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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Molecular fossil and paleovegetation records of paleosol S4 and adjacent loess layers in the Luochuan loess section, NW China显示文摘Using gas chromatography-mass spectrometry (GC-MS) technique, a series of biomarkers were identi- fied, including n-alkanes, n-alkane-2-ones, isoprenoid etc. from the loess-paleosol samples collected from the S4 and adjacent L5, L4 of the Luochuan loess section, Northwestern China. Based on these data, especially n-alkanes and high-resolution magnetic susceptibility and grain size data, the pa- leoenvironment and paleovegetation history during S4 was reconstructed. The CPI (Carbon Predomi- nance Index) and correlation between n-alkanes and magnetic susceptibility and grain size data dem- onstrated that the molecular fossils in paleosol and loess layers can reflect the vegetation condition during the loess-paleosol formation, if the allochthonous organic inputs could be excluded reasonably. The ACL (average chain length) index is correlated well with paleomagnetic susceptibility and grain size variations, displaying their good synchrony with warm and humid climate. However, it relatively lagged behind the paleomagnetic susceptibility and the grain size variations when the climate began to deteriorate. During the formation period of paleosol, the n-alkanes was dominated by C31 homologue, indicating that the primary organic input originated from herbs. Our study also demonstrated that the herbs were more flourish than wood plants in Loess Plateau, especially in the Luochuan area during the warm and humid phase, and there was no typical forest vegetation developed in the studied period. | ZHANG HuCai YANG MingSheng ZHANG WenXiang LEI GuoLiang CHANG FengQin PU Yang FAN HongFang | 2008 | Science China Earth Sciences2008，51，3： | 15 |
| 3 | Branched aliphatic alkanes of shell bar section in Qarhan Lake,Qaidam Basin and their paleoclimate significance显示文摘Biomarkers of paleolake deposits from Qarhan Salt Lake in Qaidam Basin,northwest China were sys-tematically analyzed and the A―C series compounds of branched aliphatic alkanes with quaternary substituted carbon atom(BAQCs) were identified. The homologous distinguished three series,A―C,were identified as 5,5-diethylalkanes,6,6-diethylalkanes and 5-butyl,5-ethylalkanes series,and their relative abundance was A > B > C. Series A and C were characterized by odd carbon numbers,whereas series B was characterized by even carbon numbers. The high values of series A corresponded with the high values of series B and C. Therefore,it can be concluded that series A,B and C possess a similar biological origin. The abundance of series A was relatively low in the lower part of the section compared with that in the upper part,implying that these series originated from bacteria and/or algae more prevalent in fresh-mesohaline water,and such kinds of bacteria and/or algae are most likely to be thermophilous species. The A25/nC25 ratio differences in the section show that such branched aliphatic alkanes can be treated as one kind of environmental change proxy for paleolake evolution and may provide important information for the climate reconstruction of the Late Pleistocene. | ZHANG HuCai CHANG FengQin LI Bin LEI GuoLiang CHEN Yue ZHANG WenXiang NIU Jie FAN HongFang YANG MingSheng | 2007 | Chinese Science Bulletin2007，52，9： | 13 |
| 4 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 5 | Influence of oxygen gas content on the structural and optical properties of ZnO thin films deposited by RF magnetron sputtering at room temperature显示文摘Zinc oxide (ZnO) thin films were deposited on sapphire (0001) substrates at room temperature by radiofrequency (RF) magnetron sputtering at oxygen gas contents of 0%,25%,50% and 75%,respectively.The influence of oxygen gas content on the structural and optical properties of ZnO thin films was studied by a surface profile measuring system,X-ray diffraction analysis,atomic force microscopy,and UV spectrophotometry.It is found that the size of ZnO crystalline grains increases first and then decreases with the increase of oxygen gas content,and the maximum grain size locates at the 25% oxygen gas content.The crystalline quality and average optical transmittance (>90%) in the visible-light region of the ZnO film prepared at an oxygen gas content of 25% are better than those of ZnO films at the other contents.The obtained results can be attributed to the resputtering by energetic oxygen anions in the growing process. | LIU Baoting ZHOU Yang ZHENG Hongfang LI Mana GUO Zhe HAO Qingxun PENG Yingcai | 2011 | Rare Metals2011，30，2： | 6 |
| 6 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1显示文摘As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural optimization.Target identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target prediction.However,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising activities.Here,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired compounds.Then peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal cancer.Our solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with PRDX1.New derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure analysis.Both Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer cells.The anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer cells.Several downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 treatment.Our findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer. | Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 3 |
| 7 | Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study显示文摘 | Zhao Juan Yang Jinyan Du Shuxu Tang Chaoshu Du Junbao Jin Hongfang | 2014 | Chinese Medical Journal2014，，10： | 3 |
| 8 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 9 | Delay-Differentiated Scheduling in Optical Packet Switches for Cloud Data Centers显示文摘We consider differentiated timecritical task scheduling in a N×N input queued optical packet s w itch to ens ure 100% throughput and meet different delay requirements among various modules of data center. Existing schemes either consider slot-by-slot scheduling with queue depth serving as the delay metric or assume that each input-output connection has the same delay bound in the batch scheduling mode. The former scheme neglects the effect of reconfiguration overhead, which may result in crippled system performance, while the latter cannot satisfy users' differentiated Quality of Service(Qo S) requirements. To make up these deficiencies, we propose a new batch scheduling scheme to meet the various portto-port delay requirements in a best-effort manner. Moreover, a speedup is considered to compensate for both the reconfiguration overhead and the unavoidable slots wastage in the switch fabric. With traffic matrix and delay constraint matrix given, this paper proposes two heuristic algorithms Stringent Delay First(SDF) and m-order SDF(m-SDF) to realize the 100% packet switching, while maximizing the delay constraints satisfaction ratio. The performance of our scheme is verified by extensive numerical simulations. | LI Yaofang XIAO Jie WU Bin WEN Hong YU Hongfang YANG Shu XIN Shanshan GUO Jianing | 2015 | China Communications2015，12，8： | 2 |
| 10 | Corrosion formation and phase transformation of nickel-iron hydroxide nanosheets array for efficient water oxidation显示文摘Designing earth-abundant electrocatalysts with high performance towards water oxidation is highly decisive for the sustainable energy technologies. This study develops a facile natural corrosion approach to fabricate nickel-iron hydroxides for water oxidation. The resulted electrode demonstrates an outstanding activity and stability with an overpotential of 275 mV to deliver 10 mA·cm^(−2). Experimental and theoretical results suggest the corrosion-induced formation of hydroxides and their transformation to oxyhydroxides would account for this excellent performance. This work not only provides an interesting corrosion approach for the fabrication of excellent water oxidation electrode, but also bridges traditional corrosion engineering and novel materials fabrication, which would offer some insights in the innovative principles for nanomaterials and energy technologies. | Lanqian Gong Huan Yang Hongming Wang Ruijuan Qi Junlei Wang Shenghua Chen Bo You Zehua Dong Hongfang Liu Bao Yu Xia | 2021 | Nano Research2021，14，12： | 2 |
| 11 | Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine显示文摘OBJECTIVE:To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy(DN) and non-diabetic renal disease(NDRD).METHODS:The subjects were patients with type 2 diabetes mellitus(T2DM) complicated with chronic kidney disease(CKD).Western medical history data and Traditional Chinese Medicine(TCM) symptom pattern were collected,and logistic regression was used to analyze.RESULTS:Blood deficiency pattern [odds ratio(OR) = 2.269,P = 0.017] and Qi stagnation pattern(OR = 1.999,P = 0.041) are independently related to DN.CONCLUSIONS:TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD. | QU Yilun CHENG Haimei WANG Qian LI Shuang DUAN Shuwei FENG Zhe LI Weizhen JIANG Shuangshuang YANG Hongtao MAO Yonghui GENG Yanqiu LI Jijun LIU Yuning TIAN Jinzhou LIU Hongfang DONG Zheyi CHEN Xiangmei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 1 |
| 12 | Effects of High Hydrostatic Pressure Treated Mung Bean Starch on Characteristics of Batters and Crusts from Deep-Fried Pork Nuggets显示文摘 | Lingwen Zhang Hongfang Ji Mingduo Yang Hanjun Ma | 2014 | International Journal of Food Engineering2014，，2： | 1 |
| 13 | Effect of assembling errors on the diffraction efficiency for multilyaer diffractive optical elements 显示文摘 | Gao Long Suet Yang Hongfang | 2014 | Applied Optics2014，53，37： | 1 |
| 14 | Design and experiment of a subsoiling variable rate fertilization machine显示文摘In order to improve soil fertility and fertilizer utilization,a subsoiling variable rate fertilization machine based on conservation tillage and precision agriculture was designed and tested.The relationship between suspension parameters and penetrating distance was analyzed,and a matching model between fertilizing quantity and penetrating distance was established.The variable rate fertilization control machine was developed based on an Advantech PCM-9363 industrial control mainboard.The machine operates under two patterns:DGPS-based positioning and straight-line path positioning based on a planar coordinate system.This machine can perform on-demand fertilization according to the spatial differences in soil nutrients and the prescription maps pre-set before the operation.Field experiments showed the machine has a subsoiling stability of 92.5%,a soil breaking rate of 61.1%,a maximum positioning relative error of 2.68%and a maximum variable rate fertilization error of 3.89%.The subsoiling performance and variable rate fertilization indices of this machine satisfy the requirements of GB/T24675.2-2009.The tested indices meet the national and industrial standards and satisfy the design requirements.The findings of the research can be used as the structural design of the subsoiling variable rate fertilization machine. | Jiangtao Qi Xinliang Tian Yang Li Xuhui Fan Hongfang Yuan Jiale Zhao Honglei Jia | 2020 | International Journal of Agricultural and Biological Engineering2020，13，4： | 1 |
| 15 | DDoS Attack in Software Defined Networks: A Survey显示文摘Distributed Denial of Service(DDoS) attacks have been one of the most destructive threats to Internet security. By decoupling the network control and data plane, software defined networking(SDN) offers a flexible network management paradigm to solve DDoS attack in traditional networks. However, the centralized nature of SDN is also a potential vulnerability for DDo S attack. In this paper, we first provide some SDN-supported mechanisms against DDoS attack in traditional networks. A systematic review of various SDN-self DDo S threats are then presented as well as the existing literatures on quickly DDoS detection and defense in SDN. Finally, some promising research directions in this field are introduced. | XU Xiaoqiong YU Hongfang YANG Kun | 2017 | ZTE Communications2017，15，3： | 1 |
| 16 | Postural Orthostatic Tachycardia Syndrome with Increased Erythrocytic Hydrogen Sulfide and Response to Midodrine Hydrochloride显示文摘 | Jinyan Yang Juan Zhao Shuxu Du Die Liu Chunhin Fu Xueying Li Stella Chen Chaoshu Tang Junbao Du Hongfang Jin | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 17 | The application of improved DES algorithm in Mobile Monitoring 显示文摘 | Li Hongfang Yang Lingjun Cao Sanxing | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 18 | Experimental Study of Aqueous Humor Flow in a Transparent Anterior Segment Phantom by Using PIV Technique显示文摘Pupillary block is considered as an important cause of primary angle-closure glaucoma(PACG).In order to investigate the effect of pupillary block on the hydrodynamics of aqueous humor(AH)in anterior chamber(AC)and potential risks,a 3D printed eye model was developed to mimic the AH flow driven by fluid generation,the differential pressure between AC and posterior chambers(PC)and pupillary block.Particle image velocimetry technology was applied to visualize flow distribution.The results demonstrated obvious differences in AH flow with and without pupillary block.Under the normal condition(without pupillary block),the flow filed of AH was nearly symmetric in the AC.The highest flow velocity located at the central of AC when the differential pressure between AC and PC was under 5.83 Pa,while it appeared near the cornea and iris surface when the differential pressure was greater than 33.6 Pa.Once pupillary block occurred,two asymmetric vortices with different sizes were observed and the shear stress in the paracentral cornea and iris epithelium increased greatly.It can be concluded that the pupillary block and the elevated differential pressure between AC and PC could change the flow distribution and thus increase the risk of corneal endothelial cells detachment.This study could make a further understanding of the pathogenesis of PACG. | Wenjia Wang Xiuqing Qian Qi Li Gong Zhang Huangxuan Zhao Tan Li Yang Yu Hongfang Song Zhicheng Liu | 2019 | Molecular & Cellular Biomechanics2019，16，1： | 1 |
| 19 | Facile ultrafine copper seed-mediated approach for fabricating quasi-two-dimensional palladium-copper bimetallic trigonal hierarchical nanoframes显示文摘有高度分叉的形态学的各向异性的 Pd nanoparticles 着急地由于他们的新奇结构和唯一的物理化学的性质为 nanoscale 设备,催化剂,和察觉到的材料作为积木被需要。然而,为这些材料认识到尺寸控制和分支操作是很挑战性的。在这研究,我们在水的阶段开发一条灵巧的极其细小的 Cu 调停种子的途径生产新奇 Pd-Cu 三角的层次 nanoframes (THNF ) 。大多数获得的 nanocrystals 的主要分支是像三脚架的,与沿着象有自我类似的框架单位的手臂的先进分支。在这个方法, Pd-Cu THNF 的尺寸能被操作包含 sub-3 nm Cu 种子的成核灵活地控制。这些 Pd-Cu THNF 关于他们的乙醇氧化表演超过 Pd 黑色,举办 9.7 和 6.6 分别地更高预定的一项特定的活动和集体活动。这研究为生产控制尺寸的各向异性的二金属的 nanoframes 提供一条万用的极其细小的调停种子的途径。 | Min Shen Yuanbiao Huang Dongshuang Wu Jian Lv Minna Cao Meimei Liu Yinglong Yang Hongfang Li Binbin Guo Rong Cao | 2017 | Nano Research2017，10，8： | 0 |
| 20 | Study on dosimetric and radiation safety performance parameters of helical tomotherapy unit显示文摘 | Ma Yongzhong Yang Bo Feng Zechen Wang Hongfang Wan Ling | 2015 | 中华放射医学与防护杂志2015，35，1： | 0 |
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