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| 1 | Recent glacial retreat in High Asia in China and its impact on water resource in Northwest China显示文摘Under the impact of climatic warming, the glaciers in the High Asia in China have been retreating continuously with negative glacial mass balance in recent several decades. The retreat became more intensive in the past 10 years. The spatial pattern of the glacial retreat in the High Asia in China is that the smallest magnitude of retreat is in the inland of the Tibetan Plateau, the magnitude increases from the inland to the margin of the Tibetan Plateau, and the largest magnitude at the margin of the Tibetan Plateau. The glacial retreat in the High Asia in China has an important impact on the water resource of the arid regions in Northwest China. This study shows that the glacial retreat in the 1990s has caused an increase of 5.5% in river runoff in Northwest China. In the Tarim River basin, the increase of river runoff is higher than 5.5%. | YAO Tandong 1,2 ,WANG Youqing 2 ,LIU Shiying 2,1 ,PU Jianchen 2,1 ,SHEN Yongping 2 & LU Anxin 2,1 1.Institute of Tibetan Plateau Research,Chinese Academy of Sciences,Beijing 100029,China 2.Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou 730000,China | 2004 | Science China Earth Sciences2004，47，12： | 117 |
| 2 | Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats显示文摘Ischemic stroke is a common disease with high mortality and morbidity worldwide.One of the important pathophysiological effects of ischemic stroke is apoptosis.A neuroprotective effect is defined as the inhibition of neuronal apoptosis to rescue or delay the infarction in the surviving ischemic penumbra.Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR.Therefore,this study aimed to elucidate the neuroprotective effect of resveratrol on cerebral ischemia/reperfusion injury and to investigate the signaling pathways and mechanisms through which resveratrol regulates apoptosis in the ischemic penumbra.Rats were subjected to middle cerebral artery occlusion for 2 h followed by 24 h reperfusion.Cerebral infarct volume was measured using 2%TTC staining.TUNEL staining was conducted to evaluate neuronal apoptosis.Western blotting and immunohistochemistry were used to detect the proteins involved in the JAK2/STAT3/PI3K/AKT/mTOR pathway.The results suggested that resveratrol significantly improved neurological function,reduced cerebral infarct volume,decreased neuronal damage,and markedly attenuated neuronal apoptosis;these effects were attenuated by the inhibition of PI3K/AKT with LY294002 and JAK2/STAT3 with AG490.We also found that resveratrol significantly upregulated the expression of p-JAK2,p-STAT3,p-AKT,p-mTOR,and BCL-2 and downregulated expression of cleaved caspase-3 and BAX,which was partially reversed by LY294002 and AG490.These results suggested that resveratrol provides a neuroprotective effect against cerebral ischemia/reperfusion injury,which is partially mediated by the activation of JAK2/STAT3 and PI3K/AKT/mTOR.Resveratrol may indirectly upregulate the PI3K/AKT/mTOR pathway by activating JAK2/STAT3. | Yongying Hou Ke Wang Weijun Wan Yue Cheng Xia Pu Xiufeng Ye | 2018 | Genes & Diseases2018，5，3： | 60 |
| 3 | Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration显示文摘 | Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 45 |
| 4 | Fractional differential approach to detecting textural features of digital image and its fractional differential filter implementation显示文摘This paper mainly discusses fractional differential approach to detecting textural features of digital image and its fractional differential filter. Firstly,both the geometric meaning and the kinetic physical meaning of fractional differential are clearly explained in view of information theory and kinetics,respectively. Secondly,it puts forward and discusses the definitions and theories of fractional stationary point,fractional equilibrium coefficient,fractional stable coefficient,and fractional grayscale co-occurrence matrix. At the same time,it particularly discusses fractional grayscale co-occurrence matrix approach to detecting textural features of digital image. Thirdly,it discusses in detail the structures and parameters of n×n any order fractional differential mask on negative x-coordinate,positive x-coordinate,negative y-coordinate,positive y-coordinate,left downward diagonal,left upward diagonal,right downward diagonal,and right upward diagonal,respectively. Furthermore,it discusses the numerical implementation algorithms of fractional differential mask for digital image. Lastly,based on the above-mentioned discussion,it puts forward and discusses the theory and implementation of fractional differential filter for digital image. Experiments show that the fractional differential-based image operator has excellent feedback for enhancing the textural details of rich-grained digital images. | PU YiFei WANG WeiXing ZHOU JiLiu WANG YiYang JIA HuaDing | 2008 | Science in China(Series F)2008，51，9： | 50 |
| 5 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 6 | Quantitative characterization of reservoir space in the Lower Silurian Longmaxi Shale,southern Sichuan,China显示文摘Based on the drilling data of the Upper Ordovician Wufeng Shale and the Lower Silurian Longmaxi Shale in southern Sichuan Basin,the construction of matrix pores and the development condition of fractures in a marine organic-rich shale are quantitatively evaluated through the establishment of the reservoir petrophysical models and porosity mathematical models.Our studies show that there are four major characteristics of the Longmaxi Shale confirmed by the quantitative characterization:(1)the pore volume of per unit mass is the highest in organic matter,followed in clay minerals,finally in brittle minerals;(2)the porosity of the effective shale reservoir is moderate and equal to that of the Barnett Shale,and the main parts of the shale reservoir spaces are interlayer pores of clay minerals and organic pores;(3)the porosity of the organic-rich shale is closely related to TOC and brittle mineral/clay mineral ratio,and mainly increases with TOC and clay mineral content;(4)fractures are developed in this black shale,and are mainly micro ones and medium-large ones.In the Longmaxi Shale,the fracture density increases from top to bottom,reflecting the characteristics with high brittle mineral content,high Young’s modulus,low Poisson's ratio and high brittleness at its bottom. | WANG YuMan DONG DaZhong YANG Hua HE Ling WANG ShiQian HUANG JinLiang PU BoLing WANG ShuFang | 2014 | Science China Earth Sciences2014，57，2： | 36 |
| 7 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018，3，3： | 37 |
| 8 | Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance. | LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao | 2013 | Science China(Life Sciences)2013，56，6： | 32 |
| 9 | Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors显示文摘 | Sun Tieying Sun Li Wang Rongmei Ren Xiaoping Sui Dong-jiang Pu Chun Ren Yajuan Liu Ying Yang Zhuo Li Fengzhi | 2014 | Chinese Medical Journal2014，，7： | 34 |
| 10 | Analysis of Pathological data of renal biopsy at one single center in China from 1987 to 2012显示文摘 | Zhang Xueguang Liu Shuwen Tang Li Wu Jie Chen Pu Yin Zhong Li Minxia Xie Yuansheng Cai Guangyan Wei Ribao Qiu Qiang Wang Yuanda Shi Suozhu Chen Xiangmei | 2014 | Chinese Medical Journal2014，，9： | 30 |
| 11 | Bicarbonate Daily Variations in a Karst River:the Carbon Sink Effect of Subaquatic Vegetation Photosynthesis显示文摘用 Guancun 河,一条地下的喂溪流的河在 Guangxi 的 Rong'an 县,是的中国案例研究,每天生物化学的周期基于收集的数据在这篇论文被检验一经由高分辨率数据记录程序监视和高周波的采样一周。而且,沿着它的流动路径的无机的碳的损失被估计。结果证明地下水输入的化学部件是相当稳定的,显示出很少变化程度;当所有在监视时期上来自二个下游的监视车站的化学参数显示出一天一夜的变化时,在河里建议那项植物活动在河的水化学上有强烈影响。从有 HCO3 的输出流动的地下水的输入流动的比较在高周波的采样期间在下游的监视车站估计时期显示出 HCO3 的强壮的减少,显示河正在失去沿着它的流动路径的无机的碳。损失被估计是沿着 Guancun 河的 1,350 m 节代表无机的碳的大约 94.9 kg/day 的 HCO3 的大约 1,152 mmol/day/m。它意味着秘密地从石灰岩地区常见的地形进入河的 HCO3 流是植物消费或在 authigenic 方解石套住的任何一个并且因此为 Guancun 石灰岩地区常见的地形系统组成碳的一个自然水池。 | ZHANG Cheng WANG Jinliang PU Junbing YAN Jun | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 27 |
| 12 | Determining N supplied sources and N use efficiency for peanut under applications of four forms of N fertilizers labeled by isotope^15N显示文摘Rational application of different forms of nitrogen(N) fertilizer for peanut(Arachis hypogaea L.) requires tracking the N supplied sources which are commonly not available in the differences among the three sources:root nodule,soil and fertilizer.In this study,two kinds of peanut plants(nodulated variety(Huayu 22) and non-nodulated variety(NN-1)) were choosed and four kinds of N fertilizers:urea-N(CONH_2-N),ammonium-N(NH_4^+-N),nitrate-N(NO_3^--N) and NH_4^+ +NO_3^--N labeled by^(15)N isotope were applied in the field barrel experiment in Chengyang Experimental Station,Shandong Province,China,to determine the N supplied sources and N use efficiency over peanut growing stages.The results showed that intensities and amounts of N supply from the three sources were all higher at middle growing stages(pegging phase and podding phase).The accumulated amounts of N supply from root nodule,soil and fertilizer over the growing stages were 8.3,5.3 and 3.8g m^(-2) in CONH_2-N treatment,which are all significantly higher than in the other three treatments.At seedling phase,soil supplied the most N for peanut growth,then root nodule controlled the N supply at pegging phase and podding phase,but soil mainly provided N again at the last stage(pod filling phase).For the whole growing stages,root nodule supplied the most N(47.8 and 43.0%) in CONH_2-N and NH_4^+-N treatments,whereas soil supplied the most N(41.7 and 40.9%) in NH_4^+ +NO_3^--N and NO_3^--N treatments.The N use efficiency was higher at pegging phase and podding phase,while accumulated N use efficiency over the growing stages was higher in CONH_2-N treatment(42.2%) than in other three treatments(30.4%in NH_4^+-N treatment,29.4%in NO_3^--N treatment,29.4%in NH_4^+ +NO_3^--N treatment).In peanut growing field,application of CONH_2-N is a better way to increase the supply of N from root nodule and improve the N use efficiency. | WANG Cai-bin ZHENG Yong-mei SHEN Pu ZHENG Ya-ping WU Zheng-feng SUN Xue-wu YU Tian-yi FENG Hao | 2016 | Journal of Integrative Agriculture2016，15，2： | 28 |
| 13 | Concentrations,profiles and gas-particle partitioning of PCDD/Fs,PCBs and PBDEs in the ambient air of an E-waste dismantling area,southeast China显示文摘Polychlorinated diebenzo-p-dioxins(PCDDs),polychlorinated diebenzofurans(PCDFs),polychlorinated biphenyls(PCBs) and polybrominated diphenyl ethers(PBDEs) were monitored in the ambient air of Taizhou,an E-waste dismantling area of southeast China to evaluate their concentrations,profiles and gas-particle partitioning.The ΣPCDD/Fs concentrations ranged from 2.91 to 50.6 pg/m3,with an average of 14.3 pg/m3.The I-TEQs for PCDD/Fs were in the range of 0.20-3.45 pg/m3,with an average of 1.10 pg/m3.The ΣPCBs concentrations and TEQs ranged from 4.23 to 11.35 ng/m3,0.050 to 0.859 pg(TEQ)/m3,respectively.The concentrations of ΣPBDEs ranged from 92 to 3086 pg/m3,with an average of 894 pg/m3.The pollution levels of PCDD/Fs,PCBs and PBDEs were higher than other urban sites,which may be associated with the E-waste dismantling activities.The PCDD/Fs were found exclusively in the particle phase whereas PCBs distributed dominantly in the gas phase.The gas-partilce partitioning was also assessed by correlating the gas-particle partition coefficient(Kp) with the subcooled liquid vapor pressure(PL0).The measured particulate sorptions of PCDD/Fs,PCBs and PBDEs were compared with the predictions from Junge-Pankow model and Koa absorption model.The Junge-Pankow model well estimated the particulate fractions of PCBs.However,it underestimated the sorptions of PCDD/Fs and overestimated the fractions of PBDEs.The predicted particulate fractions of PCDD/Fs and PCBs from Koa model fitted well with the measured data. | LI YingMing JIANG GuiBin WANG YaWei WANG Pu ZHANG QingHua | 2008 | Chinese Science Bulletin2008，53，4： | 26 |
| 14 | Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats显示文摘瞄准:为了决定象到 streptozotocin (STZ ) 的阴茎的 growthfactor-1 (IGF-1 ) 一样的胰岛素的 adenoviral 基因转移是否导致了糖尿病的老鼠,能改进可勃起的能力。方法:STZ 糖尿病的老鼠是有 AdCMV-β g al 或 AdCMV-IGF-1 的 transfected。Theserats 经历了多孔的神经刺激估计可勃起的功能,他们的回答与匹配年龄的控制老鼠的那些相比在 transfection 以后的 1 ~ 2 天。在控制 andtransfected STZ 糖尿病的老鼠, IGF-1 表示被反向的抄写聚合酶链反应(RT-PCR ) 检验,西方的污点和组织学。STZ 糖尿病的老鼠的阴茎β - 牛乳糖活动和本地化也是坚定的。结果:一~二天 aftertransfection,β - 牛乳糖与 AdCMV-β g al 在糖尿病的老鼠 penistransfected 的光滑的肌肉房间被发现。到在 AdCMV-IGF-1 的管理以后的 2 天, cavernosalpressure 由最大的 intracavernous pressure-to-mean 的比率决定了动脉的压力(ICP/MAP ) 和全部的 intracavernous 压力(ICP ) ,响应多孔的神经刺激被增加。Transgene 表示被 RT-PCR,西方的污点和组织学证实。结论: IGF-1 的基因转移显著地在 STZ 糖尿病的老鼠增加了可勃起的功能。Theseresults 建议在 vivo, IGF-1 的基因转移可能在 STZ 糖尿病的老鼠是为可勃起的机能障碍(编辑) 的治疗的新治疗学的干预。 | Xiao-Yong Pu Li-Quan Hu Huai-Peng Wang Yao-Xiong Luo Xing-Huan Wang | 2007 | Asian Journal of Andrology2007，9，1： | 24 |
| 15 | Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘 | Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu | 2015 | Cell Research2015，25，5： | 24 |
| 16 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 17 | Variations in equilibrium line altitude of the Qiyi Glacier,Qilian Mountains,over the past 50 years显示文摘Based on observations of the equilibrium line altitude(ELA)of the Qiyi Glacier in the Qilian Mountain,we established a statistical model between ELA and its major influencing factors,warm season air temperature(air temperature averages for September,July and August)and cold season precipitation(total precipitation in the period January through March).Warm season air temperature was the leading climatic factor influencing ELA variations.The glacier ELA ascends(descends)172 m when warm season air temperature increases(decreases)by 1°C,and ascends(descends)62 m when cold season precipitation decreases(increases)by 10%.In the period 1958-2008,the glacier ELA showed a general increasing trend,ascending 230 m and reaching its highest altitude in 2006 at 5131 m a.s.l.,close to the glacier summit.If future climate is similar to that in the period 2001-2008,the Qiyi Glacier will not stabilize until it retreats by 2.08 km. | WANG NingLian HE JianQiao PU JianChen JIANG Xi JING ZheFan | 2010 | Chinese Science Bulletin2010，55，33： | 22 |
| 18 | Progress in active compounds effective on ulcerative colitis from Chinese medicines显示文摘Ulcerative colitis(UC), a chronic inflammatory disease affecting the colon, has a rising incidence worldwide. The known pathogenesis is multifactorial and involves genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Nowadays, the drugs for UC include 5-aminosalicylic acid, steroids, and immunosuppressants. Long-term use of these drugs, however, may cause several side effects, such as hepatic and renal toxicity, drug resistance and allergic reactions. Moreover, the use of traditional Chinese medicine(TCM) in the treatment of UC shows significantly positive effects, low recurrence rate, few side effects and other obvious advantages. This paper summarizes several kinds of active compounds used in the experimental research of anti-UC effects extracted from TCM, mainly including flavonoids, acids, terpenoids, phenols, alkaloids, quinones, and bile acids from some animal medicines. It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine(IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines(TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS. This review may offer valuable reference for UC-related studies on the compounds from natural medicines. | CAO Si-Yu YE Sheng-Jie WANG Wei-Wei WANG Bing ZHANG Tong PU Yi-Qiong | 2019 | Chinese Journal of Natural Medicines2019，17，2： | 23 |
| 19 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 20 | ^(40)Ar-^(39)Ar ages of the Louzidian-Dachengzi ductile shear zone near Chifeng,Inner Mongolia and their tectonic significance显示文摘The Louzidian normal fault occurs as the eastern detachment fault of the Kalaqin metamorphic core complex. Field observations and microstructural analyses reveal that the Louzidian-Dachengzi ductile shear zone developed in its lower-plate was genetically related to sinistral strike-slips and extensional faulting. Two samples from this ductile shear zone yield 40Ar-39Ar plateau ages of 133 Ma (Bi) and 126 Ma (Kp), which are concordant with their isochron ages. The plateau age of 133 Ma (Bi) records the formation age of the ductile shear zone. The inconsistent relationship between the earlier strike-slip ductile shear zone and the later normal fault makes the Kalaqin Quasi-metamorphic core complex distinctive from Cordil-leran nietamorphic core complex. These ages provide important geochronological data for putting constraints on the formation age and genesis of such ductile shear zones. | ZHANG Xiaohui, LI Tiesheng, PU Zhiping & WANG HuiResearch Center for Mineral Resources Exploration, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, G | 2002 | Chinese Science Bulletin2002，47，15： | 21 |
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