|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Engineering the Smart Factory显示文摘The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration,application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems(CPS) engineering tools being developed by the automation systems group(ASG) at Warwick Manufacturing Group, University of Warwick, UK. | HARRISON Robert VERA Daniel AHMAD Bilal | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 7 |
| 3 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 5 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 6 | Intensive Lipid Lowering With Atorvastatin in Patients With Coronary Heart Disease and Chronic Kidney Disease显示文摘 | James Shepherd John J.P. Kastelein Vera Bittner Prakash Deedwania Andrei Breazna Stephen Dobson Daniel J. Wilson Andrea Zuckerman Nanette K. Wenger | 2008 | Journal of the American College of Cardiology2008，，15： | 1 |
| 7 | Use of Red Mud as Addition for Portland Cement Mortars显示文摘 | Daniel Veras Ribeiro Joao A. Labrincha Maircio R. Morelli | 2010 | 材料科学与工程(中英文版)2010，4，8： | 1 |
| 8 | R-spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice显示文摘 | Jingsong Zhao Josephine de Vera Seiko Narushima Eric X. Beck Servando Palencia Pauline Shinkawa Kyung–Ah Kim Yi Liu Michael D. Levy Daniel J. Berg Arie Abo Walter D. Funk | 2007 | Gastroenterology2007，，4： | 1 |
| 9 | The use of CAD/CAM technology to fabricate a custom ceramic implant abutment: A clinical report显示文摘 | Martinna de Mendon?a e Bertolini Juan Kempen Eduardo José Veras Louren?o Daniel de Moraes Telles | 2013 | The Journal of Prosthetic Dentistry2013，，： | 1 |
| 10 | Development and validation of a three-dimensional kinematic model for the MePherson steering and suspension mechanisms 显示文摘 | Daniel A Mantaras Pablo Luque Carlos Vera | 2004 | Mechanism and Machine Theory2004，39，6： | 1 |
| 11 | Colorectal cancer in patients with inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis显示文摘 | Alonso Vera Bridget K. Gunson Val Ussatoff Peter Nightingale Daniel Candinas Simon Radley A. David Mayer John A.C. Buckels Paul McMaster James Neuberger Darius F. Mirza | 2003 | Transplantation2003，，12： | 1 |
| 12 | Heart Failure as a Newly Approved Diagnosis for Cardiac Rehabilitation显示文摘 | Daniel E. Forman Bonnie K. Sanderson Richard A. Josephson Jayant Raikhelkar Vera Bittner | 2015 | Journal of the American College of Cardiology2015，，： | 1 |
| 13 | Intensive Lipid Lowering With Atorvastatin in Patients With Coronary Heart Disease and Chronic Kidney Disease显示文摘 | James Shepherd John J.P. Kastelein Vera Bittner Prakash Deedwania Andrei Breazna Stephen Dobson Daniel J. Wilson Andrea Zuckerman Nanette K. Wenger | 2008 | Journal of the American College of Cardiology2008，，15： | 1 |
| 14 | Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN显示文摘 | Niubys Cayado-Gutiérrez Vera L. Moncalero Eliana M. Rosales Walter Berón Edgardo E. Salvatierra Daiana Alvarez-Olmedo Martín Radrizzani Daniel R. Ciocca | 2013 | Cell Stress and Chaperones2013，，2： | 1 |
| 15 | The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen显示文摘 | Matthew P. Goetz Stacey K. Knox Vera J. Suman James M. Rae Stephanie L. Safgren Matthew M. Ames Daniel W. Visscher Carol Reynolds Fergus J. Couch Wilma L. Lingle Richard M. Weinshilboum Emily G. Barr Fritcher Andrea M. Nibbe Zeruesenay Desta Anne Nguyen D | 2007 | Breast Cancer Research and Treatment2007，，1： | 1 |
| 16 | Biliary, Pancreatic, and Sphincter of Oddi Electrical and Mechanical Signals Recorded During ERCP显示文摘 | Thomas L. Abell Robert F. Werkman Babajide O. Familoni Wagdy Baggous Daniel Massie Santiago Vera | 1998 | Digestive Diseases and Sciences1998，，3： | 1 |
| 17 | Intensive Lipid Lowering With Atorvastatin in Patients With Coronary Heart Disease and Chronic Kidney Disease显示文摘 | James Shepherd John J.P. Kastelein Vera Bittner Prakash Deedwania Andrei Breazna Stephen Dobson Daniel J. Wilson Andrea Zuckerman Nanette K. Wenger | 2008 | Journal of the American College of Cardiology2008，，15： | 1 |
| 18 | Development and validation of a three-dimensional kinematic model for the McPherson steering and suspension mechanisms显示文摘 | Daniel A. Mántaras Pablo Luque Carlos Vera | 2004 | Mechanism and Machine Theory2004，，6： | 1 |
| 19 | Prevalence of epilepsy in the onchocerciasis endemic middle belt of Ghana after 27 years of mass drug administration with ivermectin显示文摘BackgroundIn onchocerciasis-endemic areas with high ongoing Onchocerca volvulus transmission,a high prevalence of epilepsy has been reported.This study aimed to determine the prevalence and clinical characteristics of epilepsy in the Bono Region of Ghana following 27 years of implementation of ivermectin mass drug administration(MDA).MethodsBetween October 2020 and August 2021,cross-sectional surveys were conducted in nine communities in the Tain District and Wenchi Municipality of the Bono Region of Ghana.In the first stage,a random door-to-door approach was used to screen the population for epilepsy using a pre-tested questionnaire.Persons suspected of having epilepsy were invited for a second-stage neurological examination for case verification.Community O.volvulus microfilarial infection status and Ov16 seropositivity were also determined.Ninety-five confidence intervals(95%CI)for prevalence values were calculated using the Wilson Score Interval.ResultsOf the 971 participants,500(51.5%)were females,and the median age(interquartile range)was 26(15‒43)years.Fourteen participants(1.4%,95%CI:1.0‒2.0)were diagnosed as having epilepsy with generalized seizures being the most frequent seizure type(85.7%,12/14).The overall microfilarial prevalence of O.volvulus was 10.3%(November 2020)and 9.9%(August 2021);the Ov16 seroprevalence was 22.2%(June 2021).Only 63.2%took ivermectin in the last round of MDA distribution in March 2021.ConclusionsThe 1.4%prevalence of epilepsy in the Bono region is similar to the median epilepsy prevalence in sub-Saharan Africa.However,the persistent microfilarial prevalence and low ivermectin study coverage call for the Ghana Onchocerciasis Elimination Programme to step up its efforts to ensure that the gains achieved are consolidated and improved to achieve the elimination of onchocerciasis by 2030. | Kenneth Bentum Otabil Blessing Ankrah Emmanuel John Bart-Plange Emmanuel Sam Donkoh Fiona Amoabil Avarikame Fredrick Obeng Ofori-Appiah Theophilus Nti Babae Prince-Charles Kudzordzi Vera Achiaa Darko Joseph Ameyaw Joseph Gyekye Bamfo Raji Abdul Sakibu Daniel Antwi-Berko Joseph Nelson Siewe Fodjo María-Gloria Basáñez Henk D.F.H.Schallig Robert Colebunders | 2023 | Infectious Diseases of Poverty2023，12，4： | 0 |
| 20 | Comprehensive Flow Cytometry Analysis of PEI-Based Transfections for Virus-Like Particle Production显示文摘The generation of stable clones for biomolecule production is a common but lengthy and labor-intensive process.For complex molecules,such as viruses or virus-like particles(VLPs),the timeline becomes even more cumbersome.Thus,in the early stages of development,transient production methods serve as a reasonable alternative to stable clone construction.In this work,an investigation of a polyethylenimine-(PEI-)based transfection method for the transient production of Chikungunya(Chik)VLPs,a vaccine candidate molecule,was undertaken.This effort focuses on tracking cell population responses during transfection,understanding how process changes affect these responses,and monitoring patterns in cell performance over the culture duration.Plasmid labeling and VLP staining were employed to comprehensively track cells via flow cytometry and to draw correlations between plasmid DNA(pDNA)uptake and the resulting VLP expression.The method detected high transfection efficiency(≥97%)in all samples tested and demonstrated the capability to track kinetics of plasmid-cell binding.With varied transfection cell concentrations,the pDNA binding kinetics are altered and saturation binding is observed in the lowest cell concentration sample tested in less than 3 hours of incubation.Interestingly,in all samples,the flow cytometry analysis of relative pDNA amount versus VLP expression staining showed that cells which contained fewer pDNA complexes resulted in the highest levels of VLP stain.Finally,to determine the potential breadth of our observations,we compared daily expression patterns of ChikVLP with a reporter,monomeric GFP molecule.The similarities detected suggest the interpretations presented here to likely be more broadly informative and applicable to PEI-based transient production of additional biological products as well. | Daniel J.Blackstock Alvenne Goh Shamitha Shetty Giulia Fabozzi Rong Yang Vera BIvleva Richard Schwartz Joseph Horwitz | 2020 | Research2020，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员