|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Component analysis of Chinese medicine and advances in fuming-washing therapy for knee osteoarthritis via unsupervised data mining methods显示文摘OBJECTIVE: To analyze the component law of Chinese medicines in fuming-washing therapy for knee osteoarthritis(KOA), and develop new fuming-washing prescriptions for KOA through unsupervised data mining methods.METHODS: Chinese medicine recipes for fuming-washing therapy for KOA were collected and recorded in a database. The correlation coefficient among herbs, core combinations of herbs, andnew prescriptions were analyzed using modified mutual information, complex system entropy cluster, and unsupervised hierarchical clustering, respectively.RESULTS: Based on analysis of 345 Chinese medicine recipes for fuming-washing therapy, 68 herbs occurred frequently, 33 herb pairs occurred frequently, and 12 core combinations were found.Five new fuming-washing recipes for KOA were developed.CONCLUSION: Chinese medicines for fuming-washing therapy of KOA mainly consist of wind-dampness-dispelling and cold-dispersing herbs, blood-activating and stasis-resolving herbs,and wind-dampness-dispelling and heat-clearing herbs. The treatment of fuming-washing therapy for KOA also includes dispelling wind-dampness and dispersing cold, activating blood and resolving stasis, and dispelling wind-dampness and clearing heat. Zhenzhutougucao(Herba Speranskiae Tuberculatae), Honghua(Flos Carthami), Niuxi(Radix Achyranthis Bidentatae), Shenjincao(Herba Lycopodii Japonici), Weilingxian(Radix et Rhizoma Clematidis Chinensis), Chuanwu(Radix Aconiti), Haitongpi(Cortex Erythrinae Variegatae), Ruxiang(Olibanum),Danggui(Radix Angelicae Sinensis), Caowu(Radix Aconiti Kusnezoffii), Moyao(Myrrha), and Aiye(Folium Artemisiae Argyi) are the main herbs used in the fuming-washing treatment for KOA. | Jun Liu Jianke Pan Yanping Wang Dingkun Lin Dan Shen Hongjun Yang Xiang Li Minghui Luo Xuewei Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 32 |
| 2 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 3 | Regulation of 1, 4, 5-triphosphate receptor channel gating dynamics by mutant presenilin in Alzheimer's disease cells显示文摘 | Fang Wei Xiang Li Meichun Cai Yanping Liu Peter Jung Jianwei Shuai | 2017 | Frontiers of physics2017，12，3： | 4 |
| 4 | The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages显示文摘The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the 'eat me' signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the 'don’t eat me' signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment. | Yanping Wu Xiang Luo Qingqing Zhou Haibiao Gong Huaying Gao Tongzheng Liu Jiaxu Chen Lei Liang Hiroshi Kurihara Yi-Fang Li Rong-Rong He | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 5 | A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus显示文摘To test whether amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus(IBDV), a pair of viruses, namely the moderately virulent IBDV(rG x-F9VP2) and the attenuated strain(rGt), were used. Residue mutations A222P(P_(BC)) and S330R(PHI), selected by sequence comparison, were introduced individually into r Gx-F9VP2 by using a reverse genetics system. In addition, the reverse mutation of either P222 A or R330 S was introduced into r Gt. The four modified viruses were then rescued and evaluated in vitro(CEF cells) and in vivo(SPF chickens). Results showed that A222 P elevated the replication efficiency of rG x-F9VP2 while P222 A reduced that of rG t in CEF cells. A mutation at residue 330 did not alter IBDV replication. In addition, animal experiments showed that a single mutation at either residue 222 or 330 did not significantly influence the virulence of IBDV. In conclusion, residue 222 in PBC of VP2 is involved in the replication efficiency of IBDV in vitro but does not affect its virulence in vivo, further facilitating our understanding of the gene-function of IBDV. | Xiaole Qi Xiang Gao Zhen Lu Lizhou Zhang Yongqiang Wang Li Gao Yulong Gao Kai Li Honglei Gao Changjun Liu Hongyu Cui Yanping Zhanga Xiaomei Wang | 2016 | Science China(Life Sciences)2016，59，7： | 2 |
| 6 | Life cycle resource consumption of automotive power seats显示文摘 | Yisong Chen Yanping Yang Xiang Li | 2014 | International Journal of Environmental Studies2014，71，4： | 1 |
| 7 | ChineseJournalofclinical Rehabilitation显示文摘 | LIN YANPING RUI XIANG WANG HEMING | 2005 | September 212005，9，34： | 1 |
| 8 | MicroRNA-132 ag- gravates epileptiform discharges via suppression of BDNF/ TrkB signaling in cultured hippocampal neurons显示文摘 | Lei Xiang Yanping Ren Hao Cai | 2015 | Brain Res2015，6，： | 1 |
| 9 | Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study显示文摘 | HaiYing Chen Hui Yuan Rongbao Gao Jinxiang Zhang Dayan Wang Ying Xiong GuoYin Fan Fan Yang Xiaodan Li Jianfang Zhou Shumei Zou Lei Yang Tao Chen Libo Dong Hong Bo Xiang Zhao Ye Zhang Yu Lan Tian Bai Jie Dong Qun Li ShiWen Wang YanPing Zhang Hui Li Tian Go | 2014 | The Lancet2014，，： | 1 |
| 10 | Service task partition and distribution in star topology computer grid subject to data security constraints 显示文摘 | Xiang Yanping Gregory Levitin | 2011 | Reliability Engineering and Sys- tem Safety2011，96，11： | 1 |
| 11 | Life cy- cle resource consumption of automotive power seats显示文摘 | Chen Yisong Yang Yanping Li Xiang | 2014 | International Journal of Environmental Studies2014，71，4： | 1 |
| 12 | Multi-performanceoptimization for MAS based grid computing 显示文摘 | Yu Shengji Xiang Yanping Xu Zongyi | 2014 | International Jour-nal of Performability Engineering2014，10，2： | 1 |
| 13 | High Capacity Data Hiding in Encrypted Image Based on Compressive Sensing for Nonequivalent Resources显示文摘To fulfill the requirements of data security in environments with nonequivalent resources,a high capacity data hiding scheme in encrypted image based on compressive sensing(CS)is proposed by fully utilizing the adaptability of CS to nonequivalent resources.The original image is divided into two parts:one part is encrypted with traditional stream cipher;the other part is turned to the prediction error and then encrypted based on CS to vacate room simultaneously.The collected non-image data is firstly encrypted with simple stream cipher.For data security management,the encrypted non-image data is then embedded into the encrypted image,and the scrambling operation is used to further improve security.Finally,the original image and non-image data can be separably recovered and extracted according to the request from the valid users with different access rights.Experimental results demonstrate that the proposed scheme outperforms other data hiding methods based on CS,and is more suitable for nonequivalent resources. | Di Xiao Jia Liang Qingqing Ma Yanping Xiang Yushu Zhang | 2019 | Computers, Materials & Continua2019，，1： | 0 |
| 14 | 甲状腺肿瘤患者血清中MBL和MASP-2的表达水平及其意义(英文)显示文摘Objective:The aim of the study was to detect the levels of mannose-binding lectin(MBL),MBL-associated serine protease 2(MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms.Methods:By using ELISA method,we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma(PTC),30 patients with thyroid adenoma(TA) and 26 healthy people,respectively.Results:Serum MBL level was(565.23 ± 76.70) μg/L in PTCs higher than(324.267 ± 24.74) μg/L in TAs,and(152.69 ± 16.95) μg/L in healthy of controlling group.There was statistical significance between PTC and TA(P < 0.05),however there was no difference between TA and healthy(P > 0.05).Serum MASP-2 level was(726.153 ± 78.88) μg/L in PTCs higher than(379.266 ± 30.26) μg/L in TAs,and(203.846 ± 29.09) μg/L in healthy.Serum MASP-2 level was higher in PTCs than TAs,and the difference had statistical significance(P < 0.01).But no difference was observed between in TAs and healthy.Conclusion:These findings might reflect inflammatory processes induced by defense mechanisms,in response to the development of the tumour.MBL may also be involved in the elimination of possible tumourigenic pathogens. | Yanping Shi Geling Liu Huiqin Zhang Fang Yu Xiuxiu Xiang Yifang Lu Xiaomei Dong Xiaohua Li | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，3： | 0 |
| 15 | “Coffee ring” controlment in spray prepared >19% efficiency Cs_(0.19)FA_(0.81)PbI_(2.5)Br_(0.5) perovskite solar cells显示文摘Achieving high-quality perovskite films with uniform morphology and homogeneous crystallinity is challenging owing to the coffee ring effect(CRE) in the spray-coating technologies. In this study, an evaporation/spray-coating two-step deposition method is used to fabricate Cs_(0.19)FA_(0.81)PbI_(2.5)Br_(0.5)light harvesters for perovskite solar cells(PSCs). Considering the solid–liquid reaction, we establish a reaction-dependent regulating strategy that inhibits CRE successfully and prepare a high-quality perovskite layer, wherein the solvent for the FAI/Br solution during the spraying process is changed from isopropanol to n-butyl alcohol(NBA). The retarded-drying-enhanced spreading of the NBA solution inhibits contact line pinning to suppress the capillary flows and increases the reaction between metal halides(CsI/PbI_(2)) and organic salts(FAI/Br), which result in a reduction in the accumulation of solutes in the periphery effectively inhibiting CRE. Consequently, we obtain a high performance Cs_(0.19)FA_(0.81)PbI_(2.5)Br_(0.5) PSC with a power conversion efficiency(PCE) of 19.17%. An enlarged perovskite film(10 × 10 cm^(2)) containing 40 sub-cells is prepared. The average PCE of these devices is 18.33 ± 0.56%, proving the reliability of the 'coffee ring' regulating strategy. This study provides an effective approach for CRE controlment in spraying technology to achieve high repeatability devices with good performance. | Xinxin Yu Jing Li Yanping Mo Tianxing Xiang Zhiliang Ku Fuzhi Huang Fei Long Yong Peng Yi-Bing Cheng | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 16 | Benchmark for establishment of organoids from gastrointestinal epithelium and cancer based on available consumables and reagents显示文摘Gastrointestinal cancers are a public health problem that threatens the lives of human being. A good experimental model is a powerful tool to promote the uncovering pathogenesis and establish novel treatment methods. High-quality biomedical research requires experimental models to recapitulate the physiological and pathological states of their parental tissues as much as possible. Organoids are such experimental models. Organoids refer to small organlike cellular clusters formed by the expansion and passaging of living tissues in 3D culture medium in vitro.Organoids are highly similar to the original tissues in terms of cellular composition, cell functions, and genomic profiling. Organoids have many advantages, such as short preparation cycles, long-term storage based on cryopreservation, and reusability. In recent years, researchers carried out the establishment of organoids from gastrointestinal mucosa and cancer tissues, and accumulated valuable experiences. In order to promote effective usage and further development of organoid-related technologies in the research of gastrointestinal diseases, this study proposes a benchmark based on utilization of available experimental consumables and reagents, which are involved in the key steps such as collection and pretreatment of biospecimen, organoid construction, organoid cryopreservation and recovery, growth status evaluation, and organoid quality control. We believe that the standard for the construction and preservation of organoids derived from human gastrointestinal epithelium and cancer tissues can provide an important reference for the majority of scientific researchers. | Ruixin Yang Zhen Xiang Ranlin Yan Wingyan Kwan Lu Zang Zhenggang Zhu Yao Qi Yanping Xu Xiaoyan Zhang Hengjun Gao Yingyan Yu | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员