12 were found to be targets of 13 known cucumber micro-RNAs.Collectively,these findings provide a useful resource for further analysis of the interactions between NAC genes and genes underlying trichome organogenesis and development during fruit spine development in cucumber. | Xingwang Liu Ting wang Ezra Bartholomew Kezia Black Mingming Dong Yaqi Zhang Sen Yang Yanling Cai Shudan Xue Yiqun Weng Huazhong Ren | 2018 | Horticulture Research2018，5，1： | 10 |
| 9 | Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser显示文摘We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums. | Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu Linjie Zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai | 2019 | Photonics Research2019，7，11： | 9 |
| 10 | Perfluorinated compounds in milk, milk powder and yoghurt purchased from markets in China显示文摘The exposure to perfluorinated compounds (PFCs) through the diet for humans is of great concern. Among the diet, dairy products are in great demand. This paper reports the study on the levels of 9 perfluorinated acids and 2 fluorotelomer acids in milk, milk powder and yoghurt purchased from Chinese markets from 2008 to 2009. The analytes were quantitated by high performance liquid chromatography/electrospray tandem mass spectrometry (HPLC-ESI-MS/MS). In milk samples, perfluoroheptanoic acid (PFHpA) and perfluorononanoic acid (PFNA) were detected frequently, both in 68% of samples. In milk powder samples, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and PFNA were the only detected PFCs and none of them was observed in more than 35% of samples. In yoghurt, PFOA was the most frequently detected compound, found in 69% of samples. None of fluorotelomer acids was observed in any samples. The mean concentrations of total PFCs were 178 pg/g (wet weight) in milk, 98 pg/g (dry weight) in milk powder and 42 pg/g in yoghurt (wet weight). It is notable that the data of this study indicate significant differences (P<0.001) among three kinds of packaging of milk in the concentration of total PFCs. A preliminary human health risk assessment of milk and dairy products consumption was conducted in this study. For adults, the mean daily intake of PFOS and total PFCs was equal to or lower than 23 and 167 pg kg-1 d-1 (body weight), respectively. | WANG JieMing SHI YaLi PAN YuanYuan CAI YaQi | 2010 | Chinese Science Bulletin2010，55，11： | 9 |
| 11 | LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project显示文摘The datasets of two Ocean Model Intercomparison Project(OMIP)simulation experiments from the LASG/IAP Climate Ocean Model,version 3(LICOM3),forced by two different sets of atmospheric surface data,are described in this paper.The experiment forced by CORE-II(Co-ordinated Ocean–Ice Reference Experiments,Phase II)data(1948–2009)is called OMIP1,and that forced by JRA55-do(surface dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis)data(1958–2018)is called OMIP2.First,the improvement of LICOM from CMIP5 to CMIP6 and the configurations of the two experiments are described.Second,the basic performances of the two experiments are validated using the climatological-mean and interannual time scales from observation.We find that the mean states,interannual variabilities,and long-term linear trends can be reproduced well by the two experiments.The differences between the two datasets are also discussed.Finally,the usage of these data is described.These datasets are helpful toward understanding the origin system bias of the fully coupled model. | Pengfei LIN Zhipeng YU Hailong LIU Yongqiang YU Yiwen LI Jirong JIANG Wei XUE Kangjun CHEN Qian YANG Bowen ZHAO Jilin WEI Mengrong DING Zhikuo SUN Yaqi WANG Yao MENG Weipeng ZHENG Jinfeng MA | 2020 | Advances in Atmospheric Sciences2020，37，3： | 9 |
| 12 | Vertical Migration of Fine-Grained Sediments from Interior to Surface of Seabed Driven by Seepage Flows–‘Sub-Bottom Sediment Pump Action'显示文摘A scientific hypothesis is proposed and preliminarily verified in this paper: under the driving of seepage flows, there might be a vertical migration of fine-grained soil particles from interior to surface of seabed, which is defined as ‘sub-bottom sediment pump action' in this paper. Field experiments were performed twice on the intertidal flat of the Yellow River delta to study this process via both trapping the pumped materials and recording the pore pressures in the substrate. Experimental results are quite interesting as we did observe yellow slurry which is mainly composed of fine-grained soil particles appearing on the seabed surface; seepage gradients were also detected in the intertidal flat, under the action of tides and small wind waves. Preliminary conclusions are that ‘sediment pump' occurs when seepage force exceeds a certain threshold: firstly, it is big enough to disconnect the soil particles from the soil skeleton; secondly, the degree of seabed fluidization or bioturbation is big enough to provide preferred paths for the detached materials to migrate upwards. Then they would be firstly pumped from interior to the surface of seabed and then easily re-suspended into overlying water column. Influential factors of ‘sediment pump' are determined as hydrodynamics(wave energy), degree of consolidation, index of bioturbation(permeability) and content of fine-grained materials(sedimentary age). This new perspective of ‘sediment pump' may provide some implications for the mechanism interpretation of several unclear geological phenomena in the Yellow River delta area. | ZHANG Shaotong JIA Yonggang WEN Mingzheng WANG Zhenhao Zhang Yaqi ZHU Chaoqi Li Bowen LIU Xiaolei | 2017 | Journal of Ocean University of China2017，16，1： | 8 |
| 13 | Mechanistic understanding of the role separators playing in advanced lithium-sulfur batteries显示文摘The lithium-sulfur battery is considered one of the most promising candidates for portable energy storage devices due to its low cost and high energy density.However,many critical issues,including polysulfide shuttling,self-discharge,lithium dendritic growth,and thermal hazards need to be addressed before the commercialization of lithium-sulfur batteries.To this end,tremendous efforts have been made to explore battery configurations and components,such as electrodes,electrolytes,and separators,among which the separator plays an especially critical role in addressing aforementioned issues.Thus,this review analyzes the mechanisms and interactions of these critical issues and summarizes both the function of separators and recent progress made towards remedying such issues.Additionally,promising directions for the development of separators in lithium-sulfur batteries are proposed. | Zhaohuan Wei Yaqi Ren Joshua Sokolowski Xiaodong Zhu Gang Wu | 2020 | InfoMat2020，2，3： | 8 |
| 14 | X-ray scintillation in lead-free double perovskite crystals显示文摘Metal halide perovskites have shown great performance for various applications,including solar cells,light emitting diodes,and radiation detectors,but they still suffer from the toxicity of lead and instability.Here we report the use of lanthanide series as trivalent metals to obtain low toxicity and highly stable double perovskites(Cs_2NaLnCl_6,Ln=Tb or Eu)with high scintillation light yield.The crystals exhibit typical f-f transitions of lanthanide cations,while Cs_2NaTbCl_6exhibits strong green photoluminescence,and Cs_2NaEuCl_6exhibits red photoluminescence.Under X-ray radiations,the light yield of Cs_2NaTbCl_6reaches46600 photons MeV^(-1),much higher than that of the commercially used(Lu,Y)_2SiO_5:Ce^(3+)crystals(LYSO,28500 photons MeV^(-1)),and previously reported lead-based perovskites(14000 photons MeV^(-1)).As a new member of lead-free perovskites,lanthanide-based double perovskites open up a new route toward radiation detections and potential medical imaging. | Qingsong Hu Zhenzhou Deng Manchen Hu Anjiang Zhao Yaqi Zhang Zhifang Tan Guangda Niu Haodi Wu Jiang Tang | 2018 | Science China Chemistry2018，61，12： | 7 |
| 15 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 16 | A facile surfactant-free synthesis of Rh flower-like nanostructures constructed from ultrathin nanosheets and their enhanced catalytic properties显示文摘Rh 是广泛地在许多器官的反应被使用的重要催化剂。在最近的年里,许多努力集中了于由与控制尺寸和形态学制作催化剂 nanoparticles 改进它的催化效率。然而,也把有机化合物用作反应媒介或盖住代理人的经常采用的合成线路经常在催化剂表面上导致剩余分子,它急速地接着减少催化表演。此处,我们报导甲醛经由 Rh (acac )3 的热水的减小获得的新奇 Rh 象花的结构的灵巧的、水的、没有表面活化剂的合成。唯一的 Rh nanoflowers 从 ultrathin nanosheets 被构造,其基础表面包括了 { 111 } 有 ~ 的平均厚度的方面 1.1 nm。特定的表面区域由公司脱衣测量了 79.3 是 m 2 钟声到 134.4 食火鸟的浸透的磁化 ???? 愠汬祯湩吗?? | Yaqi Jiang Jingyun Su Yanan Yang Yanyan Jia Qiaoli Chen Zhaoxiong Xie Lansun Zheng | 2016 | Nano Research2016，9，3： | 7 |
| 17 | Wave flume experiments on the contribution of seabed fluidization to sediment resuspension显示文摘Sediment resuspension is commonly assumed to be eroded from the seabed surface by an excess bottom shear stress and evolves in layers from the top down. Although considerable investigations have argued the importance of wave-induced seabed fluidization in affecting the sediment resuspension, few studies have been able to reliably evaluate its quantitative contribution till now. Attempt is made to preliminarily quantify the contribution of fluidization to resuspension using a series of large-scale wave flume experiments. The experimental results indicated that fluidization of the sandy silts of the Huanghe Delta account for 52.5% and 66.8% of the total resuspension under model scales of 4/20 and 6/20(i.e., relative water depth: the ratio of wave height to water depth), respectively. Some previously reported results obtained using the same flume and sediments are also summarized for a contrastive analysis, through which not only the positive correlation is confirmed, but also a parametric equation for depicting the relationship between the contribution of fluidization and the model scale is established. Finally, the contribution of fluidization is attributed to two physical mechanisms:(1) an attenuation of the erosion resistance of fluidized sediments in surface layers due to the disappearing of original cohesion and the uplifting effect resulting from upward seepage flows, and(2) seepage pumping of fines from the interior to the surface of fluidized seabed. | ZHANG Shaotong JIA Yonggang WANG Zhenhao WEN Mingzheng LU Fang ZHANG Yaqi LIU Xiaolei SHAN Hongxian | 2018 | Acta Oceanologica Sinica2018，37，3： | 6 |
| 18 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 19 | Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis显示文摘Metastasis is a major cause of chemotherapeutic failure and death.Degradation of a specific component of the extracellular matrix(ECM)by matrix metalloproteinases(MMPs)affects the physical barrier of the tumor microenvironment(TME)and induces metastasis.Here,lysolipid-containing thermosensitive liposomes(LTSLs)were prepared to deliver an MMP inhibitor,marimastat(MATT),to the TME to inhibit MMP activity and expression.LTSLs rapidly released their payloads at 42°C.Compared with the saline control,MATT-LTSLs exhibited enhanced accumulation in the tumor and a 20-fold decrease in tumor growth in 4T1 tumor-bearing mice;moreover,MATT-LTSLs reduced MMP-2 and MMP-9 activity by 50%and 43%,respectively,and downregulated MMP-2 and MMP-9 expression in vivo by 30%and 43%,respectively.Most importantly,MATT-LTSL treatment caused a 7-fold decrease in metastatic lung nodules and a 6-fold reduction in microvessels inside the tumor.We believe this study provides an effective approach for the suppression of metastasis,and the use of a cytotoxic agent in combination with MATT is a potential strategy for metastatic cancer treatment. | Yaqi Lyu Qingqing Xiao Lifang Yin Lei Yang Wei He | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 5 |
| 20 | Suppression of super-knock in TC-GDI engine using two-stage injection in intake stroke(TSII)显示文摘Turbocharging and direct injection are main technologies used for energy-saving gasoline engines.But the biggest challenge is super-knock,whose mechanism is unclear and has no effective strategy to suppress this super-knock until now.The effects of injection strategies on super-knock were experimentally investigated in a turbocharged GDI engine.It was found that two-stage injections during intake stroke(TSII)can eliminate super-knock.Meanwhile,the fuel consumption,emissions and exhaust temperature can keep optimized level.By sweeping the start of the 1st injection(SOI1),end of the 2nd injection(EOI2)and the split injection ratios(ROI2)using 5000 cycles evaluation test at low-speed high load operating point,the optimized injection strategy for the typical TC-GDI engine is TSII with SOI1 at middle of intake stroke,EOI2 at end of intake stroke,and ROI2 of 0.3. | WANG Zhi XU YaQi WANG JianXin | 2014 | Science China(Technological Sciences)2014，57，1： | 5 |
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