|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CLE25 peptide regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex显示文摘The phloem, located within the vascular system, is critical for delivery of nutrients and signaling molecules throughout the plant body. Although the morphological process and several factors regulating phloem differentiation have been reported, the molecular mechanism underlying its initiation remains largely unknown. Here, we report that the small peptide-coding gene, CLAVATA 3 (CLV3)/EMBEYO SURROUNDING REGION 25 (CLE25), the expression of which begins in provascular initial cells of 64-cell-staged embryos, and continues in sieve element-procambium stem cells and phloem lineage cells, during postembryonic root development, facilitates phloem initiation in Arabidopsis. Knockout of CLE25 led to delayed protophloem formation, and in situ expression of an antagonistic CLE25G6T peptide compromised the fate-determining periclinal division of the sieve element precursor cell and the continuity of the phloem in roots. In stems of CLE25G6T plants the phloem formation was also compromised, and procambial cells were over-accumulated. Genetic and biochemical analyses indicated that a complex, consisting of the CLE-RESISTANT RECEPTOR KINASE (CLERK) leucinerich repeat (LRR) receptor kinase and the CLV2 LRR receptor- like protein, is involved in perceiving the CLE25 peptide. Similar to CLE25, CLERK was also expressed during early embryogenesis. Taken together, our findings suggest that CLE25 regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex. | Shi-Chao Ren Xiu-Fen Song Wen-Qiang Chen Ran Lu William J. Lucas Chun-Ming Liu | 2019 | Journal of Integrative Plant Biology2019，61，10： | 10 |
| 2 | On the ground in Western Africa: from the outbreak to the elapse of Ebola显示文摘 | William J. Liu | 2016 | Protein & Cell2016，7，9： | 7 |
| 3 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 4 | Expression of Bcl-x L in ovarian carcinoma is associated with chemoresistance and recurrent disease显示文摘 | Jennifer Williams Peter C. Lucas Kent A. Griffith Milheon Choi Sarah Fogoros Yuan Yuan Hu J. Rebecca Liu | 2004 | Gynecologic Oncology2004，，2： | 2 |
| 5 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
| 6 | Role of Inflammation in the Development of Renal Damage and Dysfunction in Angiotensin II–Induced Hypertension显示文摘 | Tang-Dong Liao Xiao-Ping Yang Yun-He Liu Edward G. Shesely Maria A. Cavasin William A. Kuziel Patrick J. Pagano Oscar A. Carretero | 2008 | Hypertension2008，，2： | 2 |
| 7 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 8 | Aflatoxin-albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult Ghanaian population显示文摘 | L. Tang L. Xu E. Afriyie-Gyawu W. Liu P. Wang Y. Tang Z. Wang H. J. Huebner N. -A. Ankrah D. Ofori-Adjei J. H. Williams J. -S. Wang T. D. Phillips | 2009 | Food Additives & Contaminants: Part A2009，，1： | 1 |
| 9 | Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical–pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial显示文摘 | Bradley J. Monk Jianmin Wang Samuel Im Richard J. Stock William A. Peters P.Y. Liu Rolland J. Barrett Jonathan S. Berek Luis Souhami Perry W. Grigsby William Gordon David S. Alberts | 2004 | Gynecologic Oncology2004，，3： | 1 |
| 10 | Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform显示文摘 | Esther M.G. Jacobs Jan C.M. Hendriks Berry L.J.H. van Tits Patricia J. Evans William Breuer Ding Yong Liu Eugene H.J.M. Jansen Katri Jauhiainen Brigitte Sturm John B. Porter Barbara Scheiber-Mojdehkar Leni von Bonsdorff Z. Ioav Cabantchik Robert C. Hider | 2005 | Analytical Biochemistry2005，，2： | 1 |
| 11 | Intramucosal esophageal adenocarcinoma: Primum non nocere显示文摘 | Zhigang Li Thomas W. Rice Xiuli Liu John R. Goldblum Sarah J. Williams Lisa A. Rybicki Sudish C. Murthy David P. Mason Daniel P. Raymond Eugene H. Blackstone | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，： | 1 |
| 12 | Failure Patterns in Resected Pancreas Adenocarcinoma: Lack of Predicted Benefit to SMAD4 Expression显示文摘 | Jordan M. Winter Laura H. Tang David S. Klimstra Weiguo Liu Irena Linkov Murray F. Brennan Michael I. D?Angelica Ronald P. DeMatteo Yuman Fong William R. Jarnagin Eileen M. O?Reilly Peter J. Allen | 2013 | Annals of Surgery2013，，2： | 1 |
| 13 | Glycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: Results of double‐blind and open‐label cross‐over trials of insulin lispro and insulin aspart 1型糖尿病患者连续使用胰岛素泵6天后的血糖控制情况:赖脯胰岛素与门冬胰岛素的双盲、开放标签、交叉试验显示文摘 | William V. Tamborlane Eric Renard R. Paul Wadwa Thomas Blevins Scott J. Jacober Rong Liu Deborah N. D’Souza Tina M. Rees | 2015 | Journal of Diabetes2015，，： | 1 |
| 14 | Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin显示文摘 | Wei Liu Xiongyi Huang Mu-Jeng Cheng Robert J. Nielsen William A. Goddard John T. Groves | 2012 | Science2012，，6100： | 1 |
| 15 | BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models显示文摘 | Ningshu Liu Bruce R. Rowley Cathy O. Bull Claudia Schneider Andrea Haegebarth Christoph A. Schatz Paul R. Fracasso Dean P. Wilkie Martin Hentemann Scott M. Wilhelm William J. Scott Dominik Mumberg Karl Ziegelbauer | 2013 | Molecular Cancer Therapeutics2013，，11： | 1 |
| 16 | Iron requirements based upon iron absorption tests are poorly predicted by haematological indices in patients with inactive inflammatory bowel disease显示文摘 | Miranda C. E. Lomer William B. Cook Hamid Jan B. Jan-Mohamed Carol Hutchinson Ding Yong Liu Robert C. Hider Jonathan J. Powell | 2011 | British Journal of Nutrition2011，，12： | 1 |
| 17 | Incidence, Prevalence, and Time Trends of Pediatric Inflammatory Bowel Disease in Northern California, 1996 to 2006显示文摘 | Oren Abramson Michael Durant William Mow Allen Finley Pratima Kodali Anthony Wong Venessa Tavares Erin McCroskey Liyan Liu James D. Lewis James E. Allison Nicole Flowers Susan Hutfless Fernando S. Velayos Geraldine S. Perry Robert Cannon Lisa J. Herrinton | 2010 | The Journal of Pediatrics2010，，2： | 1 |
| 18 | Adult-to-Adult Living Donor Liver Transplantation Using Extended Right Lobe Grafts显示文摘 | Chung-Mau Lo Sheung-Tat Fan Chi-Leung Liu William I. Wei Ronald J. W. Lo Ching-Lung Lai John K. F. Chan Irene O. L. Ng Amy Fung John Wong | 1997 | Annals of Surgery1997，，3： | 1 |
| 19 | Sub-ambient temperature flue gas carbon dioxide capture via Matrimid ? hollow fiber membranes显示文摘 | Lu Liu Edgar S. Sanders Sudhir S. Kulkarni David J. Hasse William J. Koros | 2014 | Journal of Membrane Science2014，，： | 1 |
| 20 | Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance显示文摘 | William L. Holland Joseph T. Brozinick Li-Ping Wang Eric D. Hawkins Katherine M. Sargent Yanqi Liu Krishna Narra Kyle L. Hoehn Trina A. Knotts Angela Siesky Don H. Nelson Sotirios K. Karathanasis Greg K. Fontenot Morris J. Birnbaum Scott A. Summers | 2007 | Cell Metabolism2007，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员