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| 1 | MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis显示文摘Multiple sclerosis(MS) is a classical inflammatory demyelinating disease of the central nervous system(CNS). Microglia are the main resident immune cells in the CNS and are closely associated with the pathogenesis of MS.In the present study, we found that mi R-30 a was highly expressed in jellyfish-like microglia in chronic active lesions of MS patients, as well as in the microglia of mice with experimental autoimmune encephalomyelitis(EAE) at the chronic phase. In vitro, the conditioned supernatant of mouse microglia overexpressing miR-30 a promoted the apoptosis of oligodendrocyte precursor cells(OPCs), and inhibited OPC differentiation. In vivo, overexpressing miR-30 a in transplanted microglia exacerbated the progression of EAE.Overexpression and knock-down experiments in primary cultured mouse microglia showed that mi R-30 a increased the expression of IL-1 b and i NOS, which are pro-inflammatory, while inhibiting the expression of Ym-1 and CD206.Mechanistically, mi R-30 a inhibited the expression of Ppargc1 b, which is the co-activator of peroxisome proliferator-activated receptor gamma, resulting in pro-inflammatory effects. Our work shows that mi R-30 a is an important regulator of the inflammatory response in microglia, and may be a promising therapeutic target for inflammatory diseases like MS in the CNS. | Xue Fang Dingya Sun Zhihong Wang Zhongwang Yu Weili Liu Yingyan Pu Dan Wang Aijun Huang Mingdong Liu Zhenghua Xiang Cheng He Li Cao | 2017 | Neuroscience Bulletin2017，33，6： | 16 |
| 2 | Molecular classification and precision therapy of cancer: immune checkpoint inhibitors显示文摘在 2017 年 5 月 23 日, US 食物药品管理局(食物及药品管理局) 与标记或失配修理的积极 microsatellite 不稳定性高度(MSI-H ) 为癌症病人同意了治疗缺乏(dMMR ) 标记。这条途径是用普通 biomarker 的首先同意的肿瘤治疗而非在身体指定肿瘤地点。食物及药品管理局以前为恶意的几种类型的治疗同意了 Keytruda,例如变形黑瘤,变形 non-small-cell 肺癌症,周期性或变形的头和颈癌症,倔强的 Hodgkin 淋巴瘤,和 urothelial 癌,所有哪个带积极规划 death-1/programmed death-ligand 1 biomarkers。因此, Keytruda 的指示显著地膨胀了。恶意的几种类型被 MSI-H 地位由于 dMMR 揭示并且由增加的 neoantigen 负担描绘了,它在肿瘤微型环境得到强烈主人免疫者反应,包括 colorectal 和胃的癌的部分。当前,基于 biomarker 的耐心的选择仍然是挑战。病理学家们在评估组织学和 biomarker 结果并且建立察觉方法起重要作用。作为一个例子拿胃的癌症,它的分子的分类在染色体畸形上被造,但是它缺乏可接受的临床的特征。病理学家们被期望充当基因翻译或基因翻译者并且与肿瘤造在分子的子类型之间的一个连接组织学的特征。由使用他们的调查结果,随后,肿瘤学家们将基于分子的分类执行指向的治疗。 | Yingyan Yu | 2018 | Frontiers of Medicine2018，12，2： | 10 |
| 3 | Identification of Differentially-expressed Genes in Intestinal Gastric Cancer by Microarray Analysis显示文摘Gastric cancer(GC) is one of the most frequent malignant tumors. In order to systematically characterize the cellular and molecular mechanisms of intestinal GC development,in this study, we used 22 K oligonucleotide microarrays and bioinformatics analysis to evaluate the gene expression profiles of GC in 45 tissue samples, including 20 intestinal GC tissue samples,20 normal appearing tissues(NATs) adjacent to tumors and 5 noncancerous gastric mucosa tissue samples. These profiles allowed us to explore the transcriptional characteristics of GC and determine the change patterns in gene expression that may be of clinical significance. 1519 and 1255 differentially-expressed genes(DEGs) were identified in intestinal GC tissues and NATs, respectively,as determined by Bayesian analysis(P < 0.001). These genes were associated with diverse functions such as mucosa secretion, metabolism, proliferation, signaling and development, which occur at different stages of GC development. | Shizhu Zang Ruifang Guo Rui Xing Liang Zhang Wenmei Li Min Zhao Jingyuan Fang Fulian Hu Bin Kang Yonghong Ren Yonglong Zhuang Siqi Liu Rong Wang Xianghong Li Yingyan Yu Jing Cheng Youyong Lu | 2014 | Genomics, Proteomics & Bioinformatics2014，12，6： | 4 |
| 4 | Repurposing glucocorticoids as adjuvant reagents for immune checkpoint inhibitors in solid cancers显示文摘Glucocorticoids are drugs that are controversial in the treatment of malignant tumors,especially in regimens using immune checkpoint inhibitors.Some oncologists warn that glucocorticoids might affect or even weaken the therapeutic efficacy of PD-1 inhibitors.Recently,Xiang et al.^(1) identified drugs that could target the dual-target of PD-L1/IDO1,and published their finding of“Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways”in Oncogene,a leading international oncology journal. | Yingyan Yu | 2021 | Cancer Biology & Medicine2021，18，4： | 1 |
| 5 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 6 | Influence of tool parameters on tool wear in two-roll cross-wedge rolling显示文摘 | Zhou Jie Xiao Chuan Yu Yingyan Jia Zhi | 2013 | The International Journal of Advanced Manufacturing Technology2013，65，58： | 1 |
| 7 | A powerful HUPAN on a pan-genome study: significance and perspectives显示文摘Recently,a report explaining the construction of a Human Pangenome ANalysis(HUPAN)system attracted wide attention in the biomedicine community.The original article was published in Genome Biology,a leading international journal in genomics1.Many researchers,particularly those conducting basic medical research. | Yingyan Yu Chaochun Wei | 2020 | Cancer Biology & Medicine2020，17，1： | 1 |
| 8 | Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation显示文摘 | Daxian zhang Tatsun Yasuda Yingyan Yu | 1996 | Free Radical Biology & Medicine1996，20，1： | 1 |
| 9 | Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related显示文摘 | Yun Lu Yingyan Yu Zhenggang Zhu Heng Xu Jun Ji Lei Bu Bingya Liu Haisong Jiang Yanzhen Lin Xiangyin Kong Landian Hu | 2004 | Cancer Letters2004，，2： | 1 |
| 10 | Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases显示文摘Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advanced types. However, not all patients are responsive to immune checkpoint inhibitors. The response rate depends on the immune microenvironment, tumor mutational burden (TMB), expression level of immune checkpoint proteins, and molecular subtypes of cancers. Along with the Cancer Genome Project, various open access databases, including The Cancer Genome Atlas and Gene Expression Omnibus, provide large volumes of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpoint inhibitors? In this review, we introduced some methodologies on database selection, biomarker screening, current progress of immune checkpoint blockade in solid tumor treatment, possible mechanisms of drug resistance, strategies of overcoming resistance, and indications for immune checkpoint inhibitor therapy. | Zhen Xiang Yingyan Yu | 2019 | Frontiers of Medicine2019，13，1： | 1 |
| 11 | Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer显示文摘 | Xiongyan Wu Xuehua Chen Quan Zhou Pu Li Beiqin Yu Jianfang Li Ying Qu Jun Yan Yingyan Yu Min Yan Zhenggang Zhu Bingya Liu Liping Su | 2013 | Cancer Letters2013，，1： | 1 |
| 12 | Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipidperoxidation显示文摘 | Daxian Zhang Tatsun Yasuda Yingyan Yu Pingdong Zheng Teruyuki Kawabata Yuxiang Ma and Shigru Okada | 1996 | Free Radical Biology& Medicine1996，20，1： | 1 |
| 13 | miR-126 functions as a tumour suppressor in human gastric cancer显示文摘 | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu | 2010 | Cancer Letters2010，，1： | 1 |
| 14 | miR-126 functions as a tumour suppressor in human gastric cancer显示文摘 | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu | 2010 | Cancer Letters2010，，1： | 1 |
| 15 | A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids显示文摘Objective:Organoids are a powerful tool with broad application prospects in biomedicine.Notably,they provide alternatives to animal models for testing potential drugs before clinical trials.However,the number of passages for which organoids maintain cellular vitality ex vivo remains unclear.Methods:Herein,we constructed 55 gastric organoids from 35 individuals,serially passaged the organoids,and captured microscopic images for phenotypic evaluation.Senescence-associatedβ-galactosidase(SA-β-Gal),cell diameter in suspension,and gene expression reflecting cell cycle regulation were examined.The YOLOv3 object detection algorithm integrated with a convolutional block attention module(CBAM)was used to evaluate organoid vitality.Results:SA-β-Gal staining intensity;single-cell diameter;and expression of p15,p16,p21,CCNA2,CCNE2,and LMNB1 reflected the progression of aging in organoids during passaging.The CBAM-YOLOv3 algorithm precisely evaluated aging organoids on the basis of organoid average diameter,organoid number,and number×diameter,and the findings positively correlated with SA-β-Gal staining and single-cell diameter.Organoids derived from normal gastric mucosa had limited passaging ability(passages 1–5),before aging,whereas tumor organoids showed unlimited passaging potential for more than 45 passages(511 days)without showing clear senescence.Conclusions:Given the lack of indicators for evaluating organoid growth status,we established a reliable approach for integrated analysis of phenotypic parameters that uses an artificial intelligence algorithm to indicate organoid vitality.This method enables precise evaluation of organoid status in biomedical studies and monitoring of living biobanks. | Ruixin Yang Yutong Du Wingyan Kwan Ranlin Yan Qimeng Shi Lu Zang Zhenggang Zhu Jianming Zhang Chen Li Yingyan Yu | 2023 | Cancer Biology & Medicine2023，20，7： | 1 |
| 16 | Multi-target combinatory strategy to overcome tumor immune escape显示文摘Immune therapy has become the fourth approach after surgery,chemotherapy,and radiotherapy in cancer treatment.Many immune checkpoints were identified in the last decade since ipilimumab,which is the first immune checkpoint inhibitor to cytotoxic T-lymphocyte associated protein 4,had been approved by the US Food and Drug Administration(FDA)for the treatment of unresectable or metastatic melanoma in 2011.The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved by the FDA.However,fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Approximately 80%of patients do not respond appropriately because of primary or acquired therapeutic resistance.Along with the characterization of more immune checkpoints,the combinatory treatment of multi-immune checkpoint inhibitors becomes a new option when monotherapy could not receive a good response.In this work,the author focuses on the combination therapy of multiple immune checkpoints(does not include targeted therapy of oncogenes or chemotherapy),introduces the current progression of multiple immune checkpoints and their related inhibitors,and discusses the advantages of combination therapy,as well as the risk of immune-related adverse events. | Yingyan Yu | 2022 | Frontiers of Medicine2022，16，2： | 1 |
| 17 | Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK显示文摘 | Ming Wang Chenglong Li Hui Nie Xin Lv Ying Qu Beiqin Yu Liping Su Jianfang Li Xuehua Chen Jingfang Ju Yingyan Yu Min Yan Qinlong Gu Zhenggang Zhu Bingya Liu | 2012 | FEBS Letters2012，，16： | 1 |
| 18 | Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron - medialed lipid peroxidation 显示文摘 | Daxian Zhang Tatsun Yasuda Yingyan YU Pingdong Zheng Teruyuki Kawabata Yuxiang Ma and Shigru Okada | 1996 | Free Radical Biology&Medicine1996，20，1： | 1 |
| 19 | Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation显示文摘 | Daxian Zhang Tatsun Yasuda Yingyan Yu | 1996 | Free Radical Biology and Medicine1996，20，1： | 1 |
| 20 | Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation显示文摘 | Daxian Zhang Tatsun Yasuda Yingyan Yu | 1996 | Free Rad Biol Med1996，20，： | 1 |
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