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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | High sensitivity SPR sensor for liquid phase sample with Ag/PbS/Graphene hybrid nanostructure显示文摘A surface plasmon resonance(SPR)sensor with Ag/PbS/GR hybrid nanostructure has been proposed for the diagnostics of liquid phase samples.Here Ag/PbS/GR hybrid nanostructure is designed as an asymmetric MIM waveguide for surface plasmon.Due to the guided wave SPR(GWSPR)modes,the index of the liquid phase samples can be measured more accurately than the conventional SPR sensors.Numerical simulation results show that the sensitivity of the sensor is about 5 times higher than the conventional SPR sensors.The origin of the enhancement mechanism is the combination of GWSPR in the Ag/PbS/GR hybrid nanostructure which enables the surface plasmon to spread along the PbS layer.In Ag/PbS/GR hybrid nanostructure,the electric field is concentrated mostly in the PbS layer,and the enhancement of the field intensity is nearly30%. | Kexiu Dong Yanping Ji Jiajia Mi Xiaotong Zhao Bin Wu Wangxia Huang Jianping Shi | 2017 | 光电工程2017，44，2： | 2 |
| 3 | The ameliorating effects of stigmasterol on scopolamine-induced memory impairments in mice显示文摘 | Se Jin Park Dong Hyun Kim Jun Man Jung Jong Min Kim Mudan Cai Xiaotong Liu Jin Gyu Hong Chang Hwan Lee Kang Ro Lee Jong Hoon Ryu | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 4 | Study on Bryophytes in Sygara Mountain显示文摘In order to identify the species of bryophytes in Sygara Mountain in Tibet,2390 samples in the area were collected,identified and analyzed. The results show that bryophytes of Sygara Mountain have 26 families,70 genera and 134 species; among them,25 families,69 genera and 133 species are mosses,and only one is liverwort,namely Conocephalum conicum( L.) Dum. 4 dominant families are in the descending order of Bryaceae,Dicranaceae,Pottiaceae,Polytrichaceae respectively,and the dominant genera are Hypnum,Brachythecium,Plagiomnium,Racomitrium and Dicranodontium. | Yulong SHI Xiaotong SONG Zhu DONG Heping MA | 2017 | Asian Agricultural Research2017，9，10： | 1 |
| 5 | Enhancement of red upconversion emission intensity of Ho^(3+) ions in NaLuF4:Yb^(3+)/Ho^(3+)/Ce^(3+)@NaLuF_(4) core-shell nanoparticles显示文摘The red upconversion emission of Ho^(3+)ions,in the optical window of biological tissue,exhibits excellent prospects in biological applications.This study aims to enhance the red upconversion emission intensity of Ho^(3+)ions in NaLuF_(4):20%Yb^(3+)/2%Ho^(3+)/12%Ce^(3+) nanoparticles through building different core–shell structures with different excitation wavelengths.A significantly enhanced red upconversion emission with a higher red-to-green ratio was successfully obtained in NaLuF_(4):20%Yb^(3+)/2%Ho^(3+)/12%Ce^(3+)@NaLuF_(4) core–shell nanoparticles by introducing the Yb^(3+)and Yb^(3+)/Nd^(3+)ions into the NaLuF_(4) shell,with enhancement of the red emission occurring when Yb^(3+)and Nd^(3+)ions in the shell transfer more excitation energy to the Ho^(3+)ions.Investigation of the red emission enhancement mechanism is based on spectral characteristics and lifetimes.We examined the synergistic effect of dual-wavelength co-excitation NaLuF_(4):20%Yb^(3+)/2%Ho^(3+)/12%Ce^(3+)@NaLuF_(4):10%Yb^(3+)/15%Nd^(3+)core–shell nanoparticles to establish optimal excitation conditions.It is hoped that this method,using red upconversion emission core–shell nanoparticles with multi-mode excitation,can provide new ways to expand the applications of rare-earth luminescent materials in biomedicine and anti-counterfeiting. | Wei Gao Xiaotong Cheng Yu Xing Shanshan Han Binhui Chen Qingyan Han Xuewen Yan Jihong Liu Lin Liu Jun Dong | 2022 | Journal of Rare Earths2022，40，4： | 1 |
| 6 | HIF1α epigenetically repressed macrophages via CRISPR/Cas9-EZH2 system for enhanced cancer immunotherapy显示文摘Immune suppressive microenvironment in tumor emerges as the main obstacle for cancer immunotherapy.In this study,we identified that HIF1α was activated in the tumor associated macrophages and acted as an important factor for the immune suppressive microenvironment.Epigenetically silencing of Hif1αvia histone H3 methylation in the promoter region was achieved by CRISPR/dCas9-EZH2 system,in which histone H3 methylase EZH2 was recruited to the promoter region specifically.The Hif1αsilenced macrophage,namely HERM(Hif1αEpigenetically Repressed Macrophage)manifested as inheritable tumor suppressing phenotype.In the subcutaneous B16-F10 melanoma syngeneic model,intratumoral injection of HERMs reprogrammed the immune suppressive microenvironment to the active one,reducing tumor burden and prolonging overall survival.Additionally,HERMs therapy remarkably inhibited tumor angiogenesis.Together,our study has not only identified a promising cellular and molecular target for reverting immune suppressive microenvironment,but also provided a potent strategy for reprogramming tumor microenvironment via epigenetically reprogrammed macrophages. | Yan Dong Siyan Zhang Xiaotong Gao Dandan Yin Tingting Wang Zhelong Li Zhuo Wan Mengying Wei Ying Luo Guodong Yang Li Liu | 2021 | Bioactive Materials2021，6，9： | 1 |
| 7 | Polysaccharides from Chinese herbal medicine:a review on the hepatoprotective and molecular mechanism显示文摘Polysaccharides,predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum,Angelica sinensis,Astragalus membranaceus,Dendrobium officinale,Ganoderma lucidum,and Poria cocos,represent principal bioactive constituents extensively utilized in Chinese medicine.These compounds have demonstrated significant anti-inflammatory capabilities,especially anti-liver injury activities,while exhibiting minimal adverse effects.This review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal polysaccharides.It underscored the role of these polysaccharides in regulating hepatic function,enhancing immunological responses,and improving antioxidant capacities,thus contributing to the attenuation of hepatocyte apoptosis and liver protection.Analyses of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury management.Therefore,this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides,thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment. | LI Jifeng GUO Haolin DONG Ying YUAN Shuo WEI Xiaotong ZHANG Yuxin DONG Lu WANG Fei BAI Ting YANG Yong | 2024 | Chinese Journal of Natural Medicines2024，22，1： | 0 |
| 8 | Mechanistic understanding of the charge storage processes in FeF_(2) aggregates assembled with cylindrical nanoparticles as a cathode material for lithium-ion batteries by in situ magnetometry显示文摘Transition metal fluorides(TMFs)cathode materials have shown extraordinary promises for electrochemical energy storage,but the understanding of their electrochemical reaction mechanisms is still a matter of debate due to the complicated and continuous changing in the battery internal environment.Here,we design a novel iron fluoride(FeF_(2))aggregate assembled with cylindrical nanoparticles as cathode material to build FeF_(2) lithium-ion batteries(LIBs)and employ advanced in situ magnetometry to detect their intrinsic electronic structure during cycling in real time.The results show that FeF_(2) cannot be involved in complete conversion reactions when the FeF_(2) LIBs operate between the conventional voltage range of 1.0–4.0 V,and that the corresponding conversion ratio of FeF_(2) can be further estimated.Importantly,we first demonstrate that the spin-polarized surface capacitance exists in the FeF_(2) cathode by monitoring the magnetic responses over various voltage ranges.The research presents an original and insightful method to examine the conversion mechanism of TMFs and significantly provides an important reference for the future artificial design of energy systems based on spinpolarized surface capacitance. | Zhengqiang Hu Fengling Zhang Huanyu Liang Hao Zhang Huaizhi Wang Tiansheng Wang Renbin Liu Jie Liu Yadong Li Xiaotong Dong Lianyu Bao Zhuan Liang Yaqun Wang Shishen Yan Qiang Li Hongsen Li | 2022 | Carbon Energy2022，4，6： | 0 |
| 9 | Significantly enhanced superconductivity in monolayer FeSe films on SrTiO_(3)(001) via metallic δ-doping显示文摘Superconductivity transition temperature(T_(c))marks the inception of a macroscopic quantum phase-coherent paired state in fermionic systems.For 2D superconductivity,the paired electrons condense into a coherent superfluid state at Tc,which is usually lower than the pairing temperature,between which intrinsic physics including Berezinskii-Kosterlitz-Thouless transition and pseudogap state are hotly debated.In the case of monolayer FeSe superconducting films on SrTiO_(3)(001),although the pairing temperature(T_(p))is revealed to be 65-83 K by using spectroscopy characterization,the measured zero-resistance temperature(T_(c)^(0))is limited to 20 K.Here,we report significantly enhanced superconductivity in monolayer FeSe films by δ-doping of Eu or Al on SrTiO_(3)(001)surface,in which T_(c)^(0) is enhanced by 12 K with a narrowed transition width ΔT_(c)~8 K,compared with non-doped samples.Using scanning tunneling microscopy/spectroscopy measurements,we demonstrate lowered work function of the δ-doped SrTiO_(3)(001)surface and enlarged superconducting gaps in the monolayer FeSe with improved morphology/electronic homogeneity.Our work provides a practical route to enhance 2D superconductivity by using interface engineering. | Xiaotong Jiao Wenfeng Dong Mingxia Shi Heng Wang Cui Ding Zhongxu Wei Guanming Gong Yanan Li Yuanzhao Li Binjie Zuo Jian Wang Ding Zhang Minghu Pan Lili Wang Qi-Kun Xue | 2024 | National Science Review2024，11，3： | 0 |
| 10 | 阳离子通道TRPV在醛缩酶和AMPK感知葡萄糖过程中起必须的作用显示文摘文章简介在激活AMPK的溶酶体途径感应葡萄糖供给下降的过程中,果糖-1,6-二磷酸醛缩酶(aldolase)起关键作用。然而,醛缩酶是如何把其与果糖-1,6-二磷酸结合的减少的信息传导引起AMPK活化的机制还尚未清楚。 | Mengqi Li Chen-Song Zhang Yue Zong Jin-Wei Feng Teng Ma Meiqin Hu Zhizhong Lin Xiaotong Li Changchuan Xie Yaying Wu Dong Jiang Ying Li Cixiong Zhang Xiao Tian Wen Wang Yanyan Yang Jie Chen Jiwen Cui Yu-Qing Wu Xin Chen Qing-Feng Liu Jianfeng Wu Shu-Yong Lin Zhiyun Ye Ying Liu Hai-Long Piao Li Yu Zhuan Zhou Xiao-Song Xie D.Grahame Hardie 林圣彩 | 2020 | 科学新闻2020，，2： | 0 |
| 11 | Leptin effects on the hypothalamic-pituitary-gonadal axis by activating proopiomelanocortin neurons Correlation between regulatory effects and duration显示文摘BACKGROUND:Leptin preserves reproductive functions by stimulating hypothalamic-pituitary-gonadal axis activities at different levels.Some interneurons play an important role in leptin regulation of the gonadal axis.It remains uncertain whether leptin regulates reproductive functions by activating proopiomelanocortin (POMC) neurons.OBJECTIVE:To investigate leptin effects on secretory function of the neuroendocrine-gonadal axis by activating POMC neurons and to observe and verify the relationship between leptin effects and various time points.DESIGN,TIME AND SETTING:The randomized,controlled,animal study was performed at the Basic Institute of Chengde Medical University and the Research Room of Reproductive Immunology of National Research Institute for Family Planning from June to September 2008.MATERIALS:Leptin (Peprotech,USA),α-melanocyte stimulating hormone and rabbit anti-POMC polyclonal antibody (SC-20148) (Santa Cruz Biotechnology,USA),follicle stimulating hormone,luteinizing hormone,and gonadotropin releasing hormone enzyme-labeled immunosorbent assay (ELISA) kit (ADL,USA) were used in the present study.METHODS:A total of 60 healthy,female,adult,Wistar rats received 17 β-estradiol for 5 consecutive days at 15 days after ovariectomy.The rats were randomly assigned to physiological saline (n=35),leptin (n=35),and α-melanocyte stimulating hormone (n=20) groups.MAIN OUTCOME MEASURES:Changes in gonadotropin releasing hormone,luteinizing hormone,and follicle stimulating hormone were compared following intraventricular injection of physiological saline,leptin,and α-melanocyte stimulating hormone at various time points.Changes in POMC mRNA and protein expression in the hypothalamus were measured following physiological saline and leptin injection via the lateral ventricle.RESULTS:Compared to the physiological saline group,leptin and α-melanocyte stimulating hormone affected secretion in the hypothalamus-pituitary axis.Leptin affected secretion of gonadotropin releasing hormone,luteinizing hormone,and follicle stimulating hormone,whereas α-melanocyte stimulating hormone inhibited secretion of these hormones.Compared to the physiological saline group,POMC mRNA expression was significantly increased in the hypothalamus at 2 and 4 hours after leptin injection (P < 0.05),but expression recovered to physiological saline group levels at 6 hours after injection (P > 0.05).POMC protein expression was significantly increased in the hypothalamus at 4 and 6 hours after leptin injection (P < 0.05).CONCLUSION:Leptin affects secretory function of the neuroendocrine-gonadal axis through combined effects on POMC neurons and other pathways.Results suggested that the regulatory effects of POMC neurons were later compared to other neurons. | Songhe Yang Luyang Cheng Xiuyan Ma Lianzhi Zhao Xiaotong Dong Peiming Feng Xiaoqiang Wang Tiecheng Sun Yuebing Qiao | 2010 | Neural Regeneration Research2010，5，9： | 0 |
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