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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Does esophagogastric anastomotic technique influence the outcome of patients with esophageal cancer显示文摘 | Sina E Thomas WR Sudish CM | 2005 | J Thorac Cardiovasc Surg2005，129，3： | 1 |
| 3 | Intramucosal esophageal adenocarcinoma: Primum non nocere显示文摘 | Zhigang Li Thomas W. Rice Xiuli Liu John R. Goldblum Sarah J. Williams Lisa A. Rybicki Sudish C. Murthy David P. Mason Daniel P. Raymond Eugene H. Blackstone | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，： | 1 |
| 4 | Does esophagogastric anastomotic technique influence the outcome of patients with esophageal cancer?显示文摘 | Sina Ercan Thomas W. Rice Sudish C. Murthy Lisa A. Rybicki Eugene H. Blackstone | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，，3： | 1 |
| 5 | A Comparison of Two Stereotactic Body Radiation Fractionation Schedules for Medically Inoperable Stage I Non-small Cell Lung Cancer: The Cleveland Clinic Experience显示文摘 | Kevin L. Stephans Toufik Djemil Chandana A. Reddy Stephen M. Gajdos Matthew Kolar David Mason Sudish Murthy Thomas W. Rice Peter Mazzone Michael Machuzak Tarek Mekhail Gregory M. M. Videtic | 2009 | Journal of Thoracic Oncology2009，，8： | 1 |
| 6 | Is FDG-PET indicated for superficial esophageal cancer? ☆显示文摘 | Sherard G. Little Thomas W. Rice Bohdan Bybel David P. Mason Sudish C. Murthy Gary W. Falk Lisa A. Rybicki Eugene H. Blackstone | 2007 | European Journal of Cardio-Thoracic Surgery2007，，5： | 1 |
| 7 | A Phase II Study of Perioperative Concurrent Chemotherapy, Gefitinib, and Hyperfractionated Radiation Followed by Maintenance Gefitinib in Locoregionally Advanced Esophagus and Gastroesophageal Junction Cancer显示文摘 | Cristina P. Rodriguez David J. Adelstein Thomas W. Rice Lisa A. Rybicki Gregory M. M. Videtic Jerrold P. Saxton Sudish C. Murthy David P. Mason Denise I. Ives | 2010 | Journal of Thoracic Oncology2010，，2： | 1 |
| 8 | Impact of anastomotic airway complications after lung transplantation显示文摘 | SUDISH C MURTHY EUGENE H | 2007 | Ann Thorac Surg2007，84，2： | 1 |
| 9 | Analysis of Reduced Death and Complication Rates After Esophageal Resection显示文摘 | Brian P. Whooley Simon Law Sudish C. Murthy Andreas Alexandrou John Wong | 2001 | Annals of Surgery2001，，3： | 1 |
| 10 | Self - expandable metallic airway stentsand flexible bronehoscopy显示文摘 | Cynthia P Sudish M Georgiann K | 2003 | Chest2003，124，： | 1 |
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