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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Assessment of source water contamination by estrogenic disrupting compounds in China显示文摘Detection of estrogenic disrupting compounds(EDCs) in drinking waters around China has led to rising concerns about health risks associated with these compounds.There is,however,a paucity of studies on the occurrence and identification of the main compounds responsible for this pollution in the source waters.To fill this void,we screened estrogenic activities of 23 source water samples from six main river systems in China,using a recombinant two-hybrid yeast assay.All sample extracts induced significant estrogenic activity,with E2 equivalents(EEQ) of raw water ranging from 0.08 to 2.40 ng/L.Additionally,16 samples were selected for chemical analysis by gas chromatography-mass spectrometry.The EDCs of most concern,including estrone(E1),17β-estradiol(E2),17α-ethinylestradiol(EE2),estriol(E3),diethylstilbestrol(DES),estradiol valerate(EV),4-t-octylphenol(4-t-OP),4-nonylphenols(4-NP) and bisphenol A(BPA),were determined at concentrations of up to 2.98,1.07,2.67,4.37,2.52,1.96,89.52,280.19 and 710.65 ng/L,respectively.Causality analysis,involving comparison of EEQ values from yeast assay and chemical analysis identified E2,EE2 and 4-NP as the main responsible compounds,accounting for the whole estrogenic activities(39.74% to 96.68%).The proposed approach using both chemical analysis and yeast assay could be used for the identification and evaluation of EDCs in source waters of China. | Weiwei Jiang YeYan Mei Ma Donghong Wang Qian Luo Zijian Wang Senthil Kumaran Satyanarayanan | 2012 | Journal of Environmental Sciences2012，24，2： | 29 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Unruptured pregnancy in a noncommunicating rudimentary horn at37 weeks with a live fetus:a case report显示文摘We report an extremely rare case of an unruptured non-communicating rudimentary horn full-term pregnancy.A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live,healthy fetus.The correct diagnosis was not made until cesarean section at 37 4/7 weeks.The case suggests that women who are pregnant in a rudimentary horn could obtain a full-term delivery and give birth to a live and healthy baby. | Chen Cheng Weiwei Tang Lei Zhang Mei Luo Meihua Huang Xiuling Wu Guiping Wan | 2015 | The Journal of Biomedical Research2015，29，1： | 11 |
| 6 | Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser显示文摘We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums. | Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu Linjie Zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai | 2019 | Photonics Research2019，7，11： | 9 |
| 7 | Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis显示文摘The occurrence of osteoarthritis(OA)is highly associated with the reduced lubrication property of the joint,where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism.In this study,bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel,we successfully developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment.Particularly,the lubricating microspheres(GelMA@DMA-MPC)were fabricated by dip coating a self-adhesive polymer(DMA-MPC,synthesized by free radical copolymerization)on superficial surface of photo-crosslinked methacrylate gelatin hydrogel microspheres(GelMA,prepared via microfluidic technology),and encapsulated with an anti-inflammatory drug of diclofenac sodium(DS)to achieve the dual-functional performance.The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the GelMA@DMA-MPC microspheres.In addition,the functionalized microspheres were intra-articularly injected into the rat knee joint with an OA model,and the biological tests including qRT-PCR,immunofluorescence staining assay,X-ray radiography and histological staining assay all revealed that the biocompatible microspheres provided significant therapeutic effect against the development of OA.In summary,the injectable hydrogel microspheres developed herein greatly improved lubrication and achieved sustained local drug release,therefore representing a facile and promising technique for the treatment of OA. | Ying Han Jielai Yang Weiwei Zhao Haimang Wang Yulong Sun Yuji Chen Jing Luo Lianfu Deng Xiangyang Xu Wenguo Cui Hongyu Zhang | 2021 | Bioactive Materials2021，6，10： | 8 |
| 8 | Defects as a factor limiting carrier mobility in WSe2: A spectroscopic investigation显示文摘二维的转变金属 dichalcogenides (TMD ) 的电的表演被结构的缺点的数字强烈影响。在这个工作,我们提供一条光分光镜的描述途径相关结构的缺点的数字和 WSe 2 设备的电的表演。electron-beam-lithographyprocessed WSe 2 的低温度的光致发光(PL ) 系列由于缺点一定的激子展出清楚的导致缺点的 PL 排出物,它将强烈降级电的表演。由采用一种 electron-beam-free 转移电极技术,我们成功地准备了包含缺点的有限数量的一台 backgated WSe 2 设备。约 200 厘米 2 | Zhangting Wu Zhongzhong Luo Yuting Shen Weiwei Zhao Wenhui Wang Haiyan Nan Xitao Guo Litao Sun Xinran Wang Yumeng You Zhenhua Ni | 2016 | Nano Research2016，9，12： | 8 |
| 9 | miR-137 inhibits melanoma cell proliferation through downregulation of GLO1显示文摘Late-stage melanoma is refractory to current therapies. MicroRNAs (miRNAs) can modulate many physiological and pathological processes of melanoma. Studies have demonstrated that miR-137 acts as a tumor suppressor by inhibiting the proliferation of melanoma cells through targeting multiple mRNAs. The glyoxalase system member glyoxalase 1 (GLO1) is the principal scavenging enzyme of methylglyoxal (MG), a toxic byproduct of glycolysis. Using 35S in vivo/vitro labelling analysis for dynamic proteomics (SiLAD), we found that miR-137 downregulated the expression of GLO1 in melanoma cells.Bioinformatics analysis predicted that GLO1 is a direct target of miR-137. This was validated by dual luciferase reporter assay.Quantitative RT-PCR (qRT-PCR) and western blot analysis indicated that miR-137 could decrease endogenous GLO1 expression.Furthermore, siRNA targeting of GLO1 mimicked inhibition of melanoma cell proliferation caused by miR-137 overexpression.Re-expression of GLO1 was able to restore miR-137-mediated suppression of melanoma cell proliferation. Therefore, these results suggest that miR-137 inhibits the proliferation of melanoma cells by targeting GLO1. | Na Lv Shuai Hao Chonglin Luo Alia Abukiwan Ying Hao Fei Gai Weiwei Huang Lingyun Huang Xueyuan Xiao Stefan B.Eichmüller Dacheng He | 2018 | Science China(Life Sciences)2018，61，5： | 7 |
| 10 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 11 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 12 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 13 | Mitochondrial genome sequences of Artemia tibetiana and Artemia urmiana:assessing molecular changes for high plateau adaptation显示文摘Brine shrimps,Artemia(Crustacea,Anostraca),inhabit hypersaline environments and have a broad geographical distribution from sea level to high plateaus.Artemia therefore possess significant genetic diversity,which gives them their outstanding adaptability.To understand this remarkable plasticity,we sequenced the mitochondrial genomes of two Artemia tibetiana isolates from the Tibetan Plateau in China and one Artemia urmiana isolate from Lake Urmia in Iran and compared them with the genome of a low-altitude Artemia,A.franciscana.We compared the ratio of the rate of nonsynonymous(Ka) and synonymous(Ks) substitutions(Ka/Ks ratio) in the mitochondrial protein-coding gene sequences and found that atp8 had the highest Ka/Ks ratios in comparisons of A.franciscana with either A.tibetiana or A.urmiana and that atp6 had the highest Ka/Ks ratio between A.tibetiana and A.urmiana.Atp6 may have experienced strong selective pressure for high-altitude adaptation because although A.tibetiana and A.urmiana are closely related they live at different altitudes.We identified two extended termination-associated sequences and three conserved sequence blocks in the D-loop region of the mitochondrial genomes.We propose that sequence variations in the D-loop region and in the subunits of the respiratory chain complexes independently or collectively contribute to the adaptation of Artemia to different altitudes. | ZHANG HangXiao LUO QiBin SUN Jing LIU Fei WU Gang YU Jun WANG WeiWei | 2013 | Science China(Life Sciences)2013，56，5： | 4 |
| 14 | Magnetic-field enhanced high-thermoelectric performance in topological Dirac semimetal Cd3As2 crystal显示文摘Thermoelectric materials can be used to convert heat to electric power through the Seebeck effect. We study magneto-thermoelectric figure of merit(ZT) in three-dimensional Dirac semimetal Cd_3As_2 crystal.It is found that enhancement of power factor and reduction of thermal conductivity can be realized at the same time through magnetic field although magnetoresistivity is greatly increased. ZT can be highly enhanced from 0.17 to 1.1 by more than six times around 350 K under a perpendicular magnetic field of 7 T. The huge enhancement of ZT by magnetic field arises from the linear Dirac band with large Fermi velocity and the large electric thermal conductivity in Cd_3As_2. Our work paves a new way to greatly enhance the thermoelectric performance in the quantum topological materials. | Honghui Wang Xigang Luo Weiwei Chen Naizhou Wang Bin Lei Fanbao Meng Chao Shang Likuan Ma Tao Wu Xi Dai Zhengfei Wang Xianhui Chen | 2018 | Science Bulletin2018，63，7： | 4 |
| 15 | Mid‐infrared all‐fiber gain‐switched pulsed laser at 3μm显示文摘Mid-infrared(MIR)fiber pulsed lasers are of tremendous application interest in eye-safe LIDAR,spectroscopy,chemical detection and medicine.So far,these MIR lasers largely required bulk optical elements,complex free-space light alignment and large footprint,precluding compact all-fiber structure.Here,we proposed and demonstrated an all-fiberized structured gain-switched Ho3+-doped ZBLAN fiber laser operating around 2.9μm.A home-made 1146 nm Raman fiber pulsed laser was utilized to pump highly concentrated single-cladding Ho3+-doped ZBLAN fiber with different lengths of 2 m or 0.25 m.A home-made MIR fiber mirror and a perpendicular-polished ZBLAN fiber end construct the all-fiberized MIR cavity.Stable gain-switched multiple states with a sub-pulse number tuned from 1 to 8 were observed.The effects of gain fiber length,pump power,pump repetition rate and output coupling ratio on performance of gain-switched pulses were further investigated in detail.The shortest pulse duration of 283 ns was attained with 10 kHz repetition rate.The pulsed laser,centered at 2.92μm,had a maximum average output power of 54.2 mW and a slope efficiency of 10.12%.It is,to the best of our knowledge,the first time to demonstrate a mid-infrared gain-switched Ho3+:ZBLAN fiber laser with compact all-fiber structure. | Xiaojin Zhang Weiwei Li Jin Li Huiying Xu Zhiping Cai Zhengqian Luo | 2020 | Opto-Electronic Advances2020，3，5： | 4 |
| 16 | Phylogenetic Analysis of Brine Shrimp (Artemia) in China Using DNA Barcoding显示文摘DNA barcoding is a powerful approach for characterizing species of organisms,especially those with almost identical morphological features,thereby helping to to establish phylogenetic relationships and reveal evolutionary histories. In this study,we chose a 648-bp segment of the mitochondrial gene,cytochrome c oxidase subunit 1 (COI),as a standard barcode region to establish phylogenetic relation-ships among brine shrimp (Artemia) species from major habitats around the world and further focused on the biodiversity of Artemia species in China,especially in the Tibetan Plateau. Samples from five major salt lakes of the Tibetan Plateau located at altitudes over 4,000 m showed clear differences from other Artemia pop-ulations in China. We also observed two consistent amino acid changes,153A/V and 183L/F,in the COI gene between the high and low altitude species in China. Moreover,indels in the COI sequence were identified in cyst and adult samples unique to the Co Qen population from the Tibetan Plateau,demonstrating the need for additional investigations of the mitochondrial genome among Tibetan Artemia populations. | Weiwei Wang Qibin Luo Haiyan Guo Peter Bossier Gilbert Van Stappen Patrick Sorgeloos Naihong Xin Qishi Sun Songnian Hu Jun Yu | 2008 | Genomics, Proteomics & Bioinformatics2008，6，3： | 3 |
| 17 | B7-DC (PD-L2) costimulation of CD4^(+) T-helper 1 response via RGMb显示文摘The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo.In addition to interacting with the coinhibitory receptor PD-1,B7-DC has also been shown to bind repulsive guidance molecule b(RGMb).The functional consequences of the B7-DC/RGMb interaction,however,remain unclear.More than a decade ago,we reported that replacement of a murine B7-DC mutant lysine with serine(K113S)at positive 113 resulted in a loss of binding capacity to PD-1.Nevertheless,K113S remained costimulatory for T cells in vitro,implicating a dual functionality for B7-DC in T-cell responses.Here we show that recombinant K113S protein interacts with RGMb with a similar affinity to wild-type B7-DC.More importantly,K113S costimulates CD4^(+)T-cell responses via RGMb and promotes Th1 polarization.RGMb is expressed on the surface of naive mouse T cells,macrophages,neutrophils and dendritic cells.Finally,K113S/RGMb costimulation suppresses Th2-mediated asthma and ameliorates small airway inflammation and lung pathology in an experimental mouse model.Our findings indicate that RGMb is a costimulatory receptor for B7-DC.These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses,but also a novel approach to investigate the B7-DC/PD-1/RGMb axis.Recombinant K113S or its derivatives could potentially be developed as an agonist for RGMb to costimulate the Th1 response without triggering PD-1-mediated T-cell inhibition. | Xinxin Nie Wenni Chen Ying Zhu Baozhu Huang Weiwei Yu Zhanshuai Wu Sizheng Guo Yiping Zhu Liqun Luo Shengdian Wang Lieping Chen | 2018 | Cellular & Molecular Immunology2018，15，10： | 3 |
| 18 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 19 | Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications显示文摘To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard segments.The obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering scaffolds.The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation.In addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test.More interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype.Thus,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing. | Hongye Hao Ya Deng Yingke Wu Siyuan Liu Weiwei Lin Jiehua Li Feng Luo | 2017 | Regenerative Biomaterials2017，4，2： | 3 |
| 20 | Influence of exit-to-throat width ratio on performance of high pressure convergent-divergent rotor in a vaneless counter-rotating turbine显示文摘This paper describes the redesign of a high pressure rotor (with exit Mach number around 1.5) for the vaneless counter-rotating turbine by choosing adequate exit-to-throat width ratio. Based on the previous design analysis and test results, effects of the exit-to-throat width ratio on the performance of the transonic turbine cascade were proposed. In order to investigate the influence of the exit-to-throat width ratio on the performance of the turbine cascade, a flow model of the convergent-divergent turbine cascade was constructed by using the theory of Laval nozzle. Then a method on how to choose the adequate exit-to-throat width ratio for the turbine cascade was proposed. To validate the method, it was used to calculate the adequate exit-to-throat width ratio for the high pressure rotor of the vaneless counter-rotating turbine. The high pressure turbine rotor was redesigned with the new exit-to-throat width ratio. Numerical simulation results show that the isentropic efficiency of the redesigned vaneless counter-rotating turbine under the design condition has increased by 0.9% and the efficiencies under the off-design conditions are also improved significantly. On the original design, a group of compressional waves are created from the suction surface after about 60% axial chord in the high pressure turbine rotor. While on the new design the compressional waves are eliminated. Furthermore, on the original design, the inner-extending waves first impinge on the next high pressure turbine rotor suction surface. Its reflection is strong enough and cannot be neglected. However on the new design the inner-extending waves are weakened or even eliminated. Another main progress is that the redesigned high pressure turbine rotor is of practical significance. In the original rotor, a part of the blade (from 60% axial chord to the trailing edge) is thin leading to the intensity problem and difficult arrangement of the cooling system. In the new design, however, the thickness distribution of the rotor airfoil along the chord is relatively reasonable. The intensity of the rotor is enhanced. It is possible to arrange the cooling system reasonably. | ZHANG Lei WANG HuiShe LUO WeiWei XU JianZhong | 2011 | Science China(Technological Sciences)2011，54，3： | 3 |
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